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Joyce U. Nyiro, Ivy K. Kombe, Charles J. Sande, James Kipkoech, Patience K. Kiyuka, Clayton O. Onyango, Patrick K. Munywoki, Timothy M. Kinyanjui, D. James Nokes
Defining the vaccination window for respiratory syncytial virus (RSV) using age-seroprevalence data for children in Kilifi, Kenya
www.plosone.org
www.plosone.org
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1.5478 0 Td
(a)Tj
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(bearing)Tj
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(RSV)Tj
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(vaccine)Tj
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q
1 j
1 J
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1 TL
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1 TL
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(12)Tj
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1.0261 0 Td
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3.2202 0 Td
(Hospital)Tj
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(\(KCH\))Tj
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(wards)Tj
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(between)Tj
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(\(inclusive\).)Tj
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(\(KDH\),)Tj
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7.4999 0 0 6.6659 364.9889 410.1165 cm
BT
/F7 1 Tf
1 TL
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ET
Q
q
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BT
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2.2054 0 Td
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4.3483 0 Td
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(\(KIDMS\))Tj
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(admission)Tj
4.3143 0 Td
(register)Tj
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(regardless)Tj
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(diagnosis)Tj
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(and)Tj
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(age)Tj
1.5421 0 Td
(groups)Tj
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(up)Tj
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(to)Tj
1.0261 0 Td
(11)Tj
1.1736 0 Td
(months,)Tj
3.5036 0 Td
(then)Tj
2.0182 0 Td
(12-)Tj
/F11 1 Tf
0 Tc
(<)Tj
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(15m,)Tj
4.2915 0 Td
(15-)Tj
/F11 1 Tf
0 Tc
(<)Tj
/F7 1 Tf
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(18m,)Tj
4.2917 0 Td
(18-)Tj
/F11 1 Tf
0 Tc
(<)Tj
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-0.004 Tc
(24m,)Tj
4.2859 0 Td
(24-)Tj
/F11 1 Tf
0 Tc
(<)Tj
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(36m,)Tj
4.2917 0 Td
(36-)Tj
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0 Tc
(<)Tj
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-33.5789 -1.2983 Td
(60m,)Tj
2.2166 0 Td
(60-84m,)Tj
3.515 0 Td
(84-)Tj
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0 Tc
(<)Tj
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-0.004 Tc
(108m)Tj
4.541 0 Td
(and)Tj
1.7292 0 Td
(108)Tj
/F11 1 Tf
0 Tc
(<)Tj
/F7 1 Tf
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(145m.)Tj
4.8925 0 Td
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2.5681 0 Td
(children)Tj
3.5546 0 Td
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1.0261 0 Td
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2.7043 0 Td
(serum)Tj
2.7269 0 Td
(samples)Tj
-34.3272 -1.2983 Td
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1.2756 0 Td
(admission,)Tj
4.541 0 Td
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2.6476 0 Td
(were)Tj
2.126 0 Td
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3.7813 0 Td
(and)Tj
1.7291 0 Td
(an)Tj
1.2019 0 Td
(aliquot)Tj
3.0047 0 Td
(screened)Tj
3.7247 0 Td
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1.3889 0 Td
(the)Tj
1.4684 0 Td
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3.7133 0 Td
(of)Tj
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(an-)Tj
-35.3533 -1.3039 Td
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3.3788 0 Td
(to)Tj
1.0262 0 Td
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2.2337 0 Td
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2.5058 0 Td
(a)Tj
0.6519 0 Td
(resident)Tj
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(of)Tj
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(KHDSS,)Tj
3.5772 0 Td
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3.8154 0 Td
(to)Tj
1.0261 0 Td
(KCH)Tj
2.3244 0 Td
(between)Tj
3.5263 0 Td
(2007)Tj
2.1203 0 Td
(and)Tj
1.7348 0 Td
(2010)Tj
2.1203 0 Td
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-34.4973 -1.2983 Td
(having)Tj
2.9139 0 Td
(a)Tj
0.6577 0 Td
(stored)Tj
2.7099 0 Td
(plasma)Tj
3.0274 0 Td
(sample)Tj
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4.3142 0 Td
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(inclusion)Tj
3.9175 0 Td
(criteria.)Tj
3.3052 0 Td
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1.3946 0 Td
(re-admissions)Tj
5.8166 0 Td
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-34.1514 -1.2982 Td
(excluded,)Tj
4.0081 0 Td
(i.e.)Tj
1.3606 0 Td
(the)Tj
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(total)Tj
2.0013 0 Td
(number)Tj
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3.3846 0 Td
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1.0317 0 Td
(the)Tj
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3.3278 0 Td
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(the)Tj
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(reduce)Tj
2.9197 0 Td
(bias)Tj
1.7915 0 Td
(due)Tj
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5.0455 0 Td
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(60)Tj
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(that)Tj
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(each)Tj
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(20)Tj
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(3)Tj
0.6973 0 Td
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(48)Tj
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1.0262 0 Td
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3.2881 0 Td
(seroprevalence)Tj
6.1512 0 Td
(precision)Tj
3.906 0 Td
(estimates)Tj
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(50%)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ethical)Tj
3.1842 0 Td
(approval)Tj
ET
Q
q
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1 J
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10 0 0 10 200.0125 109.0204 cm
BT
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1 TL
-0.004 Tc
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(parents)Tj
3.1748 0 Td
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(guardians)Tj
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(their)Tj
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(paedi-)Tj
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(inpatient)Tj
3.8211 0 Td
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1.7291 0 Td
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1.389 0 Td
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1.0375 0 Td
(future)Tj
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1.7801 0 Td
(KEMRI)Tj
3.3165 0 Td
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3.0954 0 Td
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4.7395 0 Td
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3.9742 0 Td
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1.6724 0 Td
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ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 473.3858 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(RSV)Tj
2.2464 0 Td
(serological)Tj
4.904 0 Td
(data)Tj
2.126 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
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(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
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