Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

@article{Papadia2008SynapticNR,
  title={Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses},
  author={Sofia Papadia and Francesc X. Soriano and Fr{\'e}d{\'e}ric L{\'e}veill{\'e} and Marc‐Andr{\'e} Martel and Kelly A. Dakin and Henrik H. Hansen and Angela M. Kaindl and Marco Sifringer and Jill H. Fowler and Vanya Stefovska and Grahame J. McKenzie and Marie Craigon and Roderick A. Corriveau and Peter Ghazal and Karen Horsburgh and Bruce A Yankner and David J. A. Wyllie and Chrysanthy Ikonomidou and Giles E. Hardingham},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={476-487},
  url={https://api.semanticscholar.org/CorpusID:4667922}
}
It is found that in rat neurons, synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosted antioxidant defenses by making changes to the thioredoxin-peroxiredoxin system by influencing the progression of pathological processes associated with oxidative damage.
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55 References

Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability

Exposure to low preconditioning doses of NMDA results in preferential activation of synaptic NMDA receptors because of a dramatic increase in action potential firing, in apparent contradiction with recent findings that extrasynaptic NMDA receptor signaling exerts a dominant inhibitory effect on prosurvival signaling from synapticNMDA receptors.

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Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron…

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