%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Gideon A. Erkenswick, Mrinalini Watsa, M. Andreína Pacheco, Ananias A. Escalante, Patricia G. Parker
Chronic Plasmodium brasilianum infections in wild Peruvian tamarins
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref004)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref004)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref007)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref008)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref009)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref010)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref007)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref011)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref014)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref013)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref015)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref016)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref017)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref017)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref018)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref019)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref020)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref017)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref021)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref013)>>
endobj
41 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref022)>>
endobj
42 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref023)>>
endobj
43 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref017)>>
endobj
44 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref018)>>
endobj
45 0 obj
<>/Border[0 0 0]/A 48 0 R>>
endobj
48 0 obj
<>
endobj
46 0 obj
<>/Border[0 0 0]/A 49 0 R>>
endobj
49 0 obj
<>
endobj
47 0 obj
<>/Border[0 0 0]/A 50 0 R>>
endobj
50 0 obj
<>
endobj
15 0 obj
[51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R]
endobj
51 0 obj
<>stream
q
0.83 0.64 0.02 0 k
300.6992 674.9858 m
305.4614 674.9858 l
h
f*
332.1638 635.9811 m
336.926 635.9811 l
h
f*
513.9213 622.9984 m
518.6835 622.9984 l
h
f*
304.1575 596.9764 m
308.9197 596.9764 l
h
f*
350.1921 532.0063 m
354.9543 532.0063 l
h
f*
229.4929 493.0016 m
234.2551 493.0016 l
h
f*
539.9433 480.0189 m
544.7055 480.0189 l
h
f*
546.9732 480.0189 m
551.6787 480.0189 l
h
f*
553.9465 480.0189 m
558.7087 480.0189 l
h
f*
241.2283 441.0142 m
245.9339 441.0142 l
h
f*
248.1449 441.0142 m
257.4992 441.0142 l
h
f*
413.6315 402.0094 m
418.337 402.0094 l
h
f*
420.548 402.0094 m
429.9591 402.0094 l
h
f*
435.0614 402.0094 m
444.4724 402.0094 l
h
f*
526.337 402.0094 m
535.748 402.0094 l
h
f*
242.8157 311.0173 m
252.1701 311.0173 l
h
f*
526.5638 272.0126 m
535.9748 272.0126 l
h
f*
457.1717 233.0079 m
466.6961 233.0079 l
h
f*
486.5386 220.0252 m
496.063 220.0252 l
h
f*
498.3307 220.0252 m
507.7984 220.0252 l
h
f*
341.6315 194.0031 m
351.1559 194.0031 l
h
f*
353.3669 194.0031 m
362.8913 194.0031 l
h
f*
203.4142 167.9811 m
212.9386 167.9811 l
h
f*
215.1496 167.9811 m
224.674 167.9811 l
h
f*
310.0535 154.9984 m
319.578 154.9984 l
h
f*
321.8457 154.9984 m
331.3701 154.9984 l
h
f*
333.5811 154.9984 m
343.1055 154.9984 l
h
f*
252.1134 128.9764 m
261.6378 128.9764 l
h
f*
263.9055 128.9764 m
273.3732 128.9764 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(2015)Tj
2.1259 0 Td
(malaria)Tj
3.2258 0 Td
(was)Tj
1.6951 0 Td
(diagnosed)Tj
4.286 0 Td
(in)Tj
1.0318 0 Td
(approximately)Tj
5.9754 0 Td
(212)Tj
1.6498 0 Td
(million)Tj
3.1237 0 Td
(people,)Tj
3.0784 0 Td
(and)Tj
1.7291 0 Td
(resulted)Tj
3.4016 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(loss)Tj
1.6951 0 Td
(of)Tj
-36.629 -1.3039 Td
(438,000)Tj
3.2995 0 Td
(lives)Tj
1.9729 0 Td
(worldwide)Tj
4.456 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(In)Tj
1.1055 0 Td
(malaria-endemic)Tj
7.0129 0 Td
(regions,)Tj
3.3845 0 Td
(infections)Tj
4.1556 0 Td
(are)Tj
1.4456 0 Td
(unevenly)Tj
3.8495 0 Td
(distributed)Tj
-32.2864 -1.2982 Td
(among)Tj
2.9933 0 Td
(human)Tj
3.0784 0 Td
(populations,)Tj
5.1761 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(highest)Tj
3.0954 0 Td
(prevalence)Tj
4.4844 0 Td
(among)Tj
2.9933 0 Td
(children)Tj
3.5547 0 Td
(and)Tj
1.7347 0 Td
(adolescents.)Tj
-30.5742 -1.2983 Td
(Today,)Tj
2.9763 0 Td
(malaria)Tj
3.2258 0 Td
(control)Tj
3.1238 0 Td
(programs)Tj
4.0648 0 Td
(remain)Tj
3.0841 0 Td
(among)Tj
2.999 0 Td
(the)Tj
1.4684 0 Td
(largest)Tj
2.8176 0 Td
(public)Tj
2.7099 0 Td
(health)Tj
2.6759 0 Td
(efforts,)Tj
2.982 0 Td
(costing)Tj
3.0898 0 Td
(an)Tj
-35.2174 -1.3039 Td
(estimated)Tj
4.0705 0 Td
($4.75)Tj
2.3414 0 Td
(billion)Tj
2.8063 0 Td
(annually)Tj
3.6566 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(],)Tj
1.5988 0 Td
(despite)Tj
3.0387 0 Td
(the)Tj
1.4626 0 Td
(fact)Tj
1.6611 0 Td
(that)Tj
1.7745 0 Td
(the)Tj
1.4684 0 Td
(causative)Tj
3.8437 0 Td
(agents)Tj
2.7439 0 Td
(of)Tj
1.0148 0 Td
(malaria)Tj
3.2202 0 Td
(\(proto-)Tj
-34.7015 -1.2983 Td
(zoan)Tj
2.1203 0 Td
(parasites)Tj
3.6906 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(genus)Tj
/F13 1 Tf
2.5455 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
(\))Tj
5.4708 0 Td
(were)Tj
2.126 0 Td
(first)Tj
1.8028 0 Td
(discovered)Tj
4.5071 0 Td
(as)Tj
1.0147 0 Td
(early)Tj
2.1487 0 Td
(as)Tj
1.0148 0 Td
(1880)Tj
2.126 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
1.5987 0 Td
(A)Tj
0.9071 0 Td
(potential)Tj
-33.5563 -1.2982 Td
(challenge)Tj
3.9571 0 Td
(faced)Tj
2.3187 0 Td
(by)Tj
1.1792 0 Td
(ongoing)Tj
3.5263 0 Td
(efforts)Tj
2.7609 0 Td
(to)Tj
1.0262 0 Td
(eliminate)Tj
3.9458 0 Td
(malaria)Tj
3.2258 0 Td
(in)Tj
1.0374 0 Td
(human)Tj
3.0784 0 Td
(communities)Tj
5.4822 0 Td
(is)Tj
0.8447 0 Td
(the)Tj
1.474 0 Td
(possibil-)Tj
-33.8567 -1.304 Td
(ity)Tj
1.2302 0 Td
(of)Tj
1.0091 0 Td
(zoonotic)Tj
3.685 0 Td
(infections)Tj
4.1499 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.5931 0 Td
(In)Tj
1.1055 0 Td
(particular,)Tj
4.3256 0 Td
(there)Tj
2.2621 0 Td
(is)Tj
0.839 0 Td
(compelling)Tj
4.6771 0 Td
(evidence)Tj
3.7077 0 Td
(that)Tj
1.7745 0 Td
(some)Tj
/F13 1 Tf
2.3244 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
-32.6832 -1.2982 Td
(species)Tj
2.9933 0 Td
(infecting)Tj
3.7531 0 Td
(humans)Tj
3.4355 0 Td
(are)Tj
1.4514 0 Td
(also)Tj
1.7688 0 Td
(circulating)Tj
4.49 0 Td
(in)Tj
1.0375 0 Td
(nearby)Tj
2.9593 0 Td
(simian)Tj
2.914 0 Td
(and)Tj
1.7348 0 Td
(ape)Tj
1.5931 0 Td
(communities.)Tj
5.7089 0 Td
(Whether)Tj
-33.8397 -1.2983 Td
(such)Tj
2.0579 0 Td
(non-human)Tj
5.0343 0 Td
(primate)Tj
3.3505 0 Td
(host)Tj
1.9162 0 Td
(can)Tj
1.6214 0 Td
(act)Tj
1.3777 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(reservoir)Tj
3.7701 0 Td
(of)Tj
1.0148 0 Td
(human)Tj
3.0784 0 Td
(malarias)Tj
3.5886 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(matter)Tj
2.8629 0 Td
(of)Tj
1.0148 0 Td
(great)Tj
-33.8567 -1.2983 Td
(interest.)Tj
1.1962 -1.3039 Td
(According)Tj
4.439 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(Global)Tj
2.8799 0 Td
(Mammal)Tj
3.8665 0 Td
(Parasite)Tj
3.3675 0 Td
(Database,)Tj
4.0705 0 Td
(27)Tj
1.1736 0 Td
(species)Tj
2.9933 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
5.1364 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
-34.6901 -1.2982 Td
(documented)Tj
5.244 0 Td
(in)Tj
1.0375 0 Td
(nonhuman)Tj
4.6828 0 Td
(primates)Tj
3.7134 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(],)Tj
1.5987 0 Td
(three)Tj
2.2677 0 Td
(of)Tj
1.0148 0 Td
(which)Tj
2.6475 0 Td
(\()Tj
/F13 1 Tf
[()4()4()10()6()4()12()12( )12()]TJ
5.4709 0 Td
[(\n)9()11()4()1()10()4()16(\r)-9( )12()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
4.7054 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
-32.3827 -1.2983 Td
[()-13()15()3()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
2.5284 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
5.1364 0 Td
[()18()6()12()3()4()8()10()]TJ
/F7 1 Tf
(,)Tj
3.787 0 Td
(and)Tj
/F13 1 Tf
1.7348 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
5.1307 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
(\))Tj
4.0535 0 Td
(frequently)Tj
4.3087 0 Td
(occur)Tj
2.4718 0 Td
(in)Tj
1.0374 0 Td
(humans.)Tj
3.6624 0 Td
(Along)Tj
-33.8511 -1.3039 Td
(with)Tj
/F13 1 Tf
1.9955 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
5.1307 0 Td
[()12()3()11()4()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
2.4605 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
5.1306 0 Td
(species)Tj
2.9991 0 Td
(that)Tj
1.7801 0 Td
(infect)Tj
2.4661 0 Td
(humans)Tj
3.4413 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.576 0 Td
(form)Tj
2.2054 0 Td
(a)Tj
0.6519 0 Td
(monophyletic)Tj
-31.0901 -1.2983 Td
(group)Tj
2.6078 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5987 0 Td
(The)Tj
1.7859 0 Td
(two)Tj
1.7064 0 Td
(parasites)Tj
3.6907 0 Td
(that)Tj
1.7745 0 Td
(cause)Tj
2.3924 0 Td
(the)Tj
1.4683 0 Td
(greatest)Tj
3.2939 0 Td
(morbidity)Tj
4.2406 0 Td
(\()Tj
/F13 1 Tf
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
1.3322 0 Td
[(\n)9()11()4()1()10()4()16(\r)-9( )12()]TJ
/F7 1 Tf
4.4788 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()-13()15()3()]TJ
/F7 1 Tf
(\))Tj
2.6475 0 Td
(are)Tj
-35.7389 -1.2982 Td
(part)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(larger)Tj
2.5284 0 Td
(clades)Tj
2.6362 0 Td
(of)Tj
1.0148 0 Td
(species)Tj
2.9991 0 Td
(that)Tj
1.7745 0 Td
(include)Tj
3.1861 0 Td
(many)Tj
2.4774 0 Td
(that)Tj
1.7802 0 Td
(parasitize)Tj
4.0025 0 Td
(nonhuman)Tj
4.6828 0 Td
(primates)Tj
3.7134 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
-0.01 Tc
-32.4565 -1.304 Td
(In)Tj
1.0998 0 Td
(South)Tj
2.5285 0 Td
(America,)Tj
/F13 1 Tf
3.8154 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
5.074 0 Td
[()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
4.8982 0 Td
(was)Tj
1.6781 0 Td
(first)Tj
1.7802 0 Td
(described)Tj
3.9968 0 Td
(in)Tj
1.0205 0 Td
(monkeys)Tj
3.7927 0 Td
(in)Tj
1.0205 0 Td
(the)Tj
1.4513 0 Td
(beginning)Tj
-33.3522 -1.2982 Td
(of)Tj
1.0034 0 Td
(the)Tj
1.4513 0 Td
(20)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 233.9149 459.5527 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 242.1921 455.074 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(century)Tj
3.2258 0 Td
(and)Tj
1.7121 0 Td
(has)Tj
1.525 0 Td
(now)Tj
1.9446 0 Td
(been)Tj
2.0976 0 Td
(documented)Tj
5.1873 0 Td
(in)Tj
1.0205 0 Td
(approximately)Tj
5.9017 0 Td
(31)Tj
1.1565 0 Td
(species)Tj
2.9537 0 Td
(of)Tj
1.0035 0 Td
(New)Tj
2.0466 0 Td
(World)Tj
-33.9928 -1.2982 Td
(monkeys)Tj
3.7871 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
2.7381 0 Td
(This)Tj
1.9616 0 Td
(broad)Tj
2.5342 0 Td
(host)Tj
1.8935 0 Td
(range)Tj
2.4321 0 Td
(is)Tj
0.8334 0 Td
(unusual)Tj
3.3505 0 Td
(among)Tj
2.965 0 Td
(other)Tj
2.3188 0 Td
(non-human)Tj
4.9776 0 Td
(primate)Tj
3.3108 0 Td
(malarias)Tj
-33.1027 -1.2983 Td
(and)Tj
1.7121 0 Td
(may)Tj
1.9106 0 Td
(indicate)Tj
3.3617 0 Td
(a)Tj
0.6463 0 Td
(very)Tj
1.8992 0 Td
(resilient)Tj
3.3732 0 Td
(parasite)Tj
3.2825 0 Td
(species.)Tj
3.1692 0 Td
(To)Tj
1.3266 0 Td
(date,)Tj
2.1033 0 Td
(numerous)Tj
4.2576 0 Td
(studies)Tj
2.9423 0 Td
(have)Tj
2.0353 0 Td
(looked)Tj
2.8913 0 Td
(for,)Tj
-34.9112 -1.3039 Td
(but)Tj
1.5364 0 Td
(not)Tj
1.5534 0 Td
(found,)Tj
2.8061 0 Td
(any)Tj
1.6441 0 Td
(reliable)Tj
3.0898 0 Td
(morphological,)Tj
6.1965 0 Td
(serological,)Tj
4.6261 0 Td
(or)Tj
1.0885 0 Td
(genetic)Tj
3.0274 0 Td
(differences)Tj
4.5014 0 Td
(between)Tj
/F13 1 Tf
3.4865 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()11(\r)20()10()]TJ
-34.537 -1.2983 Td
[()12()4()16()18( )12()]TJ
/F7 1 Tf
3.0047 0 Td
(and)Tj
/F13 1 Tf
1.7064 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
5.074 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
3.6623 0 Td
(that)Tj
1.7518 0 Td
(infect)Tj
2.4321 0 Td
(humans)Tj
3.3959 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
4.1896 0 Td
(Lalremruata)Tj
5.0456 0 Td
(et)Tj
0.9298 0 Td
(al.)Tj
1.1055 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
1.8255 0 Td
(collected)Tj
-34.1232 -1.2982 Td
(blood)Tj
2.4832 0 Td
(samples)Tj
3.339 0 Td
(from)Tj
2.1827 0 Td
(several)Tj
2.8913 0 Td
(remote)Tj
3.0274 0 Td
(populations)Tj
4.8869 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4513 0 Td
(Yanomami)Tj
4.6318 0 Td
(people)Tj
2.8233 0 Td
(in)Tj
1.0204 0 Td
(Venezuela,)Tj
4.5241 0 Td
(and)Tj
1.7121 0 Td
(iso-)Tj
-35.977 -1.3039 Td
(lated)Tj
2.1203 0 Td
(33)Tj
1.1566 0 Td
(infections)Tj
4.0931 0 Td
(by)Tj
1.1678 0 Td
(nested-PCR)Tj
4.9379 0 Td
(screening)Tj
4.0025 0 Td
(for)Tj
1.3663 0 Td
(the)Tj
1.4514 0 Td
(small)Tj
2.296 0 Td
(subunit)Tj
3.2145 0 Td
(ribosomal)Tj
4.1896 0 Td
(RNA)Tj
2.245 0 Td
(gene)Tj
2.0523 0 Td
(\(18S)Tj
-34.2933 -1.2983 Td
(SSU)Tj
1.8879 0 Td
(rRNA\))Tj
2.9422 0 Td
(of)Tj
/F13 1 Tf
1.0035 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
(.)Tj
3.8834 0 Td
(Of)Tj
1.2472 0 Td
(these,)Tj
2.4435 0 Td
(12)Tj
1.1565 0 Td
(sequences)Tj
4.1669 0 Td
(were)Tj
2.0977 0 Td
(100%)Tj
2.381 0 Td
(identical)Tj
3.6 0 Td
(to)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
4.8982 0 Td
(strains)Tj
-34.6844 -1.2983 Td
(recovered)Tj
4.0932 0 Td
(from)Tj
2.1769 0 Td
(howler)Tj
2.948 0 Td
(monkeys)Tj
3.7871 0 Td
(in)Tj
1.0261 0 Td
(French)Tj
3.0047 0 Td
(Guiana,)Tj
3.3279 0 Td
(and)Tj
1.7121 0 Td
(the)Tj
1.457 0 Td
(remainder)Tj
4.3483 0 Td
(were)Tj
2.1033 0 Td
(99100%)Tj
3.8268 0 Td
(identical)Tj
-33.8114 -1.3039 Td
(to)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
3.6622 0 Td
(strains)Tj
2.8177 0 Td
(from)Tj
2.1826 0 Td
(Myanmar)Tj
4.1329 0 Td
(and)Tj
1.7121 0 Td
(Papua)Tj
2.6646 0 Td
(New)Tj
2.0466 0 Td
(Guinea.)Tj
3.3165 0 Td
(Although)Tj
3.9571 0 Td
(the)Tj
1.4514 0 Td
(18S)Tj
1.6327 0 Td
(gene)Tj
2.0523 0 Td
(does)Tj
2.0182 0 Td
(not)Tj
-35.6425 -1.2983 Td
(allow)Tj
2.3074 0 Td
(us)Tj
1.0942 0 Td
(to)Tj
1.0147 0 Td
(accurately)Tj
4.1952 0 Td
(discern)Tj
3.1011 0 Td
(recent)Tj
2.6759 0 Td
(host)Tj
1.8879 0 Td
(switches)Tj
3.5206 0 Td
(due)Tj
1.6781 0 Td
(to)Tj
1.0148 0 Td
(its)Tj
1.1281 0 Td
(rate)Tj
1.7235 0 Td
(and)Tj
1.7121 0 Td
(semi-concerted)Tj
6.3042 0 Td
(mode)Tj
2.4775 0 Td
(of)Tj
-35.8353 -1.2982 Td
(evolution)Tj
3.9458 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(],)Tj
2.0465 0 Td
(the)Tj
1.4514 0 Td
(genetic)Tj
3.0273 0 Td
(distances)Tj
3.8098 0 Td
(between)Tj
3.4866 0 Td
(all)Tj
1.1282 0 Td
(33)Tj
1.1622 0 Td
(strains)Tj
2.8176 0 Td
(seems)Tj
2.5795 0 Td
(consistent)Tj
4.1952 0 Td
(with)Tj
1.9729 0 Td
(intraspecific)Tj
-31.623 -1.3039 Td
(variation)Tj
3.7474 0 Td
(observed)Tj
3.7473 0 Td
(within)Tj
2.7779 0 Td
(other)Tj
2.3187 0 Td
(single)Tj
2.4945 0 Td
(species)Tj
2.9537 0 Td
(of)Tj
/F13 1 Tf
1.0035 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
(.)Tj
5.295 0 Td
(The)Tj
1.7632 0 Td
(only)Tj
1.9502 0 Td
(factor)Tj
2.5058 0 Td
(that)Tj
1.7575 0 Td
(has)Tj
1.525 0 Td
(ever)Tj
1.8652 0 Td
(been)Tj
-35.7049 -1.2983 Td
(used)Tj
2.0353 0 Td
(to)Tj
1.0148 0 Td
(differentiate)Tj
5.0002 0 Td
(these)Tj
2.2223 0 Td
(two)Tj
1.6895 0 Td
(parasites)Tj
3.6339 0 Td
(is)Tj
0.8391 0 Td
(host-identity)Tj
5.2724 0 Td
(\(human)Tj
3.3789 0 Td
(or)Tj
1.0885 0 Td
(not\),)Tj
2.1089 0 Td
(and)Tj
1.7122 0 Td
(yet)Tj
1.3776 0 Td
(experimental)Tj
-31.3736 -1.2983 Td
(studies)Tj
2.9424 0 Td
(have)Tj
2.0351 0 Td
(demonstrated)Tj
5.692 0 Td
(that)Tj
1.7518 0 Td
(nonhuman)Tj
4.6374 0 Td
(primates)Tj
3.6624 0 Td
(are)Tj
1.4286 0 Td
(susceptible)Tj
4.5127 0 Td
(to)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
3.6624 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
2.0466 0 Td
(These)Tj
-34.367 -1.2982 Td
(findings)Tj
3.4469 0 Td
(suggest)Tj
3.0783 0 Td
(that)Tj
/F13 1 Tf
1.7518 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
4.8983 0 Td
(and)Tj
/F13 1 Tf
1.7121 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
3.668 0 Td
(could)Tj
2.4207 0 Td
(very)Tj
1.8992 0 Td
(well)Tj
1.7972 0 Td
(be)Tj
1.1395 0 Td
(the)Tj
1.4513 0 Td
(same)Tj
2.2337 0 Td
(organism.)Tj
/F13 1 Tf
-0.004 Tc
-30.2624 -1.3039 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()6()11()4()16(\r)-9()4()6()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
8.7589 0 Td
(causes)Tj
2.7553 0 Td
(quartan)Tj
3.3392 0 Td
(malaria,)Tj
3.4526 0 Td
(so)Tj
1.0884 0 Td
(termed)Tj
3.0841 0 Td
(for)Tj
1.3833 0 Td
(having)Tj
2.9197 0 Td
(72-hour)Tj
3.4526 0 Td
(erythrocytic)Tj
-32.4281 -1.2983 Td
(cycles,)Tj
2.778 0 Td
(unlike)Tj
/F13 1 Tf
2.7268 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[(\n)9()11()4()1()10()4()16(\r)-9( )12()]TJ
/F7 1 Tf
4.473 0 Td
(or)Tj
/F13 1 Tf
1.0998 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9922 0 Td
[()-13()15()3()]TJ
/F7 1 Tf
2.3073 0 Td
(that)Tj
1.7802 0 Td
(cycle)Tj
2.1883 0 Td
(every)Tj
2.3471 0 Td
(48)Tj
1.1735 0 Td
(hours)Tj
2.5115 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
/F13 1 Tf
2.0806 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
3.7134 0 Td
(has)Tj
1.542 0 Td
(led)Tj
1.4174 0 Td
(to)Tj
-35.121 -1.2983 Td
(nephrotic)Tj
4.1046 0 Td
(syndromes)Tj
4.592 0 Td
(in)Tj
1.0374 0 Td
(humans)Tj
3.4356 0 Td
(and)Tj
1.7348 0 Td
(experimentally)Tj
6.1568 0 Td
(infected)Tj
3.4186 0 Td
(monkeys)Tj
3.8324 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(],)Tj
3.2541 0 Td
(and)Tj
1.7292 0 Td
(has)Tj
1.542 0 Td
(been)Tj
-34.8375 -1.3039 Td
(shown)Tj
2.846 0 Td
(to)Tj
1.0261 0 Td
(persist)Tj
2.8175 0 Td
(in)Tj
1.0375 0 Td
(humans)Tj
3.4413 0 Td
(for)Tj
1.3833 0 Td
(years,)Tj
2.4888 0 Td
(suggesting)Tj
4.405 0 Td
(that)Tj
1.7801 0 Td
(a)Tj
0.652 0 Td
(similar)Tj
2.9877 0 Td
(pattern)Tj
3.1124 0 Td
(may)Tj
1.9275 0 Td
(occur)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(non-)Tj
-33.4145 -1.2983 Td
(human)Tj
3.0784 0 Td
(primates)Tj
3.7076 0 Td
(like)Tj
1.6554 0 Td
(chimpanzees)Tj
5.3802 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
3.2541 0 Td
(Recrudescent)Tj
5.5899 0 Td
(infections)Tj
4.1556 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()6()11()4()16(\r)-9()4()6()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
-28.8281 -1.2982 Td
(can)Tj
1.6271 0 Td
(occur)Tj
2.4718 0 Td
(when)Tj
2.4037 0 Td
(hosts)Tj
2.2733 0 Td
(are)Tj
1.4514 0 Td
(subjected)Tj
3.9684 0 Td
(to)Tj
1.0262 0 Td
(stressful)Tj
3.4582 0 Td
(conditions)Tj
4.4731 0 Td
(or)Tj
1.0998 0 Td
(become)Tj
3.3222 0 Td
(immunocompromised)Tj
-27.5752 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
3.2542 0 Td
(In)Tj
1.1054 0 Td
(malaria-endemic)Tj
7.0129 0 Td
(regions,)Tj
3.3902 0 Td
(co-infections)Tj
5.4311 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()6()11()4()16(\r)-9()4()6()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
8.7647 0 Td
(with)Tj
1.9956 0 Td
(other)Tj
/F13 1 Tf
2.347 0 Td
[()4()4()]TJ
-35.308 -1.2983 Td
[()6()4()12()12( )12()]TJ
/F7 1 Tf
3.532 0 Td
(spp.)Tj
1.8367 0 Td
(are)Tj
1.4513 0 Td
(common)Tj
3.8438 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
4.4334 0 Td
(Since)Tj
2.3584 0 Td
(host)Tj
1.9105 0 Td
(parasitemia)Tj
4.8472 0 Td
(for)Tj
/F13 1 Tf
1.3833 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()6()11()4()16(\r)-9()4()6()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
8.759 0 Td
(is)Tj
0.8504 0 Td
(rel-)Tj
-36.2038 -1.2983 Td
(atively)Tj
2.795 0 Td
(low,)Tj
1.8877 0 Td
(co-infections)Tj
5.4312 0 Td
(are)Tj
1.4456 0 Td
(probably)Tj
3.7644 0 Td
(under-detected)Tj
6.3156 0 Td
(when)Tj
2.4037 0 Td
(screenings)Tj
4.4164 0 Td
(are)Tj
1.4456 0 Td
(performed)Tj
4.4731 0 Td
(only)Tj
1.9729 0 Td
(by)Tj
-36.3512 -1.3039 Td
(microscopy)Tj
4.8698 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(],)Tj
3.2542 0 Td
(and)Tj
1.7291 0 Td
(yet)Tj
1.4003 0 Td
(microscopy)Tj
4.8699 0 Td
(remains)Tj
3.4469 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(broadly)Tj
3.2655 0 Td
(utilized)Tj
3.1918 0 Td
(diagnostic)Tj
4.3199 0 Td
(tech-)Tj
-34.0211 -1.2983 Td
(nique)Tj
2.4945 0 Td
(around)Tj
3.135 0 Td
(the)Tj
1.4683 0 Td
(world)Tj
2.5569 0 Td
(today.)Tj
-8.4585 -1.2982 Td
(The)Tj
1.7859 0 Td
(ability)Tj
2.6927 0 Td
(to)Tj
1.0262 0 Td
(reside)Tj
2.5965 0 Td
(in)Tj
1.0318 0 Td
(non-human)Tj
5.0343 0 Td
(primates,)Tj
3.9345 0 Td
(induce)Tj
2.9423 0 Td
(renal)Tj
2.2394 0 Td
(pathology,)Tj
4.405 0 Td
(persist)Tj
2.8176 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(chronic)Tj
-33.3748 -1.2983 Td
(infection)Tj
3.7928 0 Td
(in)Tj
1.0317 0 Td
(humans,)Tj
3.668 0 Td
(and)Tj
1.7291 0 Td
(interact)Tj
3.2825 0 Td
(with)Tj
1.9956 0 Td
(other)Tj
2.3527 0 Td
(species)Tj
2.9934 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
5.1363 0 Td
(qualifies)Tj
/F13 1 Tf
3.5376 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
3.7077 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 400.9322 745.7952 cm
BT
/F6 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Plasmodi)Tj
4.0394 0 Td
(um)Tj
1.5874 0 Td
(brasilianum)Tj
/F0 1 Tf
5.237 0 Td
(infections)Tj
4.3654 0 Td
(in)Tj
0.978 0 Td
(wild)Tj
1.8992 0 Td
(tamarins)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01845)Tj
4.089 0 Td
(04)Tj
0 g
2.0906 0 Td
(September)Tj
5.0386 0 Td
(13,)Tj
1.5874 0 Td
(2017)Tj
32.2798 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(14)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
124.1008 707.6409 m
174.7276 707.6409 l
h
f*
36 696.6425 m
53.6882 696.6425 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F10 1 Tf
1 TL
-0.025 Tc
0 0 Td
(Harris)Tj
2.459 0 Td
(World)Tj
2.4733 0 Td
(Ecology)Tj
3.1465 0 Td
(Center)Tj
2.6291 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(www.um)Tj
3.6709 0 Td
(sl.edu/~)Tj
-14.3788 -1.3748 Td
(hwec/)Tj
0 g
(\),)Tj
2.9622 0 Td
(and)Tj
1.5874 0 Td
(The)Tj
1.5874 0 Td
(Des)Tj
1.6512 0 Td
(Lee)Tj
1.5378 0 Td
(Collaborat)Tj
3.7347 0 Td
(ive)Tj
1.2614 0 Td
(Vision)Tj
2.4945 0 Td
(at)Tj
0.9 0 Td
(the)Tj
-17.7166 -1.3748 Td
(University)Tj
3.9189 0 Td
(of)Tj
0.9425 0 Td
(Missouri-St.)Tj
4.7693 0 Td
(Louis.)Tj
2.4804 0 Td
(The)Tj
1.5874 0 Td
(funders)Tj
3.0473 0 Td
(had)Tj
-16.7458 -1.3748 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.9055 0 Td
(data)Tj
1.7859 0 Td
(collection)Tj
3.7417 0 Td
(and)Tj
-14.3646 -1.3748 Td
(analysis,)Tj
3.4086 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9497 0 Td
(publish,)Tj
3.1393 0 Td
(or)Tj
1.0064 0 Td
(prepara)Tj
2.8205 0 Td
(tion)Tj
1.6157 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-17.1851 -1.3748 Td
(manuscript.)Tj
/F9 1 Tf
0 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
BT
10.3394 -10.3748 Td
(exist.)Tj
ET
Q
endstream
endobj
75 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 77 0 R/Contents 78 0 R/TrimBox[0 0 612 792]>>
endobj
77 0 obj
[79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R]
endobj
79 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref009)>>
endobj
80 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref010)>>
endobj
81 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref014)>>
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref022)>>
endobj
83 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref024)>>
endobj
84 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref025)>>
endobj
85 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref026)>>
endobj
86 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref028)>>
endobj
87 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref029)>>
endobj
88 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref005)>>
endobj
89 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref010)>>
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref010)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref030)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref031)>>
endobj
93 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref032)>>
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref032)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref033)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref014)>>
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref005)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref034)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref035)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.ref036)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184504.g001)>>
endobj
102 0 obj
<>/Border[0 0 0]/A 103 0 R>>
endobj
103 0 obj
<>
endobj
78 0 obj
[104 0 R 105 0 R 106 0 R 107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R]
endobj
104 0 obj
<>stream
q
0.83 0.64 0.02 0 k
397.1906 641.3102 m
401.9528 641.3102 l
h
f*
404.1638 641.3102 m
413.6882 641.3102 l
h
f*
415.9559 641.3102 m
425.4803 641.3102 l
h
f*
427.748 641.3102 m
437.2157 641.3102 l
h
f*
313.4551 615.3449 m
322.9228 615.3449 l
h
f*
325.1906 615.3449 m
334.715 615.3449 l
h
f*
425.0835 602.3055 m
434.6079 602.3055 l
h
f*
439.7669 602.3055 m
449.2913 602.3055 l
h
f*
345.2031 576.3402 m
354.6709 576.3402 l
h
f*
415.1622 498.3307 m
419.9244 498.3307 l
h
f*
422.1921 498.3307 m
431.7165 498.3307 l
h
f*
233.9717 420.3213 m
243.4961 420.3213 l
h
f*
245.7638 420.3213 m
255.2882 420.3213 l
h
f*
459.6094 407.3386 m
469.1339 407.3386 l
h
f*
549.5811 407.3386 m
559.1055 407.3386 l
h
f*
328.3654 394.2992 m
337.8898 394.2992 l
h
f*
340.1575 394.2992 m
349.6819 394.2992 l
h
f*
455.8677 394.2992 m
465.3921 394.2992 l
h
f*
340.7244 368.3339 m
345.4866 368.3339 l
h
f*
321.3921 290.3244 m
330.9165 290.3244 l
h
f*
333.1843 290.3244 m
342.652 290.3244 l
h
f*
216.1134 238.337 m
225.6378 238.337 l
h
f*
529.7953 94.9039 m
549.3543 94.9039 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(important)Tj
4.2802 0 Td
(health)Tj
2.6759 0 Td
(concern)Tj
3.4696 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(human-wildlife)Tj
6.3779 0 Td
(interface)Tj
3.6964 0 Td
(given)Tj
2.381 0 Td
(that)Tj
1.7802 0 Td
(present)Tj
3.1634 0 Td
(research)Tj
3.5547 0 Td
(suggests)Tj
-33.8001 -1.3039 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(as)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
(.)Tj
5.1874 0 Td
(Fundamental)Tj
5.5558 0 Td
(to)Tj
1.0262 0 Td
(assessing)Tj
3.7984 0 Td
(health)Tj
2.6815 0 Td
(risks)Tj
2.075 0 Td
(are)Tj
1.4456 0 Td
(the)Tj
1.474 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
-37.0372 -1.2982 Td
(clear)Tj
2.1146 0 Td
(understanding)Tj
6.0718 0 Td
(of)Tj
1.0148 0 Td
(host)Tj
1.9162 0 Td
(breadth)Tj
3.3051 0 Td
(and)Tj
1.7348 0 Td
(associated)Tj
4.252 0 Td
(prevalence)Tj
4.49 0 Td
(for)Tj
1.3833 0 Td
(these)Tj
2.2564 0 Td
(\(or)Tj
1.44 0 Td
(this\))Tj
2.0126 0 Td
(species.)Tj
3.2201 0 Td
(The)Tj
-35.2117 -1.2983 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(infections)Tj
4.1499 0 Td
(found)Tj
2.6192 0 Td
(in)Tj
1.0374 0 Td
(wild)Tj
1.9446 0 Td
(New)Tj
2.0636 0 Td
(World)Tj
2.8403 0 Td
(monkeys)Tj
3.8267 0 Td
(are)Tj
1.4514 0 Td
(confined)Tj
3.753 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(Atelidae,)Tj
3.753 0 Td
(Pithe-)Tj
-34.5767 -1.2983 Td
(ciidae,)Tj
2.7892 0 Td
(and)Tj
1.7291 0 Td
(Cebidae,)Tj
3.6907 0 Td
(while)Tj
2.3698 0 Td
(detection)Tj
3.9344 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(Callitrichidae,)Tj
5.845 0 Td
(perhaps)Tj
3.3732 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2053 0 Td
(speciose)Tj
3.5036 0 Td
(and)Tj
1.7292 0 Td
(wide-)Tj
-35.1437 -1.3039 Td
(spread)Tj
2.8516 0 Td
(Neotropical)Tj
4.9549 0 Td
(primate)Tj
3.3505 0 Td
(family,)Tj
2.9537 0 Td
(remains)Tj
3.4469 0 Td
(rare)Tj
1.8199 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
5.1306 0 Td
(Callitrichids)Tj
5.1194 0 Td
(are)Tj
1.4513 0 Td
(always)Tj
2.8346 0 Td
(found)Tj
2.6136 0 Td
(in)Tj
-36.527 -1.2982 Td
(sympatry)Tj
3.9287 0 Td
(with)Tj
1.9956 0 Td
(other)Tj
2.3528 0 Td
(New)Tj
2.0636 0 Td
(World)Tj
2.8346 0 Td
(primate)Tj
3.3505 0 Td
(species,)Tj
3.2258 0 Td
(frequently)Tj
4.3087 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(context)Tj
3.1804 0 Td
(of)Tj
1.0148 0 Td
(mixed-species,)Tj
-30.7613 -1.2983 Td
(or)Tj
1.0941 0 Td
(polyspecific)Tj
4.9209 0 Td
(associations)Tj
4.989 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
3.2541 0 Td
(Unlike)Tj
2.9367 0 Td
(the)Tj
1.4683 0 Td
(majority)Tj
3.6284 0 Td
(of)Tj
1.0148 0 Td
(other)Tj
2.347 0 Td
(New)Tj
2.0636 0 Td
(World)Tj
2.8403 0 Td
(primates)Tj
3.7134 0 Td
(they)Tj
-34.2706 -1.3039 Td
(can)Tj
1.627 0 Td
(also)Tj
1.7632 0 Td
(persist)Tj
2.8233 0 Td
(in)Tj
1.0318 0 Td
(disturbed)Tj
4.0365 0 Td
(and)Tj
1.7291 0 Td
(human)Tj
3.0784 0 Td
(occupied)Tj
3.8324 0 Td
(areas)Tj
2.245 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(].)Tj
3.549 0 Td
(Moreover,)Tj
4.3937 0 Td
(continuing)Tj
-30.1094 -1.2983 Td
(removal)Tj
3.4752 0 Td
(of)Tj
1.0148 0 Td
(large)Tj
2.16 0 Td
(Neotropical)Tj
4.9492 0 Td
(primates)Tj
3.7134 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(poaching)Tj
3.9061 0 Td
(and)Tj
1.7348 0 Td
(hunting)Tj
3.4016 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(leading)Tj
3.1351 0 Td
(to)Tj
1.0205 0 Td
(a)Tj
0.6576 0 Td
(popu-)Tj
-34.9736 -1.2983 Td
(lation)Tj
2.5171 0 Td
(expansion)Tj
4.2973 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(callitrichids)Tj
4.8813 0 Td
([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(].)Tj
2.0749 0 Td
(If)Tj
0.8504 0 Td
(proven)Tj
3.0387 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(reservoirs)Tj
4.1329 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
5.1307 0 Td
(infections,)Tj
-32.5982 -1.3039 Td
(these)Tj
2.2506 0 Td
(characteristics)Tj
5.9074 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(callitrichids)Tj
4.8813 0 Td
(might)Tj
2.5965 0 Td
(implicate)Tj
3.9174 0 Td
(them)Tj
2.2904 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(important)Tj
4.2803 0 Td
(sylvatic)Tj
3.1634 0 Td
(compo-)Tj
-33.9871 -1.2982 Td
(nent)Tj
2.0352 0 Td
(for)Tj
1.389 0 Td
(malaria)Tj
3.2258 0 Td
(control)Tj
3.1237 0 Td
(efforts.)Tj
-8.5775 -1.2983 Td
(When)Tj
2.6872 0 Td
(considering)Tj
4.9322 0 Td
(accessible)Tj
4.0876 0 Td
(survey)Tj
2.8119 0 Td
(data)Tj
1.9162 0 Td
(on)Tj
/F13 1 Tf
1.2756 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
5.1307 0 Td
(infections)Tj
4.1556 0 Td
(from)Tj
2.2053 0 Td
(wild)Tj
1.9446 0 Td
(populations)Tj
-32.3431 -1.3039 Td
(of)Tj
1.0091 0 Td
(callitrichids)Tj
4.8812 0 Td
(to)Tj
1.0205 0 Td
(date,)Tj
2.1316 0 Td
(several)Tj
2.931 0 Td
(biases)Tj
2.5682 0 Td
(stand)Tj
2.3924 0 Td
(out.)Tj
1.7745 0 Td
(First,)Tj
2.2677 0 Td
(although)Tj
3.753 0 Td
(five)Tj
1.6498 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(seven)Tj
2.4265 0 Td
(callitrichid)Tj
4.5184 0 Td
(gen-)Tj
-35.807 -1.2983 Td
(era)Tj
1.4456 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(tested)Tj
2.5512 0 Td
(for)Tj
/F13 1 Tf
1.389 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
4.9606 0 Td
(\()Tj
/F13 1 Tf
[()-6()15()-8( )12()12()18( )-4()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
4.3199 0 Td
[()-2()20()11( )4()15()4()4()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
3.8155 0 Td
[()-2()11()4()12()14()10()18(\r)-9()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
4.1895 0 Td
[()-3()7()11()22()11()11()11()14()10()6()7()1( )-4()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
6.2872 0 Td
[()16()6()]TJ
-34.1345 -1.2982 Td
[()29()4()7()]TJ
/F7 1 Tf
(\),)Tj
2.7609 0 Td
(the)Tj
1.4683 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(species)Tj
2.9991 0 Td
(have)Tj
2.0579 0 Td
(not)Tj
1.5761 0 Td
(been)Tj
2.1203 0 Td
(sampled)Tj
3.5489 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
2.778 0 Td
(Of)Tj
1.2529 0 Td
(the)Tj
1.474 0 Td
(~24)Tj
1.7461 0 Td
(species)Tj
2.999 0 Td
(investigated)Tj
4.989 0 Td
(so)Tj
-36.4136 -1.2983 Td
(far,)Tj
1.5363 0 Td
(nine)Tj
2.0069 0 Td
(have)Tj
2.0636 0 Td
(shown)Tj
2.846 0 Td
(an)Tj
1.2019 0 Td
(infection,)Tj
4.0195 0 Td
(including)Tj
/F13 1 Tf
4.0422 0 Td
[()-6()15()-8( )12()12()18( )-4()]TJ
3.753 0 Td
[()18()4()4()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
2.8006 0 Td
[()-6()15()-8( )12()12()18( )-4()]TJ
3.7531 0 Td
[()18()10()2()2(\r)]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
2.4094 0 Td
[()-6()15()-8( )12()12()18( )-4()]TJ
3.7531 0 Td
[()2()7()11(\n)]TJ
-34.1856 -1.3039 Td
[(\n)-8(\r)20()12()-13()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
2.2393 0 Td
[()-6()15()-8( )12()12()18( )-4()]TJ
3.7531 0 Td
[()6()16(\r)-19()7()12()10()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
3.7587 0 Td
[()29()4()7()]TJ
2.194 0 Td
[()18( )12()6()2(\r)20()11()12()12(\n)9()2(\r)]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
5.0229 0 Td
[()-3()7()11()22()11()11()11()14()10()18()4()1( )-4()]TJ
5.9414 0 Td
[()13()18(\r)-20()2()-3()11()6()15()4()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
5.1364 0 Td
[()-3()7()11()22()11()11()11()14()10()6()7()1( )-4()]TJ
6.0604 0 Td
[()13()18(\r)-20()2()-3()]TJ
-34.1062 -1.2983 Td
[()12()-3()-8( )-4()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
2.6248 0 Td
[()-3()7()11()22()11()11()11()14()10()6()7()1( )-4()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
6.2872 0 Td
[(\r)20()7()-3()11()12()4()]TJ
/F7 1 Tf
(,)Tj
3.0784 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()-2()11()4()12()14()10()18(\r)-9()]TJ
3.9685 0 Td
[()2()7()11(\n\n)-8(\r)20()12()-13()]TJ
/F7 1 Tf
(.)Tj
3.7758 0 Td
(However,)Tj
4.0761 0 Td
(only)Tj
1.9786 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8028 0 Td
(three)Tj
2.2677 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
-34.0722 -1.2983 Td
(species)Tj
2.9933 0 Td
(\()Tj
/F13 1 Tf
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
1.2416 0 Td
[()18()4()4()]TJ
/F7 1 Tf
(,)Tj
/F13 1 Tf
2.8006 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()18()10()2()2(\r)]TJ
/F7 1 Tf
(,)Tj
2.4094 0 Td
(and)Tj
/F13 1 Tf
1.7292 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()2()7()11(\n\n)-8(\r)20()12()-13()]TJ
/F7 1 Tf
(\))Tj
3.8891 0 Td
(are)Tj
1.4513 0 Td
(clear)Tj
2.1146 0 Td
(cases)Tj
2.2224 0 Td
(of)Tj
1.0148 0 Td
(infection)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(natural)Tj
3.0784 0 Td
(environments;)Tj
-31.5777 -1.3039 Td
(the)Tj
1.4683 0 Td
(other)Tj
2.3471 0 Td
(infections)Tj
4.1555 0 Td
(were)Tj
2.1203 0 Td
(recently)Tj
3.4072 0 Td
(detected)Tj
3.566 0 Td
(from)Tj
2.211 0 Td
(captive)Tj
3.0387 0 Td
(animals)Tj
3.3279 0 Td
(at)Tj
0.9524 0 Td
(primate)Tj
3.3506 0 Td
(research)Tj
3.5546 0 Td
(or)Tj
1.0998 0 Td
(rescue)Tj
-34.5994 -1.2982 Td
(centers)Tj
3.0557 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(].)Tj
3.2428 0 Td
(Of)Tj
1.2472 0 Td
(the)Tj
1.457 0 Td
(cases)Tj
2.2167 0 Td
(representing)Tj
5.2271 0 Td
(natural)Tj
3.0727 0 Td
(infections,)Tj
4.3653 0 Td
(the)Tj
1.457 0 Td
(number)Tj
3.4072 0 Td
(of)Tj
1.0092 0 Td
(infected)Tj
3.4072 0 Td
(individuals)Tj
-33.1651 -1.2983 Td
(and)Tj
1.7291 0 Td
(corresponding)Tj
6.0604 0 Td
(sample)Tj
3.0217 0 Td
(sizes)Tj
2.0466 0 Td
(consist)Tj
2.9821 0 Td
(of)Tj
1.0147 0 Td
(1/1000)Tj
2.9311 0 Td
(for)Tj
/F13 1 Tf
1.3833 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()2()7()11(\n\n)-8(\r)20()12()-13()]TJ
/F7 1 Tf
3.5489 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(],)Tj
2.0806 0 Td
(4/109)Tj
2.4492 0 Td
(for)Tj
/F13 1 Tf
1.3889 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()18()10()2()2(\r)]TJ
/F7 1 Tf
2.177 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(],)Tj
2.0806 0 Td
(4/)Tj
-36.697 -1.3039 Td
(178)Tj
1.644 0 Td
(in)Tj
1.0375 0 Td
(another)Tj
3.3279 0 Td
(study)Tj
2.3924 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()18()10()2()2(\r)]TJ
/F7 1 Tf
2.177 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(],)Tj
3.2541 0 Td
(and)Tj
1.7292 0 Td
(3)Tj
0.6973 0 Td
(in)Tj
1.0375 0 Td
(54)Tj
1.1678 0 Td
(for)Tj
/F13 1 Tf
1.389 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()18()4()4()]TJ
/F7 1 Tf
2.5738 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
2.0807 0 Td
(This)Tj
1.9842 0 Td
(is)Tj
0.8504 0 Td
(relevant)Tj
3.4186 0 Td
(since)Tj
/F13 1 Tf
2.245 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
-35.824 -1.2983 Td
[()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
4.9605 0 Td
(tends)Tj
2.3811 0 Td
(to)Tj
1.0205 0 Td
(exhibit)Tj
2.9764 0 Td
(low)Tj
1.6611 0 Td
(prevalence,)Tj
4.7111 0 Td
(averaging)Tj
4.0819 0 Td
(0.045)Tj
/F14 1 Tf
[()]TJ
/F7 1 Tf
(0.043)Tj
5.0456 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(Callitrichidae)Tj
5.6182 0 Td
(and)Tj
-35.3137 -1.2983 Td
(0.023)Tj
/F14 1 Tf
[()]TJ
/F7 1 Tf
(0.024)Tj
5.0456 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(Primate)Tj
3.3959 0 Td
(Order[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
4.0422 0 Td
(Third,)Tj
2.7496 0 Td
(no)Tj
1.2756 0 Td
(studies)Tj
2.9877 0 Td
(to)Tj
1.0261 0 Td
(date)Tj
1.8992 0 Td
(report)Tj
2.7099 0 Td
(chronic)Tj
3.2882 0 Td
(natural)Tj
3.084 0 Td
(infec-)Tj
-34.3556 -1.2982 Td
(tions)Tj
2.1996 0 Td
(by)Tj
1.1849 0 Td
(sampling)Tj
3.8778 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(individuals)Tj
4.6488 0 Td
(across)Tj
2.6815 0 Td
(years.)Tj
2.4888 0 Td
(If)Tj
0.8447 0 Td
(true,)Tj
2.0693 0 Td
(this)Tj
1.6724 0 Td
(would)Tj
2.7156 0 Td
(provide)Tj
3.2882 0 Td
(evidence)Tj
3.7134 0 Td
(that)Tj
-35.1097 -1.3039 Td
(the)Tj
1.4626 0 Td
(Callitrichidae)Tj
5.6183 0 Td
(could)Tj
2.4434 0 Td
(be)Tj
1.1509 0 Td
(suitable)Tj
3.2825 0 Td
(hosts)Tj
2.2677 0 Td
(for)Tj
/F13 1 Tf
1.3833 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()6()11()4()16(\r)-9()4()6()11(\r)20()10()4()12()4()16()18( )12()]TJ
/F7 1 Tf
8.759 0 Td
(and)Tj
1.7234 0 Td
(may)Tj
1.9276 0 Td
(act)Tj
1.3719 0 Td
(as)Tj
1.0092 0 Td
(a)Tj
0.6519 0 Td
(reservoir)Tj
-34.0438 -1.2983 Td
(for)Tj
1.3832 0 Td
(human)Tj
3.0785 0 Td
(malaria.)Tj
-3.2655 -1.2983 Td
(Here)Tj
2.211 0 Td
(we)Tj
1.3266 0 Td
(screen)Tj
2.7722 0 Td
(for)Tj
1.3833 0 Td
(natural)Tj
/F13 1 Tf
3.0784 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
5.1364 0 Td
(infections)Tj
4.1499 0 Td
(longitudinally)Tj
5.8053 0 Td
(across)Tj
2.6759 0 Td
(four)Tj
1.9162 0 Td
(years)Tj
2.262 0 Td
(in)Tj
1.0375 0 Td
(two)Tj
-34.9509 -1.3039 Td
(sympatric)Tj
4.1669 0 Td
(species)Tj
2.9933 0 Td
(of)Tj
1.0148 0 Td
(callitrichids,)Tj
5.108 0 Td
(the)Tj
1.4684 0 Td
(saddleback)Tj
4.6034 0 Td
(tamarin,)Tj
/F13 1 Tf
3.617 0 Td
[()-6()15()-8( )12()12()18( )-4()]TJ
3.753 0 Td
[(\n)-8( )-4()-3()1()4()7()10()4()12()-4()]TJ
3.8891 0 Td
[()3()7()4()4()15()4()12()]TJ
/F7 1 Tf
3.4016 0 Td
(\(but)Tj
1.8935 0 Td
(see)Tj
-35.909 -1.2982 Td
(ongoing)Tj
3.5262 0 Td
(taxonomic)Tj
4.4901 0 Td
(revisions)Tj
3.7814 0 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
(]\),)Tj
3.5943 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(emperor)Tj
3.6567 0 Td
(tamarin,)Tj
/F13 1 Tf
3.617 0 Td
[()-6()15()-8( )12()12()18( )-4()]TJ
3.753 0 Td
[()12()15()4()2(\r)20()22()11()11(\r)]TJ
/F7 1 Tf
(.)Tj
4.3314 0 Td
(Given)Tj
-33.9475 -1.2983 Td
(the)Tj
1.4683 0 Td
(observed)Tj
3.7984 0 Td
(host)Tj
1.9105 0 Td
(breadth)Tj
3.3109 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()11(\r)20()10()4()12()4()16()18( )12()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
8.7647 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(small)Tj
2.3301 0 Td
(sample)Tj
3.0217 0 Td
(sizes)Tj
2.0466 0 Td
(of)Tj
1.0148 0 Td
(prior)Tj
-32.8703 -1.3039 Td
(efforts,)Tj
2.982 0 Td
(we)Tj
1.3266 0 Td
(predict)Tj
3.05 0 Td
(that)Tj
1.7745 0 Td
(callitrichine)Tj
4.9663 0 Td
(species)Tj
2.999 0 Td
(could)Tj
2.4491 0 Td
(be)Tj
1.1509 0 Td
(competent)Tj
4.4787 0 Td
(reservoirs)Tj
4.1329 0 Td
(for)Tj
1.389 0 Td
(this)Tj
1.6724 0 Td
(parasite,)Tj
3.549 0 Td
(in)Tj
-35.9204 -1.2983 Td
(which)Tj
/F13 1 Tf
2.6475 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
5.1363 0 Td
(is)Tj
0.8448 0 Td
(permanently)Tj
5.3064 0 Td
(maintained)Tj
4.7905 0 Td
(and)Tj
1.7291 0 Td
(infections)Tj
4.1499 0 Td
(are)Tj
1.4513 0 Td
(vectored)Tj
3.651 0 Td
(between)Tj
3.5263 0 Td
(conspecif-)Tj
-33.2331 -1.2983 Td
(ics)Tj
1.2699 0 Td
([)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(].)Tj
2.0749 0 Td
(Second,)Tj
3.3562 0 Td
(since)Tj
/F13 1 Tf
2.2394 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()6()11()4()16(\r)-9()4()6()]TJ
/F7 1 Tf
3.7076 0 Td
(infection)Tj
3.7928 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1508 0 Td
(chronic)Tj
3.2882 0 Td
(in)Tj
1.0375 0 Td
(humans,)Tj
3.6623 0 Td
(we)Tj
1.3266 0 Td
(predict)Tj
3.0501 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
-34.3613 -1.3039 Td
(same)Tj
2.2563 0 Td
(will)Tj
1.6668 0 Td
(be)Tj
1.1452 0 Td
(true)Tj
1.8425 0 Td
(for)Tj
1.3889 0 Td
(these)Tj
2.2507 0 Td
(callitrichine)Tj
4.9663 0 Td
(hosts.)Tj
2.5001 0 Td
(In)Tj
1.1055 0 Td
(addition)Tj
3.6 0 Td
(to)Tj
1.0262 0 Td
(testing)Tj
2.8799 0 Td
(these)Tj
2.2564 0 Td
(predictions,)Tj
4.9549 0 Td
(our)Tj
1.6271 0 Td
(goal)Tj
-35.4668 -1.2982 Td
(is)Tj
0.8447 0 Td
(to)Tj
1.0261 0 Td
(establish)Tj
3.6453 0 Td
(the)Tj
1.4684 0 Td
(prevalence)Tj
4.49 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F7 1 Tf
(,)Tj
5.3575 0 Td
(and)Tj
1.7291 0 Td
(incidence)Tj
4.0762 0 Td
(of)Tj
1.0148 0 Td
(new)Tj
1.8765 0 Td
(infections,)Tj
4.3767 0 Td
(in)Tj
1.0318 0 Td
(both)Tj
2.0636 0 Td
(species,)Tj
-34.0155 -1.2983 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0261 0 Td
(explore)Tj
3.1748 0 Td
(any)Tj
1.6554 0 Td
(patterns)Tj
3.4753 0 Td
(in)Tj
1.0318 0 Td
(how)Tj
1.9389 0 Td
(infections)Tj
4.1555 0 Td
(are)Tj
1.4457 0 Td
(distributed)Tj
4.5977 0 Td
(across)Tj
2.6759 0 Td
(host)Tj
1.9162 0 Td
(characteristics)Tj
5.9074 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
-36.7877 -1.2983 Td
(sex,)Tj
1.6951 0 Td
(age)Tj
1.542 0 Td
(class,)Tj
2.2677 0 Td
(and)Tj
1.7348 0 Td
(group)Tj
2.6078 0 Td
(membership.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 156.9826 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F0 1 Tf
-6.4961 -1.4976 Td
(Study)Tj
2.7543 0 Td
(subjects)Tj
3.8457 0 Td
(and)Tj
1.8614 0 Td
(sampling)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 122.0031 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Samples)Tj
3.4979 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(from)Tj
2.2053 0 Td
(a)Tj
0.652 0 Td
(free-ranging)Tj
5.176 0 Td
(population)Tj
4.5921 0 Td
(of)Tj
1.0148 0 Td
(saddleback)Tj
4.5978 0 Td
(\()Tj
/F13 1 Tf
[()-6()15()-8( )12()12()18( )-4()]TJ
4.0989 0 Td
[(\n)-8( )-4()-3()1()4()7()10()4()12()-4()]TJ
/F7 1 Tf
(\))Tj
-31.6968 -1.2982 Td
(and)Tj
1.7291 0 Td
(emperor)Tj
3.651 0 Td
(\()Tj
/F13 1 Tf
[()-6()15()-8( )12()12()18( )-4()]TJ
4.0988 0 Td
[()12()15()4()2(\r)20()22()11()11(\r)]TJ
/F7 1 Tf
(\))Tj
4.4447 0 Td
(tamarins)Tj
3.7531 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(Estacio)Tj
0 Tc
2.4151 0.051 Td
()Tj
-0.004 Tc
0.4422 -0.051 Td
(n)Tj
0.771 0 Td
(Biolo)Tj
0 Tc
1.6611 0.051 Td
()Tj
-0.004 Tc
0.4478 -0.051 Td
(gica)Tj
1.8085 0 Td
(Rio)Tj
1.6158 0 Td
(Los)Tj
1.6271 0 Td
(Amigos)Tj
3.3221 0 Td
(\(EBLA\))Tj
-34.2082 -1.3039 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(Madre)Tj
2.8686 0 Td
(de)Tj
1.1679 0 Td
(Dios)Tj
2.0919 0 Td
(Department)Tj
5.091 0 Td
(of)Tj
1.0148 0 Td
(southeastern)Tj
5.3008 0 Td
(Peru)Tj
0 Tc
1.4286 0.0453 Td
()Tj
-0.004 Tc
0.6747 -0.0453 Td
(\(1234'07S,)Tj
5.1136 0 Td
(7005'57W\))Tj
5.3802 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(\).)Tj
-34.4577 -1.2983 Td
(This)Tj
1.9842 0 Td
(privately)Tj
3.6907 0 Td
(owned)Tj
2.9083 0 Td
(field)Tj
1.9729 0 Td
(station)Tj
2.9367 0 Td
(is)Tj
0.8447 0 Td
(managed)Tj
3.8721 0 Td
(and)Tj
1.7291 0 Td
(protected)Tj
4.0139 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(Amazon)Tj
3.6226 0 Td
(Conservation)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 400.9322 745.7952 cm
BT
/F6 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Plasmodi)Tj
4.0394 0 Td
(um)Tj
1.5874 0 Td
(brasilianum)Tj
/F0 1 Tf
5.237 0 Td
(infections)Tj
4.3654 0 Td
(in)Tj
0.978 0 Td
(wild)Tj
1.8992 0 Td
(tamarins)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01845)Tj
4.089 0 Td
(04)Tj
0 g
2.0906 0 Td
(September)Tj
5.0386 0 Td
(13,)Tj
1.5874 0 Td
(2017)Tj
32.2798 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
105 0 obj
<>stream
endstream
endobj
106 0 obj
<>stream
endstream
endobj
107 0 obj
<>stream
endstream
endobj
108 0 obj
<>stream
endstream
endobj
109 0 obj
<>stream
endstream
endobj
110 0 obj
<>stream
endstream
endobj
111 0 obj
<>stream
endstream
endobj
112 0 obj
<>stream
endstream
endobj
113 0 obj
<>stream
endstream
endobj
114 0 obj
<>stream
endstream
endobj
115 0 obj
<>stream
endstream
endobj
116 0 obj
<>stream
endstream
endobj
117 0 obj
<>stream
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
endstream
endobj
124 0 obj
<>stream
BT
66.402 0 Td
(14)Tj
ET
Q
endstream
endobj
125 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 127 0 R/Contents 128 0 R/TrimBox[0 0 612 792]>>
endobj
126 0 obj
<>stream
xx}ݝ)%D'rcOybrB PU쨑.I`
؝wQHZ.JH*,)gf1X 7x0X?ۂwjտƚ5#YspEk֬]ݾz,;=Nڎ=QXb-EҍqG1wk8uyv4f駟'o[V]FQ;qرh4/}뮻lْH$ī߶9ذ6@{/eaL;hf8i;5Z38i;ڐ 91Ⱥ]p(gWD7#Ox묶|DcޑG19'WZ:Xka,;uhsG42h^-0yWxf+)sz\o4xV\YgmZ7~_ߘј/#먥VkM6y/Z;|!?ݑQ{ˎCjXj;z.7yGc+dhpJC@~qw ّ{
9vd]3OxNL_?G9f:s9Ƴܙ.3\|t/фvd7%B],C:xGudf+S=^VIDUEQ$drѢEg$I[֯_x)w֭Lwgr&GYiMߎE$GfFKlF=o_IM=w(wi7ԝn%ΝzL]Oϟ@ @ @ @ xg4*x"@4]K֕JҐJopyU=w~
7Hя~KR+{CC
΄٦䢁 vpMtɾ&͛
Lvp__R3L9{sy" \^0
\,L%I+CVG#w|jcR V=<0pםwI}l挙~?Wz"qWUOh
]et