The anti-miR21 antagomir, a therapeutic tool for colorectal cancer, has a potential synergistic effect by perturbing an angiogenesis-associated miR30

@article{Song2014TheAA,
  title={The anti-miR21 antagomir, a therapeutic tool for colorectal cancer, has a potential synergistic effect by perturbing an angiogenesis-associated miR30},
  author={Min‐sun Song and John J. Rossi},
  journal={Frontiers in Genetics},
  year={2014},
  volume={4},
  url={https://api.semanticscholar.org/CorpusID:18212349}
}
Treatment with the anti-miR21 antagomir may have a synergistic effect mediated through suppression of miR30, which is involved in angiogenesis, and results suggest anti- miR21 has a role not only in tumor growth but also inAngiogenesis.

Figures from this paper

MicroRNA‑21 contributes to renal cell carcinoma cell invasiveness and angiogenesis via the PDCD4/c‑Jun (AP‑1) signalling pathway.

It is demonstrated that miR‑21 expression promoted the migration, invasion and angiogenic abilities of RCC cells by directly targeting the PDCD4/c‑Jun signalling pathway.

An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells

The results showed that miR-21 negatively regulated VMP1 transcription through the PTEN/AKT/TFEB pathway, and TFEB-induced transcriptional activation of V MP1 could inhibit mi R-21 expression, thus forming a feedback regulatory loop of miR -21/VMP1.

High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222.

The studies on apoptosis confirmed that the R8-PNA-a221 induces apoptosis and demonstrated the pro-apoptotic effects of R9-P NA-a222, and these experiments support the concept that the effects ofR8- PNA- a221 and R8/miRNA interactions are specific.

Angioregulatory microRNAs in Colorectal Cancer

The aim of this article is to review the current literature on angioregulatory miRNAs in CRC and to understand the interaction between these miRNA and their target mRNAs to unravel molecular mechanisms involved in CRC progression.

Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma.

It is confirmed thatmiR-7a and miR-24-3p are more highly expressed in NMLTs than in the AC samples, and that they modulate the SOX18 transcript in NSCLC cells.

AngiomiRs: MicroRNAs driving angiogenesis in cancer (Review).

The present review discusses the current progress towards understanding the functions of miRNAs in tumor angiogenesis regulation in diverse types of human cancer and the potential clinical application of angiomiRs towards anti‑angiogenic tumor therapy was explored.

Targeting miR-155-5p and miR-221-3p by peptide nucleic acids induces caspase-3 activation and apoptosis in temozolomide-resistant T98G glioma cells

It is confirmed that both PNAs induced apoptosis when used on the temozolomide-resistant T98G glioma cell line, and co-administration of both anti-miR-155 and anti- miR-221 PN as was associated with an increased proapoptotic activity.

Epigenetic Drug Therapy in the Treatment of Colorectal Cancer.

In this review, the recent pre-clinical and clinical trial studies investigating the therapeutic value of using epigenetic drugs as novel therapeutic approach in CRC treatment are summarized.

Role of miR-21 in determining sensitivity of mammary epithelial cells to radiation treatment

The response to the combined treatment differs between cancer and non-cancer cells, this may hold a significant therapy potential for the breast cancer patients.

MiR expression profiles of paired primary colorectal cancer and metastases by next-generation sequencing

NGS results indicate that previously unrecognized candidate miRs expressed in advanced CRC were identified using NGS, and miR expression profiles of pCRC and metastatic lesions are highly comparable and may be of similar predictive value for prognosis or treatment in patients with advanced CRC.

MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.

It is shown for the first time that miR-21 targets multiple important components of the p53, transforming growth factor-beta (TGF-beta), and mitochondrial apoptosis tumor-suppressive pathways in glioblastoma cells.

MicroRNA-21 is involved in osteosarcoma cell invasion and migration

The results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma, likely through regulating RECK and may serve as a therapeutic target.

Altered Expression of miR-21, miR-31, miR-143 and miR-145 Is Related to Clinicopathologic Features of Colorectal Cancer

expression of miR-21 correlated with CRC clinical stage, and a high expression was associated with lymph node positivity and the development of distant metastases in CRC patients, suggesting possible roles of microRNAs in CRC.

MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)*

Two-dimensional differentiation in-gel electrophoresis of tumors treated with anti-mir-21 and identified the tumor suppressor tropomyosin 1 (TPM1) as a potential mir-21 target found that down-regulation of TPM1 by mir- 21 may explain, at least in part, why suppression of mir-23 can inhibit tumor growth, further supporting the notion that mir-20 functions as an oncogene.

A microRNA expression signature of human solid tumors defines cancer gene targets

The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.

MicroRNAs in colorectal cancer: translation of molecular biology into clinical application

The knowledge regarding miRNAs' functioning in CRC is summarized while emphasizing their significance in pathogenetic signaling pathways and their potential to serve as disease biomarkers and novel therapeutic targets.

Highly Increased Maspin Expression Corresponds With Up-Regulation of miR-21 in Endometrial Cancer: A Preliminary Report

Background: Maspin and programmed cell death 4 (Pdcd4) are tumor suppressor genes, and miR-21 is overexpressed in many solid tumors and was proven to negatively regulate a number of tumor suppressor
...