Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age

@article{Baker2008CytokineassociatedNE,
  title={Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age},
  author={Virginia Baker and Godwin E Imade and Norman B Molta and Pallavi Tawde and Sunday D. Pam and Michael O. Obadofin and Soloman A. Sagay and Daniel Zanyu Egah and Dan Iya and Bangmboye B. Afolabi and Murray Baker and Karen Jackson Ford and Robert Ford and Kenneth H. Roux and Thomas C. S. Keller},
  journal={Malaria Journal},
  year={2008},
  volume={7},
  pages={41 - 41},
  url={https://api.semanticscholar.org/CorpusID:8459584}
}
The results of this investigation suggest that NET formation and ANA to dsDNA may induce pathology in falciparum-infected children, but activate a protective mechanism against falcIParum malaria in adults.
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164 Citations
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164 Citations

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Neutrophil extracellular traps generation and degradation in patients with granulomatosis with polyangiitis and systemic lupus erythematosus

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It is shown that infected red blood cells produce a cytokine, macrophage migration inhibitory factor (MIF) that stimulates neutrophils to release NETs, and an important participation of this process in malaria control is suggested.

Circulating Neutrophil Extracellular Traps and Neutrophil Activation Are Increased in Proportion to Disease Severity in Human Malaria.

Although NETs may inhibit parasite growth in asymptomatic P falciparum infection, neutrophil activation and NET release may contribute to pathogenesis in severe falcIParum malaria.

Defining a pro‐inflammatory neutrophil phenotype in response to schistosome eggs

It is shown that S. japonicum eggs can induce the inflammatory phenotype of neutrophils, and further the understanding of the host–parasite interplay that takes place within the in vivo microenvironment of schistosome‐induced granuloma.

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...

71 References

Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria.

Anemia and Interleukin-10, Tumor Necrosis Factor Alpha, and Erythropoietin Levels among Children with Acute, Uncomplicated Plasmodium falciparum Malaria

The data suggest that younger children do not maintain IL-10 production in response to the inflammatory process, and this mechanism may contribute to the more severe anemia found in younger children.

Increased levels of interleukin‐12 in Plasmodium falciparum malaria: correlation with the severity of disease

In this study, the levels of IL‐12 were determined in 73 African children, aged 2–144 months (median 19·5 months), who had severe or mild P. falciparum malaria, using the enzyme‐linked immunosorbent assay.

Hemozoin Differentially Regulates Proinflammatory Cytokine Production in Human Immunodeficiency Virus-Seropositive and -Seronegative Women with Placental Malaria

The findings suggest that the influences of hemozoin accumulation and high-density parasitemia on placental cytokine production are not equivalent and may involve different mechanisms, all of which may operate differently in the context of HIV infection.

Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia.

Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria

Cytokine profile suggesting that murine cerebral malaria is an encephalitis

Cerebral malaria (CM) remains a poorly understood and life-threatening complication of malaria caused by the parasite Plasmodium falciparum. The discovery that murine CM caused by Plasmodium berghei…

Plasmodium falciparum induces apoptosis in human mononuclear cells

Results strongly suggest that acute as well as chronic asymptomatic P. falciparum infections were consistently associated with a marked increase in the level of mononuclear cell apoptosis, which could be implicated in some of the alterations reported for the proliferative T-cell responses in areas where malaria is endemic.

Hyperhomocysteinemia in acute Plasmodium falciparum malaria: an effect of host-parasite interaction.

Cerebral malaria -- a neurovascular pathology with many riddles still to be solved.

A better understanding of the molecular mechanisms involved in CM pathogenesis is needed if the authors are capable of preventing cerebral complications and improving the quality of patient management.
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