%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Alberto Fernández-Villar, Cristina Represas-Represas, Cecilia Mouronte-Roibás, Cristina Ramos-Hernández, Ana Priegue-Carrera, Sara Fernández-García, José Luis López-Campos
Reliability and usefulness of spirometry performed during admission for COPD exacerbation
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref001)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref002)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref004)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref005)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref006)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref007)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref009)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref009)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref012)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref005)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref009)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref012)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref013)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref009)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref014)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref015)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref001)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref002)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref010)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref010)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref012)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref016)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref009)>>
endobj
41 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref010)>>
endobj
42 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref014)>>
endobj
43 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref017)>>
endobj
44 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref018)>>
endobj
45 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref014)>>
endobj
46 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref017)>>
endobj
47 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref018)>>
endobj
48 0 obj
<>/Border[0 0 0]/A 49 0 R>>
endobj
49 0 obj
<>
endobj
15 0 obj
[50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R]
endobj
50 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 647.9101 m
199.9998 647.9101 l
199.9998 648.4102 l
575.9997 648.4102 l
f*
0.83 0.64 0.02 0 k
378.7654 574.8661 m
383.5276 574.8661 l
h
f*
388.6866 574.8661 m
393.4488 574.8661 l
h
f*
386.3055 548.9008 m
391.0677 548.9008 l
h
f*
393.3354 548.9008 m
398.0409 548.9008 l
h
f*
425.3102 535.8614 m
430.0724 535.8614 l
h
f*
432.3402 535.8614 m
437.1024 535.8614 l
h
f*
516.6425 496.8567 m
521.4047 496.8567 l
h
f*
269.4614 457.852 m
274.2236 457.852 l
h
f*
279.4394 457.852 m
284.1449 457.852 l
h
f*
237.0898 444.8693 m
241.852 444.8693 l
h
f*
247.011 444.8693 m
256.5354 444.8693 l
h
f*
425.537 405.8646 m
430.2425 405.8646 l
h
f*
432.5102 405.8646 m
437.2724 405.8646 l
h
f*
439.5402 405.8646 m
449.0646 405.8646 l
h
f*
437.9528 392.8819 m
447.4772 392.8819 l
h
f*
386.9858 366.8598 m
391.748 366.8598 l
h
f*
393.9591 366.8598 m
403.4835 366.8598 l
h
f*
405.7512 366.8598 m
415.2756 366.8598 l
h
f*
248.8819 327.8551 m
253.6441 327.8551 l
h
f*
255.9118 327.8551 m
260.674 327.8551 l
h
f*
407.7354 327.8551 m
417.2598 327.8551 l
h
f*
216.8504 288.8504 m
226.3748 288.8504 l
h
f*
228.5858 288.8504 m
238.1102 288.8504 l
h
f*
240.378 288.8504 m
249.9024 288.8504 l
h
f*
495.2693 262.885 m
500.0315 262.885 l
h
f*
502.2992 262.885 m
511.7669 262.885 l
h
f*
514.0346 262.885 m
523.5591 262.885 l
h
f*
525.8268 262.885 m
535.3512 262.885 l
h
f*
537.5622 262.885 m
547.0866 262.885 l
h
f*
364.3654 223.8803 m
373.8898 223.8803 l
h
f*
376.1008 223.8803 m
385.6252 223.8803 l
h
f*
387.8929 223.8803 m
397.4173 223.8803 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(This)Tj
2.0886 0 Td
(study)Tj
2.59 0 Td
(provides)Tj
3.9506 0 Td
(information)Tj
5.1083 0 Td
(on)Tj
1.3188 0 Td
(the)Tj
1.5934 0 Td
(role)Tj
1.8619 0 Td
(of)Tj
1.0503 0 Td
(spirometry)Tj
4.8398 0 Td
(prior)Tj
2.1901 0 Td
(to)Tj
1.0444 0 Td
(hospital)Tj
3.6223 0 Td
(discharge)Tj
4.4996 0 Td
(in)Tj
-35.7581 -1.474 Td
(patients)Tj
3.682 0 Td
(admitted)Tj
4.0103 0 Td
(for)Tj
1.3785 0 Td
(COPD)Tj
3.0912 0 Td
(exacerbation,)Tj
6.1527 0 Td
(demonstratin)Tj
5.723 0 Td
(g)Tj
0.7698 0 Td
(that)Tj
1.8679 0 Td
(it)Tj
0.7161 0 Td
(is)Tj
0.9309 0 Td
(a)Tj
0.7699 0 Td
(valid)Tj
2.2438 0 Td
(and)Tj
1.8619 0 Td
(reproducible)Tj
-33.198 -1.468 Td
(method,)Tj
3.8013 0 Td
(representing)Tj
5.7051 0 Td
(an)Tj
1.3189 0 Td
(opportunity)Tj
5.1083 0 Td
(toimprove)Tj
4.5652 0 Td
(COPD)Tj
3.0913 0 Td
(diagnosis.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 605.9338 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 588.9826 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Chronic)Tj
3.5262 0 Td
(obstructive)Tj
4.6602 0 Td
(pulmonary)Tj
4.6487 0 Td
(disease)Tj
3.0161 0 Td
(\(COPD\))Tj
3.6056 0 Td
(is)Tj
0.8448 0 Td
(a)Tj
0.6576 0 Td
(chronic)Tj
3.2882 0 Td
(disease)Tj
3.016 0 Td
(with)Tj
1.9956 0 Td
(high)Tj
2.0126 0 Td
(prevalence)Tj
4.4843 0 Td
(and)Tj
-35.7559 -1.3039 Td
(mortality,)Tj
4.1385 0 Td
(leading)Tj
3.1351 0 Td
(to)Tj
1.0261 0 Td
(significant)Tj
4.388 0 Td
(health)Tj
2.6759 0 Td
(costs)Tj
2.1714 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
2.5965 0 Td
(The)Tj
1.7801 0 Td
(diagnosis)Tj
3.9572 0 Td
(of)Tj
1.0148 0 Td
(COPD)Tj
2.9253 0 Td
(is)Tj
0.8504 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(inhaled)Tj
-34.4067 -1.2982 Td
(exposure)Tj
3.8154 0 Td
(to)Tj
1.0261 0 Td
(different)Tj
3.6567 0 Td
(toxins,)Tj
2.8913 0 Td
(mainly)Tj
2.9877 0 Td
(tobacco,)Tj
3.5489 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(respiratory)Tj
4.5978 0 Td
(symptoms,)Tj
4.5808 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
-35.0303 -1.2983 Td
(demonstration)Tj
6.1284 0 Td
(of)Tj
1.0148 0 Td
(chronic)Tj
3.2882 0 Td
(airflow)Tj
3.0217 0 Td
(obstruction)Tj
4.8359 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
2.3017 0 Td
(Although)Tj
4.0025 0 Td
(COPD)Tj
2.9253 0 Td
(is)Tj
0.8504 0 Td
(remarkably)Tj
4.7792 0 Td
(underdiag-)Tj
-33.1481 -1.3039 Td
(nosed,)Tj
2.8119 0 Td
(imprecision)Tj
4.9946 0 Td
(in)Tj
1.0318 0 Td
(this)Tj
1.6781 0 Td
(diagnosis)Tj
3.9572 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(described)Tj
4.0535 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
-20.9932 -1.2983 Td
(Spirometry)Tj
4.7281 0 Td
(is)Tj
0.8504 0 Td
(essential)Tj
3.583 0 Td
(to)Tj
1.0204 0 Td
(assessing)Tj
3.8041 0 Td
(airflow)Tj
3.0161 0 Td
(obstruction)Tj
4.8415 0 Td
(and)Tj
1.7291 0 Td
(COPD)Tj
2.9254 0 Td
(diagnosis.)Tj
4.1839 0 Td
(The)Tj
1.7801 0 Td
(results)Tj
2.812 0 Td
(of)Tj
-36.4703 -1.2982 Td
(this)Tj
1.6724 0 Td
(measurement)Tj
5.6692 0 Td
(play)Tj
1.8766 0 Td
(a)Tj
0.6519 0 Td
(fundamental)Tj
5.3178 0 Td
(role)Tj
1.7688 0 Td
(in)Tj
1.0318 0 Td
(scales)Tj
2.4718 0 Td
(and)Tj
1.7291 0 Td
(classifications)Tj
5.709 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(disease,)Tj
3.2428 0 Td
(making)Tj
3.2485 0 Td
(it)Tj
-36.8728 -1.304 Td
(essential)Tj
3.5829 0 Td
(to)Tj
1.0262 0 Td
(patient)Tj
3.0047 0 Td
(characterization.)Tj
6.8881 0 Td
(However,)Tj
4.0762 0 Td
(spirometry)Tj
4.6148 0 Td
(is)Tj
0.8447 0 Td
(widely)Tj
2.8233 0 Td
(underused)Tj
4.4617 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5987 0 Td
(Conse-)Tj
-32.9213 -1.2982 Td
(quently,)Tj
3.4412 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8391 0 Td
(not)Tj
1.5647 0 Td
(uncommon)Tj
4.9153 0 Td
(for)Tj
1.3776 0 Td
(a)Tj
0.6463 0 Td
(patient)Tj
2.999 0 Td
(to)Tj
1.0205 0 Td
(be)Tj
1.1395 0 Td
(diagnosed)Tj
4.2746 0 Td
(with)Tj
1.9899 0 Td
(COPD)Tj
2.9197 0 Td
(only)Tj
1.9672 0 Td
(on)Tj
1.2699 0 Td
(the)Tj
1.4627 0 Td
(basis)Tj
2.143 0 Td
(of)Tj
1.0091 0 Td
(clin-)Tj
-35.7616 -1.2983 Td
(ical)Tj
1.5873 0 Td
(suspicion,)Tj
4.2293 0 Td
(without)Tj
3.3279 0 Td
(proper)Tj
2.931 0 Td
(confirmation)Tj
5.4991 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4684 0 Td
(demonstration)Tj
6.1341 0 Td
(of)Tj
1.0148 0 Td
(airflow)Tj
3.016 0 Td
(obstruction)Tj
-32.9553 -1.3039 Td
(with)Tj
1.9955 0 Td
(spirometry)Tj
4.6091 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
2.5966 0 Td
(Consistently,)Tj
5.4254 0 Td
(spirometry)Tj
4.6091 0 Td
(confirms)Tj
3.8041 0 Td
(COPD)Tj
2.9253 0 Td
(diagnosis)Tj
3.9629 0 Td
(in)Tj
1.0318 0 Td
(2070%)Tj
3.3958 0 Td
(of)Tj
-34.3556 -1.2983 Td
(patients)Tj
3.3675 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
-2.1713 -1.2982 Td
(Inadequate)Tj
4.6884 0 Td
(diagnosis)Tj
3.9572 0 Td
(of)Tj
1.0148 0 Td
(COPD)Tj
2.9253 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6577 0 Td
(considerable)Tj
5.261 0 Td
(health)Tj
2.6759 0 Td
(problem,)Tj
3.8381 0 Td
(as)Tj
1.0148 0 Td
(it)Tj
0.7824 0 Td
(can)Tj
1.627 0 Td
(lead)Tj
1.8539 0 Td
(to)Tj
1.0261 0 Td
(inade-)Tj
-33.3635 -1.2983 Td
(quate)Tj
2.4094 0 Td
(treatment)Tj
4.1329 0 Td
(prescriptions,)Tj
5.6806 0 Td
(with)Tj
2.0012 0 Td
(health)Tj
2.6759 0 Td
(costs)Tj
2.1713 0 Td
(and)Tj
1.7291 0 Td
(risks)Tj
2.075 0 Td
(for)Tj
1.389 0 Td
(patients,)Tj
3.5943 0 Td
(leading)Tj
3.1294 0 Td
(to)Tj
1.0261 0 Td
(delays)Tj
2.6646 0 Td
(in)Tj
-34.6788 -1.3039 Td
(diagnosing)Tj
4.6091 0 Td
(and)Tj
1.7291 0 Td
(treating)Tj
3.3278 0 Td
(the)Tj
1.4684 0 Td
(true)Tj
1.8425 0 Td
(cause)Tj
2.3924 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(symptoms)Tj
4.3597 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
3.4752 0 Td
(In)Tj
1.1112 0 Td
(addition,)Tj
3.8211 0 Td
(the)Tj
1.4683 0 Td
(lack)Tj
1.8199 0 Td
(of)Tj
1.0148 0 Td
(spiro-)Tj
-34.9226 -1.2983 Td
(metric)Tj
2.8232 0 Td
(assessment)Tj
4.6091 0 Td
(increases)Tj
3.8325 0 Td
(the)Tj
1.474 0 Td
(probability)Tj
4.5921 0 Td
(of)Tj
1.0148 0 Td
(readmission)Tj
5.108 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
2.0806 0 Td
(Therefore,)Tj
4.388 0 Td
(hospital)Tj
3.3789 0 Td
(admission)Tj
-33.3012 -1.2982 Td
(isa)Tj
1.2812 0 Td
(pertinent)Tj
3.9175 0 Td
(time)Tj
2.0296 0 Td
(to)Tj
1.0204 0 Td
(review)Tj
2.846 0 Td
(diagnostic)Tj
4.32 0 Td
(adequacy,)Tj
4.1782 0 Td
(confirming)Tj
4.7225 0 Td
(it)Tj
0.788 0 Td
(when)Tj
2.4038 0 Td
(previous)Tj
3.651 0 Td
(spirometry)Tj
4.6091 0 Td
(data)Tj
-35.7673 -1.304 Td
(are)Tj
1.4456 0 Td
(avalaible)Tj
3.668 0 Td
(or)Tj
1.0999 0 Td
(actualizing)Tj
4.541 0 Td
(lung)Tj
2.0126 0 Td
(function)Tj
3.6283 0 Td
(tests)Tj
1.9616 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
3.9515 0 Td
(Spirometry)Tj
4.7281 0 Td
(before)Tj
2.7383 0 Td
(discharge)Tj
4.0195 0 Td
(may)Tj
1.9332 0 Td
(con-)Tj
-35.7276 -1.2982 Td
(firm)Tj
1.9672 0 Td
(the)Tj
1.4683 0 Td
(diagnosis,)Tj
4.1839 0 Td
(but)Tj
1.5534 0 Td
(current)Tj
3.1805 0 Td
(guidelines)Tj
4.2802 0 Td
(and)Tj
1.7292 0 Td
(recommendations)Tj
7.5004 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.5761 0 Td
(include)Tj
3.1861 0 Td
(it)Tj
0.7823 0 Td
(within)Tj
2.812 0 Td
(the)Tj
-35.4725 -1.2983 Td
(protocols)Tj
3.9571 0 Td
(for)Tj
1.389 0 Td
(managing)Tj
4.2009 0 Td
(COPD)Tj
2.9253 0 Td
(exacerbation;)Tj
5.5445 0 Td
(they)Tj
1.9276 0 Td
(advise)Tj
2.6872 0 Td
(postponing)Tj
4.7565 0 Td
(spirometry)Tj
4.6091 0 Td
(until)Tj
2.109 0 Td
(stability)Tj
-34.1062 -1.3039 Td
(is)Tj
0.8447 0 Td
(achieved)Tj
3.702 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(])Tj
2.0806 0 Td
(as)Tj
1.0148 0 Td
(usually)Tj
3.0161 0 Td
(done)Tj
2.228 0 Td
(in)Tj
1.0318 0 Td
(general)Tj
3.1351 0 Td
(practice)Tj
3.3788 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
2.075 0 Td
(However,)Tj
4.0762 0 Td
(this)Tj
1.6781 0 Td
(is)Tj
0.8447 0 Td
(not)Tj
1.5761 0 Td
(always)Tj
2.8346 0 Td
(possible)Tj
-33.5166 -1.2983 Td
(because)Tj
3.3165 0 Td
(a)Tj
0.6576 0 Td
(significant)Tj
4.388 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(relapse)Tj
2.9934 0 Td
(or)Tj
1.0998 0 Td
(are)Tj
1.4513 0 Td
(readmitted)Tj
4.6091 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(weeks)Tj
2.6079 0 Td
(following)Tj
3.9798 0 Td
(hos-)Tj
-35.4101 -1.2982 Td
(pitalization)Tj
4.7168 0 Td
(due)Tj
1.7007 0 Td
(to)Tj
1.0262 0 Td
(COPD)Tj
2.9196 0 Td
(exacerbation,)Tj
5.5503 0 Td
(are)Tj
1.4513 0 Td
(lost)Tj
1.6327 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(follow-up,)Tj
4.3143 0 Td
(or)Tj
1.0999 0 Td
(followed)Tj
3.651 0 Td
(without)Tj
3.3278 0 Td
(spirome-)Tj
-33.8964 -1.304 Td
(try)Tj
1.3436 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
-0.1474 -1.2982 Td
(Currently,)Tj
4.354 0 Td
(evidence)Tj
3.7133 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(validity)Tj
3.1691 0 Td
(and)Tj
1.7292 0 Td
(reliability)Tj
4.0025 0 Td
(of)Tj
1.0148 0 Td
(spirometry)Tj
4.6147 0 Td
(performed)Tj
4.4674 0 Td
(during)Tj
2.9253 0 Td
(admis-)Tj
-33.9304 -1.2983 Td
(sion)Tj
1.9048 0 Td
(is)Tj
0.8447 0 Td
(scarce)Tj
2.6589 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(heterogeneity)Tj
5.6579 0 Td
(and)Tj
1.7291 0 Td
(limitations)Tj
4.5354 0 Td
(of)Tj
1.0148 0 Td
(available)Tj
3.6624 0 Td
(studies)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
-29.1853 -1.2983 Td
(Accordingly,)Tj
5.3631 0 Td
(we)Tj
1.3266 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.576 0 Td
(know)Tj
2.4548 0 Td
(whether)Tj
3.4809 0 Td
(differences)Tj
4.5638 0 Td
(between)Tj
3.5263 0 Td
(spirometry)Tj
4.6147 0 Td
(performed)Tj
4.4674 0 Td
(during)Tj
2.9254 0 Td
(or)Tj
-35.5519 -1.3039 Td
(after)Tj
2.0352 0 Td
(hospitalization)Tj
6.1115 0 Td
(lead)Tj
1.8538 0 Td
(to)Tj
1.0262 0 Td
(changes)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(symptoms)Tj
4.3597 0 Td
(or)Tj
1.0941 0 Td
(impact)Tj
2.9821 0 Td
(of)Tj
1.0148 0 Td
(COPD,)Tj
3.1521 0 Td
(or)Tj
1.0941 0 Td
(predict)Tj
3.0501 0 Td
(subse-)Tj
-33.681 -1.2982 Td
(quent)Tj
2.5228 0 Td
(events)Tj
2.7325 0 Td
(in)Tj
1.0319 0 Td
(the)Tj
1.474 0 Td
(course)Tj
2.8289 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(disease)Tj
3.0161 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
-14.8988 -1.2983 Td
(This)Tj
1.9899 0 Td
(study)Tj
2.3867 0 Td
(aims)Tj
2.1033 0 Td
(to)Tj
1.0262 0 Td
(provide)Tj
3.2881 0 Td
(evidence)Tj
3.7134 0 Td
(on)Tj
1.2756 0 Td
(these)Tj
2.2507 0 Td
(aspects)Tj
3.0387 0 Td
(after)Tj
2.0352 0 Td
(evaluating)Tj
4.32 0 Td
(the)Tj
1.4684 0 Td
(reliability)Tj
4.0025 0 Td
(of)Tj
1.0148 0 Td
(spiro-)Tj
-35.1097 -1.3039 Td
(metric)Tj
2.8232 0 Td
(parameters)Tj
4.6715 0 Td
(at)Tj
0.9524 0 Td
(hospital)Tj
3.3789 0 Td
(discharge)Tj
4.0195 0 Td
(and)Tj
1.7348 0 Td
(comparing)Tj
4.5694 0 Td
(them)Tj
2.2904 0 Td
(to)Tj
1.0261 0 Td
(those)Tj
2.3358 0 Td
(obtained)Tj
3.736 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6577 0 Td
(stable)Tj
-33.2275 -1.2983 Td
(phase.)Tj
2.7099 0 Td
(In)Tj
1.1055 0 Td
(addition,)Tj
3.821 0 Td
(this)Tj
1.6781 0 Td
(study)Tj
2.3868 0 Td
(assesses)Tj
3.3052 0 Td
(whether)Tj
3.4809 0 Td
(any)Tj
1.6554 0 Td
(differences)Tj
4.5638 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
1.4683 0 Td
(results)Tj
2.8063 0 Td
(imply)Tj
2.5285 0 Td
(signif-)Tj
-35.0416 -1.2982 Td
(icant)Tj
2.1883 0 Td
(changes)Tj
3.4072 0 Td
(in)Tj
1.0318 0 Td
(symptoms,)Tj
4.5864 0 Td
(alter)Tj
1.9956 0 Td
(the)Tj
1.4684 0 Td
(impact)Tj
2.9763 0 Td
(of)Tj
1.0148 0 Td
(COPD,)Tj
3.1521 0 Td
(or)Tj
1.0999 0 Td
(help)Tj
1.9332 0 Td
(predict)Tj
3.05 0 Td
(subsequent)Tj
4.7055 0 Td
(events)Tj
2.7269 0 Td
(in)Tj
-35.3364 -1.304 Td
(the)Tj
1.4683 0 Td
(course)Tj
2.8346 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(disease.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 131.0173 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
/F10 1 Tf
0 -1.5023 Td
(Design)Tj
3.1228 0 Td
(and)Tj
1.7906 0 Td
(patient)Tj
3.1984 0 Td
(recruitment)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(longitudinal)Tj
5.108 0 Td
(prospective)Tj
4.7792 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.7008 0 Td
(performed)Tj
4.4673 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(Spanish)Tj
3.3505 0 Td
(universitary)Tj
5.0003 0 Td
(hospital.)Tj
3.6056 0 Td
(The)Tj
-34.0778 -1.2982 Td
(results)Tj
2.8062 0 Td
(of)Tj
1.0148 0 Td
(spirometry)Tj
4.6148 0 Td
(2448)Tj
2.6362 0 Td
(hours)Tj
2.5172 0 Td
(before)Tj
2.7382 0 Td
(discharge)Tj
4.0195 0 Td
(and)Tj
1.7348 0 Td
(8)Tj
0.6916 0 Td
(weeks)Tj
2.6079 0 Td
(after)Tj
2.0353 0 Td
(discharge)Tj
4.0251 0 Td
(were)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 260.9574 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Reliability)Tj
4.4008 0 Td
(and)Tj
1.8567 0 Td
(usefulness)Tj
4.9181 0 Td
(of)Tj
1.0418 0 Td
(spirometr)Tj
4.0961 0 Td
(y)Tj
0.7157 0 Td
(perform)Tj
3.3874 0 Td
(ed)Tj
1.3111 0 Td
(during)Tj
2.9409 0 Td
(admission)Tj
4.6418 0 Td
(for)Tj
1.3677 0 Td
(COPD)Tj
3.0757 0 Td
(exacerba)Tj
4.0394 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01949)Tj
4.089 0 Td
(83)Tj
0 g
2.0906 0 Td
(March)Tj
2.9622 0 Td
(26,)Tj
1.5874 0 Td
(2018)Tj
34.3562 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(12)Tj
/F8 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(laboratories.)Tj
4.8047 0 Td
(This)Tj
1.7859 0 Td
(does)Tj
2.0055 0 Td
(not)Tj
1.4244 0 Td
(alter)Tj
1.8142 0 Td
(our)Tj
1.474 0 Td
(adherence)Tj
4.0607 0 Td
(to)Tj
-17.3694 -1.3748 Td
(PLOS)Tj
2.3315 0 Td
(ONE)Tj
1.8708 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
1.1622 0 Td
(sharing)Tj
2.9835 0 Td
(data)Tj
1.7929 0 Td
(and)Tj
1.5874 0 Td
(materials.)Tj
/F7 1 Tf
-14.7402 -2.126 Td
(Abbreviati)Tj
3.9118 0 Td
(ons:)Tj
/F8 1 Tf
1.8425 0 Td
(ACOS,)Tj
2.6079 0 Td
(Asthma-COP)Tj
4.7977 0 Td
(D)Tj
0.8079 0 Td
(overlap)Tj
-13.9678 -1.3749 Td
(syndrome;)Tj
4.1882 0 Td
(AECOPD,)Tj
3.6709 0 Td
(Acute)Tj
2.3173 0 Td
(exacerbati)Tj
3.7559 0 Td
(on)Tj
1.1693 0 Td
(of)Tj
0.9497 0 Td
(COPD;)Tj
-16.0513 -1.3748 Td
(CAT,)Tj
1.97 0 Td
(COPD)Tj
2.4449 0 Td
(Assessme)Tj
3.8056 0 Td
(nt)Tj
0.9496 0 Td
(Test;)Tj
2.0197 0 Td
(COPD,)Tj
2.6646 0 Td
(Chronic)Tj
-13.8544 -1.3748 Td
(obstructive)Tj
4.337 0 Td
(pulmonary)Tj
4.2095 0 Td
(disease;)Tj
3.2173 0 Td
(FEV)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 141.5055 646.4125 cm
BT
/F8 1 Tf
1 TL
-0.0334 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 144.2834 647.7165 cm
BT
/F8 1 Tf
1 TL
-0.025 Tc
0 0 Td
(,)Tj
0.4464 0 Td
(Forced)Tj
-13.9819 -1.3748 Td
(expiratory)Tj
3.9189 0 Td
(volume)Tj
2.9552 0 Td
(in)Tj
0.8858 0 Td
(the)Tj
1.3677 0 Td
(first)Tj
1.6512 0 Td
(second;)Tj
3.1322 0 Td
(FVC,)Tj
1.9134 0 Td
(Forced)Tj
-15.8244 -1.3748 Td
(vital)Tj
1.7079 0 Td
(capaci)Tj
2.3457 0 Td
(ty;)Tj
1.1268 0 Td
(GOLD,)Tj
2.6787 0 Td
(Global)Tj
2.5583 0 Td
(Initiative)Tj
3.3023 0 Td
(for)Tj
1.2614 0 Td
(Chronic)Tj
-14.9811 -1.3748 Td
(Obstructive)Tj
4.4504 0 Td
(Lung)Tj
2.1119 0 Td
(Disease;)Tj
3.3378 0 Td
(IC,)Tj
1.2189 0 Td
(Inhaled)Tj
-11.119 -1.3748 Td
(corticostero)Tj
4.4221 0 Td
(id;)Tj
1.1126 0 Td
(LABA,)Tj
2.4945 0 Td
(Long)Tj
2.1118 0 Td
(acting)Tj
/F9 1 Tf
2.4591 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 140.2582 602.3622 cm
BT
/F8 1 Tf
1 TL
-0.0334 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 144.7937 603.7228 cm
BT
/F8 1 Tf
1 TL
-0.025 Tc
0 0 Td
(agonist;)Tj
-13.5993 -1.3748 Td
(LAMA,)Tj
2.7213 0 Td
(Long)Tj
2.1118 0 Td
(acting)Tj
2.4591 0 Td
(muscarinic)Tj
4.3016 0 Td
(antagonist;)Tj
4.3086 0 Td
(LTOT,)Tj
-15.9024 -1.3748 Td
(Long-term)Tj
4.1599 0 Td
(oxygen)Tj
2.9055 0 Td
(therapy;)Tj
3.2174 0 Td
(mMRC,)Tj
3.0614 0 Td
(Modified)Tj
-13.3442 -1.3748 Td
(British)Tj
2.5867 0 Td
(Medical)Tj
3.0968 0 Td
(Research)Tj
3.6993 0 Td
(Council)Tj
2.9693 0 Td
(dyspnea)Tj
3.3306 0 Td
(scale;)Tj
-15.6827 -1.3748 Td
(NIV,)Tj
1.8142 0 Td
(Non-invas)Tj
3.7701 0 Td
(ive)Tj
ET
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
BT
-6.7606 -5.4992 Td
(ventilation.)Tj
ET
Q
endstream
endobj
70 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 74 0 R/Contents 75 0 R/TrimBox[0 0 612 792]>>
endobj
74 0 obj
[76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R]
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref001)>>
endobj
77 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref019)>>
endobj
78 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref020)>>
endobj
79 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref021)>>
endobj
80 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref022)>>
endobj
81 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref001)>>
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194983.ref023)>>
endobj
83 0 obj
<>/Border[0 0 0]/A 84 0 R>>
endobj
84 0 obj
<>
endobj
75 0 obj
[85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R]
endobj
85 0 obj
<>stream
q
0.83 0.64 0.02 0 k
223.9937 667.3323 m
228.7559 667.3323 l
h
f*
525.5433 498.1039 m
535.0677 498.1039 l
h
f*
328.989 485.1213 m
338.5134 485.1213 l
h
f*
342.5386 394.1291 m
352.063 394.1291 l
h
f*
453.3732 394.1291 m
462.8976 394.1291 l
h
f*
355.9181 381.1465 m
360.6803 381.1465 l
h
f*
203.4142 238.1102 m
212.9386 238.1102 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(compared.)Tj
4.4673 0 Td
(Between)Tj
3.6 0 Td
(January)Tj
3.3222 0 Td
(2014)Tj
2.1203 0 Td
(and)Tj
1.7348 0 Td
(June)Tj
2.0466 0 Td
(2016,)Tj
2.3471 0 Td
(consecutive)Tj
4.8812 0 Td
(patients)Tj
3.3675 0 Td
(admitted)Tj
3.8154 0 Td
(to)Tj
1.0262 0 Td
(our)Tj
1.627 0 Td
(pneu-)Tj
-34.3556 -1.3039 Td
(mology)Tj
3.2201 0 Td
(ward)Tj
2.2337 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(COPD)Tj
2.9253 0 Td
(exacerbation)Tj
5.3235 0 Td
(were)Tj
2.1203 0 Td
(included)Tj
3.7133 0 Td
(until)Tj
2.109 0 Td
(the)Tj
1.4683 0 Td
(defined)Tj
3.2258 0 Td
(sample)Tj
3.0217 0 Td
(size)Tj
1.6838 0 Td
(was)Tj
-33.7717 -1.2982 Td
(reached)Tj
3.3505 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0204 0 Td
(Global)Tj
2.88 0 Td
(Initiative)Tj
3.8154 0 Td
(for)Tj
1.389 0 Td
(Chronic)Tj
3.5263 0 Td
(Obstructive)Tj
4.8982 0 Td
(Lung)Tj
2.3017 0 Td
(Disease)Tj
3.2258 0 Td
(\(GOLD\))Tj
3.6397 0 Td
(guide-)Tj
-34.2366 -1.2983 Td
(lines)Tj
2.0579 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5987 0 Td
(Patients)Tj
3.4016 0 Td
(with)Tj
1.9899 0 Td
(any)Tj
1.6554 0 Td
(psychic)Tj
3.1861 0 Td
(limitation)Tj
4.1669 0 Td
(that)Tj
1.7745 0 Td
(prevented)Tj
4.2066 0 Td
(them)Tj
2.279 0 Td
(from)Tj
2.1997 0 Td
(performing)Tj
4.7962 0 Td
(the)Tj
1.4627 0 Td
(correct)Tj
-34.7752 -1.2983 Td
(spirometric)Tj
4.8472 0 Td
(maneuvers,)Tj
4.8075 0 Td
(who)Tj
1.9389 0 Td
(presented)Tj
4.1159 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.6577 0 Td
(contraindication)Tj
6.8881 0 Td
(for)Tj
1.389 0 Td
(this)Tj
1.6724 0 Td
(test)Tj
1.5987 0 Td
(and)Tj
1.7348 0 Td
(those)Tj
2.3358 0 Td
(that)Tj
-33.9815 -1.3039 Td
(were)Tj
2.1203 0 Td
(shown)Tj
2.8516 0 Td
(by)Tj
1.1792 0 Td
(spirometry)Tj
4.6091 0 Td
(to)Tj
1.0261 0 Td
(have)Tj
2.0636 0 Td
(no)Tj
1.2756 0 Td
(airflow)Tj
3.0161 0 Td
(obstruction)Tj
4.8358 0 Td
(before)Tj
2.7383 0 Td
(discharge,orwho)Tj
6.8428 0 Td
(presented)Tj
-32.5585 -1.2982 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.652 0 Td
(new)Tj
1.8765 0 Td
(exacerbation)Tj
5.3234 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(8)Tj
0.6916 0 Td
(weeks)Tj
2.6079 0 Td
(after)Tj
2.0352 0 Td
(discharge)Tj
4.0252 0 Td
(were)Tj
2.1203 0 Td
(excluded.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 594.1984 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Study)Tj
2.6173 0 Td
(protocol)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 577.1905 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Admission)Tj
4.5637 0 Td
(variables)Tj
3.719 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(2448)Tj
2.6362 0 Td
(hours)Tj
2.5172 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0261 0 Td
(discharge)Tj
4.0195 0 Td
(using)Tj
2.3925 0 Td
(a)Tj
0.6519 0 Td
(standardized)Tj
5.3575 0 Td
(ques-)Tj
-34.9963 -1.2982 Td
(tionnaire)Tj
3.8834 0 Td
(administered)Tj
5.4878 0 Td
(by)Tj
1.1849 0 Td
(a)Tj
0.652 0 Td
(nurse)Tj
2.4548 0 Td
(specialized)Tj
4.524 0 Td
(in)Tj
1.0318 0 Td
(research)Tj
3.5603 0 Td
(projects.)Tj
-21.5828 -1.2983 Td
(Variables)Tj
3.9514 0 Td
(included)Tj
3.7077 0 Td
(age,)Tj
1.7575 0 Td
(sex,)Tj
1.6894 0 Td
(education)Tj
4.1726 0 Td
(level)Tj
2.0013 0 Td
(\(primary,)Tj
4.0138 0 Td
(secondary,)Tj
4.49 0 Td
(or)Tj
1.0942 0 Td
(university\),)Tj
4.7508 0 Td
(place)Tj
2.2564 0 Td
(of)Tj
1.0091 0 Td
(res-)Tj
-36.0904 -1.3039 Td
(idence,)Tj
3.0557 0 Td
(personal)Tj
3.6283 0 Td
(history)Tj
3.0104 0 Td
(\(current)Tj
3.5263 0 Td
(or)Tj
1.0941 0 Td
(former)Tj
3.0047 0 Td
(tobacco)Tj
3.3165 0 Td
(exposure,)Tj
4.0422 0 Td
(pack-years,)Tj
4.7112 0 Td
(previous)Tj
3.651 0 Td
(asthma)Tj
-33.0404 -1.2983 Td
(diagnosis,)Tj
4.1839 0 Td
(previous)Tj
3.651 0 Td
(COPD)Tj
2.9196 0 Td
(diagnosis,)Tj
4.1839 0 Td
(and)Tj
1.7348 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(exacerbations)Tj
5.6806 0 Td
(and)Tj
1.7291 0 Td
(hospitalizations)Tj
6.4743 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
-36.0281 -1.2982 Td
(previous)Tj
3.651 0 Td
(12)Tj
1.1678 0 Td
(months\),)Tj
3.8494 0 Td
(clinical)Tj
3.0728 0 Td
(situation)Tj
3.7303 0 Td
(before)Tj
2.744 0 Td
(discharge)Tj
4.0195 0 Td
(\(Charlson)Tj
4.2179 0 Td
(Comorbidity)Tj
5.4085 0 Td
(Index,)Tj
2.7496 0 Td
(dys-)Tj
-34.6108 -1.3039 Td
(pnea)Tj
2.1429 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(modified)Tj
3.8437 0 Td
(British)Tj
2.8914 0 Td
(Medical)Tj
3.4355 0 Td
(Research)Tj
3.8098 0 Td
(Council)Tj
3.4015 0 Td
([mMRC])Tj
3.8948 0 Td
(scale)Tj
2.109 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(],)Tj
2.0806 0 Td
(and)Tj
-34.2933 -1.2983 Td
(COPD)Tj
2.9253 0 Td
(Assessment)Tj
4.8585 0 Td
(Test)Tj
1.9162 0 Td
([CAT])Tj
2.8574 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(]\),)Tj
2.4151 0 Td
(and)Tj
1.7347 0 Td
(data)Tj
1.9106 0 Td
(from)Tj
2.2053 0 Td
(discharge)Tj
4.0252 0 Td
(\(pharmacological)Tj
7.1829 0 Td
(treatment)Tj
-32.0312 -1.2983 Td
(after)Tj
2.0352 0 Td
(discharge)Tj
4.0195 0 Td
(and)Tj
1.7291 0 Td
(hospitalization)Tj
6.1172 0 Td
(duration)Tj
3.702 0 Td
(in)Tj
1.0318 0 Td
(days\).)Tj
-17.4386 -1.3039 Td
(Spirometry)Tj
4.7281 0 Td
(was)Tj
1.7008 0 Td
(performed)Tj
4.4674 0 Td
(after)Tj
2.0352 0 Td
(a)Tj
0.652 0 Td
(bronchodilator)Tj
6.2645 0 Td
(test)Tj
1.6044 0 Td
(\(30)Tj
1.508 0 Td
(min)Tj
1.8539 0 Td
(after)Tj
2.0353 0 Td
(administering)Tj
5.8223 0 Td
(nebu-)Tj
-33.8681 -1.2983 Td
(lized)Tj
2.0976 0 Td
(2.5)Tj
1.3946 0 Td
(mg)Tj
1.508 0 Td
(salbutamol)Tj
4.5978 0 Td
(and)Tj
1.7291 0 Td
(0.5)Tj
1.4003 0 Td
(mg)Tj
1.5024 0 Td
(ipratropium)Tj
5.1193 0 Td
(bromide\))Tj
3.9855 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6519 0 Td
(Datospir)Tj
3.7134 0 Td
(120)Tj
1.6441 0 Td
(spirometer)Tj
-31.3396 -1.2982 Td
(\(Sibelmed,)Tj
4.473 0 Td
(Barcelona\))Tj
4.5297 0 Td
(in)Tj
1.0375 0 Td
(which)Tj
2.6475 0 Td
(we)Tj
1.3266 0 Td
(included)Tj
3.7134 0 Td
(the)Tj
1.4683 0 Td
(body)Tj
2.2167 0 Td
(mass)Tj
2.194 0 Td
(index)Tj
2.4548 0 Td
(\(BMI\),)Tj
2.9367 0 Td
(forcedvital)Tj
4.4617 0 Td
(capacity)Tj
-33.4599 -1.3039 Td
(\(FVC\),)Tj
3.0103 0 Td
(forced)Tj
2.761 0 Td
(expiratory)Tj
4.3313 0 Td
(volume)Tj
3.1974 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8029 0 Td
(second)Tj
3.0103 0 Td
(\(FEV)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 427.5212 419.5275 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 431.0929 421.1716 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\),)Tj
0.788 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(FEV)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 488.8629 419.5275 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 492.4346 421.1716 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(/FVC)Tj
2.4377 0 Td
(ratio.)Tj
2.3188 0 Td
(FVC)Tj
-33.9985 -1.2982 Td
(and)Tj
1.7292 0 Td
(FEV)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 235.2188 406.5448 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 241.0015 408.1889 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(values)Tj
2.6645 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(as)Tj
1.0148 0 Td
(absolute)Tj
3.5263 0 Td
(and)Tj
1.7291 0 Td
(relative,)Tj
3.3619 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(percentage)Tj
4.5467 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(predicted)Tj
4.0025 0 Td
(value)Tj
-34.9622 -1.2982 Td
(following)Tj
3.9798 0 Td
(Spanish)Tj
3.3504 0 Td
(reference)Tj
3.9175 0 Td
(values)Tj
2.6645 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
1.8539 0 Td
(and)Tj
1.7291 0 Td
(recommendations)Tj
7.5004 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.075 0 Td
(Relative)Tj
3.3902 0 Td
(FEV)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 522.5385 393.5622 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 528.3212 395.2062 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(values)Tj
2.6645 0 Td
(were)Tj
-35.4951 -1.2982 Td
(classified)Tj
3.8154 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0261 0 Td
(GOLD)Tj
2.9537 0 Td
(cut-offs)Tj
3.2655 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(])Tj
1.3776 0 Td
(as)Tj
1.0148 0 Td
(mild)Tj
2.0806 0 Td
(\()Tj
/F11 1 Tf
0 Tc
()Tj
/F5 1 Tf
-0.004 Tc
(80%\),)Tj
3.6057 0 Td
(moderate)Tj
4.0251 0 Td
(\(5079%\),)Tj
4.303 0 Td
(severe)Tj
2.6758 0 Td
(\(30)Tj
-34.3329 -1.3039 Td
(49%\),)Tj
2.4945 0 Td
(and)Tj
1.7291 0 Td
(very)Tj
1.9219 0 Td
(severe)Tj
2.6815 0 Td
(\()Tj
/F12 1 Tf
0 Tc
(<)Tj
/F5 1 Tf
-0.004 Tc
(30%\).)Tj
3.6057 0 Td
(Finally,)Tj
3.1691 0 Td
(blood)Tj
2.5115 0 Td
(count)Tj
2.5285 0 Td
(was)Tj
1.6951 0 Td
(obtained)Tj
3.736 0 Td
(in)Tj
1.0375 0 Td
(order)Tj
2.4207 0 Td
(to)Tj
1.0205 0 Td
(determine)Tj
4.3256 0 Td
(the)Tj
-34.8772 -1.2983 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0147 0 Td
(eosinophils.)Tj
-3.2371 -1.2983 Td
(Patients)Tj
3.4129 0 Td
(were)Tj
2.1203 0 Td
(reviewed)Tj
3.7984 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(outpatient)Tj
4.3426 0 Td
(clinic)Tj
2.3924 0 Td
(8)Tj
0.6974 0 Td
(\()Tj
/F13 1 Tf
[()]TJ
/F5 1 Tf
(1\))Tj
1.9445 0 Td
(weeks)Tj
2.6079 0 Td
(after)Tj
2.0352 0 Td
(discharge.)Tj
4.2463 0 Td
(The)Tj
1.7801 0 Td
(CAT)Tj
2.1826 0 Td
(and)Tj
-35.1776 -1.3039 Td
(mMRC)Tj
3.2145 0 Td
(questionnaires,)Tj
6.2928 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8199 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(new)Tj
1.8765 0 Td
(spirometry)Tj
4.6148 0 Td
(test,)Tj
1.8255 0 Td
(were)Tj
2.1203 0 Td
(performed)Tj
4.4731 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2619 0 Td
(nurse)Tj
-33.8283 -1.2982 Td
(with)Tj
1.9842 0 Td
(the)Tj
1.4627 0 Td
(same)Tj
2.245 0 Td
(spirometer.)Tj
4.7962 0 Td
(All)Tj
1.389 0 Td
(spirometries)Tj
5.1987 0 Td
(\(both)Tj
2.3867 0 Td
(prior)Tj
2.2451 0 Td
(to)Tj
1.0148 0 Td
(discharge)Tj
4.0081 0 Td
(and)Tj
1.7235 0 Td
(at)Tj
0.9411 0 Td
(follow-up\))Tj
4.4219 0 Td
(were)Tj
2.1146 0 Td
(per-)Tj
-35.9316 -1.2983 Td
(formed)Tj
3.1578 0 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.4683 0 Td
(mornings)Tj
4.1102 0 Td
(from)Tj
2.2054 0 Td
(09:00)Tj
2.3471 0 Td
(to)Tj
1.0261 0 Td
(13:00)Tj
2.3471 0 Td
(h.)Tj
0.9751 0 Td
(After)Tj
2.2847 0 Td
(this)Tj
1.6724 0 Td
(visit,)Tj
2.0976 0 Td
(monthly)Tj
3.617 0 Td
(passive)Tj
3.0387 0 Td
(follow-up)Tj
-33.2728 -1.3039 Td
(was)Tj
1.6951 0 Td
(carried)Tj
3.0387 0 Td
(out)Tj
1.5534 0 Td
(for)Tj
1.389 0 Td
(a)Tj
0.6519 0 Td
(minimum)Tj
4.2917 0 Td
(of)Tj
1.0148 0 Td
(6)Tj
0.6973 0 Td
(months)Tj
3.2825 0 Td
(by)Tj
1.1792 0 Td
(reviewing)Tj
4.1272 0 Td
(electronic)Tj
4.1499 0 Td
(medical)Tj
3.3619 0 Td
(recordsin)Tj
4.0194 0 Td
(order)Tj
-34.452 -1.2983 Td
(to)Tj
1.0261 0 Td
(assess)Tj
2.5172 0 Td
(readmissions)Tj
5.4708 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0204 0 Td
(COPD)Tj
2.9254 0 Td
(exacerbation)Tj
5.3234 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(emergency)Tj
4.5694 0 Td
(room)Tj
2.4264 0 Td
(visits.)Tj
-33.4202 -1.2983 Td
(For)Tj
1.6271 0 Td
(the)Tj
1.4683 0 Td
(purpose)Tj
3.4469 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6725 0 Td
(study,)Tj
2.6191 0 Td
(an)Tj
1.2019 0 Td
(increase)Tj
3.4696 0 Td
(in)Tj
1.0375 0 Td
(FEV)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 405.4677 263.5086 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 411.2503 265.2094 cm
BT
/F11 1 Tf
1 TL
0 0 Td
()Tj
/F5 1 Tf
-0.004 Tc
0.9921 0 Td
(200)Tj
1.6441 0 Td
(mL)Tj
1.576 0 Td
(was)Tj
1.7008 0 Td
(considered)Tj
4.6034 0 Td
(because)Tj
3.3165 0 Td
(it)Tj
0.7881 0 Td
(is)Tj
-35.7446 -1.2982 Td
(usually)Tj
3.016 0 Td
(significant)Tj
4.3881 0 Td
(and)Tj
1.7291 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(clinically)Tj
3.7814 0 Td
(important)Tj
4.2803 0 Td
(according)Tj
4.1894 0 Td
(to)Tj
1.0205 0 Td
(ERS/ATS)Tj
3.9912 0 Td
(recommendations)Tj
-29.4744 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 203.9811 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Statistical)Tj
4.3228 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 186.9732 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(A)Tj
0.9014 0 Td
(descriptive)Tj
4.558 0 Td
(analysis)Tj
3.3222 0 Td
(was)Tj
1.7008 0 Td
(performed)Tj
4.473 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1452 0 Td
(included)Tj
3.7134 0 Td
(variables.)Tj
3.9458 0 Td
(Results)Tj
3.0557 0 Td
(were)Tj
2.126 0 Td
(expressed)Tj
4.0932 0 Td
(as)Tj
1.0148 0 Td
(per-)Tj
-35.4328 -1.2982 Td
(centages)Tj
3.5886 0 Td
(and)Tj
1.7234 0 Td
(absolute)Tj
3.515 0 Td
(frequencies)Tj
4.7792 0 Td
(for)Tj
1.3776 0 Td
(the)Tj
1.4627 0 Td
(qualitative)Tj
4.371 0 Td
(variables)Tj
3.7133 0 Td
(and)Tj
1.7235 0 Td
(as)Tj
1.0034 0 Td
(mean)Tj
2.4435 0 Td
(and)Tj
1.7234 0 Td
(standard)Tj
3.7134 0 Td
(devia-)Tj
-35.138 -1.2983 Td
(tion)Tj
1.8425 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(numeric)Tj
3.6056 0 Td
(data.)Tj
2.1373 0 Td
(Data)Tj
2.1204 0 Td
(were)Tj
2.1259 0 Td
(analyzed)Tj
3.702 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.4683 0 Td
(statistical)Tj
3.9118 0 Td
(package)Tj
3.4129 0 Td
(IBM)Tj
2.0296 0 Td
(SPSS)Tj
2.211 0 Td
(Statistics)Tj
-33.8057 -1.2982 Td
(21.0)Tj
1.8708 0 Td
(\(IBM)Tj
2.3754 0 Td
(Corporation,)Tj
5.4368 0 Td
(Armonk,)Tj
3.8721 0 Td
(NY\).)Tj
2.1544 0 Td
(The)Tj
1.7801 0 Td
(numbers)Tj
3.7814 0 Td
(of)Tj
1.0148 0 Td
(readmissions)Tj
5.4652 0 Td
(and)Tj
1.7291 0 Td
(emergency)Tj
4.5751 0 Td
(room)Tj
-34.0552 -1.304 Td
(visitswererecorded)Tj
7.7045 0 Td
(absolutely)Tj
4.2292 0 Td
(and)Tj
1.7292 0 Td
(adjusted)Tj
3.5773 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(follow-up)Tj
4.0932 0 Td
(months)Tj
3.2825 0 Td
(for)Tj
1.3889 0 Td
(each)Tj
-33.0857 -1.2982 Td
(patient)Tj
3.0047 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(comparative)Tj
5.1703 0 Td
(analysis)Tj
3.3279 0 Td
(in)Tj
1.0318 0 Td
(order)Tj
2.4208 0 Td
(toobtainan)Tj
4.5694 0 Td
(annualized)Tj
4.5921 0 Td
(value.)Tj
-25.7781 -1.2983 Td
(The)Tj
1.7858 0 Td
(student)Tj
3.2031 0 Td
(T)Tj
0.8334 0 Td
(test)Tj
1.5987 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0262 0 Td
(comparequantitative)Tj
8.4755 0 Td
(variables)Tj
3.719 0 Td
(between)Tj
3.5263 0 Td
(discharge)Tj
4.0252 0 Td
(and)Tj
1.7291 0 Td
(evalu-)Tj
-34.8772 -1.3039 Td
(ation)Tj
2.2677 0 Td
(at)Tj
0.9524 0 Td
(8)Tj
0.6916 0 Td
(weeks.)Tj
2.829 0 Td
(The)Tj
1.7801 0 Td
(other)Tj
2.3414 0 Td
(cross-sectional)Tj
6.1002 0 Td
(comparisons)Tj
5.3347 0 Td
(between)Tj
3.5206 0 Td
(numerical)Tj
4.2803 0 Td
(variables)Tj
3.7134 0 Td
(were)Tj
2.1203 0 Td
(per-)Tj
-35.9317 -1.2983 Td
(formed)Tj
3.1577 0 Td
(using)Tj
2.3868 0 Td
(T)Tj
0.8334 0 Td
(tests)Tj
1.9615 0 Td
(for)Tj
1.3833 0 Td
(independent)Tj
5.2781 0 Td
(data)Tj
1.9105 0 Td
(after)Tj
2.0353 0 Td
(evaluatingvarianceeq)Tj
8.3905 0 Td
(ualitywith)Tj
4.2236 0 Td
(the)Tj
1.4683 0 Td
(Levene)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 260.9574 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Reliability)Tj
4.4008 0 Td
(and)Tj
1.8567 0 Td
(usefulness)Tj
4.9181 0 Td
(of)Tj
1.0418 0 Td
(spirometr)Tj
4.0961 0 Td
(y)Tj
0.7157 0 Td
(perform)Tj
3.3874 0 Td
(ed)Tj
1.3111 0 Td
(during)Tj
2.9409 0 Td
(admission)Tj
4.6418 0 Td
(for)Tj
1.3677 0 Td
(COPD)Tj
3.0757 0 Td
(exacerba)Tj
4.0394 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01949)Tj
4.089 0 Td
(83)Tj
0 g
2.0906 0 Td
(March)Tj
2.9622 0 Td
(26,)Tj
1.5874 0 Td
(2018)Tj
34.3562 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
endstream
endobj
90 0 obj
<>stream
endstream
endobj
91 0 obj
<>stream
endstream
endobj
92 0 obj
<>stream
endstream
endobj
93 0 obj
<>stream
BT
66.402 0 Td
(12)Tj
ET
Q
endstream
endobj
94 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 96 0 R/Contents 97 0 R/TrimBox[0 0 612 792]>>
endobj
95 0 obj
<>stream
x]UJyRTDbcMQ,Qc/1&iHSJ U齿}3{ν=5d;w̷圙R!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`!`? b %%%?U6C0C0C0C0C
gz}q4oCLC0C0 c,!`!`3w0C0CWD(--mɒ%SN}wnj{7a)S >={~:ǂ!`!`!"wip