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Robert Wilson, Jonathan M. Cohen, Mark Reglinski, Ricardo J. Jose, Win Yan Chan, Helina Marshall, Corné de Vogel, Stephen Gordon, David Goldblatt, Fernanda C. Petersen, Helen Baxendale, Jeremy S. Brown
Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens
www.plospathogens.org
www.plospathogens.org
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446.2866 432.0567 m
475.3701 432.0567 l
h
f*
412.611 406.0346 m
441.7512 406.0346 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
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(mechanisms)Tj
5.2043 0 Td
(are)Tj
1.4514 0 Td
(serotype-independent.)Tj
9.2068 0 Td
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0.8447 0 Td
(the)Tj
1.4684 0 Td
(protection)Tj
4.3823 0 Td
(against)Tj
3.0274 0 Td
(IPD)Tj
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(that)Tj
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(develops)Tj
3.685 0 Td
(naturally)Tj
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(through)Tj
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(colonisation)Tj
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3.4753 0 Td
(anti-protein)Tj
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(responses)Tj
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(serotype-specific)Tj
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(antibody,)Tj
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(this)Tj
1.6724 0 Td
(would)Tj
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(represent)Tj
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(an)Tj
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(readjustment)Tj
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(our)Tj
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(understanding)Tj
-31.4246 -1.2983 Td
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(immunity)Tj
4.2236 0 Td
(to)Tj
/F9 1 Tf
1.0262 0 Td
[()]TJ
/F10 1 Tf
(.)Tj
/F9 1 Tf
0.8957 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F10 1 Tf
(.)Tj
5.2894 0 Td
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0.8561 0 Td
(would)Tj
2.7099 0 Td
(have)Tj
2.0636 0 Td
(major)Tj
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(implications)Tj
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1.389 0 Td
(identifying)Tj
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(with)Tj
-35.206 -1.2983 Td
(an)Tj
1.2018 0 Td
(increased)Tj
3.9969 0 Td
(risk)Tj
1.7177 0 Td
(of)Tj
1.0148 0 Td
(infection,)Tj
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(of)Tj
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(increase)Tj
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1.0261 0 Td
[()]TJ
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(.)Tj
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0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
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(with)Tj
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(and)Tj
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(globulin)Tj
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(\(IVIG\))Tj
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(an)Tj
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(in)Tj
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(individuals)Tj
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(primary)Tj
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(deficiency)Tj
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(.)Tj
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[()6()11(\n)18()4(\r)6()]TJ
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(a)Tj
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(leading)Tj
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(cause)Tj
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(disease)Tj
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(mice)Tj
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(\(IgG\))Tj
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1 j
1 J
0 w
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BT
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1 TL
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(that)Tj
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(.)Tj
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(pneumoniae)Tj
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(capsular)Tj
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Q
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BT
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(that)Tj
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[()]TJ
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(.)Tj
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0.8901 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
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(1)Tj
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(\).)Tj
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[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
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[()]TJ
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[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
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(immunoblots)Tj
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[()]TJ
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(.)Tj
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[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
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(generally)Tj
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(conserved)Tj
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(serotypes)Tj
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(of)Tj
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1.0148 0 Td
[()]TJ
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(.)Tj
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0.8958 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
200.0001 308.0015 m
576 308.0015 l
576 307.5015 l
200.0001 307.5015 l
f*
576 295.0016 m
200.0001 295.0016 l
200.0001 295.5016 l
576 295.5016 l
f*
363.0027 295.0016 m
363.0027 282.5016 l
362.5027 283.0017 l
362.5027 295.0016 l
f*
363.0027 282.5016 m
200.0001 282.5016 l
200.0001 283.0017 l
362.5027 283.0017 l
f*
576 282.5016 m
363.0027 282.5016 l
363.0027 283.0017 l
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f*
363.0027 282.5016 m
363.0027 270.0017 l
362.5027 270.5017 l
362.5027 282.5016 l
f*
363.0027 270.0017 m
200.0001 270.0017 l
200.0001 270.5017 l
362.5027 270.5017 l
f*
576 270.0017 m
363.0027 270.0017 l
363.0027 270.5017 l
576 270.5017 l
f*
363.0027 270.0017 m
363.0027 257.5018 l
362.5027 258.0018 l
362.5027 270.0017 l
f*
363.0027 257.5018 m
200.0001 257.5018 l
200.0001 258.0018 l
362.5027 258.0018 l
f*
576 257.5018 m
363.0027 257.5018 l
363.0027 258.0018 l
576 258.0018 l
f*
363.0027 257.5018 m
363.0027 245.0018 l
362.5027 245.5019 l
362.5027 257.5018 l
f*
363.0027 245.0018 m
200.0001 245.0018 l
200.0001 245.5019 l
362.5027 245.5019 l
f*
576 245.0018 m
363.0027 245.0018 l
363.0027 245.5019 l
576 245.5019 l
f*
576 232.5019 m
200.0001 232.5019 l
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576 233.0019 l
f*
363.0027 232.5019 m
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362.5027 220.502 l
362.5027 232.5019 l
f*
363.0027 220.002 m
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200.0001 220.502 l
362.5027 220.502 l
f*
576 220.002 m
363.0027 220.002 l
363.0027 220.502 l
576 220.502 l
f*
363.0027 220.002 m
363.0027 207.502 l
362.5027 208.002 l
362.5027 220.002 l
f*
363.0027 207.502 m
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362.5027 208.002 l
f*
576 207.502 m
363.0027 207.502 l
363.0027 208.002 l
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f*
363.0027 207.502 m
363.0027 195.0021 l
362.5027 195.5021 l
362.5027 207.502 l
f*
363.0027 195.0021 m
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200.0001 195.5021 l
362.5027 195.5021 l
f*
576 195.0021 m
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363.0027 195.5021 l
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f*
363.0027 195.0021 m
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362.5027 183.0022 l
362.5027 195.0021 l
f*
363.0027 182.5021 m
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362.5027 183.0022 l
f*
576 182.5021 m
363.0027 182.5021 l
363.0027 183.0022 l
576 183.0022 l
f*
363.0027 182.5021 m
363.0027 170.0022 l
362.5027 170.5022 l
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f*
363.0027 170.0022 m
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200.0001 170.5022 l
362.5027 170.5022 l
f*
576 170.0022 m
363.0027 170.0022 l
363.0027 170.5022 l
576 170.5022 l
f*
363.0027 170.0022 m
363.0027 157.5023 l
362.5027 158.0023 l
362.5027 170.0022 l
f*
363.0027 157.5023 m
200.0001 157.5023 l
200.0001 158.0023 l
362.5027 158.0023 l
f*
576 157.5023 m
363.0027 157.5023 l
363.0027 158.0023 l
576 158.0023 l
f*
363.0027 157.5023 m
363.0027 145.0023 l
362.5027 145.5024 l
362.5027 157.5023 l
f*
363.0027 145.0023 m
200.0001 145.0023 l
200.0001 145.5024 l
362.5027 145.5024 l
f*
576 145.0023 m
363.0027 145.0023 l
363.0027 145.5024 l
576 145.5024 l
f*
363.0027 145.0023 m
363.0027 132.5024 l
362.5027 133.0024 l
362.5027 145.0023 l
f*
363.0027 132.5024 m
200.0001 132.5024 l
200.0001 133.0024 l
362.5027 133.0024 l
f*
576 132.5024 m
363.0027 132.5024 l
363.0027 133.0024 l
576 133.0024 l
f*
363.0027 132.5024 m
363.0027 120.0025 l
362.5027 120.5025 l
362.5027 132.5024 l
f*
363.0027 120.0025 m
200.0001 120.0025 l
200.0001 120.5025 l
362.5027 120.5025 l
f*
576 120.0025 m
363.0027 120.0025 l
363.0027 120.5025 l
576 120.5025 l
f*
363.0027 120.0025 m
363.0027 107.5025 l
362.5027 108.0026 l
362.5027 120.0025 l
f*
363.0027 107.5025 m
200.0001 107.5025 l
200.0001 108.0026 l
362.5027 108.0026 l
f*
576 107.5025 m
363.0027 107.5025 l
363.0027 108.0026 l
576 108.0026 l
f*
363.0027 107.5025 m
363.0027 95.0026 l
362.5027 95.5026 l
362.5027 107.5025 l
f*
363.0027 95.0026 m
200.0001 95.0026 l
200.0001 95.5026 l
362.5027 95.5026 l
f*
576 95.0026 m
363.0027 95.0026 l
363.0027 95.5026 l
576 95.5026 l
f*
0 g
7.9999 0 0 7.9999 200.0125 331.8236 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
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