• Corpus ID: 25808891

In vitro determination of the short-chain synthetic peptide RP13 antimicrobial activity.

@article{Sanchez2014InVD,
  title={In vitro determination of the short-chain synthetic peptide RP13 antimicrobial activity.},
  author={Adriano Santana Sanchez and Ernesto Alfonso Calder{\'o}n and Sandra L. Casta{\~n}{\'o}n-Alonso and Ara Itzel P{\'e}rez de los Santos and Beatriz Hernández and Alfredo V{\'a}zquez},
  journal={Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion},
  year={2014},
  volume={66 6},
  pages={
          527-33
        },
  url={https://api.semanticscholar.org/CorpusID:25808891}
}
  • A. SanchezE. Calderón A. Vázquez
  • Published in Revista de investigacion… 25 November 2014
  • Biology, Chemistry, Medicine
  • Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
The structural modification of peptide RP11, obtained from human platelets, resulted in a new peptide with improved antimicrobial activity, demonstrating that peptides of natural origin, as well as their synthetic analogs, represent an attractive alternative against pathogenic agents.
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Platelet Microbicidal Protein 1: Structural Themes of a Multifunctional Antimicrobial Peptide

The hypothesis that stimuli in the setting of infection prompt platelets to release PF-4-class or related kinocidins, which have structures consistent with their likely multiple roles that bridge molecular and cellular mechanisms of antimicrobial host defense, is advanced.

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