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Sara Cajander, Gunlög Rasmussen, Elisabet Tina, Anders Magnuson, Bo Söderquist, Jan Källman, Kristoffer Strålin
Dynamics of monocytic HLA-DR expression differs between bacterial etiologies during the course of bloodstream infection
www.plosone.org
www.plosone.org
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-0.004 Tc
0 0 Td
(Levels)Tj
2.6645 0 Td
(of)Tj
1.0148 0 Td
(inflammatory)Tj
5.7089 0 Td
(markers)Tj
3.498 0 Td
(are)Tj
1.4513 0 Td
(presented)Tj
4.1102 0 Td
(as)Tj
1.0148 0 Td
(medians)Tj
3.6057 0 Td
(with)Tj
1.9955 0 Td
(interquartile)Tj
5.2044 0 Td
(range)Tj
2.4605 0 Td
(\(IQR\).)Tj
-32.7286 -1.2982 Td
(Analyses)Tj
3.719 0 Td
(of)Tj
1.0091 0 Td
(mHLA-DR)Tj
4.7282 0 Td
(were)Tj
2.1089 0 Td
(performed)Tj
4.4617 0 Td
(after)Tj
2.024 0 Td
(logarithmic)Tj
4.8358 0 Td
(transformation)Tj
6.2646 0 Td
(since)Tj
2.2336 0 Td
(the)Tj
1.4627 0 Td
(distribution)Tj
-32.8476 -1.3039 Td
(was)Tj
1.6951 0 Td
(evaluated)Tj
3.9911 0 Td
(as)Tj
1.0148 0 Td
(log-normal.)Tj
4.9436 0 Td
(Unadjusted)Tj
4.8586 0 Td
(and)Tj
1.7291 0 Td
(adjusted)Tj
3.5773 0 Td
(linear)Tj
2.5115 0 Td
(regression)Tj
4.3199 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0262 0 Td
(evaluate)Tj
-33.4259 -1.2983 Td
(mHLA-DR)Tj
4.7281 0 Td
(on)Tj
1.2699 0 Td
(day)Tj
1.6328 0 Td
(12)Tj
1.6781 0 Td
(in)Tj
1.0318 0 Td
(respect)Tj
3.033 0 Td
(to)Tj
1.0148 0 Td
(different)Tj
3.651 0 Td
(patient)Tj
3.0047 0 Td
(characteristics)Tj
5.8961 0 Td
(and)Tj
1.7234 0 Td
(bacterial)Tj
3.617 0 Td
(etiology.)Tj
3.6113 0 Td
(Lin-)Tj
-35.892 -1.2983 Td
(ear)Tj
1.4456 0 Td
(mixed)Tj
2.7269 0 Td
(models)Tj
3.1011 0 Td
(for)Tj
1.389 0 Td
(repeated)Tj
3.6396 0 Td
(measurements)Tj
6.0321 0 Td
(were)Tj
2.1203 0 Td
(used)Tj
2.058 0 Td
(to)Tj
1.0261 0 Td
(evaluate)Tj
3.4639 0 Td
(the)Tj
1.4684 0 Td
(dynamic)Tj
3.6963 0 Td
(variation)Tj
3.8041 0 Td
(in)Tj
-35.9714 -1.3039 Td
(mHLA-DR)Tj
4.7338 0 Td
(at)Tj
0.9524 0 Td
(different)Tj
3.6567 0 Td
(time)Tj
2.0296 0 Td
(points)Tj
2.7212 0 Td
(unadjusted)Tj
4.6545 0 Td
(and)Tj
1.7291 0 Td
(adjusted)Tj
3.5773 0 Td
(for)Tj
1.3833 0 Td
(sepsis-3)Tj
3.3392 0 Td
(\(severity\))Tj
3.9515 0 Td
(and)Tj
1.7291 0 Td
(pre-)Tj
-34.4577 -1.2982 Td
(existing)Tj
3.3051 0 Td
(immunosuppression.)Tj
8.691 0 Td
(A)Tj
0.8957 0 Td
(heterogeneous,)Tj
6.2419 0 Td
(first-order)Tj
4.3483 0 Td
(autoregressive)Tj
5.9017 0 Td
(correlation)Tj
4.6091 0 Td
(structure)Tj
-33.9928 -1.2983 Td
(was)Tj
1.6951 0 Td
(chosen)Tj
3.016 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(best)Tj
1.8085 0 Td
(model)Tj
2.744 0 Td
(fit,)Tj
1.2982 0 Td
(evaluated)Tj
3.9912 0 Td
(using)Tj
2.3924 0 Td
(Akaike)Tj
3.0217 0 Td
(information)Tj
5.074 0 Td
(criteria)Tj
3.0784 0 Td
(\(AIC\).)Tj
2.812 0 Td
(Time)Tj
2.3414 0 Td
(was)Tj
-35.9941 -1.3039 Td
(modeled)Tj
3.6963 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.652 0 Td
(continuous)Tj
4.7338 0 Td
(scale)Tj
2.1089 0 Td
(to)Tj
1.0262 0 Td
(evaluate)Tj
3.4639 0 Td
(whether)Tj
3.4752 0 Td
(the)Tj
1.4684 0 Td
(slope)Tj
2.2734 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(geometric)Tj
4.2179 0 Td
(mean)Tj
2.4434 0 Td
(of)Tj
-33.3238 -1.2983 Td
(mHLA-DR)Tj
4.7338 0 Td
(over)Tj
1.9785 0 Td
(time)Tj
2.0296 0 Td
(showed)Tj
3.2485 0 Td
(significant)Tj
4.388 0 Td
(interaction)Tj
4.6091 0 Td
(with)Tj
1.9956 0 Td
(bacterial)Tj
3.6283 0 Td
(etiology,)Tj
3.6114 0 Td
(indicating)Tj
4.2689 0 Td
(differ-)Tj
-34.4917 -1.2983 Td
(ent)Tj
1.491 0 Td
(dynamics.)Tj
4.2803 0 Td
(The)Tj
1.7801 0 Td
(slopes)Tj
2.6362 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(mean)Tj
2.4492 0 Td
(mHLA-DR)Tj
4.7395 0 Td
(changes)Tj
3.4015 0 Td
(over)Tj
1.9786 0 Td
(time)Tj
2.0239 0 Td
(were)Tj
2.126 0 Td
(estimated)Tj
4.0705 0 Td
(for)Tj
1.389 0 Td
(differ-)Tj
-34.8489 -1.3039 Td
(ent)Tj
1.491 0 Td
(etiologies)Tj
3.9855 0 Td
(and)Tj
1.7291 0 Td
(stratified)Tj
3.753 0 Td
(for)Tj
1.389 0 Td
(presence/absence)Tj
7.1603 0 Td
(of)Tj
1.0148 0 Td
(sepsis.)Tj
2.7382 0 Td
(Time)Tj
2.3414 0 Td
(was)Tj
1.7008 0 Td
(also)Tj
1.7688 0 Td
(modeled)Tj
3.6907 0 Td
(on)Tj
-32.7626 -1.2982 Td
(categorical)Tj
4.507 0 Td
(scale)Tj
2.1033 0 Td
(to)Tj
1.0205 0 Td
(estimate)Tj
3.5376 0 Td
(the)Tj
1.4627 0 Td
(mean)Tj
2.4377 0 Td
(ratios)Tj
2.4548 0 Td
(in)Tj
1.0318 0 Td
(mHLA-DR)Tj
4.7282 0 Td
(between)Tj
3.5263 0 Td
(subpopulations)Tj
6.3382 0 Td
(of)Tj
1.0091 0 Td
(different)Tj
-34.1572 -1.2983 Td
(factors)Tj
2.9026 0 Td
(at)Tj
0.9524 0 Td
(each)Tj
2.0296 0 Td
(time)Tj
2.024 0 Td
(point.)Tj
2.5851 0 Td
(BonferroniHolm)Tj
7.4891 0 Td
(corrections)Tj
4.7225 0 Td
(were)Tj
2.126 0 Td
(performed)Tj
4.4674 0 Td
(for)Tj
1.3833 0 Td
(adjustments)Tj
5.0796 0 Td
(of)Tj
-35.7616 -1.2983 Td
(multiple)Tj
3.5659 0 Td
(comparisons)Tj
5.3348 0 Td
(over)Tj
1.9786 0 Td
(time.)Tj
2.2506 0 Td
(Mann-Whitney)Tj
6.48 0 Td
(U-test)Tj
2.6929 0 Td
(was)Tj
1.6951 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
1.0205 0 Td
(compare)Tj
3.719 0 Td
(differences)Tj
4.5638 0 Td
(in)Tj
-35.3648 -1.3039 Td
(CRP,)Tj
2.2903 0 Td
(neutrophil,)Tj
4.6772 0 Td
(lymphocyte)Tj
4.8925 0 Td
(and)Tj
1.7292 0 Td
(monocyte)Tj
4.2065 0 Td
(counts)Tj
2.8857 0 Td
(between)Tj
3.5263 0 Td
(outcome)Tj
3.7247 0 Td
(groups)Tj
2.9707 0 Td
(at)Tj
0.9524 0 Td
(each)Tj
2.0296 0 Td
(time)Tj
-33.8851 -1.2982 Td
(point.)Tj
1.1962 -1.2983 Td
(Spearman's)Tj
4.8245 0 Td
(rho)Tj
1.6214 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0262 0 Td
(assess)Tj
2.5228 0 Td
(correlations)Tj
4.9776 0 Td
(between)Tj
3.5319 0 Td
(mHLA-DR)Tj
4.7339 0 Td
(and)Tj
1.7348 0 Td
(markers)Tj
3.4922 0 Td
(of)Tj
1.0148 0 Td
(inflam-)Tj
-34.435 -1.3039 Td
(mation)Tj
3.0954 0 Td
(\(CRP,)Tj
2.6248 0 Td
(neutrophil)Tj
4.4561 0 Td
(count,)Tj
2.7496 0 Td
(lymphocyte)Tj
4.8925 0 Td
(and)Tj
1.7348 0 Td
(monocyte)Tj
4.2009 0 Td
(count\).)Tj
3.0898 0 Td
(A)Tj
0.9014 0 Td
(p-value)Tj
/F15 1 Tf
0 Tc
3.1748 0 Td
(<)Tj
/F8 1 Tf
-0.004 Tc
(0.05)Tj
2.6475 0 Td
(was)Tj
1.6951 0 Td
(con-)Tj
-35.2627 -1.2983 Td
(sidered)Tj
3.118 0 Td
(statistically)Tj
4.6148 0 Td
(significant.)Tj
4.6091 0 Td
(Unpaired)Tj
4.0479 0 Td
(T-test,)Tj
2.7892 0 Td
(with)Tj
1.9956 0 Td
(Bonferroni-Holm)Tj
7.3247 0 Td
(correction)Tj
4.3597 0 Td
(for)Tj
1.3889 0 Td
(multiple)Tj
-34.2479 -1.2983 Td
(comparisons)Tj
5.3347 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(for)Tj
1.389 0 Td
(pairwise)Tj
3.5433 0 Td
(comparison)Tj
4.9776 0 Td
(of)Tj
1.0148 0 Td
(mHLA-DR)Tj
4.7395 0 Td
(between)Tj
3.5263 0 Td
(blood)Tj
2.5171 0 Td
(donor)Tj
2.6816 0 Td
(controls)Tj
-33.4826 -1.3039 Td
(and)Tj
1.7291 0 Td
(study)Tj
2.3867 0 Td
(patients)Tj
3.3732 0 Td
(at)Tj
0.9525 0 Td
(each)Tj
2.0239 0 Td
(sampling)Tj
3.8834 0 Td
(time)Tj
2.024 0 Td
(point.)Tj
2.5851 0 Td
(All)Tj
1.4003 0 Td
(statistical)Tj
3.9062 0 Td
(analyses)Tj
3.4809 0 Td
(were)Tj
2.126 0 Td
(performed)Tj
4.4673 0 Td
(with)Tj
-34.3386 -1.2982 Td
(SPSS)Tj
2.2053 0 Td
(version)Tj
3.1521 0 Td
(22)Tj
1.1735 0 Td
(\(IBM)Tj
2.3698 0 Td
(Corp.,)Tj
2.7326 0 Td
(Armonk,)Tj
3.8721 0 Td
(NY,)Tj
1.8141 0 Td
(USA\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 318.3874 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ethics)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 301.3795 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Ethical)Tj
2.982 0 Td
(approval)Tj
3.6963 0 Td
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1.3833 0 Td
(the)Tj
1.4627 0 Td
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3.7304 0 Td
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2.1996 0 Td
(the)Tj
1.4684 0 Td
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3.7247 0 Td
(Ethics)Tj
2.6645 0 Td
(Review)Tj
3.0898 0 Td
(Board)Tj
2.6362 0 Td
(of)Tj
1.0091 0 Td
(Uppsala,)Tj
-34.1232 -1.3039 Td
(Sweden)Tj
3.2995 0 Td
(\(approval)Tj
4.0421 0 Td
(number)Tj
3.4186 0 Td
(2009/024\).)Tj
4.4447 0 Td
(A)Tj
0.9071 0 Td
(written)Tj
3.1067 0 Td
(informed)Tj
3.9742 0 Td
(consent)Tj
3.3335 0 Td
(was)Tj
1.6951 0 Td
(obtained)Tj
3.736 0 Td
(in)Tj
1.0375 0 Td
(all)Tj
1.1452 0 Td
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-34.1402 -1.2982 Td
(and)Tj
1.7291 0 Td
(controls.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 247.9748 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F12 1 Tf
0 -1.4976 Td
(Characteristics)Tj
6.4772 0 Td
(of)Tj
1.0677 0 Td
(the)Tj
1.5402 0 Td
(study)Tj
2.5039 0 Td
(population)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 212.9952 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Altogether)Tj
4.4617 0 Td
(116)Tj
1.6497 0 Td
(adult)Tj
2.2507 0 Td
(patients)Tj
3.3732 0 Td
(with)Tj
1.9956 0 Td
(positive)Tj
3.3165 0 Td
(blood)Tj
2.5115 0 Td
(culture)Tj
3.0387 0 Td
(were)Tj
2.126 0 Td
(enrolled)Tj
3.5149 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(study.)Tj
2.6192 0 Td
(Six)Tj
-33.3579 -1.2982 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(excluded,)Tj
4.0138 0 Td
(as)Tj
1.0148 0 Td
(presented)Tj
4.1159 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(flow)Tj
1.9503 0 Td
(chart)Tj
2.2733 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1)Tj
1.5081 0 Td
(Fig)Tj
0 g
(\).)Tj
2.0466 0 Td
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3.4979 0 Td
(for)Tj
1.389 0 Td
(19)Tj
1.1678 0 Td
(patients)Tj
3.3676 0 Td
(were)Tj
-34.333 -1.3039 Td
(unavailable)Tj
4.7338 0 Td
(on)Tj
1.2699 0 Td
(days)Tj
1.9956 0 Td
(1)Tj
0.6916 0 Td
(and)Tj
1.7235 0 Td
(2;)Tj
0.9127 0 Td
(the)Tj
1.4684 0 Td
(remaining)Tj
4.3596 0 Td
(91)Tj
1.1622 0 Td
(patients)Tj
3.3619 0 Td
(were)Tj
2.1203 0 Td
(sampled)Tj
3.5433 0 Td
(within)Tj
2.8063 0 Td
(12)Tj
1.6837 0 Td
(days)Tj
1.9899 0 Td
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1.0148 0 Td
(admis-)Tj
-34.8375 -1.2983 Td
(sion)Tj
1.9048 0 Td
(and)Tj
1.7291 0 Td
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2.1203 0 Td
(eligible)Tj
3.0671 0 Td
(for)Tj
1.3833 0 Td
(inclusion)Tj
3.9175 0 Td
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1.0374 0 Td
(the)Tj
1.4684 0 Td
(study.)Tj
2.6135 0 Td
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2.5795 0 Td
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1.7008 0 Td
(no)Tj
1.2756 0 Td
(systematic)Tj
4.3596 0 Td
(reason)Tj
2.863 0 Td
(for)Tj
1.389 0 Td
(missing)Tj
-33.4089 -1.2983 Td
(samples,)Tj
3.6056 0 Td
(and)Tj
1.7291 0 Td
(no)Tj
1.2756 0 Td
(significant)Tj
4.388 0 Td
(difference)Tj
4.2066 0 Td
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1.0375 0 Td
(baseline)Tj
3.4299 0 Td
(data)Tj
1.9162 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(missing)Tj
3.3108 0 Td
(data)Tj
1.9106 0 Td
(compared)Tj
-33.1878 -1.2982 Td
(to)Tj
1.0261 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(full)Tj
1.5307 0 Td
(sample)Tj
3.0217 0 Td
(series)Tj
2.4265 0 Td
(\(data)Tj
2.2506 0 Td
(not)Tj
1.5761 0 Td
(shown\).)Tj
3.4129 0 Td
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3.0501 0 Td
(characteristics)Tj
5.9016 0 Td
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1.0148 0 Td
(the)Tj
1.4741 0 Td
(study)Tj
2.3867 0 Td
(popula-)Tj
-34.435 -1.3039 Td
(tion)Tj
1.8425 0 Td
(and)Tj
1.7291 0 Td
(baseline)Tj
3.4299 0 Td
(laboratory)Tj
4.3483 0 Td
(parameters)Tj
4.6771 0 Td
(are)Tj
1.4457 0 Td
(given)Tj
2.3811 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Table)Tj
2.4377 0 Td
(1)Tj
0 g
(.)Tj
0.9241 0 Td
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3.2428 0 Td
(the)Tj
1.4684 0 Td
(91)Tj
1.1735 0 Td
(study)Tj
2.3868 0 Td
(patients,)Tj
3.5943 0 Td
(the)Tj
-36.1188 -1.2983 Td
(median)Tj
3.2371 0 Td
(age)Tj
1.542 0 Td
(was)Tj
1.7008 0 Td
(70)Tj
1.1735 0 Td
(years)Tj
2.2621 0 Td
(and)Tj
1.7291 0 Td
(56%)Tj
1.9332 0 Td
(were)Tj
2.1203 0 Td
(males.)Tj
2.7269 0 Td
(According)Tj
4.4391 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(Sepsis-3)Tj
3.4526 0 Td
(definition,)Tj
4.388 0 Td
(52%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-36.1415 -1.2983 Td
(patients)Tj
3.3675 0 Td
(had)Tj
1.7064 0 Td
(sepsis)Tj
2.5115 0 Td
(on)Tj
1.2756 0 Td
(admission.)Tj
4.5411 0 Td
(All)Tj
1.3946 0 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.126 0 Td
(hospitalized)Tj
5.006 0 Td
(and)Tj
1.7291 0 Td
(13%)Tj
1.9332 0 Td
(were)Tj
2.1203 0 Td
(admitted)Tj
3.8154 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
-35.9204 -1.3039 Td
(ICU.)Tj
2.1826 0 Td
(The)Tj
1.7858 0 Td
(four)Tj
1.9106 0 Td
(most)Tj
2.2053 0 Td
(frequently)Tj
4.3086 0 Td
(detected)Tj
3.566 0 Td
(pathogens)Tj
4.303 0 Td
(in)Tj
1.0374 0 Td
(blood)Tj
2.5172 0 Td
(culture)Tj
3.033 0 Td
(were)Tj
/F16 1 Tf
2.126 0 Td
[()10()7()20()2()12()11()4()7()4()7()1()-4( )]TJ
5.4028 0 Td
[()11(\n)6()2()]TJ
-34.3783 -1.2983 Td
[()6()11(\n)18(\r)4()6()]TJ
/F8 1 Tf
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(1)Tj
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(5)Tj
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(\(5\))Tj
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(1)Tj
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(x\).)Tj
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(variables)Tj
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(presented)Tj
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(=)Tj
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(Organ)Tj
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(https://do)Tj
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(i.org/10.1371/j)Tj
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ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 247.2752 m
576 247.2752 l
576 246.7752 l
36 246.7752 l
f*
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183.7519 212.2753 l
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f*
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f*
261.6982 234.2752 m
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f*
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575.9989 234.7753 l
f*
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261.6982 212.2753 l
261.6982 234.2752 l
f*
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f*
367.9957 212.2753 m
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183.7519 199.7753 m
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f*
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261.6982 199.7753 m
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f*
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f*
183.7519 187.2754 m
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183.7519 187.7754 l
f*
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f*
261.6982 187.2754 m
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f*
367.9957 187.2754 m
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433.5917 531.39 l
433.5917 543.89 l
f*
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f*
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0.83 0.64 0.02 0 k
36 423.0425 m
186.7465 423.0425 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(3.)Tj
1.1763 0 Td
(mHLA-DR)Tj
4.819 0 Td
(expression)Tj
4.6134 0 Td
(on)Tj
1.2898 0 Td
(day)Tj
1.6937 0 Td
(12)Tj
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(in)Tj
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(patients)Tj
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(with)Tj
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(potential)Tj
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(confoun)Tj
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(ding)Tj
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(baseline)Tj
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(factors.)Tj
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(tion)Tj
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(factors)Tj
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(N)Tj
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(=)Tj
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(91)Tj
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(mHLA)Tj
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(x)Tj
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(10)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F12 1 Tf
1 TL
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(3)Tj
ET
Q
q
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1 J
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BT
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(sted)Tj
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(24.5)Tj
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(Ref)Tj
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(\(Sepsis-3\))Tj
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(47)Tj
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4.4505 0 Td
(12.8)Tj
1.8921 0 Td
(\(9.522.0\))Tj
10.7645 0 Td
(0.60)Tj
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(score)Tj
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(0)Tj
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(31)Tj
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4.4505 0 Td
(16.0)Tj
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(Ref)Tj
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(Charlson)Tj
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(score)Tj
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(1)Tj
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(18.3)Tj
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(0.94)Tj
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(26\))Tj
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7.278 0 Td
(0.95)Tj
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18.312 0 Td
(51)Tj
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(\(56%\))Tj
4.4505 0 Td
(16.7)Tj
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(Ref)Tj
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(Ref)Tj
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18.312 0 Td
(40)Tj
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(18.8)Tj
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(\(12.626.0\))Tj
10.7645 0 Td
(1.04)Tj
2.4733 0 Td
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3.2244 0 Td
(39\))Tj
4.741 0 Td
(0.78)Tj
7.278 0 Td
(1.06)Tj
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(\(0.801.41)Tj
4.1811 0 Td
(\))Tj
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(0.68)Tj
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1.8638 0 Td
(<)Tj
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(65)Tj
1.9913 0 Td
(yrs)Tj
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14.4569 0 Td
(30)Tj
1.1834 0 Td
(\(33%\))Tj
4.4505 0 Td
(21.2)Tj
1.8921 0 Td
(\(15.037.0\))Tj
11.0834 0 Td
(Ref)Tj
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(Ref)Tj
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(Age)Tj
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1.8638 0 Td
()Tj
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(65)Tj
1.9913 0 Td
(yrs)Tj
/F8 1 Tf
14.4569 0 Td
(61)Tj
1.1834 0 Td
(\(67%\))Tj
4.4505 0 Td
(15.2)Tj
1.8921 0 Td
(\(10.831.9\))Tj
10.7645 0 Td
(0.75)Tj
2.4733 0 Td
(\(0.561.)Tj
3.2244 0 Td
(01\))Tj
4.741 0 Td
(0.06)Tj
7.278 0 Td
(0.86)Tj
2.4733 0 Td
(\(0.651.14)Tj
4.1811 0 Td
(\))Tj
3.8055 0 Td
(0.28)Tj
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(immuno)Tj
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(suppression)Tj
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(prior)Tj
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(to)Tj
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(sepsis)Tj
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4.4859 0 Td
(84)Tj
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(\(92%\))Tj
4.4505 0 Td
(17.8)Tj
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11.0834 0 Td
(Ref)Tj
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(Ref)Tj
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-54.6381 -1.559 Td
(Immunos)Tj
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(uppression)Tj
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(prior)Tj
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(to)Tj
1.0913 0 Td
(sepsis)Tj
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5.8891 0 Td
(7)Tj
0.7086 0 Td
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(0.80)Tj
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(0.04)Tj
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[()]TJ
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(.)Tj
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[()3()4()5()]TJ
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(.)Tj
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2.8985 0 Td
[()4( )5(\n)-7()5()5()4( )13()]TJ
4.1103 0 Td
[(\r)5(\n)]TJ
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1.1551 0 Td
(etiology)Tj
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9.1064 0 Td
(23)Tj
1.1834 0 Td
(\(25%\))Tj
4.4505 0 Td
(30.9)Tj
1.8921 0 Td
(\(18.351.9\))Tj
11.0834 0 Td
(Ref)Tj
17.7167 0 Td
(Ref)Tj
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-54.6381 -1.559 Td
[()]TJ
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(.)Tj
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0.9567 0 Td
[(\r)12()5()8(\n)-7()-13()]TJ
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2.9622 0 Td
(etiology)Tj
/F8 1 Tf
14.3931 0 Td
(22)Tj
1.1834 0 Td
(\(24%\))Tj
4.4505 0 Td
(15.4)Tj
1.8921 0 Td
(\(10.326.9\))Tj
10.7645 0 Td
(0.56)Tj
2.4733 0 Td
(\(0.390.)Tj
3.2244 0 Td
(81\))Tj
/F15 1 Tf
3.9757 0 Td
(<)Tj
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(0.01)Tj
8.0433 0 Td
(0.61)Tj
2.4733 0 Td
(\(0.410.90)Tj
4.1811 0 Td
(\))Tj
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3.7843 0 Td
(0.01)Tj
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-64.7579 -1.5662 Td
[()]TJ
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(.)Tj
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0.9567 0 Td
[()4( )5(\n)-7()5()5()4( )13()]TJ
4.1103 0 Td
[(\r)5(\n)]TJ
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1.1551 0 Td
(etiology)Tj
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12.0899 0 Td
(27)Tj
1.1834 0 Td
(\(30%\))Tj
4.4505 0 Td
(12.3)Tj
1.8921 0 Td
(\(9.616.8\))Tj
10.7645 0 Td
(0.44)Tj
2.4733 0 Td
(\(0.310.)Tj
3.2244 0 Td
(63\))Tj
/F15 1 Tf
3.9757 0 Td
(<)Tj
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(0.01)Tj
8.0433 0 Td
(0.49)Tj
2.4733 0 Td
(\(0.340.71)Tj
4.1811 0 Td
(\))Tj
/F15 1 Tf
3.0189 0 Td
(<)Tj
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(0.01)Tj
-63.9925 -1.5591 Td
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2.7355 0 Td
(etiolog)Tj
2.8701 0 Td
(y)Tj
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12.7064 0 Td
(19)Tj
1.1834 0 Td
(\(21%\))Tj
4.4505 0 Td
(22.9)Tj
1.8921 0 Td
(\(13.141.0\))Tj
10.7645 0 Td
(0.77)Tj
2.4733 0 Td
(\(0.531.)Tj
3.2244 0 Td
(13\))Tj
4.741 0 Td
(0.18)Tj
7.278 0 Td
(0.82)Tj
2.4733 0 Td
(\(0.561.20)Tj
4.1811 0 Td
(\))Tj
3.8055 0 Td
(0.30)Tj
-64.7791 -2.3457 Td
(Adjusted)Tj
3.8551 0 Td
(regression)Tj
4.3513 0 Td
(with)Tj
2.0126 0 Td
(Sepsis-related)Tj
5.7473 0 Td
(Organ)Tj
2.8063 0 Td
(Failure)Tj
3.0402 0 Td
(Assessment)Tj
4.8969 0 Td
(\(SOFA\))Tj
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(score)Tj
2.3315 0 Td
(change)Tj
3.0614 0 Td
(per)Tj
1.552 0 Td
(unit)Tj
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(and)Tj
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(age)Tj
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(per)Tj
1.5449 0 Td
(years)Tj
2.289 0 Td
(on)Tj
1.2898 0 Td
(a)Tj
0.6661 0 Td
(continuous)Tj
4.7623 0 Td
(scale)Tj
2.1331 0 Td
(showed)Tj
3.274 0 Td
(similar)Tj
3.0118 0 Td
(results)Tj
2.8347 0 Td
(\(SOFA)Tj
-63.9996 -1.5023 Td
(score)Tj
2.3244 0 Td
(change:)Tj
3.2953 0 Td
(mean)Tj
2.4662 0 Td
(ratio)Tj
2.1189 0 Td
(0.88)Tj
1.8921 0 Td
(\(0.820.)Tj
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