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Noémie Le Gouellec, Alain Duhamel, Thierry Perez, Anne-Lise Hachulla, Vincent Sobanski, Jean-Baptiste Faivre, Sandrine Morell-Dubois, Marc Lambert, Pierre-Yves Hatron, Eric Hachulla, Hélène Béhal, Regis Matran, David Launay, Martine Remy-Jardin
Predictors of lung function test severity and outcome in systemic sclerosis-associated interstitial lung disease
www.plosone.org
www.plosone.org
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203.4142 409.7764 m
212.9386 409.7764 l
h
f*
217.3606 409.7764 m
226.885 409.7764 l
h
f*
314.6457 282.2173 m
365.8394 282.2173 l
h
f*
332.5039 94.9039 m
341.9717 94.9039 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
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1 TL
-0.004 Tc
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(population)Tj
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(75)Tj
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2.4264 0.0567 Td
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0.6237 -0.0567 Td
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(DC-2008-642\))Tj
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1 J
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11.9999 0 0 11.9999 200.0125 641.1401 cm
BT
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1 TL
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(data)Tj
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Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 624.1322 cm
BT
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1 TL
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1.7292 0 Td
(Medsger)Tj
3.685 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
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(gastro-oesophageal)Tj
7.8519 0 Td
(reflux)Tj
2.5398 0 Td
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(\(GERD\),)Tj
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(York)Tj
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(\(NYHA\))Tj
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4.3086 0 Td
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2.0466 0 Td
(and)Tj
1.7291 0 Td
(modified)Tj
3.8495 0 Td
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(phenomenon)Tj
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(\(RP\))Tj
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(and)Tj
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3.3562 0 Td
(symp-)Tj
-34.0268 -1.2982 Td
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1.8425 0 Td
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1.7291 0 Td
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 518.8535 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
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(PFTs)Tj
ET
Q
q
1 j
1 J
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10 0 0 10 200.0125 501.8456 cm
BT
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1 TL
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(the)Tj
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(expiratory)Tj
4.3256 0 Td
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(\(TLC\))Tj
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(17\).)Tj
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Q
q
1 j
1 J
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BT
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1 TL
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Q
q
1 j
1 J
0 w
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BT
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1 TL
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Q
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1 J
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Q
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1 j
1 J
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BT
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1 TL
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4.4504 0 Td
(analysis)Tj
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Q
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(results)Tj
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(Shapiro-Wilk)Tj
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575.9997 563.3586 m
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f*
482.1324 563.3586 m
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481.6324 563.3586 l
f*
481.6324 550.8587 m
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f*
575.9997 550.8587 m
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f*
482.1324 550.8587 m
482.1324 538.3587 l
481.6324 538.3587 l
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f*
481.6324 538.3587 m
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481.6324 538.8588 l
f*
575.9997 538.3587 m
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f*
482.1324 538.3587 m
482.1324 516.3588 l
481.6324 516.3588 l
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f*
481.6324 516.3588 m
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f*
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f*
482.1324 516.3588 m
482.1324 503.8588 l
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f*
481.6324 503.8588 m
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f*
575.9997 503.8588 m
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f*
482.1324 503.8588 m
482.1324 491.3589 l
481.6324 491.3589 l
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f*
481.6324 491.3589 m
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481.6324 491.8589 l
f*
575.9997 491.3589 m
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482.1324 491.8589 l
575.9997 491.8589 l
f*
482.1324 491.3589 m
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481.6324 478.859 l
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f*
481.6324 478.859 m
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481.6324 479.359 l
f*
575.9997 478.859 m
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f*
482.1324 478.859 m
482.1324 466.359 l
481.6324 466.359 l
481.6324 478.859 l
f*
481.6324 466.359 m
199.9998 466.359 l
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481.6324 466.8591 l
f*
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482.1324 466.8591 l
575.9997 466.8591 l
f*
482.1324 466.359 m
482.1324 453.8591 l
481.6324 453.8591 l
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f*
481.6324 453.8591 m
199.9998 453.8591 l
199.9998 454.3591 l
481.6324 454.3591 l
f*
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f*
575.9997 441.3591 m
199.9998 441.3591 l
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f*
482.1324 441.3591 m
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481.6324 428.8592 l
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f*
481.6324 428.8592 m
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f*
575.9997 428.8592 m
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f*
482.1324 428.8592 m
482.1324 416.3593 l
481.6324 416.3593 l
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f*
481.6324 416.3593 m
199.9998 416.3593 l
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481.6324 416.8593 l
f*
575.9997 416.3593 m
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482.1324 416.8593 l
575.9997 416.8593 l
f*
482.1324 416.3593 m
482.1324 403.8593 l
481.6324 403.8593 l
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f*
481.6324 403.8593 m
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f*
575.9997 403.8593 m
482.1324 403.8593 l
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575.9997 404.3594 l
f*
482.1324 403.8593 m
482.1324 391.3594 l
481.6324 391.3594 l
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f*
481.6324 391.3594 m
199.9998 391.3594 l
199.9998 391.8594 l
481.6324 391.8594 l
f*
575.9997 391.3594 m
482.1324 391.3594 l
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575.9997 391.8594 l
f*
482.1324 391.3594 m
482.1324 378.8595 l
481.6324 378.8595 l
481.6324 391.3594 l
f*
481.6324 378.8595 m
199.9998 378.8595 l
199.9998 379.3595 l
481.6324 379.3595 l
f*
575.9997 378.8595 m
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575.9997 379.3595 l
f*
482.1324 378.8595 m
482.1324 366.3595 l
481.6324 366.3595 l
481.6324 378.8595 l
f*
481.6324 366.3595 m
199.9998 366.3595 l
199.9998 366.8596 l
481.6324 366.8596 l
f*
575.9997 366.3595 m
482.1324 366.3595 l
482.1324 366.8596 l
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f*
482.1324 366.3595 m
482.1324 353.8596 l
481.6324 353.8596 l
481.6324 366.3595 l
f*
481.6324 353.8596 m
199.9998 353.8596 l
199.9998 354.3596 l
481.6324 354.3596 l
f*
575.9997 353.8596 m
482.1324 353.8596 l
482.1324 354.3596 l
575.9997 354.3596 l
f*
575.9997 341.3597 m
199.9998 341.3597 l
199.9998 341.8597 l
575.9997 341.8597 l
f*
482.1324 341.3597 m
482.1324 328.8597 l
481.6324 328.8597 l
481.6324 341.3597 l
f*
481.6324 328.8597 m
199.9998 328.8597 l
199.9998 329.3597 l
481.6324 329.3597 l
f*
575.9997 328.8597 m
482.1324 328.8597 l
482.1324 329.3597 l
575.9997 329.3597 l
f*
482.1324 328.8597 m
482.1324 316.3598 l
481.6324 316.3598 l
481.6324 328.8597 l
f*
481.6324 316.3598 m
199.9998 316.3598 l
199.9998 316.8598 l
481.6324 316.8598 l
f*
575.9997 316.3598 m
482.1324 316.3598 l
482.1324 316.8598 l
575.9997 316.8598 l
f*
482.1324 316.3598 m
482.1324 303.8598 l
481.6324 303.8598 l
481.6324 316.3598 l
f*
481.6324 303.8598 m
199.9998 303.8598 l
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f*
575.9997 303.8598 m
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482.1324 304.3599 l
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f*
482.1324 303.8598 m
482.1324 291.3599 l
481.6324 291.3599 l
481.6324 303.8598 l
f*
481.6324 291.3599 m
199.9998 291.3599 l
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481.6324 291.8599 l
f*
575.9997 291.3599 m
482.1324 291.3599 l
482.1324 291.8599 l
575.9997 291.8599 l
f*
482.1324 291.3599 m
482.1324 278.86 l
481.6324 278.86 l
481.6324 291.3599 l
f*
481.6324 278.86 m
199.9998 278.86 l
199.9998 279.36 l
481.6324 279.36 l
f*
575.9997 278.86 m
482.1324 278.86 l
482.1324 279.36 l
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f*
482.1324 278.86 m
482.1324 266.36 l
481.6324 266.36 l
481.6324 278.86 l
f*
481.6324 266.36 m
199.9998 266.36 l
199.9998 266.8601 l
481.6324 266.8601 l
f*
575.9997 266.36 m
482.1324 266.36 l
482.1324 266.8601 l
575.9997 266.8601 l
f*
482.1324 266.36 m
482.1324 253.8601 l
481.6324 253.8601 l
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f*
481.6324 253.8601 m
199.9998 253.8601 l
199.9998 254.3601 l
481.6324 254.3601 l
f*
575.9997 253.8601 m
482.1324 253.8601 l
482.1324 254.3601 l
575.9997 254.3601 l
f*
482.1324 253.8601 m
482.1324 231.8601 l
481.6324 231.8601 l
481.6324 253.8601 l
f*
481.6324 231.8601 m
199.9998 231.8601 l
199.9998 232.3602 l
481.6324 232.3602 l
f*
575.9997 231.8601 m
482.1324 231.8601 l
482.1324 232.3602 l
575.9997 232.3602 l
f*
575.9997 162.1103 m
199.9998 162.1103 l
199.9998 162.6103 l
575.9997 162.6103 l
f*
0.83 0.64 0.02 0 k
200.0126 149.0457 m
350.7591 149.0457 l
h
f*
0 g
7.9999 0 0 7.9999 200.0125 718.696 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(Demogra)Tj
4.2733 0 Td
(phic)Tj
2.2535 0 Td
(data)Tj
2.2465 0 Td
(and)Tj
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(ILD)Tj
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(characte)Tj
4.0394 0 Td
(ristics)Tj
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(at)Tj
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(baseline.)Tj
0 Tc
-24.8812 -1.8567 Td
(Variable)Tj
39.8058 0 Td
(Value)Tj
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-39.8058 -1.559 Td
(Age,)Tj
2.2748 0 Td
(years)Tj
36.6593 0 Td
(52.0)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(15.)Tj
3.8481 0 Td
(8)Tj
-42.7822 -1.5662 Td
(Sex,)Tj
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(n)Tj
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(M:F)Tj
36.8861 0 Td
(18:57)Tj
-39.8908 -1.559 Td
(BMI,)Tj
2.2819 0 Td
(kg/cm)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 239.5275 669.9401 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 513.6377 666.3685 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(24.6)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(4.1)Tj
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(duration)Tj
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(since)Tj
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(first)Tj
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(Raynaud)Tj
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('s)Tj
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(phenom)Tj
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(enon,)Tj
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(years)Tj
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(6.7)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(8.5)Tj
-39.4797 -1.5591 Td
(Disease)Tj
3.8126 0 Td
(duration)Tj
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(since)Tj
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(first)Tj
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(non-R)Tj
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(aynaud's)Tj
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(phenom)Tj
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(enon,)Tj
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(years)Tj
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(2.8)Tj
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[( )]TJ
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(3.8)Tj
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(Ethnicity)Tj
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(Caucasian,)Tj
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(n\(%\))Tj
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(67)Tj
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(\(89\))Tj
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(an,)Tj
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(n\(%\))Tj
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(8)Tj
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(\(11\))Tj
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(Active)Tj
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(tobacco)Tj
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(use,)Tj
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(n\(%\))Tj
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(6)Tj
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(\(8\))Tj
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(Type)Tj
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(of)Tj
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(scleroderm)Tj
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(a)Tj
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(n\(%\))Tj
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(52)Tj
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(\(69\))Tj
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(Diffuse,)Tj
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(n\(%\))Tj
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(23)Tj
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(\(31\))Tj
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(mRSS)Tj
38.9342 0 Td
(11.9)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(10.)Tj
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(9)Tj
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(Anticentro)Tj
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(mere)Tj
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(antibodies/)Tj
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(antitopois)Tj
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(omerase)Tj
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(antibodies)Tj
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(/anti)Tj
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(RNP)Tj
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(antibodies,)Tj
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(n)Tj
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(\(%\))Tj
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(9)Tj
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(\(12%\)/41)Tj
4.2589 0 Td
(\(55%\)/2)Tj
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(\(3%\))Tj
-44.4546 -2.7496 Td
(NYHA)Tj
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(functional)Tj
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(class)Tj
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(I-II/III-IV,)Tj
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(n\(%\))Tj
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(60)Tj
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(\(80%\)/15)Tj
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(\(20%\))Tj
-42.605 -1.5591 Td
(Respirat)Tj
3.6921 0 Td
(ory)Tj
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(symptoms)Tj
4.7693 0 Td
(leading)Tj
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(to)Tj
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(ILD)Tj
1.7717 0 Td
(diagnosis,)Tj
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(n\(%\))Tj
18.1136 0 Td
(16)Tj
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(\(24%\))Tj
-40.4719 -1.5662 Td
(GERD,)Tj
3.3874 0 Td
(n\(%\))Tj
35.7523 0 Td
(57)Tj
1.3322 0 Td
(\(76%\))Tj
-40.4719 -1.559 Td
(Digital)Tj
2.9835 0 Td
(ulcers)Tj
2.8772 0 Td
(\(presen)Tj
3.359 0 Td
(ce)Tj
1.2827 0 Td
(or)Tj
1.1126 0 Td
(history\),)Tj
3.7702 0 Td
(n\(%\))Tj
23.7545 0 Td
(25)Tj
1.3322 0 Td
(\(33%\))Tj
-40.4719 -1.5662 Td
(Arthralgi)Tj
3.6921 0 Td
(a/synovitis)Tj
4.6418 0 Td
(,)Tj
0.5103 0 Td
(n\(%\))Tj
28.1695 0 Td
(27)Tj
1.3323 0 Td
(\(36%\)/11)Tj
4.259 0 Td
(\(15%\))Tj
-42.605 -1.559 Td
(PFT)Tj
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(FVC)Tj
2.2252 0 Td
(\(%)Tj
1.4457 0 Td
(predictive)Tj
4.4788 0 Td
(value\))Tj
29.7924 0 Td
(90.0)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(19.)Tj
3.8479 0 Td
(9)Tj
-41.79 -1.5662 Td
(DLCO)Tj
2.9977 0 Td
(\(%)Tj
1.4457 0 Td
(predictiv)Tj
3.6921 0 Td
(e)Tj
0.7796 0 Td
(value\))Tj
29.027 0 Td
(67.2)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(23.)Tj
3.8479 0 Td
(9)Tj
-41.79 -1.559 Td
(FEV1)Tj
2.7284 0 Td
(\(%)Tj
1.4386 0 Td
(predictive)Tj
4.4788 0 Td
(value\))Tj
29.2963 0 Td
(88.8)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(19.)Tj
3.8479 0 Td
(8)Tj
-41.79 -1.5662 Td
(FEV1/FVC,)Tj
5.2796 0 Td
(%)Tj
32.6625 0 Td
(78.8)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(12.)Tj
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(5)Tj
-41.79 -1.5591 Td
(CRP,)Tj
2.6079 0 Td
(mg/L)Tj
35.6034 0 Td
(7.5)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(11.6)Tj
-38.2113 -1.5661 Td
(Hb,)Tj
1.7788 0 Td
(g/dL)Tj
36.4325 0 Td
(13.0)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(1.4)Tj
-38.2113 -1.5591 Td
(Creatinine,)Tj
5.0316 0 Td
(mg/L)Tj
32.9105 0 Td
(77.9)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(21.)Tj
3.8479 0 Td
(4)Tj
-42.7821 -1.5661 Td
(HRCT)Tj
0.9921 -1.5591 Td
(ILD)Tj
1.7788 0 Td
(extent)Tj
2.9409 0 Td
(\(%)Tj
1.4457 0 Td
(of)Tj
1.063 0 Td
(parench)Tj
3.5788 0 Td
(yma\))Tj
27.1349 0 Td
(20.9)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(18.)Tj
3.8479 0 Td
(8)Tj
-41.79 -1.5662 Td
(Reticular)Tj
4.1457 0 Td
(pattern)Tj
3.3237 0 Td
(extent)Tj
2.9409 0 Td
(\(%)Tj
1.4457 0 Td
(of)Tj
1.063 0 Td
(parench)Tj
3.5788 0 Td
(yma\))Tj
21.9898 0 Td
(6.0)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(9.5)Tj
-38.4876 -1.559 Td
(Proportion)Tj
4.8119 0 Td
(of)Tj
1.063 0 Td
(ground-g)Tj
3.9614 0 Td
(lass)Tj
1.9985 0 Td
(opacifica)Tj
3.9118 0 Td
(tion)Tj
1.8355 0 Td
(\(%)Tj
1.4385 0 Td
(of)Tj
1.063 0 Td
(ILD\))Tj
17.8585 0 Td
(74.4)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(27.)Tj
3.8479 0 Td
(7)Tj
-41.79 -1.5662 Td
(Coarsenes)Tj
4.7977 0 Td
(s)Tj
33.6899 0 Td
(3.2)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(2.7)Tj
-38.4876 -1.559 Td
(Global)Tj
3.0969 0 Td
(score)Tj
2.6646 0 Td
(of)Tj
1.0559 0 Td
(bronchecta)Tj
4.9111 0 Td
(sia)Tj
26.7591 0 Td
(2.5)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(2.8)Tj
-38.4876 -1.5662 Td
(Emphysem)Tj
4.9749 0 Td
(a)Tj
0.7795 0 Td
(extent)Tj
2.941 0 Td
(\(%)Tj
1.4457 0 Td
(of)Tj
1.063 0 Td
(parench)Tj
3.5787 0 Td
(yma\))Tj
23.1593 0 Td
(0.26)Tj
/F7 1 Tf
[( )]TJ
/F0 1 Tf
(0.)Tj
3.2952 0 Td
(84)Tj
-41.2373 -1.5591 Td
(ILD)Tj
1.7788 0 Td
(extension)Tj
4.4788 0 Td
(according)Tj
4.5283 0 Td
(to)Tj
1.063 0 Td
(Goh)Tj
/F16 1 Tf
2.1048 0 Td
(et)Tj
1.063 0 Td
(al)Tj
/F0 1 Tf
(.:)Tj
1.559 0 Td
(limited/exte)Tj
5.0245 0 Td
(nsive,)Tj
2.8276 0 Td
(n\(%\))Tj
11.3599 0 Td
(57)Tj
1.3323 0 Td
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