• Corpus ID: 24401397

Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis.

@article{Huang2015GeneticPO,
  title={Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis.},
  author={Hai-dong Huang and Chun-min Yang and Hai-Feng Shu and Yong-qin Kuang and Tao Yang and Wei-qi He and Kai Zhao and Xun Xia and Jing-min Cheng and Yuan Ma and Jian-wen Gu},
  journal={International journal of clinical and experimental medicine},
  year={2015},
  volume={8 1},
  pages={
          1315-23
        },
  url={https://api.semanticscholar.org/CorpusID:24401397}
}
Strong evidences suggest that genetic risk factors contribute to common multifactorial stroke, and many genetic risk genes have been implicated in the literatures.

Tables from this paper

Family History and Stroke Risk in China: Evidence from a Large Cohort Study

FHS is an independent risk factor for stroke in Chinese adults and the more first degree relatives are affected by stroke, the higher are individuals’ risk of suffering from stroke.

The relationship between the prognosis of children with acute arterial stroke and polymorphisms of CDKN2B, HDAC9, NINJ2, NAA25 genes

This study showed, the patients who inherit CDKN2B-AS1 and HDCA9 gene mutations had poor prognosis, however, this study should be replicated for a wider sample of patient population.

Association of MicroRNA-146a and MicroRNA-149 Polymorphisms With Strokes in Asian Populations: An Updated Meta-Analysis

It is suggested thatmiR-149 might be a risk factor for the development of a stroke, while miR-146a might not be, and well-designed studies with large populations are needed to clarify the association.

Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease

Results showed that intake of long-chain omega-3 (ω-3) PUFAs can modify the associated effects of FADS1 genetic variations on LDL-C concentrations, and suggested that a high quality diet that reflects the Swedish nutrition recommendations might attenuate the association between genetic risk for high HDL-C and increased risk of ischemic stroke compared to a low quality diet.

Association of lifestyle, inflammatory factors, and dietary patterns with the risk of suffering a stroke: A case–control study

Lifestyle variables such as physical activity, smoking habit, and a dietary pattern including foods with low inflammatory potential play an important role in the reduction of the risk of suffering a stroke.

On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease

This review deals with ischemic damage and AD, with the main emphasis on the common properties of these CNS disorders, and discusses the Wnt signaling pathway as a significant factor in the cell fate determination and cell survival in the diseased adult CNS.

Genetic, clinical and population priors for brain images

This thesis shows how genetic and clinical indicators can be used to predict MRI scans of anatomical change through a semi-parametric generative model, and demonstrates that a cohort of subjects with cerebrovascular disease can help identify the spatially complex pathology in a new subject through a generative computational model.

Effects of aquatic physiotherapy on the improvement of balance and corporal symmetry in stroke survivors.

The results suggest that aquatic physiotherapy using the method of Halliwick can be a useful tool during stroke rehabilitation to improve balance, however, this improvement may not have significant impact of their quality of life.

Young, healthy males and females present cardiometabolic protection against the detrimental effects of a 7-day high-fat high-calorie diet

Lean, healthy young males and females appear to be protected from the negative cardio-metabolic effects of a 7-day HFHC diet, and future research should use a prolonged positive energy balance achieved via increased energy intake and reduced energy expenditure to exacerbate negative metabolic and cardiovascular functional outcomes.

Genetic basis of stroke: an overview.

The first genome wide association study on ischemic stroke has been published recently and further studies will hopefully tell us how far the genetic information will assist us to tailor clinical and therapeutic decisions to an individual's genotype.

Stroke Genetics Update: 2011

The substantial evidence for the contribution of genetic variation to the development of stroke, and the difficulties posed in the study of stroke given the numerous genetically driven risk factors and stroke subtypes are presented.

A Systematic Literature Review of Risk Factors for Stroke in China

Evidence of the association between hypertension and stroke was the strongest of the 5 factors reported in studies, with adjusted odds ratios ranging between 2.75 and 5.47; the association among obesity, diabetes, smoking, and the risk for stroke was evident, but not as strong as for hypertension.

Genetic and Environmental Risk Factors for Intracerebral Hemorrhage: Preliminary Results of a Population-Based Study

A preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of Intracerebral hemorrhage estimates that a third of all cases of lobar ICH are attributable to possession of an apolipoprotein E4 or E2 allele and that half of all Cases of nonlobar ICH is attributable to hypertension.

Genetic Risk for Ischemic and Hemorrhagic Stroke

The IL6 genotype may be useful in assessing the genetic risk for atherothrombotic cerebral infarction and intracerebral hemorrhage, and genotypes for UCP3, TNF, and PKD1-like may be similarly beneficial in assessment of the risk for subarachnoid hemorrhage.

The Role of TNF-&agr; 308G>A Polymorphism in the Risk for Ischemic Stroke

This study suggests that TNF-&agr; 308G>A polymorphism is associated with the risk for juvenile isChemic stroke, whereas it is a protective factor for ischemic stroke in Asians and the adult population.

Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus

This investigation was designed to identify the genetic component responsible for large infarct volumes in theSHRSP in response to a focal ischaemic insult by performance of a genome scan in an F2 cross derived from the SHRSP and the normotensive reference strain, WKY rat.
...