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Yu Yun, Hua Yin, Zhiyi Gao, Yue Li, Tao Gao, Jinlian Duan, Rong Yang, Xianxiang Dong, Lumei Zhang, Weigang Duan
Intestinal tract is an important organ for lowering serum uric acid in rats
www.plosone.org
www.plosone.org
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(cm)Tj
1.4627 0 Td
(of)Tj
1.0148 0 Td
(ileum)Tj
2.5058 0 Td
(were)Tj
2.1203 0 Td
(harvested.)Tj
4.2689 0 Td
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1.7802 0 Td
(intestinal)Tj
3.9118 0 Td
(tract)Tj
-34.9396 -1.3039 Td
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1.6951 0 Td
(opened)Tj
3.1691 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(inner)Tj
2.3754 0 Td
(wall)Tj
1.8312 0 Td
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1.7008 0 Td
(cleaned)Tj
3.2484 0 Td
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1.9956 0 Td
(a)Tj
0.652 0 Td
(cotton)Tj
2.8063 0 Td
(swab,)Tj
2.4264 0 Td
(and)Tj
1.7348 0 Td
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1.6951 0 Td
(rinsed)Tj
2.7213 0 Td
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1.9955 0 Td
(1)Tj
0.6974 0 Td
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1.2869 0 Td
(nor-)Tj
-35.2344 -1.2982 Td
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(saline)Tj
2.5002 0 Td
(twice.)Tj
2.5455 0 Td
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1.7801 0 Td
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3.0217 0 Td
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1.0148 0 Td
(organs)Tj
2.9084 0 Td
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1.0941 0 Td
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1.6951 0 Td
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0.9524 0 Td
(-40C)Tj
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1.5364 0 Td
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1.0942 0 Td
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-31.419 -1.2983 Td
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1.2755 0 Td
(ice)Tj
1.3323 0 Td
(immediately.)Tj
-1.4116 -1.3039 Td
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1.1111 0 Td
(order)Tj
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1.0261 0 Td
(investigate)Tj
4.4617 0 Td
(uric)Tj
1.8085 0 Td
(acid)Tj
1.8709 0 Td
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(juice,)Tj
2.347 0 Td
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(rats)Tj
1.6837 0 Td
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3.8494 0 Td
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1.3833 0 Td
(3)Tj
0.6973 0 Td
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-35.3534 -1.2983 Td
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1.7291 0 Td
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(randomized)Tj
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1.0262 0 Td
(different)Tj
3.6566 0 Td
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3.1918 0 Td
(namely,)Tj
3.3732 0 Td
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1.7291 0 Td
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1.7177 0 Td
(group)Tj
2.6079 0 Td
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(served)Tj
2.7779 0 Td
(as)Tj
1.0148 0 Td
(control)Tj
3.1238 0 Td
(and)Tj
1.7291 0 Td
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2.999 0 Td
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1.9956 0 Td
(normal)Tj
3.1464 0 Td
(saline)Tj
2.5002 0 Td
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1.0148 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.262 0 Td
(volume.)Tj
3.4243 0 Td
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-33.9078 -1.2982 Td
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1.0318 0 Td
(the)Tj
1.474 0 Td
(treatment)Tj
4.1328 0 Td
(groups)Tj
2.9707 0 Td
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2.1203 0 Td
(intraperitoneally)Tj
6.8768 0 Td
(or)Tj
1.0999 0 Td
(intragastrically)Tj
6.1398 0 Td
(administrated)Tj
5.7996 0 Td
(with)Tj
1.9956 0 Td
(antibiot-)Tj
-33.6413 -1.3039 Td
(ics)Tj
1.2699 0 Td
(\(antibiotic)Tj
4.3766 0 Td
(treated)Tj
2.9991 0 Td
(group\),)Tj
3.1747 0 Td
(adenine)Tj
3.3903 0 Td
(\(400)Tj
1.9899 0 Td
(mg/kg,)Tj
3.0217 0 Td
(adenine-po)Tj
4.7678 0 Td
(or)Tj
1.0942 0 Td
(ip)Tj
1.0091 0 Td
(group\),)Tj
3.1691 0 Td
(sodium)Tj
3.2315 0 Td
(urate)Tj
2.2734 0 Td
(\(400)Tj
-35.7673 -1.2983 Td
(mg/kg,)Tj
3.0217 0 Td
(urate-po)Tj
3.651 0 Td
(or)Tj
1.0941 0 Td
(ip)Tj
1.0035 0 Td
(group\),)Tj
3.1748 0 Td
(or)Tj
1.0998 0 Td
(inosine)Tj
3.1408 0 Td
(\(680)Tj
1.9899 0 Td
(mg/kg,)Tj
3.0217 0 Td
(inosine-po)Tj
4.5184 0 Td
(or)Tj
1.0942 0 Td
(ip)Tj
1.0034 0 Td
(group\))Tj
2.9537 0 Td
(for)Tj
1.3833 0 Td
(5)Tj
0.6973 0 Td
(days.)Tj
2.2224 0 Td
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-35.07 -1.2983 Td
(ease)Tj
1.8595 0 Td
(of)Tj
1.0148 0 Td
(collection)Tj
4.1102 0 Td
(of)Tj
1.0148 0 Td
(intestinal)Tj
3.9118 0 Td
(juice,)Tj
2.347 0 Td
(all)Tj
1.1452 0 Td
(the)Tj
1.4684 0 Td
(rats)Tj
1.6837 0 Td
(were)Tj
2.126 0 Td
(fasted)Tj
2.5512 0 Td
(for)Tj
1.3889 0 Td
(36)Tj
1.1679 0 Td
(h)Tj
0.7483 0 Td
(before)Tj
2.7383 0 Td
(sacrificing.)Tj
4.5637 0 Td
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-33.8397 -1.3039 Td
(the)Tj
1.4683 0 Td
(last)Tj
1.559 0 Td
(administration)Tj
6.1682 0 Td
(was)Tj
1.7008 0 Td
(taken)Tj
2.4207 0 Td
(for)Tj
1.389 0 Td
(2)Tj
0.6916 0 Td
(h,)Tj
0.9752 0 Td
(rats)Tj
1.6837 0 Td
(were)Tj
2.1203 0 Td
(intraperitoneally)Tj
6.8825 0 Td
(anaesthetized)Tj
5.5956 0 Td
(with)Tj
2.0012 0 Td
(ure-)Tj
-34.6561 -1.2982 Td
(thane)Tj
2.4491 0 Td
(\(1.0)Tj
1.7404 0 Td
(g/kg\).)Tj
2.5399 0 Td
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1.7801 0 Td
(abdomen)Tj
3.9912 0 Td
(of)Tj
1.0148 0 Td
(rat)Tj
1.3209 0 Td
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1.7008 0 Td
(opened,)Tj
3.3902 0 Td
(blood)Tj
2.5171 0 Td
(samples)Tj
3.3846 0 Td
(were)Tj
2.1203 0 Td
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2.7836 0 Td
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1.3776 0 Td
(the)Tj
1.4684 0 Td
(abdomi-)Tj
-33.579 -1.2983 Td
(nal)Tj
1.4456 0 Td
(aorta,)Tj
2.4945 0 Td
(then)Tj
2.0182 0 Td
(the)Tj
1.4684 0 Td
(stomach)Tj
3.5886 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(intestinal)Tj
3.9118 0 Td
(tract)Tj
2.0466 0 Td
(from)Tj
2.2054 0 Td
(duodenum)Tj
4.6261 0 Td
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1.0261 0 Td
(rectum)Tj
3.0841 0 Td
(were)Tj
2.126 0 Td
(harvested.)Tj
-33.2445 -1.3039 Td
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1.7801 0 Td
(stomach)Tj
3.5943 0 Td
(juice)Tj
2.1146 0 Td
(was)Tj
1.7008 0 Td
(directly)Tj
3.2315 0 Td
(collected.)Tj
3.9685 0 Td
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1.7801 0 Td
(intestinal)Tj
3.9118 0 Td
(tract)Tj
2.0466 0 Td
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1.7008 0 Td
(equally)Tj
3.0557 0 Td
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3.2145 0 Td
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1.8425 0 Td
(20)Tj
1.1735 0 Td
(seg-)Tj
-35.1153 -1.2983 Td
(ments)Tj
2.6702 0 Td
(\(about)Tj
2.8346 0 Td
(5)Tj
0.6973 0 Td
(cm)Tj
1.4627 0 Td
(per)Tj
1.5307 0 Td
(segment,)Tj
3.787 0 Td
(segment)Tj
3.5547 0 Td
(1)Tj
0.6973 0 Td
(was)Tj
1.7008 0 Td
(duodenum\))Tj
4.9662 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(length)Tj
2.7326 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.333 -1.2983 Td
(intestinal)Tj
3.9117 0 Td
(tract)Tj
2.0466 0 Td
(except)Tj
2.7723 0 Td
(cecum)Tj
2.8346 0 Td
(\(about)Tj
2.8347 0 Td
(10)Tj
1.1735 0 Td
(cm\).)Tj
2.0239 0 Td
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2.1373 0 Td
(ends)Tj
2.0806 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(intestinal)Tj
3.9118 0 Td
(segment)Tj
3.5603 0 Td
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2.1203 0 Td
(clamped)Tj
-33.8908 -1.3039 Td
(with)Tj
1.9955 0 Td
(tissue)Tj
2.4605 0 Td
(forceps)Tj
3.1124 0 Td
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1.0205 0 Td
(prevent)Tj
3.2598 0 Td
(intestinal)Tj
3.9118 0 Td
(juice)Tj
2.1203 0 Td
(losing)Tj
2.6135 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(intestinal)Tj
3.9118 0 Td
(juice)Tj
2.1147 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(segments)Tj
-32.2297 -1.2982 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(as)Tj
1.0148 0 Td
(soon)Tj
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1.0148 0 Td
(a)Tj
0.652 0 Td
(segment)Tj
3.5603 0 Td
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1.7008 0 Td
(cut,)Tj
1.6951 0 Td
(and)Tj
1.7291 0 Td
(pH)Tj
1.5023 0 Td
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1.4741 0 Td
(juice)Tj
2.1146 0 Td
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1.7008 0 Td
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2.0013 0 Td
(the)Tj
1.4683 0 Td
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1.5024 0 Td
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-34.7015 -1.2983 Td
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1.9955 0 Td
(micro)Tj
2.6079 0 Td
(electrode.)Tj
4.0932 0 Td
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1.7801 0 Td
(inner)Tj
2.3811 0 Td
(wall)Tj
1.8312 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(intestinal)Tj
3.9118 0 Td
(segment)Tj
3.5603 0 Td
(was)Tj
1.7008 0 Td
(rinsed)Tj
2.7156 0 Td
(with)Tj
2.0012 0 Td
(normal)Tj
3.1464 0 Td
(saline)Tj
2.5002 0 Td
(of)Tj
-36.7084 -1.2983 Td
(200)Tj
/F11 1 Tf
1.644 0 Td
[()]TJ
/F7 1 Tf
(l,)Tj
1.2019 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(two)Tj
1.7121 0 Td
(parts)Tj
2.1997 0 Td
(of)Tj
1.0148 0 Td
(liquid)Tj
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(intesitnal)Tj
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(juice)Tj
2.1146 0 Td
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(assay.)Tj
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(the)Tj
1.4683 0 Td
(blood)Tj
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(sample)Tj
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(coagulated,)Tj
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(the)Tj
1.4683 0 Td
(serum)Tj
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(sample)Tj
3.0217 0 Td
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(by)Tj
1.1792 0 Td
(spinning)Tj
-33.8341 -1.2983 Td
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0.9524 0 Td
(3,000)Tj
/F11 1 Tf
[()]TJ
/F7 1 Tf
(g)Tj
3.3789 0 Td
(for)Tj
1.3889 0 Td
(5)Tj
0.6973 0 Td
(min)Tj
1.8539 0 Td
(at)Tj
0.9524 0 Td
(4C.)Tj
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1.4003 0 Td
(samples)Tj
3.3789 0 Td
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(-40C)Tj
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(or)Tj
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(assayed)Tj
3.2145 0 Td
(immediately.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 208.4598 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Uric)Tj
1.9748 0 Td
(acid)Tj
2.0268 0 Td
(assay)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 191.4519 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
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(The)Tj
1.7801 0 Td
(concentration)Tj
5.8223 0 Td
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1.0148 0 Td
(uric)Tj
1.8085 0 Td
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1.8709 0 Td
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[()]TJ
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(g/ml\))Tj
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(serum)Tj
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(juice,)Tj
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(the)Tj
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(acid)Tj
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(kits)Tj
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(according)Tj
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1.0261 0 Td
(the)Tj
1.4683 0 Td
(standard)Tj
-31.6287 -1.2983 Td
(operation)Tj
4.0932 0 Td
(procedure)Tj
4.3143 0 Td
(\(SOP\))Tj
2.6815 0 Td
(provided)Tj
3.8154 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(manufacturer.)Tj
5.913 0 Td
(The)Tj
1.7858 0 Td
(protein)Tj
3.1521 0 Td
(in)Tj
1.0375 0 Td
(all)Tj
1.1452 0 Td
(the)Tj
1.4683 0 Td
(samples)Tj
3.3846 0 Td
(was)Tj
-35.4385 -1.3039 Td
(assayed)Tj
3.2144 0 Td
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1.9956 0 Td
(protein)Tj
3.1521 0 Td
(assay)Tj
2.2677 0 Td
(kits.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(RNA)Tj
2.3102 0 Td
(sequencing)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
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(After)Tj
2.2847 0 Td
(harvesting)Tj
4.371 0 Td
(the)Tj
1.4683 0 Td
(intestinal)Tj
3.9118 0 Td
(tract)Tj
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(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(normal)Tj
3.1464 0 Td
(group,)Tj
2.8347 0 Td
(the)Tj
1.4683 0 Td
(tract)Tj
2.0466 0 Td
(was)Tj
1.7008 0 Td
(opened,)Tj
3.3902 0 Td
(the)Tj
1.4683 0 Td
(contents)Tj
-32.6435 -1.3039 Td
(were)Tj
2.1203 0 Td
(removed,)Tj
3.9741 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(inner)Tj
2.381 0 Td
(wall)Tj
1.8312 0 Td
(was)Tj
1.7008 0 Td
(cleaned)Tj
3.2428 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(cotton)Tj
2.8006 0 Td
(swab)Tj
2.2054 0 Td
(and)Tj
1.7348 0 Td
(rinsed)Tj
2.7155 0 Td
(with)Tj
2.0013 0 Td
(1.0)Tj
1.3946 0 Td
(ml)Tj
1.2869 0 Td
(nor-)Tj
-35.24 -1.2982 Td
(mal)Tj
1.7177 0 Td
(saline)Tj
2.5002 0 Td
(twice.)Tj
2.5455 0 Td
(The)Tj
1.7801 0 Td
(tract)Tj
2.0466 0 Td
(was)Tj
1.6951 0 Td
(frozen)Tj
2.7723 0 Td
(with)Tj
2.0012 0 Td
(liquid)Tj
2.5625 0 Td
(nitrogen)Tj
3.6454 0 Td
(and)Tj
1.7348 0 Td
(ground)Tj
3.1634 0 Td
(to)Tj
1.0261 0 Td
(powder.)Tj
3.4753 0 Td
(The)Tj
1.7858 0 Td
(total)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 334.3748 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Intestinal)Tj
4.1527 0 Td
(tract)Tj
2.1331 0 Td
(is)Tj
0.9284 0 Td
(an)Tj
1.311 0 Td
(importan)Tj
3.8197 0 Td
(t)Tj
0.4961 0 Td
(organ)Tj
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1.3677 0 Td
(lowering)Tj
3.8693 0 Td
(serum)Tj
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(uric)Tj
1.8 0 Td
(acid)Tj
2.0197 0 Td
(in)Tj
0.9779 0 Td
(rats)Tj
ET
Q
q
1 j
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