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Celia Dechavanne, Sebastien Dechavanne, Ibrahim Sadissou, Adjimon Gatien Lokossou, Fernanda Alvarado, Magalie Dambrun, Kabirou Moutairou, David Courtin, Gregory Nuel, Andre Garcia, Florence Migot-Nabias, Christopher L. King
Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin
www.plosmedicine.org
www.plosmedicine.org
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0 g
(].)Tj
1.5987 0 Td
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1.7859 0 Td
(neonatal)Tj
3.6566 0 Td
(Fc)Tj
1.1736 0 Td
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3.5546 0 Td
(\(FcRn\),)Tj
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(\(IGHG\))Tj
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(and)Tj
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(\(H310)Tj
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(H435\))Tj
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(6.5,)Tj
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6.0604 0 Td
(FcRn)Tj
2.3414 0 Td
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3.4809 0 Td
([)Tj
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(10)Tj
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(12)Tj
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(].)Tj
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1.7801 0 Td
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2.3414 0 Td
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1.389 0 Td
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3.6283 0 Td
(circulation)Tj
4.5354 0 Td
([)Tj
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5.4936 0 Td
(IgG3)Tj
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(7)Tj
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(21)Tj
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1.9955 0 Td
(for)Tj
1.389 0 Td
(IgG1)Tj
2.2167 0 Td
([)Tj
0.83 0.64 0.02 0 k
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(].)Tj
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(difference)Tj
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(\(R435\))Tj
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(\(H435\),)Tj
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(IgG2,)Tj
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(IgG4)Tj
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([)Tj
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(studies)Tj
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([)Tj
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(IgG3-R435)Tj
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4.9776 0 Td
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4.3596 0 Td
(\(allotypes\).)Tj
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(\(IGHG3)Tj
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Q
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6.9998 0 0 6.9998 233.5181 347.0173 cm
BT
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Q
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BT
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ET
Q
q
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6.9998 0 0 6.9998 281.5937 347.0173 cm
BT
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ET
Q
q
1 j
1 J
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10 0 0 10 285.5622 343.3889 cm
BT
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Q
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6.9998 0 0 6.9998 346.8472 347.0173 cm
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Q
q
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BT
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(19\),)Tj
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(G3m16,)Tj
3.4016 0 Td
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(a)Tj
0.652 0 Td
(histidine)Tj
3.7077 0 Td
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2.1372 0 Td
(IgG3-H435)Tj
4.7565 0 Td
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1.7348 0 Td
(IgG3-R435)Tj
4.6148 0 Td
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1.9275 0 Td
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1.491 0 Td
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1.0318 0 Td
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1.474 0 Td
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1.0148 0 Td
(heterozygous)Tj
5.499 0 Td
(individuals)Tj
4.6488 0 Td
([)Tj
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(17)Tj
0 g
(].)Tj
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1.7802 0 Td
(H435)Tj
2.4151 0 Td
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3.0274 0 Td
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(uncommon)Tj
4.9209 0 Td
(in)Tj
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(Europeans)Tj
4.4787 0 Td
(\(~1%\),)Tj
2.9367 0 Td
(but)Tj
1.5534 0 Td
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2.3414 0 Td
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3.9343 0 Td
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1.0375 0 Td
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2.8743 0 Td
(\(10%25%\))Tj
4.8359 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0375 0 Td
(Africans)Tj
3.5943 0 Td
(\(30%60%\))Tj
-31.2035 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(],)Tj
2.075 0 Td
(suggesting)Tj
4.405 0 Td
(it)Tj
0.7823 0 Td
(may)Tj
1.9276 0 Td
(be)Tj
1.1509 0 Td
(under)Tj
2.6191 0 Td
(positive)Tj
3.3165 0 Td
(selection)Tj
3.719 0 Td
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1.0375 0 Td
(malaria)Tj
3.2258 0 Td
(endemic)Tj
3.651 0 Td
(areas.)Tj
2.4718 0 Td
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1.7801 0 Td
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-32.1616 -1.2982 Td
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4.938 0 Td
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1.0147 0 Td
(this)Tj
1.6725 0 Td
(polymorphism)Tj
6.1341 0 Td
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1.3889 0 Td
(IgG3)Tj
2.2167 0 Td
(transplacental)Tj
5.8053 0 Td
(transfer)Tj
3.3108 0 Td
(and)Tj
1.7348 0 Td
(IgG3)Tj
2.2167 0 Td
(half-life,)Tj
3.5149 0 Td
(espe-)Tj
-33.9474 -1.3039 Td
(cially)Tj
2.2904 0 Td
(with)Tj
1.9956 0 Td
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3.0387 0 Td
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1.0261 0 Td
(malaria,)Tj
3.4526 0 Td
(has)Tj
1.5421 0 Td
(not)Tj
1.576 0 Td
(been)Tj
2.1202 0 Td
(much)Tj
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(investigated)Tj
4.9889 0 Td
([)Tj
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(19)Tj
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(].)Tj
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3.1408 0 Td
(that)Tj
1.7801 0 Td
(impair)Tj
2.897 0 Td
(or)Tj
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(enhance)Tj
3.549 0 Td
(transplacental)Tj
5.8053 0 Td
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3.3165 0 Td
(can)Tj
1.6214 0 Td
(alter)Tj
1.9955 0 Td
(the)Tj
1.4683 0 Td
(amount)Tj
3.3562 0 Td
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1.0148 0 Td
(pathogen-specific)Tj
7.2624 0 Td
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1.0375 0 Td
(the)Tj
1.4683 0 Td
(newborn)Tj
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(circulation)Tj
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(and)Tj
1.7292 0 Td
(therefore)Tj
3.8551 0 Td
(susceptibility)Tj
5.4367 0 Td
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1.0261 0 Td
(infections,)Tj
4.3767 0 Td
(including)Tj
4.0421 0 Td
(malaria.)Tj
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2.2054 0 Td
(we)Tj
1.3209 0 Td
(examine)Tj
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(the)Tj
1.4684 0 Td
(association)Tj
4.6204 0 Td
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3.5262 0 Td
(the)Tj
1.4627 0 Td
(IgG3-H435)Tj
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(polymorphism)Tj
6.1341 0 Td
(and)Tj
1.7234 0 Td
(transplacental)Tj
-32.0085 -1.2983 Td
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1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
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[(\n)9()11()4()1()10()4()16(\r)-9( )12()]TJ
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7.9426 0 Td
(IgG1)Tj
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(IgG3)Tj
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1.6441 0 Td
(Beninese)Tj
3.7984 0 Td
(mothernewborn)Tj
7.2737 0 Td
(pairs,)Tj
2.3981 0 Td
(and)Tj
-35.5802 -1.2982 Td
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1.3266 0 Td
(investigate)Tj
4.4617 0 Td
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1.9389 0 Td
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(explored)Tj
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3.7927 0 Td
(IgG3-H435)Tj
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(IgG3)Tj
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(newborn,)Tj
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(IgG3)Tj
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(malaria)Tj
3.2258 0 Td
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1.0375 0 Td
(infancy.)Tj
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q
1 j
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BT
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(Methods)Tj
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0 -1.5023 Td
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BT
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5.091 0 Td
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Q
q
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576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 134.7591 23.6976 re
W* n
q
134.7024 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 256.2519 745.7952 cm
BT
/F0 1 Tf
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(IgG3-H4)Tj
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