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Tomoko Naito, Koji Namiguchi, Keiji Yoshikawa, Kazuhisa Miyamoto, Shiro Mizoue, Yoichi Kawashima, Atushi Shiraishi, Fumio Shiraga
Factors affecting eye drop instillation in glaucoma patients with visual field defect
www.plosone.org
www.plosone.org
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4.6261 0 Td
(VF)Tj
1.4457 0 Td
(Ana-)Tj
-34.3103 -1.2982 Td
(lyzer)Tj
2.1259 0 Td
(\(Carl)Tj
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(Zeiss)Tj
2.2281 0 Td
(Meditec)Tj
3.4809 0 Td
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(Dublin,)Tj
3.2825 0 Td
(CA,)Tj
1.7914 0 Td
(USA\))Tj
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1.9956 0 Td
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(302)Tj
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1.7801 0 Td
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4.0138 0 Td
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1.4684 0 Td
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(the)Tj
1.4683 0 Td
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(instillation)Tj
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1.7008 0 Td
(analyzed.)Tj
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5.4595 0 Td
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1.474 0 Td
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2.1429 0 Td
(instillation)Tj
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1.7291 0 Td
(the)Tj
1.474 0 Td
(presence)Tj
3.7077 0 Td
(or)Tj
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(absence)Tj
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1.0148 0 Td
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2.9707 0 Td
(VFD.)Tj
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(acuity)Tj
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-31.4643 -1.2983 Td
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(a)Tj
0.6576 0 Td
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(Japanese)Tj
3.6906 0 Td
(decimal)Tj
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(VA)Tj
1.5987 0 Td
(chart,)Tj
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(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
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3.9912 0 Td
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1.5987 0 Td
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1.6951 0 Td
(calculated)Tj
4.2066 0 Td
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2.3868 0 Td
(the)Tj
-34.9963 -1.3039 Td
(decimal)Tj
3.3618 0 Td
(visual)Tj
2.5115 0 Td
(acuity)Tj
2.6249 0 Td
(scale.)Tj
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Q
q
1 j
1 J
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11.9999 0 0 11.9999 200.0125 491.9244 cm
BT
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1 TL
-0.0033 Tc
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(the)Tj
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1.8029 0 Td
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3.5376 0 Td
(eye)Tj
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3.2258 0 Td
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1.0261 0 Td
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1.1509 0 Td
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-12.5574 -1.2983 Td
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2.9991 0 Td
(\(1\))Tj
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1.7121 0 Td
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1.4683 0 Td
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3.8834 0 Td
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1.0375 0 Td
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1.6951 0 Td
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(\(3\))Tj
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(one)Tj
1.6951 0 Td
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1.7008 0 Td
(delivered)Tj
3.8834 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.474 0 Td
(first)Tj
1.8028 0 Td
(attempt)Tj
3.3108 0 Td
(but)Tj
1.5534 0 Td
(the)Tj
1.4683 0 Td
(drop)Tj
2.143 0 Td
(flowed)Tj
-33.6583 -1.2983 Td
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1.8425 0 Td
(the)Tj
1.4683 0 Td
(conjunctival)Tj
5.1533 0 Td
(sac)Tj
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1.4683 0 Td
(lid)Tj
1.2643 0 Td
(margin,)Tj
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(and)Tj
1.7291 0 Td
(\(4\))Tj
1.3776 0 Td
(the)Tj
1.4684 0 Td
(tip)Tj
1.3039 0 Td
(of)Tj
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(the)Tj
1.4683 0 Td
(bottle)Tj
2.5002 0 Td
(touched)Tj
3.4526 0 Td
(the)Tj
1.474 0 Td
(bulbar)Tj
-33.9815 -1.2983 Td
(conjunctiva,)Tj
5.1363 0 Td
(cornea,)Tj
3.1521 0 Td
(eyelid)Tj
2.5625 0 Td
(or)Tj
1.0998 0 Td
(eyelashes.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 337.4929 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
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(Statistical)Tj
4.4504 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
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(8.0)Tj
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(\(SAS)Tj
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(Cary,)Tj
-33.8057 -1.3039 Td
(NC,)Tj
1.8425 0 Td
(USA\).)Tj
2.6815 0 Td
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0.9071 0 Td
[()]TJ
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1.0942 0 Td
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(exact)Tj
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5.5161 0 Td
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(assess)Tj
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(variables)Tj
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(\(age,)Tj
2.1089 0 Td
(gender,)Tj
3.2088 0 Td
(cor-)Tj
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2.6872 0 Td
(VA,)Tj
1.8255 0 Td
(spherical)Tj
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(power,)Tj
2.9537 0 Td
(the)Tj
1.4684 0 Td
(duration)Tj
3.702 0 Td
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(glaucoma,)Tj
4.3029 0 Td
(the)Tj
1.4684 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(current)Tj
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(eye)Tj
1.525 0 Td
(drops,)Tj
2.7269 0 Td
(mean)Tj
-35.0756 -1.3039 Td
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3.9458 0 Td
(\(MD\),)Tj
2.7552 0 Td
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1.0148 0 Td
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(defects,)Tj
3.1918 0 Td
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1.7291 0 Td
(central)Tj
2.965 0 Td
(VF)Tj
1.4457 0 Td
(defects\))Tj
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(that)Tj
1.7802 0 Td
(may)Tj
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(predict)Tj
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1.0148 0 Td
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-36.1131 -1.2983 Td
(drop)Tj
2.1429 0 Td
(instillation)Tj
4.5071 0 Td
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1.0375 0 Td
(glaucoma)Tj
4.0762 0 Td
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3.3675 0 Td
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1.7291 0 Td
(non-glaucoma)Tj
6.0321 0 Td
(volunteers.)Tj
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1.7802 0 Td
(significance)Tj
4.9379 0 Td
(level)Tj
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1.3039 0 Td
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0.9524 0 Td
[()]TJ
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0 Tc
0.771 0 Td
(<)Tj
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-0.004 Tc
0.9922 0 Td
(0.05.)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 209.0267 cm
BT
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1 TL
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0 -1.5023 Td
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6.0945 0 Td
(and)Tj
1.8661 0 Td
(clinical)Tj
3.1701 0 Td
(characteristics)Tj
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(of)Tj
1.0441 0 Td
(each)Tj
2.3622 0 Td
(group)Tj
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Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 173.9905 cm
BT
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1 TL
-0.004 Tc
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(A)Tj
0.9014 0 Td
(total)Tj
2.0069 0 Td
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(163)Tj
1.6441 0 Td
(subjects)Tj
3.3788 0 Td
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4.7679 0 Td
(78)Tj
1.1735 0 Td
(glaucoma)Tj
4.0762 0 Td
(patients)Tj
3.3675 0 Td
(\(glaucoma)Tj
4.4164 0 Td
(group\))Tj
2.948 0 Td
(and)Tj
1.7291 0 Td
(85)Tj
1.1736 0 Td
(non-glau-)Tj
-32.5982 -1.2982 Td
(coma)Tj
2.4037 0 Td
(volunteers)Tj
4.3823 0 Td
(\(non-glaucoma)Tj
6.3723 0 Td
(group\))Tj
2.948 0 Td
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1.9389 0 Td
(fulfilled)Tj
3.2768 0 Td
(all)Tj
1.1509 0 Td
(criteria)Tj
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(enrolled.)Tj
3.736 0 Td
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1.7858 0 Td
(demo-)Tj
-33.1934 -1.2983 Td
(graphic)Tj
3.2258 0 Td
(and)Tj
1.7291 0 Td
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(characteristics)Tj
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(shown)Tj
2.846 0 Td
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0.83 0.64 0.02 0 k
1.0374 0 Td
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2.4378 0 Td
(1)Tj
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(.)Tj
0.9241 0 Td
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1.4627 0 Td
(significant)Tj
-30.4212 -1.3039 Td
(difference)Tj
4.2009 0 Td
(\()Tj
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[()]TJ
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1.1111 0 Td
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0.7994 0 Td
(0.1156\))Tj
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f*
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f*
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f*
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f*
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f*
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f*
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0.83 0.64 0.02 0 k
36 251.5465 m
186.7465 251.5465 l
h
f*
0 g
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(1.)Tj
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(and)Tj
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(ristics)Tj
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q
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1 J
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q
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1 J
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(to)Tj
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(9)Tj
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(0.001)Tj
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[()]TJ
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(surgery)Tj
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(to)Tj
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f*
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f*
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f*
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(2.)Tj
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q
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1 J
0 w
35.9997 703.8425 m
158.5372 703.8425 l
158.5372 691.3426 l
35.9997 691.3426 l
f*
158.5372 703.8425 m
301.1998 703.8425 l
301.1998 691.3426 l
158.5372 691.3426 l
f*
301.1998 703.8425 m
380.9534 703.8425 l
380.9534 691.3426 l
301.1998 691.3426 l
f*
380.9534 703.8425 m
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480.5609 691.3426 l
380.9534 691.3426 l
f*
480.5609 703.8425 m
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480.5609 691.3426 l
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35.9997 691.3426 m
158.5372 691.3426 l
158.5372 678.8426 l
35.9997 678.8426 l
f*
158.5372 691.3426 m
301.1998 691.3426 l
301.1998 678.8426 l
158.5372 678.8426 l
f*
301.1998 691.3426 m
380.9534 691.3426 l
380.9534 678.8426 l
301.1998 678.8426 l
f*
380.9534 691.3426 m
480.5609 691.3426 l
480.5609 678.8426 l
380.9534 678.8426 l
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480.5609 691.3426 m
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35.9997 653.8428 m
158.5372 653.8428 l
158.5372 641.3428 l
35.9997 641.3428 l
f*
158.5372 653.8428 m
301.1998 653.8428 l
301.1998 641.3428 l
158.5372 641.3428 l
f*
301.1998 653.8428 m
380.9534 653.8428 l
380.9534 641.3428 l
301.1998 641.3428 l
f*
380.9534 653.8428 m
480.5609 653.8428 l
480.5609 641.3428 l
380.9534 641.3428 l
f*
480.5609 653.8428 m
575.9997 653.8428 l
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f*
35.9997 616.343 m
158.5372 616.343 l
158.5372 603.843 l
35.9997 603.843 l
f*
158.5372 616.343 m
301.1998 616.343 l
301.1998 603.843 l
158.5372 603.843 l
f*
301.1998 616.343 m
380.9534 616.343 l
380.9534 603.843 l
301.1998 603.843 l
f*
380.9534 616.343 m
480.5609 616.343 l
480.5609 603.843 l
380.9534 603.843 l
f*
480.5609 616.343 m
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35.9997 578.8431 m
158.5372 578.8431 l
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35.9997 566.3432 l
f*
158.5372 578.8431 m
301.1998 578.8431 l
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158.5372 566.3432 l
f*
301.1998 578.8431 m
380.9534 578.8431 l
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301.1998 566.3432 l
f*
380.9534 578.8431 m
480.5609 578.8431 l
480.5609 566.3432 l
380.9534 566.3432 l
f*
480.5609 578.8431 m
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0.45 0.36 0.35 0.01 k
35.9997 704.3426 m
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575.9997 703.8425 l
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158.5372 703.8425 m
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f*
158.0372 691.3426 m
35.9997 691.3426 l
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158.0372 691.8426 l
f*
301.1998 703.8425 m
301.1998 691.3426 l
300.6998 691.3426 l
300.6998 703.8425 l
f*
300.6998 691.3426 m
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300.6998 691.8426 l
f*
380.9534 703.8425 m
380.9534 691.3426 l
380.4534 691.3426 l
380.4534 703.8425 l
f*
380.4534 691.3426 m
301.1998 691.3426 l
301.1998 691.8426 l
380.4534 691.8426 l
f*
480.5609 703.8425 m
480.5609 691.3426 l
480.0609 691.3426 l
480.0609 703.8425 l
f*
480.0609 691.3426 m
380.9534 691.3426 l
380.9534 691.8426 l
480.0609 691.8426 l
f*
575.9997 691.3426 m
480.5609 691.3426 l
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575.9997 691.8426 l
f*
158.5372 691.3426 m
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f*
158.0372 678.8426 m
35.9997 678.8426 l
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158.0372 679.3427 l
f*
301.1998 691.3426 m
301.1998 678.8426 l
300.6998 678.8426 l
300.6998 691.3426 l
f*
300.6998 678.8426 m
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300.6998 679.3427 l
f*
380.9534 691.3426 m
380.9534 678.8426 l
380.4534 678.8426 l
380.4534 691.3426 l
f*
380.4534 678.8426 m
301.1998 678.8426 l
301.1998 679.3427 l
380.4534 679.3427 l
f*
480.5609 691.3426 m
480.5609 678.8426 l
480.0609 678.8426 l
480.0609 691.3426 l
f*
480.0609 678.8426 m
380.9534 678.8426 l
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480.0609 679.3427 l
f*
575.9997 678.8426 m
480.5609 678.8426 l
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575.9997 679.3427 l
f*
158.5372 678.8426 m
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158.0372 666.3427 l
158.0372 678.8426 l
f*
158.0372 666.3427 m
35.9997 666.3427 l
35.9997 666.8427 l
158.0372 666.8427 l
f*
301.1998 678.8426 m
301.1998 666.3427 l
300.6998 666.3427 l
300.6998 678.8426 l
f*
300.6998 666.3427 m
158.5372 666.3427 l
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300.6998 666.8427 l
f*
380.9534 678.8426 m
380.9534 666.3427 l
380.4534 666.3427 l
380.4534 678.8426 l
f*
380.4534 666.3427 m
301.1998 666.3427 l
301.1998 666.8427 l
380.4534 666.8427 l
f*
480.5609 678.8426 m
480.5609 666.3427 l
480.0609 666.3427 l
480.0609 678.8426 l
f*
480.0609 666.3427 m
380.9534 666.3427 l
380.9534 666.8427 l
480.0609 666.8427 l
f*
575.9997 666.3427 m
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575.9997 666.8427 l
f*
158.5372 666.3427 m
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f*
158.0372 653.8428 m
35.9997 653.8428 l
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158.0372 654.3428 l
f*
301.1998 666.3427 m
301.1998 653.8428 l
300.6998 653.8428 l
300.6998 666.3427 l
f*
300.6998 653.8428 m
158.5372 653.8428 l
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300.6998 654.3428 l
f*
380.9534 666.3427 m
380.9534 653.8428 l
380.4534 653.8428 l
380.4534 666.3427 l
f*
380.4534 653.8428 m
301.1998 653.8428 l
301.1998 654.3428 l
380.4534 654.3428 l
f*
480.5609 666.3427 m
480.5609 653.8428 l
480.0609 653.8428 l
480.0609 666.3427 l
f*
480.0609 653.8428 m
380.9534 653.8428 l
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f*
575.9997 653.8428 m
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f*
158.5372 653.8428 m
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f*
158.0372 641.3428 m
35.9997 641.3428 l
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f*
301.1998 653.8428 m
301.1998 641.3428 l
300.6998 641.3428 l
300.6998 653.8428 l
f*
300.6998 641.3428 m
158.5372 641.3428 l
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300.6998 641.8429 l
f*
380.9534 653.8428 m
380.9534 641.3428 l
380.4534 641.3428 l
380.4534 653.8428 l
f*
380.4534 641.3428 m
301.1998 641.3428 l
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380.4534 641.8429 l
f*
480.5609 653.8428 m
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480.0609 641.3428 l
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f*
480.0609 641.3428 m
380.9534 641.3428 l
380.9534 641.8429 l
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f*
575.9997 641.3428 m
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158.5372 641.3428 m
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158.0372 641.3428 l
f*
158.0372 628.8429 m
35.9997 628.8429 l
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158.0372 629.3429 l
f*
301.1998 641.3428 m
301.1998 628.8429 l
300.6998 628.8429 l
300.6998 641.3428 l
f*
300.6998 628.8429 m
158.5372 628.8429 l
158.5372 629.3429 l
300.6998 629.3429 l
f*
380.9534 641.3428 m
380.9534 628.8429 l
380.4534 628.8429 l
380.4534 641.3428 l
f*
380.4534 628.8429 m
301.1998 628.8429 l
301.1998 629.3429 l
380.4534 629.3429 l
f*
480.5609 641.3428 m
480.5609 628.8429 l
480.0609 628.8429 l
480.0609 641.3428 l
f*
480.0609 628.8429 m
380.9534 628.8429 l
380.9534 629.3429 l
480.0609 629.3429 l
f*
575.9997 628.8429 m
480.5609 628.8429 l
480.5609 629.3429 l
575.9997 629.3429 l
f*
158.5372 628.8429 m
158.5372 616.343 l
158.0372 616.343 l
158.0372 628.8429 l
f*
158.0372 616.343 m
35.9997 616.343 l
35.9997 616.843 l
158.0372 616.843 l
f*
301.1998 628.8429 m
301.1998 616.343 l
300.6998 616.343 l
300.6998 628.8429 l
f*
300.6998 616.343 m
158.5372 616.343 l
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300.6998 616.843 l
f*
380.9534 628.8429 m
380.9534 616.343 l
380.4534 616.343 l
380.4534 628.8429 l
f*
380.4534 616.343 m
301.1998 616.343 l
301.1998 616.843 l
380.4534 616.843 l
f*
480.5609 628.8429 m
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480.0609 616.343 l
480.0609 628.8429 l
f*
480.0609 616.343 m
380.9534 616.343 l
380.9534 616.843 l
480.0609 616.843 l
f*
575.9997 616.343 m
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575.9997 616.843 l
f*
158.5372 616.343 m
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158.0372 603.843 l
158.0372 616.343 l
f*
158.0372 603.843 m
35.9997 603.843 l
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158.0372 604.3431 l
f*
301.1998 616.343 m
301.1998 603.843 l
300.6998 603.843 l
300.6998 616.343 l
f*
300.6998 603.843 m
158.5372 603.843 l
158.5372 604.3431 l
300.6998 604.3431 l
f*
380.9534 616.343 m
380.9534 603.843 l
380.4534 603.843 l
380.4534 616.343 l
f*
380.4534 603.843 m
301.1998 603.843 l
301.1998 604.3431 l
380.4534 604.3431 l
f*
480.5609 616.343 m
480.5609 603.843 l
480.0609 603.843 l
480.0609 616.343 l
f*
480.0609 603.843 m
380.9534 603.843 l
380.9534 604.3431 l
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f*
575.9997 603.843 m
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575.9997 604.3431 l
f*
158.5372 603.843 m
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158.0372 603.843 l
f*
158.0372 591.3431 m
35.9997 591.3431 l
35.9997 591.8431 l
158.0372 591.8431 l
f*
301.1998 603.843 m
301.1998 591.3431 l
300.6998 591.3431 l
300.6998 603.843 l
f*
300.6998 591.3431 m
158.5372 591.3431 l
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300.6998 591.8431 l
f*
380.9534 603.843 m
380.9534 591.3431 l
380.4534 591.3431 l
380.4534 603.843 l
f*
380.4534 591.3431 m
301.1998 591.3431 l
301.1998 591.8431 l
380.4534 591.8431 l
f*
480.5609 603.843 m
480.5609 591.3431 l
480.0609 591.3431 l
480.0609 603.843 l
f*
480.0609 591.3431 m
380.9534 591.3431 l
380.9534 591.8431 l
480.0609 591.8431 l
f*
575.9997 591.3431 m
480.5609 591.3431 l
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575.9997 591.8431 l
f*
158.5372 591.3431 m
158.5372 578.8431 l
158.0372 578.8431 l
158.0372 591.3431 l
f*
158.0372 578.8431 m
35.9997 578.8431 l
35.9997 579.3432 l
158.0372 579.3432 l
f*
301.1998 591.3431 m
301.1998 578.8431 l
300.6998 578.8431 l
300.6998 591.3431 l
f*
300.6998 578.8431 m
158.5372 578.8431 l
158.5372 579.3432 l
300.6998 579.3432 l
f*
380.9534 591.3431 m
380.9534 578.8431 l
380.4534 578.8431 l
380.4534 591.3431 l
f*
380.4534 578.8431 m
301.1998 578.8431 l
301.1998 579.3432 l
380.4534 579.3432 l
f*
480.5609 591.3431 m
480.5609 578.8431 l
480.0609 578.8431 l
480.0609 591.3431 l
f*
480.0609 578.8431 m
380.9534 578.8431 l
380.9534 579.3432 l
480.0609 579.3432 l
f*
575.9997 578.8431 m
480.5609 578.8431 l
480.5609 579.3432 l
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0 Tc
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ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 117.9779 cm
BT
/F2 1 Tf
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/FontType 1 def
/FontBBox {-20 -958 1114 770} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Maths_Symbols) readonly def
/BaseFontName (TeX_CM_Maths_Symbols) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
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dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
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dup 20 /C20 put
dup 21 /C21 put
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dup 36 /dollar put
dup 37 /percent put
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