Rapid HPLC Method for Determination of Parachloroaniline in Chlorhexidine Antiseptic Agent in Mouthrinses, Ophthalmic and Skin Solution
@article{Nicolay2011RapidHM, title={Rapid HPLC Method for Determination of Parachloroaniline in Chlorhexidine Antiseptic Agent in Mouthrinses, Ophthalmic and Skin Solution}, author={Alain Nicolay and Estelle Wolff and M F Vergnes and Jacques Kaloustian and Henri Portugal}, journal={American Journal of Analytical Chemistry}, year={2011}, volume={02}, pages={422-428}, url={https://api.semanticscholar.org/CorpusID:30465123} }
A validated method for dosage of CHD and its major impurity pCA, known to be carcinogen, available into medical products or medicinal device for in-vitro diagnostic is presented.
14 Citations
Development and Validation of a Novel RP-HPLC Method for the Determination of Cetrimide and Chlorhexidine Gluconate in Antiseptic Solution
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Chemistry, Medicine
The present work displays the development and validation of an RP-HPLC isocratic method for the simultaneous determination of CE and Chlorhexidine Gluconate and was successfully validated according to ICH guidelines for specificity, linearity, accuracy, precision and stability for sample and standard solutions.
Liquid Chromatography-Tandem Mass Spectrometry Determination of p-Chloroaniline in Gel and Aqueous Chlorhexidine Products Used in Dentistry
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Medicine, Chemistry
A rapid and selective method to determine p-chloroaniline (pCA) in gel, 2 % aqueous solutions, and 0.12 % oral rinse formulas of chlorhexidine digluconate (CHX) used in dentistry treatments was…
Development and validation of a simple, fast, isocratic stability indicating RP-HPLC-UV method for the determination of chlorhexidine and its impurity para-chloroaniline in bulk and finished product
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Chemistry, Medicine
The results show that this is a simple method that can be applied to the analysis of Chlorhexidine productswith satisfactory degrees of accuracy and precision and can be used with the minimum requirements of an isocratic HPLC system.
Spectrophotometric Methods for Quantitative Determination of Chlorhexidine Gluconate and its Major Impurity, Metabolite and Degradation Product: Para-chloro-aniline
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Chemistry, Medicine
Four simple, specific, accurate and precise spectrophotometric methods are developed for determination of chlorhexidine gluconate in presence of its impurity and/or degradation product namely; para-chloro-aniline (PCA), assuring their applicability in quality control analysis of drug product.
A green stability indicating ISE-potentiometric method for the monitoring of chlorhexidine in the presence of its rapidly absorbed toxic degradation product; a kinetic study
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DETERMINATION OF CHLORHEXIDINE DIGLUCONATE IN DISINFECTANTS
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A new simple technique for the determination of chlorhexidine digluconate in technical products and disinfectants based on acid-base titration in alcohol-ketone is developed and it is shown that a charged aerosol detector can be used to analyze chlor hexidinedigluconates in cases where it is difficult to analyze with an ultraviolet or diode array detector.
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Chemistry, Medicine
Hydrophilic stationary phases (ZIC1 and ZIC5) were investigated for chromatographic prednisolone acetate separation and the methods proposed have been effective for pharmaceutical samples and their precision and accuracy are comparable.
Carbon-nanotube amperometric sensor for selective determination of 4-chloroaniline in commercial chlorhexidine solutions
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Voltammetric determination of traces of 4-chloroaniline in antiseptic samples on a cathodically-treated boron-doped diamond electrode
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An acrylic reline resin loaded with chlorhexidine: Insights on drug release
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Medicine, Chemistry
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The biological variation in saliva is such that chlorhexidine determinations by means of fluorescence can be done only with a reproducibility of +/- 10 ppm, andvantages and disadvantages of the ultraviolet spectroscopy method, the radioactive labelling technique, and the fluorescence method for chlorhexine determinations are discussed.