%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Melvyn W. B. Zhang, Ying X. Hong, Syeda F. Husain, Keith M. Harris, Roger C. M. Ho
Analysis of print news media framing of ketamine treatment in the United States and Canada from 2000 to 2015
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 9 0 R/Annots 10 0 R/Contents 11 0 R/TrimBox[0 0 612 792]>>
endobj
10 0 obj
[12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R]
endobj
12 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref001)>>
endobj
13 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref002)>>
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref003)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref004)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref005)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref005)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref006)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref007)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref008)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref009)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref010)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref011)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref012)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref013)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref014)>>
endobj
11 0 obj
[27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R]
endobj
27 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 652.2299 m
199.9998 652.2299 l
199.9998 652.7299 l
575.9997 652.7299 l
f*
0.83 0.64 0.02 0 k
358.4126 562.9039 m
363.1748 562.9039 l
h
f*
441.2409 549.9213 m
445.9465 549.9213 l
h
f*
356.2016 536.9386 m
360.9638 536.9386 l
h
f*
358.4126 497.9339 m
363.1748 497.9339 l
h
f*
476.3339 458.9291 m
480.926 458.9291 l
h
f*
460.6866 432.9071 m
465.2787 432.9071 l
h
f*
360 393.9024 m
364.5921 393.9024 l
h
f*
331.5402 341.915 m
336.3024 341.915 l
h
f*
388.1197 276.9449 m
392.8252 276.9449 l
h
f*
531.4961 250.9228 m
536.2583 250.9228 l
h
f*
527.8677 185.8961 m
537.3921 185.8961 l
h
f*
255.4016 159.9307 m
264.926 159.9307 l
h
f*
304.3843 120.926 m
313.852 120.926 l
h
f*
476.9008 107.9433 m
486.4252 107.9433 l
h
f*
491.4709 94.9039 m
500.9953 94.9039 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(changes)Tj
3.9565 0 Td
(in)Tj
0.9847 0 Td
(news)Tj
2.5303 0 Td
(media)Tj
2.9062 0 Td
(reporting)Tj
4.1177 0 Td
(might)Tj
2.6377 0 Td
(influence)Tj
4.1714 0 Td
(the)Tj
1.5933 0 Td
(popularity)Tj
4.4997 0 Td
(of)Tj
1.0443 0 Td
(ketamine)Tj
4.2311 0 Td
(use)Tj
1.8141 0 Td
(to)Tj
1.0503 0 Td
(treat)Tj
2.2021 0 Td
(clin-)Tj
-37.7394 -1.474 Td
(ical)Tj
1.6948 0 Td
(depression.)Tj
5.3291 0 Td
(Guidance)Tj
4.4519 0 Td
(is)Tj
0.9309 0 Td
(required)Tj
3.8372 0 Td
(for)Tj
1.3726 0 Td
(journalists)Tj
4.6607 0 Td
(on)Tj
1.3189 0 Td
(objective)Tj
4.1176 0 Td
(reporting)Tj
4.1118 0 Td
(of)Tj
1.0503 0 Td
(medical)Tj
-32.8758 -1.474 Td
(research)Tj
4.0639 0 Td
(findings,)Tj
3.8969 0 Td
(including)Tj
4.1057 0 Td
(limitations)Tj
4.6071 0 Td
(of)Tj
1.0443 0 Td
(current)Tj
3.3001 0 Td
(research)Tj
4.07 0 Td
(evidence)Tj
4.1714 0 Td
(and)Tj
1.8678 0 Td
(potential)Tj
3.9447 0 Td
(risks)Tj
2.2557 0 Td
(of)Tj
-37.3276 -1.474 Td
(ketamine.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 607.011 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 590.0031 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Print)Tj
2.2563 0 Td
(news)Tj
2.2337 0 Td
(media)Tj
2.6872 0 Td
(plays)Tj
2.228 0 Td
(an)Tj
1.2019 0 Td
(important)Tj
4.2746 0 Td
(role)Tj
1.7632 0 Td
(in)Tj
1.0318 0 Td
(influencing)Tj
4.7735 0 Td
(the)Tj
1.4627 0 Td
(public)Tj
2.7042 0 Td
(perceptions)Tj
4.8756 0 Td
(of)Tj
1.0091 0 Td
(psychoactive)Tj
-32.5018 -1.2982 Td
(substances.)Tj
4.6884 0 Td
(There)Tj
2.5795 0 Td
(is)Tj
0.8448 0 Td
(a)Tj
0.6576 0 Td
(strong)Tj
2.7723 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.5262 0 Td
(media)Tj
2.6929 0 Td
(reporting)Tj
3.9912 0 Td
(and)Tj
1.7291 0 Td
(an)Tj
1.2019 0 Td
(increase)Tj
3.4753 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(use)Tj
-35.2911 -1.3039 Td
(and)Tj
1.7291 0 Td
(misuse)Tj
2.982 0 Td
(of)Tj
1.0148 0 Td
(psychoactive)Tj
5.3121 0 Td
(substances)Tj
4.4617 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.4683 0 Td
(United)Tj
3.0217 0 Td
(States)Tj
2.5115 0 Td
(\(US\),)Tj
2.3414 0 Td
(news)Tj
2.2337 0 Td
(media)Tj
2.6929 0 Td
(framing)Tj
-32.4791 -1.2983 Td
(often)Tj
2.2847 0 Td
(sets)Tj
1.6611 0 Td
(the)Tj
1.474 0 Td
(public)Tj
2.7042 0 Td
(opinion)Tj
3.3845 0 Td
(about)Tj
2.4945 0 Td
(psychoactive)Tj
5.3121 0 Td
(substances)Tj
4.4674 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5987 0 Td
(Hence,)Tj
3.0331 0 Td
(media)Tj
2.6929 0 Td
(is)Tj
0.8447 0 Td
(expected)Tj
3.7247 0 Td
(to)Tj
-35.6766 -1.2983 Td
(practice)Tj
3.3788 0 Td
(socially)Tj
3.1578 0 Td
(responsible)Tj
4.7508 0 Td
(reporting)Tj
3.9912 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
1.6044 0 Td
(Research)Tj
3.8041 0 Td
(on)Tj
1.2755 0 Td
(news)Tj
2.2394 0 Td
(media)Tj
2.6872 0 Td
(framing)Tj
3.4186 0 Td
(provides)Tj
3.6453 0 Td
(valuable)Tj
-33.9531 -1.3039 Td
(insights)Tj
3.3165 0 Td
(into)Tj
1.8368 0 Td
(the)Tj
1.474 0 Td
(opinions)Tj
3.7417 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(general)Tj
3.1351 0 Td
(public)Tj
2.7042 0 Td
(on)Tj
1.2756 0 Td
(psychoactive)Tj
5.3121 0 Td
(substances,)Tj
4.6941 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
-33.8227 -1.2982 Td
(impact)Tj
2.9763 0 Td
(on)Tj
1.2756 0 Td
(society)Tj
2.9593 0 Td
(when)Tj
2.4038 0 Td
(there)Tj
2.262 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(change)Tj
3.0444 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(classification)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(psychoactive)Tj
5.3121 0 Td
(substance)Tj
4.1045 0 Td
(or)Tj
-35.3591 -1.2983 Td
(governmental)Tj
5.7599 0 Td
(policies)Tj
3.2315 0 Td
(on)Tj
1.2756 0 Td
(drug)Tj
2.1146 0 Td
(control)Tj
3.1181 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
-0.017 Tc
-14.3035 -1.3039 Td
(There)Tj
2.5171 0 Td
(was)Tj
1.6554 0 Td
(a)Tj
0.6407 0 Td
(recent)Tj
2.6362 0 Td
(epidemic)Tj
3.7814 0 Td
(of)Tj
0.9921 0 Td
(opioid)Tj
2.7326 0 Td
(analgesic)Tj
3.7077 0 Td
(abuse)Tj
2.4094 0 Td
(in)Tj
1.0091 0 Td
(North)Tj
2.5965 0 Td
(America,)Tj
3.7644 0 Td
(and)Tj
1.6895 0 Td
(studies)Tj
2.8969 0 Td
(on)Tj
1.2473 0 Td
(news)Tj
-35.4725 -1.2983 Td
(media)Tj
2.6248 0 Td
(framing)Tj
3.3222 0 Td
(were)Tj
2.0749 0 Td
(conducted.)Tj
4.5184 0 Td
(McGinty)Tj
3.7304 0 Td
(and)Tj
1.6951 0 Td
(colleagues)Tj
4.1442 0 Td
(\(2016\))Tj
2.727 0 Td
(studied)Tj
3.0614 0 Td
(how)Tj
1.8992 0 Td
(opioid)Tj
2.7325 0 Td
(analgesic)Tj
3.7077 0 Td
(use)Tj
-36.2378 -1.2983 Td
(and)Tj
1.6894 0 Td
(abuse)Tj
2.4094 0 Td
(was)Tj
1.6611 0 Td
(framed)Tj
3.0047 0 Td
(by)Tj
1.1565 0 Td
(the)Tj
1.4287 0 Td
(news)Tj
2.1883 0 Td
(media)Tj
2.6249 0 Td
(in)Tj
1.0091 0 Td
(the)Tj
1.4287 0 Td
(US)Tj
1.406 0 Td
(from)Tj
2.1543 0 Td
(1998)Tj
2.0749 0 Td
(to)Tj
0.9978 0 Td
(2012)Tj
2.0693 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.5477 0 Td
(This)Tj
1.9389 0 Td
(study)Tj
2.3244 0 Td
(revealed)Tj
-33.1141 -1.2982 Td
(that)Tj
1.7234 0 Td
(news)Tj
2.1883 0 Td
(media)Tj
2.6249 0 Td
(framed)Tj
3.0047 0 Td
(the)Tj
1.4343 0 Td
(issue)Tj
2.092 0 Td
(of)Tj
0.9921 0 Td
(opioid)Tj
2.7326 0 Td
(analgesic)Tj
3.7077 0 Td
(abuse)Tj
2.4094 0 Td
(under)Tj
2.5512 0 Td
(the)Tj
1.4343 0 Td
(criminal)Tj
3.4923 0 Td
(jurisdiction,)Tj
4.8982 0 Td
(and)Tj
-35.2854 -1.3039 Td
(the)Tj
1.4286 0 Td
(most)Tj
2.1543 0 Td
(commonly)Tj
4.4447 0 Td
(proposed)Tj
3.8438 0 Td
(solutions)Tj
3.7303 0 Td
(were)Tj
2.0693 0 Td
(through)Tj
3.3562 0 Td
(legal)Tj
1.9673 0 Td
(means)Tj
2.7439 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.5477 0 Td
(In)Tj
1.0828 0 Td
(contrast,)Tj
3.5716 0 Td
(another)Tj
3.2372 0 Td
(study)Tj
-35.1777 -1.2983 Td
(found)Tj
2.5511 0 Td
(that)Tj
1.7291 0 Td
(the)Tj
1.4287 0 Td
(print)Tj
2.16 0 Td
(news)Tj
2.1826 0 Td
(media)Tj
2.6306 0 Td
(in)Tj
1.0091 0 Td
(North)Tj
2.5965 0 Td
(America)Tj
3.549 0 Td
(portrayed)Tj
4.0081 0 Td
(the)Tj
1.4344 0 Td
(abuse)Tj
2.4037 0 Td
(of)Tj
0.9921 0 Td
(another)Tj
3.2372 0 Td
(opioid)Tj
2.7382 0 Td
(analge-)Tj
-34.6504 -1.2983 Td
(sic,)Tj
1.4456 0 Td
(oxycodone,)Tj
4.6771 0 Td
(as)Tj
0.9922 0 Td
(a)Tj
0.6406 0 Td
(social)Tj
2.3754 0 Td
(problem,)Tj
3.736 0 Td
(and)Tj
1.6895 0 Td
(it)Tj
0.7597 0 Td
(coincided)Tj
4.0195 0 Td
(with)Tj
1.9445 0 Td
(the)Tj
1.4343 0 Td
(reduction)Tj
3.9969 0 Td
(in)Tj
1.0091 0 Td
(oxycodone)Tj
4.4674 0 Td
(prescrip-)Tj
-33.1878 -1.3039 Td
(tions)Tj
2.1373 0 Td
(by)Tj
1.1565 0 Td
(doctors)Tj
3.1237 0 Td
(in)Tj
1.0092 0 Td
(Nova)Tj
2.3017 0 Td
(Scotia,)Tj
2.7553 0 Td
(Canada)Tj
3.1861 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5477 0 Td
(Although)Tj
3.9004 0 Td
(news)Tj
2.1884 0 Td
(media)Tj
2.6248 0 Td
(framing)Tj
3.3222 0 Td
(research)Tj
3.4526 0 Td
(has)Tj
1.5023 0 Td
(been)Tj
-34.2082 -1.2982 Td
(conducted)Tj
4.3086 0 Td
(on)Tj
1.2529 0 Td
(opioid)Tj
2.7326 0 Td
(analgesics,)Tj
4.2689 0 Td
(there)Tj
2.1997 0 Td
(is)Tj
0.822 0 Td
(a)Tj
0.6407 0 Td
(paucity)Tj
3.05 0 Td
(of)Tj
0.9865 0 Td
(similar)Tj
2.897 0 Td
(research)Tj
3.4525 0 Td
(on)Tj
1.2473 0 Td
(ketamine,)Tj
4.0422 0 Td
(which)Tj
2.5851 0 Td
(is)Tj
0.8221 0 Td
(a)Tj
0.6406 0 Td
(psy-)Tj
-35.9487 -1.2983 Td
(choactive)Tj
3.8607 0 Td
(substance)Tj
3.9855 0 Td
(with)Tj
1.9502 0 Td
(abuse)Tj
2.4038 0 Td
(potential.)Tj
-0.004 Tc
-11.004 -1.3039 Td
(In)Tj
1.1111 0 Td
(1962,)Tj
2.3471 0 Td
(ketamine)Tj
3.9345 0 Td
(was)Tj
1.6951 0 Td
(first)Tj
1.8085 0 Td
(synthesized)Tj
4.8245 0 Td
(by)Tj
1.1792 0 Td
(Parke-Davis)Tj
5.108 0 Td
(laboratory,)Tj
4.5808 0 Td
(which)Tj
2.6475 0 Td
(subsequently)Tj
5.4085 0 Td
(pat-)Tj
-35.841 -1.2983 Td
(ented)Tj
2.4377 0 Td
(ketamine)Tj
3.9345 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(anesthetic)Tj
4.2236 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.6044 0 Td
(Ketamine)Tj
4.1045 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(non-competitive)Tj
6.8768 0 Td
(N-methyl-D-aspartic)Tj
8.6229 0 Td
(acid)Tj
-35.5235 -1.2983 Td
(\(NMDA\))Tj
3.9458 0 Td
(receptor)Tj
3.5602 0 Td
(antagonist)Tj
4.3824 0 Td
(and)Tj
1.7291 0 Td
(derived)Tj
3.2145 0 Td
(from)Tj
2.2053 0 Td
(phencyclidine)Tj
5.8223 0 Td
(\(PCP\),)Tj
2.9027 0 Td
(which)Tj
2.6532 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6577 0 Td
(hallucinogen.)Tj
-31.9179 -1.2982 Td
(Ketamine)Tj
4.1045 0 Td
(binds)Tj
2.4321 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(PCP)Tj
2.0012 0 Td
(binding)Tj
3.3562 0 Td
(site)Tj
1.5647 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(NMDA)Tj
3.2655 0 Td
(receptor)Tj
3.5603 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(human)Tj
3.0784 0 Td
(brain.)Tj
2.5738 0 Td
(In)Tj
1.1112 0 Td
(the)Tj
-34.5314 -1.3039 Td
(1960s,)Tj
2.7099 0 Td
(ketamine)Tj
3.9287 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.058 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(battlefield)Tj
4.1839 0 Td
(anesthetic)Tj
4.2236 0 Td
(during)Tj
2.9254 0 Td
(the)Tj
1.474 0 Td
(Vietnam)Tj
3.702 0 Td
(War.)Tj
2.2167 0 Td
(Ketamine)Tj
4.1102 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
-35.7503 -1.2983 Td
(dissociative)Tj
4.8131 0 Td
(anesthetic,)Tj
4.4504 0 Td
(which)Tj
2.6476 0 Td
(is)Tj
0.8503 0 Td
(helpful)Tj
2.9934 0 Td
(in)Tj
1.0375 0 Td
(treating)Tj
3.3278 0 Td
(wounded)Tj
3.9628 0 Td
(soldiers)Tj
3.2882 0 Td
(by)Tj
1.1792 0 Td
(keeping)Tj
3.3619 0 Td
(them)Tj
2.2904 0 Td
(con-)Tj
-34.2026 -1.2983 Td
(scious)Tj
2.6645 0 Td
(but)Tj
1.5534 0 Td
(cognitively)Tj
4.5751 0 Td
(separated)Tj
4.0138 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(pain)Tj
1.9899 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
1.5987 0 Td
(Ketamine)Tj
4.1102 0 Td
(was)Tj
1.6951 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(FDA)Tj
2.1656 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
-35.6822 -1.3039 Td
(anesthetic)Tj
4.2235 0 Td
(for)Tj
1.389 0 Td
(cardiac)Tj
3.1011 0 Td
(catheterization,)Tj
6.3779 0 Td
(skin)Tj
1.8935 0 Td
(grafting,)Tj
3.583 0 Td
(orthopedic)Tj
4.5921 0 Td
(and)Tj
1.7291 0 Td
(extraperitoneal)Tj
6.2475 0 Td
(proce-)Tj
-33.1367 -1.2983 Td
(dures,)Tj
2.6532 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(diagnostic)Tj
4.32 0 Td
(procedures)Tj
4.6771 0 Td
(performed)Tj
4.4674 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(eye,)Tj
1.7461 0 Td
(ear,)Tj
1.6781 0 Td
(nose,)Tj
2.2847 0 Td
(and)Tj
1.7292 0 Td
(throat)Tj
2.6588 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
1.5988 0 Td
(Keta-)Tj
-34.4067 -1.2982 Td
(mine)Tj
2.279 0 Td
(has)Tj
1.542 0 Td
(remained)Tj
4.0365 0 Td
(in)Tj
1.0318 0 Td
(use)Tj
1.5364 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(induction)Tj
4.1386 0 Td
(of)Tj
1.0148 0 Td
(general)Tj
3.1294 0 Td
(anesthesia)Tj
4.303 0 Td
(in)Tj
1.0318 0 Td
(adult)Tj
2.2564 0 Td
(populations;)Tj
-29.1513 -1.3039 Td
(however,)Tj
3.838 0 Td
(this)Tj
1.6725 0 Td
(practice)Tj
3.3788 0 Td
(is)Tj
0.8448 0 Td
(now)Tj
1.9615 0 Td
(very)Tj
1.9276 0 Td
(uncommon)Tj
4.9209 0 Td
(owing)Tj
2.6929 0 Td
(to)Tj
1.0204 0 Td
(the)Tj
1.4741 0 Td
(side)Tj
1.7971 0 Td
(effects)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
(ketamine,)Tj
4.1556 0 Td
(including)Tj
-33.4259 -1.2983 Td
(an)Tj
1.2018 0 Td
(increase)Tj
3.4696 0 Td
(in)Tj
1.0375 0 Td
(sympathetic)Tj
5.0456 0 Td
(tone,)Tj
2.2224 0 Td
(amnesia,)Tj
3.736 0 Td
(emergence)Tj
4.5411 0 Td
(delirium,)Tj
3.8948 0 Td
(and)Tj
1.7291 0 Td
(hallucinations.)Tj
6.0831 0 Td
(Ketamine)Tj
-32.961 -1.2983 Td
(is)Tj
0.8447 0 Td
(sometimes)Tj
4.5014 0 Td
(used)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(sedative)Tj
3.4073 0 Td
(for)Tj
1.3889 0 Td
(children)Tj
3.5546 0 Td
(undergoing)Tj
4.8699 0 Td
(dental)Tj
2.6986 0 Td
(and)Tj
1.7348 0 Td
(emergency)Tj
4.5694 0 Td
(procedures)Tj
-31.2999 -1.3039 Td
(because)Tj
3.3165 0 Td
(it)Tj
0.788 0 Td
(does)Tj
2.0409 0 Td
(not)Tj
1.5704 0 Td
(cause)Tj
2.3924 0 Td
(respiratory)Tj
4.5978 0 Td
(depression)Tj
4.5241 0 Td
(and)Tj
1.7291 0 Td
(preserves)Tj
3.9288 0 Td
(the)Tj
1.4683 0 Td
(airway)Tj
2.8687 0 Td
(reflexes)Tj
3.2201 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
2.0749 0 Td
(The)Tj
-34.52 -1.2982 Td
(intravenous)Tj
4.9605 0 Td
(route)Tj
2.3471 0 Td
(is)Tj
0.8504 0 Td
(preferred)Tj
3.9345 0 Td
(because)Tj
3.3222 0 Td
(it)Tj
0.7823 0 Td
(allows)Tj
2.6986 0 Td
(precise)Tj
3.0104 0 Td
(dosing)Tj
2.8969 0 Td
(and)Tj
1.7292 0 Td
(dose)Tj
2.0409 0 Td
(adjustment)Tj
4.7111 0 Td
(when)Tj
2.4038 0 Td
(side)Tj
-35.6879 -1.2983 Td
(effects)Tj
2.7269 0 Td
(occur)Tj
2.4718 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
-4.0025 -1.2983 Td
(Ketamine,)Tj
4.3369 0 Td
(also)Tj
1.7689 0 Td
(known)Tj
3.0047 0 Td
(as)Tj
1.0148 0 Td
(K)Tj
1.6781 0 Td
(or)Tj
1.0941 0 Td
(Special)Tj
3.4016 0 Td
(K,)Tj
1.5137 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6576 0 Td
(psychoactive)Tj
5.3121 0 Td
(substance)Tj
4.1046 0 Td
(with)Tj
1.9955 0 Td
(abuse)Tj
2.4718 0 Td
(poten-)Tj
-34.3953 -1.3039 Td
(tial)Tj
1.4626 0 Td
(because)Tj
3.3222 0 Td
(it)Tj
0.7824 0 Td
(causes)Tj
2.7552 0 Td
(euphoria,)Tj
4.0195 0 Td
(sensory)Tj
3.2485 0 Td
(distortions,)Tj
4.7565 0 Td
(impairments)Tj
5.3461 0 Td
(in)Tj
1.0375 0 Td
(set-shifting,)Tj
4.9039 0 Td
(and)Tj
1.7291 0 Td
(height-)Tj
-33.3635 -1.2983 Td
(ened)Tj
2.1429 0 Td
(feelings)Tj
3.2428 0 Td
(of)Tj
1.0148 0 Td
(empathy)Tj
3.6964 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
2.0749 0 Td
(In)Tj
1.1112 0 Td
(the)Tj
1.4684 0 Td
(US,)Tj
1.6554 0 Td
(ketamine)Tj
3.9344 0 Td
(is)Tj
0.8448 0 Td
(a)Tj
0.6519 0 Td
(Schedule)Tj
3.7984 0 Td
(III)Tj
1.2416 0 Td
(drug)Tj
2.109 0 Td
(under)Tj
2.6192 0 Td
(the)Tj
1.4683 0 Td
(Controlled)Tj
-33.0744 -1.2982 Td
(Substances)Tj
4.5807 0 Td
(Act,)Tj
1.8482 0 Td
(which)Tj
2.6532 0 Td
(limits)Tj
2.4775 0 Td
(its)Tj
1.1452 0 Td
(prescription)Tj
5.0966 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0262 0 Td
(its)Tj
1.1451 0 Td
(abuse)Tj
2.4775 0 Td
(liability)Tj
3.2031 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
2.0807 0 Td
(From)Tj
2.4434 0 Td
(1995)Tj
2.1203 0 Td
(to)Tj
1.0261 0 Td
(2002,)Tj
-35.0189 -1.3039 Td
(emergency)Tj
4.575 0 Td
(room)Tj
2.4208 0 Td
(visits)Tj
2.228 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(ketamine)Tj
3.9288 0 Td
(abuse)Tj
2.4775 0 Td
(had)Tj
1.7064 0 Td
(increased)Tj
4.0025 0 Td
(by)Tj
1.1792 0 Td
(20)Tj
1.1736 0 Td
(times)Tj
2.3867 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
2.0807 0 Td
(Ketamine)Tj
4.1045 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
-35.841 -1.2983 Td
(common)Tj
3.8437 0 Td
(psychoactive)Tj
5.3121 0 Td
(substance)Tj
4.1045 0 Td
(abused)Tj
2.9991 0 Td
(by)Tj
1.1848 0 Td
(young)Tj
2.7213 0 Td
(people,)Tj
3.0784 0 Td
(and)Tj
1.7348 0 Td
(1.5%)Tj
2.1543 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(US)Tj
1.4287 0 Td
(12th)Tj
2.0012 0 Td
(graders)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 439.6535 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Media)Tj
2.8984 0 Td
(analysis)Tj
3.763 0 Td
(of)Tj
1.0418 0 Td
(ketamine)Tj
4.2094 0 Td
(new)Tj
2.0197 0 Td
(articles)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0173)Tj
3.5434 0 Td
(202)Tj
2.6362 0 Td
(March)Tj
2.9551 0 Td
(3,)Tj
1.0418 0 Td
(2017)Tj
39.1042 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
28 0 obj
<>stream
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
43 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 9 0 R/Annots 44 0 R/Contents 45 0 R/TrimBox[0 0 612 792]>>
endobj
44 0 obj
[46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R]
endobj
46 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref015)>>
endobj
47 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref016)>>
endobj
48 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref017)>>
endobj
49 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref018)>>
endobj
50 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref019)>>
endobj
51 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref020)>>
endobj
52 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref021)>>
endobj
53 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref022)>>
endobj
54 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref020)>>
endobj
55 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref023)>>
endobj
56 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref024)>>
endobj
57 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref007)>>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref024)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref025)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref026)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref007)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref011)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref019)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref024)>>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref027)>>
endobj
66 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref024)>>
endobj
67 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref028)>>
endobj
68 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref029)>>
endobj
69 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref030)>>
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173202.ref005)>>
endobj
45 0 obj
[71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R]
endobj
71 0 obj
<>stream
q
0.83 0.64 0.02 0 k
304.0441 706.337 m
313.5685 706.337 l
h
f*
289.8142 693.2976 m
299.3386 693.2976 l
h
f*
332.4472 667.3323 m
341.9717 667.3323 l
h
f*
287.0929 641.3102 m
296.6173 641.3102 l
h
f*
460.6299 641.3102 m
470.1543 641.3102 l
h
f*
508.7055 641.3102 m
518.2299 641.3102 l
h
f*
395.263 628.3276 m
404.7874 628.3276 l
h
f*
203.4142 615.3449 m
212.9386 615.3449 l
h
f*
509.8394 615.3449 m
519.3638 615.3449 l
h
f*
469.3606 602.3055 m
478.885 602.3055 l
h
f*
275.2441 576.3402 m
284.7685 576.3402 l
h
f*
429.8457 576.3402 m
434.6079 576.3402 l
h
f*
433.0205 524.2961 m
442.4882 524.2961 l
h
f*
446.9669 524.2961 m
456.4913 524.2961 l
h
f*
485.5181 498.3307 m
495.0425 498.3307 l
h
f*
238.7339 472.3087 m
243.4961 472.3087 l
h
f*
437.1024 446.3433 m
446.6268 446.3433 l
h
f*
203.4142 407.3386 m
212.9386 407.3386 l
h
f*
399.2315 368.3339 m
408.6992 368.3339 l
h
f*
536.8252 329.3291 m
546.2929 329.3291 l
h
f*
539.8299 277.3417 m
549.3543 277.3417 l
h
f*
553.7764 277.3417 m
563.3008 277.3417 l
h
f*
200.0126 264.3024 m
209.537 264.3024 l
h
f*
478.5449 225.2976 m
488.0693 225.2976 l
h
f*
536.0315 81.9213 m
540.7937 81.9213 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(reported)Tj
3.6566 0 Td
(ketamine)Tj
3.9345 0 Td
(abuse)Tj
2.4718 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0749 0 Td
(Ketamine)Tj
4.1102 0 Td
(abuse)Tj
2.4718 0 Td
(is)Tj
0.8504 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(amnesia,)Tj
3.7304 0 Td
(dependence,)Tj
5.2327 0 Td
(and)Tj
-34.7865 -1.3039 Td
(urinary)Tj
3.1917 0 Td
(incontinence)Tj
5.4482 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
-7.4437 -1.2982 Td
(Ketamine)Tj
4.1102 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(key)Tj
1.5931 0 Td
(compound)Tj
4.5978 0 Td
(in)Tj
1.0374 0 Td
(neurobiological)Tj
6.4686 0 Td
(research)Tj
3.5547 0 Td
(testing)Tj
2.8856 0 Td
(the)Tj
1.4684 0 Td
(glutamatergic)Tj
5.6919 0 Td
(hypoth-)Tj
-34.1062 -1.2983 Td
(esis)Tj
1.6327 0 Td
(of)Tj
1.0148 0 Td
(psychosis)Tj
3.9968 0 Td
(and)Tj
1.7348 0 Td
(depression)Tj
4.5241 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.0749 0 Td
(Several)Tj
3.0501 0 Td
(clinical)Tj
3.0784 0 Td
(trials)Tj
2.1997 0 Td
(have)Tj
2.0579 0 Td
(evaluated)Tj
3.9912 0 Td
(the)Tj
1.4683 0 Td
(slow)Tj
2.0182 0 Td
(intravenous)Tj
-32.8419 -1.2983 Td
(\(IV\))Tj
1.9332 0 Td
(infusion)Tj
3.5376 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
3.9288 0 Td
(at)Tj
0.9524 0 Td
(sub-anesthetic)Tj
5.9697 0 Td
(doses)Tj
2.4038 0 Td
(\(0.5)Tj
1.7348 0 Td
(mg/kg\))Tj
3.1351 0 Td
(and)Tj
1.7291 0 Td
(have)Tj
2.0636 0 Td
(explored)Tj
3.702 0 Td
(its)Tj
1.1452 0 Td
(effect)Tj
2.3641 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
-36.629 -1.3039 Td
(rapid)Tj
2.3357 0 Td
(antidepressant)Tj
6.0321 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.0806 0 Td
(Response)Tj
3.9798 0 Td
(rates)Tj
2.109 0 Td
(have)Tj
2.0636 0 Td
(ranged)Tj
2.9877 0 Td
(from)Tj
2.2053 0 Td
(29%)Tj
1.9276 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(])Tj
1.8538 0 Td
(to)Tj
1.0261 0 Td
(79%)Tj
1.9276 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.0749 0 Td
(Around)Tj
-32.6038 -1.2982 Td
(two-third)Tj
4.0535 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(patients)Tj
3.3675 0 Td
(relapsed)Tj
3.5263 0 Td
(within)Tj
2.812 0 Td
(1)Tj
0.6916 0 Td
(week)Tj
2.2507 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
1.8482 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(short)Tj
2.2847 0 Td
(half-life)Tj
3.2939 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
-31.8215 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.0749 0 Td
(Hence,)Tj
3.033 0 Td
(some)Tj
2.3301 0 Td
(researchers)Tj
4.7112 0 Td
(have)Tj
2.0636 0 Td
(proposed)Tj
3.9514 0 Td
(repeated)Tj
3.6397 0 Td
(infusions)Tj
3.8948 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
3.9288 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(];)Tj
2.0749 0 Td
(however,)Tj
-32.7172 -1.3039 Td
(repeated)Tj
3.6396 0 Td
(infusions)Tj
3.8948 0 Td
(may)Tj
1.9275 0 Td
(lead)Tj
1.8539 0 Td
(to)Tj
1.0205 0 Td
(detrimental)Tj
4.8812 0 Td
(side)Tj
1.7971 0 Td
(effects)Tj
2.7269 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(brain)Tj
2.347 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
2.075 0 Td
(The)Tj
1.7858 0 Td
(main)Tj
2.2904 0 Td
(difference)Tj
-32.7456 -1.2983 Td
(between)Tj
3.5262 0 Td
(the)Tj
1.4684 0 Td
(application)Tj
4.6828 0 Td
(in)Tj
1.0374 0 Td
(clinical)Tj
3.0728 0 Td
(trials)Tj
2.1997 0 Td
(and)Tj
1.7291 0 Td
(illicit)Tj
2.2337 0 Td
(use)Tj
1.5363 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
3.9288 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(dosage)Tj
2.9367 0 Td
(and)Tj
1.7291 0 Td
(frequency)Tj
-33.4145 -1.2983 Td
(of)Tj
1.0147 0 Td
(administration)Tj
6.1682 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(],)Tj
2.0749 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8199 0 Td
(as)Tj
1.0148 0 Td
(route)Tj
2.3527 0 Td
(of)Tj
1.0148 0 Td
(administration)Tj
6.1682 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.5987 0 Td
(In)Tj
1.1112 0 Td
(clinical)Tj
3.0727 0 Td
(trials,)Tj
2.4264 0 Td
(the)Tj
1.4684 0 Td
(average)Tj
3.2258 0 Td
(dose)Tj
-35.5462 -1.3039 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6576 0 Td
(single)Tj
2.5285 0 Td
(infusion)Tj
3.5376 0 Td
(of)Tj
1.0148 0 Td
(35)Tj
1.1679 0 Td
(mg)Tj
1.508 0 Td
(for)Tj
1.3833 0 Td
(57)Tj
1.6894 0 Td
(days;)Tj
2.2224 0 Td
(however,)Tj
3.8381 0 Td
(illicit)Tj
2.2336 0 Td
(users)Tj
2.2678 0 Td
(may)Tj
1.9275 0 Td
(take)Tj
1.8709 0 Td
(several)Tj
2.9366 0 Td
(grams)Tj
2.6702 0 Td
(of)Tj
1.0148 0 Td
(keta-)Tj
-35.3137 -1.2982 Td
(mine)Tj
2.279 0 Td
(per)Tj
1.5307 0 Td
(day)Tj
1.6384 0 Td
(by)Tj
1.1792 0 Td
(smoking,)Tj
3.9118 0 Td
(insufflation,)Tj
5.023 0 Td
(or)Tj
1.0998 0 Td
(intramuscular)Tj
5.8507 0 Td
(injection.)Tj
3.9855 0 Td
(Furthermore,)Tj
5.6182 0 Td
(clinical)Tj
3.0727 0 Td
(trials)Tj
-35.189 -1.2983 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.576 0 Td
(provide)Tj
3.2882 0 Td
(evidence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(real-world)Tj
4.3823 0 Td
(experience)Tj
4.5071 0 Td
(to)Tj
1.0261 0 Td
(predict)Tj
3.0444 0 Td
(how)Tj
1.9389 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
2.0013 0 Td
(depression)Tj
-32.5812 -1.3039 Td
(interact)Tj
3.2824 0 Td
(with)Tj
1.9956 0 Td
(ketamine)Tj
3.9345 0 Td
(outside)Tj
3.1294 0 Td
(the)Tj
1.474 0 Td
(rigors)Tj
2.5625 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(clinical)Tj
3.0784 0 Td
(trial)Tj
1.8368 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(25)Tj
0 g
(].)Tj
1.7348 0 Td
(Rasmussen)Tj
4.6772 0 Td
(\(2015\))Tj
2.8062 0 Td
(empha-)Tj
-33.9134 -1.2983 Td
(sized)Tj
2.211 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4683 0 Td
(safety)Tj
2.4775 0 Td
(of)Tj
1.0148 0 Td
(prolonged)Tj
4.337 0 Td
(ketamine)Tj
3.9288 0 Td
(use)Tj
1.5307 0 Td
(in)Tj
1.0375 0 Td
(clinical)Tj
3.0784 0 Td
(settings)Tj
3.2428 0 Td
(has)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(been)Tj
2.126 0 Td
(established,)Tj
-31.3453 -1.2982 Td
(and)Tj
1.7291 0 Td
(therapeutic)Tj
4.7338 0 Td
(enthusiasm)Tj
4.7849 0 Td
(must)Tj
2.228 0 Td
(be)Tj
1.1508 0 Td
(tempered)Tj
4.0252 0 Td
(by)Tj
1.1792 0 Td
(its)Tj
1.1509 0 Td
(addiction)Tj
4.0195 0 Td
(liability)Tj
3.2088 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
2.0749 0 Td
(Ho)Tj
1.4967 0 Td
(and)Tj
1.7291 0 Td
(Zhang)Tj
-33.5109 -1.2983 Td
(\(2016\))Tj
2.8006 0 Td
(performed)Tj
4.4673 0 Td
(a)Tj
0.6577 0 Td
(critical)Tj
2.948 0 Td
(appraisal)Tj
3.8041 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(clinical)Tj
3.0784 0 Td
(trials)Tj
2.1997 0 Td
(that)Tj
1.7744 0 Td
(evaluated)Tj
3.9912 0 Td
(ketamine)Tj
3.9288 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(antide-)Tj
-34.35 -1.3039 Td
(pressant)Tj
3.5319 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.6044 0 Td
(The)Tj
1.7801 0 Td
(results)Tj
2.812 0 Td
(should)Tj
2.914 0 Td
(be)Tj
1.1508 0 Td
(interpreted)Tj
4.6942 0 Td
(with)Tj
1.9956 0 Td
(caution)Tj
3.2258 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0204 0 Td
(the)Tj
1.474 0 Td
(following)Tj
3.9798 0 Td
(reasons.)Tj
3.447 0 Td
(First,)Tj
-35.3308 -1.2983 Td
(most)Tj
2.2053 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2507 0 Td
(trials)Tj
2.1997 0 Td
(compared)Tj
4.2462 0 Td
(ketamine)Tj
3.9288 0 Td
(with)Tj
1.9956 0 Td
(placebo.)Tj
3.5036 0 Td
(There)Tj
2.5795 0 Td
(was)Tj
1.7008 0 Td
(a)Tj
0.6519 0 Td
(lack)Tj
1.8199 0 Td
(of)Tj
1.0148 0 Td
(direct)Tj
2.5341 0 Td
(comparisons)Tj
-31.6457 -1.2983 Td
(between)Tj
3.5262 0 Td
(ketamine)Tj
3.9345 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.3471 0 Td
(antidepressants)Tj
6.3949 0 Td
(in)Tj
1.0375 0 Td
(most)Tj
2.2053 0 Td
(trials)Tj
2.194 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
2.0806 0 Td
(Second,)Tj
3.3506 0 Td
(the)Tj
1.4683 0 Td
(follow-up)Tj
4.0932 0 Td
(period)Tj
-34.3613 -1.3039 Td
(was)Tj
1.6951 0 Td
(too)Tj
1.5363 0 Td
(short)Tj
2.2847 0 Td
(to)Tj
1.0262 0 Td
(rule)Tj
1.7858 0 Td
(out)Tj
1.5534 0 Td
(addiction)Tj
4.0195 0 Td
(and)Tj
1.7348 0 Td
(complications)Tj
5.8393 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(regular)Tj
3.0614 0 Td
(ketamine)Tj
3.9288 0 Td
(infu-)Tj
-34.7185 -1.2982 Td
(sion.)Tj
2.1259 0 Td
(Third,)Tj
2.7496 0 Td
(ketamine)Tj
3.9345 0 Td
(was)Tj
1.7007 0 Td
(used)Tj
2.058 0 Td
(with)Tj
1.9956 0 Td
(other)Tj
2.347 0 Td
(psychotropic)Tj
5.3972 0 Td
(medications)Tj
5.0966 0 Td
(in)Tj
1.0375 0 Td
(some)Tj
2.3301 0 Td
(clinical)Tj
3.0784 0 Td
(trials)Tj
-33.8511 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
2.0749 0 Td
(Fourth,)Tj
3.2031 0 Td
(the)Tj
1.474 0 Td
(aforementioned)Tj
6.6047 0 Td
(studies)Tj
2.9877 0 Td
(were)Tj
2.1203 0 Td
(not)Tj
1.5761 0 Td
(able)Tj
1.8311 0 Td
(to)Tj
1.0262 0 Td
(ascertain)Tj
3.7814 0 Td
(the)Tj
1.4683 0 Td
(differences)Tj
4.5638 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
-36.2435 -1.3039 Td
(rapid)Tj
2.3357 0 Td
(antidepressant)Tj
6.0321 0 Td
(effect)Tj
2.3697 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
3.9288 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(drug)Tj
2.5058 0 Td
(high)Tj
2.3981 0 Td
(of)Tj
1.0148 0 Td
(psychoactive)Tj
5.3177 0 Td
(substances.)Tj
4.6885 0 Td
(Keta-)Tj
-34.8035 -1.2983 Td
(mine)Tj
2.279 0 Td
(use)Tj
1.5307 0 Td
(for)Tj
1.389 0 Td
(treating)Tj
3.3221 0 Td
(severe)Tj
2.6816 0 Td
(depression)Tj
4.5241 0 Td
(leads)Tj
2.211 0 Td
(to)Tj
1.0261 0 Td
(major)Tj
2.6079 0 Td
(ethical)Tj
2.8403 0 Td
(concerns)Tj
3.8267 0 Td
(including)Tj
4.0422 0 Td
(the)Tj
1.474 0 Td
(lack)Tj
1.8198 0 Td
(of)Tj
-35.5745 -1.2983 Td
(safety)Tj
2.4774 0 Td
(data)Tj
1.9162 0 Td
(in)Tj
1.0318 0 Td
(off-label)Tj
3.515 0 Td
(use)Tj
1.5307 0 Td
(and)Tj
1.7291 0 Td
(its)Tj
1.1452 0 Td
(abuse)Tj
2.4718 0 Td
(potential)Tj
3.7644 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
-18.3854 -1.2982 Td
(Due)Tj
1.9105 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(growing)Tj
3.5263 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
3.9345 0 Td
(trials,)Tj
2.4207 0 Td
(print)Tj
2.2224 0 Td
(news)Tj
2.2393 0 Td
(media)Tj
2.6929 0 Td
(has)Tj
1.5421 0 Td
(conducted)Tj
4.4277 0 Td
(interviews)Tj
-33.0404 -1.3039 Td
(with)Tj
1.9955 0 Td
(researchers)Tj
4.7112 0 Td
(and)Tj
1.7291 0 Td
(reported)Tj
3.6623 0 Td
(their)Tj
2.109 0 Td
(findings.)Tj
3.719 0 Td
(A)Tj
0.9014 0 Td
(2016)Tj
2.126 0 Td
(Washington)Tj
5.142 0 Td
(Post)Tj
1.9446 0 Td
(article)Tj
2.6815 0 Td
(was)Tj
1.7008 0 Td
(headlined)Tj
-32.4224 -1.2983 Td
(One-time)Tj
4.49 0 Td
(party)Tj
2.296 0 Td
(drug)Tj
2.109 0 Td
(\(ketamine\))Tj
4.6148 0 Td
(hailed)Tj
2.6419 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(miracle)Tj
3.2031 0 Td
(for)Tj
1.389 0 Td
(treating)Tj
3.3222 0 Td
(severe)Tj
2.6815 0 Td
(depression)Tj
4.9209 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
2.075 0 Td
(In)Tj
-35.4158 -1.2983 Td
(this)Tj
1.6724 0 Td
(article,)Tj
2.9083 0 Td
(ketamine)Tj
3.9345 0 Td
(was)Tj
1.6951 0 Td
(described)Tj
4.0535 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(next)Tj
2.3528 0 Td
(big)Tj
1.457 0 Td
(thing)Tj
2.7212 0 Td
(in)Tj
1.0318 0 Td
(psychiatry)Tj
4.3313 0 Td
(with)Tj
1.9956 0 Td
(rapid)Tj
2.3414 0 Td
(effect)Tj
2.3641 0 Td
(and)Tj
-35.3421 -1.3039 Td
(booster)Tj
3.1917 0 Td
(treatment.)Tj
4.3654 0 Td
(After)Tj
2.2847 0 Td
(reading)Tj
3.2541 0 Td
(this)Tj
1.6781 0 Td
(article,)Tj
2.9084 0 Td
(patients)Tj
3.3675 0 Td
(may)Tj
1.9275 0 Td
(request)Tj
3.1295 0 Td
(their)Tj
2.1089 0 Td
(doctors)Tj
3.2202 0 Td
(to)Tj
1.0204 0 Td
(prescribe)Tj
-32.4564 -1.2982 Td
(ketamine)Tj
3.9287 0 Td
(that)Tj
1.7802 0 Td
(is)Tj
0.8447 0 Td
(described)Tj
4.0535 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6577 0 Td
(miracle)Tj
3.2031 0 Td
(anti-depressant.)Tj
6.6103 0 Td
(Cautious)Tj
3.8041 0 Td
(clinicians)Tj
4.0082 0 Td
(and)Tj
1.7291 0 Td
(academics)Tj
4.337 0 Td
(are)Tj
-35.9714 -1.2983 Td
(concerned)Tj
4.4163 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4684 0 Td
(benefits)Tj
3.3335 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
3.9345 0 Td
(could)Tj
2.4491 0 Td
(be)Tj
1.1508 0 Td
(exaggerated)Tj
4.955 0 Td
(by)Tj
1.1792 0 Td
(print)Tj
2.2223 0 Td
(media)Tj
2.6929 0 Td
(articles)Tj
3.0444 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(28)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-35.3761 -1.3039 Td
(29)Tj
0 g
(].)Tj
1.7347 0 Td
(The)Tj
1.7859 0 Td
(aforementioned)Tj
6.6046 0 Td
(article)Tj
2.6816 0 Td
(is)Tj
0.8504 0 Td
(very)Tj
1.9219 0 Td
(different)Tj
3.6566 0 Td
(from)Tj
2.2054 0 Td
(a)Tj
0.6576 0 Td
(2003)Tj
2.1203 0 Td
(Portsmouth)Tj
5.0003 0 Td
(Herald)Tj
2.9877 0 Td
(article)Tj
2.6872 0 Td
(with)Tj
-34.8942 -1.2983 Td
(the)Tj
1.4683 0 Td
(headline)Tj
3.617 0 Td
(Parents)Tj
3.6113 0 Td
(enlisted)Tj
3.3165 0 Td
(drug)Tj
2.109 0 Td
(battle.)Tj
3.0444 0 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(article,)Tj
2.9083 0 Td
(ketamine)Tj
3.9345 0 Td
(was)Tj
1.6951 0 Td
(described)Tj
4.0535 0 Td
(as)Tj
1.0148 0 Td
(special)Tj
2.8913 0 Td
(K)Tj
-36.4476 -1.2983 Td
(or)Tj
1.0941 0 Td
(a)Tj
0.6576 0 Td
(horse)Tj
2.4095 0 Td
(tranquilizer)Tj
4.8926 0 Td
(that)Tj
1.7801 0 Td
(produced)Tj
4.0478 0 Td
(superhuman)Tj
5.2781 0 Td
(strength,)Tj
3.7417 0 Td
(lysergic)Tj
3.2315 0 Td
(acid)Tj
1.8709 0 Td
(diethylamide)Tj
5.4368 0 Td
(\(LSD\)-)Tj
-34.4407 -1.3039 Td
(like)Tj
1.6497 0 Td
(hallucinations,)Tj
6.0831 0 Td
(amnesia,)Tj
3.7361 0 Td
(depression,)Tj
4.7508 0 Td
(and)Tj
1.7291 0 Td
(long-term)Tj
4.252 0 Td
(memory)Tj
3.6169 0 Td
(loss)Tj
1.6951 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(].)Tj
2.075 0 Td
(Given)Tj
2.6305 0 Td
(the)Tj
1.4684 0 Td
(changes)Tj
-33.6867 -1.2982 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(uses)Tj
1.8935 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
3.9288 0 Td
(across)Tj
2.6759 0 Td
(the)Tj
1.474 0 Td
(years,)Tj
2.4888 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(recent)Tj
2.7099 0 Td
(media)Tj
2.6929 0 Td
(promotion)Tj
4.5638 0 Td
(of)Tj
1.0148 0 Td
(ketamine)Tj
3.9288 0 Td
(as)Tj
-36.2095 -1.2983 Td
(a)Tj
0.6519 0 Td
(rapid)Tj
2.3357 0 Td
(antidepressant,)Tj
6.2646 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(pertinent)Tj
3.9175 0 Td
(to)Tj
1.0204 0 Td
(evaluate)Tj
3.464 0 Td
(any)Tj
1.6554 0 Td
(changes)Tj
3.4072 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(trends)Tj
2.7496 0 Td
(of)Tj
1.0148 0 Td
(how)Tj
1.9389 0 Td
(print)Tj
2.2223 0 Td
(news)Tj
-34.7808 -1.2983 Td
(media)Tj
2.6928 0 Td
(reports)Tj
3.0671 0 Td
(on)Tj
1.2756 0 Td
(ketamine.)Tj
4.1556 0 Td
(To)Tj
1.3379 0 Td
(our)Tj
1.6271 0 Td
(knowledge,)Tj
4.7678 0 Td
(no)Tj
1.2756 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.0579 0 Td
(examined)Tj
4.1273 0 Td
(the)Tj
1.474 0 Td
(print)Tj
2.2223 0 Td
(news)Tj
-33.0687 -1.3039 Td
(media)Tj
2.6928 0 Td
(coverage)Tj
3.7191 0 Td
(of)Tj
1.0148 0 Td
(ketamine.)Tj
4.1555 0 Td
(Our)Tj
1.8709 0 Td
(objective)Tj
3.7757 0 Td
(was)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(examine)Tj
3.6 0 Td
(how)Tj
1.9389 0 Td
(ketamine)Tj
3.9345 0 Td
(had)Tj
1.7064 0 Td
(been)Tj
2.126 0 Td
(portrayed)Tj
-33.2615 -1.2983 Td
(by)Tj
1.1792 0 Td
(print)Tj
2.2223 0 Td
(news)Tj
2.2394 0 Td
(media)Tj
2.6929 0 Td
(framing)Tj
3.4128 0 Td
(research)Tj
3.5547 0 Td
(analysis.)Tj
3.5546 0 Td
(The)Tj
1.7801 0 Td
(results)Tj
2.8063 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6781 0 Td
(study)Tj
2.3868 0 Td
(have)Tj
2.0636 0 Td
(important)Tj
4.2803 0 Td
(impli-)Tj
-34.8659 -1.2982 Td
(cations)Tj
3.0557 0 Td
(for)Tj
1.3889 0 Td
(media,)Tj
2.9197 0 Td
(medical)Tj
3.3562 0 Td
(professionals,)Tj
5.6409 0 Td
(and)Tj
1.7291 0 Td
(patients.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 112.9889 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methodology)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(study)Tj
2.3924 0 Td
(followed)Tj
3.6453 0 Td
(the)Tj
1.4741 0 Td
(systematic)Tj
4.3596 0 Td
(and)Tj
1.7291 0 Td
(quantitative)Tj
4.9776 0 Td
(approach)Tj
3.9515 0 Td
(proposed)Tj
3.9572 0 Td
(by)Tj
1.1792 0 Td
(McGinty)Tj
3.821 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
-34.4123 -1.2982 Td
(\(2016\))Tj
2.8006 0 Td
(for)Tj
1.3889 0 Td
(their)Tj
2.1033 0 Td
(analyses)Tj
3.4866 0 Td
(of)Tj
1.0148 0 Td
(how)Tj
1.9389 0 Td
(news)Tj
2.2337 0 Td
(media)Tj
2.6929 0 Td
(frame)Tj
2.5568 0 Td
(opioid)Tj
2.812 0 Td
(analgesic)Tj
3.8267 0 Td
(abuse)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(US)Tj
1.4287 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.6044 0 Td
(For)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 439.6535 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Media)Tj
2.8984 0 Td
(analysis)Tj
3.763 0 Td
(of)Tj
1.0418 0 Td
(ketamine)Tj
4.2094 0 Td
(new)Tj
2.0197 0 Td
(articles)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0173)Tj
3.5434 0 Td
(202)Tj
2.6362 0 Td
(March)Tj
2.9551 0 Td
(3,)Tj
1.0418 0 Td
(2017)Tj
39.1042 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
endstream
endobj
80 0 obj
<>stream
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
endstream
endobj
90 0 obj
<>stream
endstream
endobj
91 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
92 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 9 0 R/Annots 95 0 R/Contents 96 0 R/TrimBox[0 0 612 792]>>
endobj
93 0 obj
<>
endobj
97 0 obj
<>
endobj
98 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Maths_Symbols def
/FontType 1 def
/FontBBox {-20 -958 1114 770} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Maths_Symbols) readonly def
/BaseFontName (TeX_CM_Maths_Symbols) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
dup 128 /ff put
dup 129 /ffi put
dup 130 /ffl put
dup 131 /C131 put
dup 132 /Eth put
dup 133 /eth put
dup 134 /Thorn put
dup 135 /thorn put
dup 136 /onequarter put
dup 137 /onehalf put
dup 138 /C138 put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤(HwK7X7
Mr:E%]3<Ӝ$wrAQ4ADt%̏>E hAجm*pu@>#6aZi}NRmƼ%
,OgX' EX?ڞ\#JEG<IXS}Eh[ş8ї48ٶ.w4bJ?_nfulqD?둓\C%+' { L9K7isW+ӕ(6oɧVҺlS;5K
Z%.oQՕW*9Qk_S+B-}%lYC@WP0b\KKdi>t,n_S[ '9`-z+cڦEb#c@;yɸoAT O_H~i -6ϰ豟Ae&BF+
wNX!=hhUF8(hZ6pgJc m'9dx*^wXc
գ<.쯶c ln)/LvXY2jbF:ȸ3'>\Ȥmzj,!:ZK' (q/ -&&S ؤ-bm KQSxLGu `D3yԱKaVMU§ %iq5%s 2SdR#ho45H.4TdՊa<K>BqG- Ao, (e&F2gG`z8*༠&
x#B
B;8!93~T/ \>nLazCSKm~,!_<ӾX@X@N2vEt בFmBYa wRG[i;+oM+%(8 jԀlIW>t