The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide

@article{Laurentiis2010TheHE,
  title={The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide},
  author={Andrea De Laurentiis and Javier Fern{\'a}ndez-Solari and Claudia Ester Mohn and Berenice Burdet and Mar{\'i}a Aurelia Zorrilla Zubilete and Val{\'e}ria Rettori},
  journal={Journal of Neuroimmunology},
  year={2010},
  volume={221},
  pages={32-41},
  url={https://api.semanticscholar.org/CorpusID:12899399}
}
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62 References

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