%PDF-1.4
%
1 0 obj
<< /S /URI /IsMap false /URI (dx.doi.org/10.1038/nri2456)
>>
endobj
2 0 obj
<< /Subtype /XML /Type /Metadata /Length 3366
>>
stream
image/tiff
Adobe Photoshop CS3 Windows
2009-12-03T11:57:08-05:00
2009-12-11T09:22:29-05:00
2009-12-11T09:22:29-05:00
uuid:9A8D4E1728E0DE1182BDA38A282A24B6
uuid:85E71D1E60E6DE11B339DE87F70897BB
uuid:F08E22CE69DFDE11B1238E99EEB2A7CD
uuid:8F745AEB10D8DE118CB9A35A1BC8805E
1
8300000/10000
8300000/10000
2
256,257,258,259,262,274,277,284,530,531,282,283,296,301,318,319,529,532,306,270,271,272,305,315,33432;9E74395D03254675520580B5110BA098
4150
4639
5
1
1
8
4150
4639
-1
36864,40960,40961,37121,37122,40962,40963,37510,40964,36867,36868,33434,33437,34850,34852,34855,34856,37377,37378,37379,37380,37381,37382,37383,37384,37385,37386,37396,41483,41484,41486,41487,41488,41492,41493,41495,41728,41729,41730,41985,41986,41987,41988,41989,41990,41991,41992,41993,41994,41995,41996,42016,0,2,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,20,22,23,24,25,26,27,28,30;03F9CD5BDF895467EAC6D031B70D4E21
1
Dot Gain 20%
endstream
endobj
3 0 obj
<< /Subtype /Type0 /BaseFont /QUINXN+MathematicalPi-Five /Encoding /Identity-H /DescendantFonts 86 0 R /Type /Font /ToUnicode 145 0 R
>>
endobj
4 0 obj
<< /Subtype /CIDFontType0C /Filter /FlateDecode /Length 402
>>
stream
Hbd`ab`dd quM,HM,LN u/-I!#C89-L~de=ǣ{2<*l|AY)I)y%%E%
ɚ
`ybϼĒ=ǜ bԢ2?ʂT}i@"Y/?}
pDw&¿N>=j٪\.E$)_=w<3Sw_ys^sRIe%
%%/5e~V6n)TBT<3gNݍ`#T=gliq ɥ|
endstream
endobj
5 0 obj
<< /Nums
[ 0 77 0 R
]
>>
endobj
6 0 obj
<< /CropBox
[ 0 0 612 792
] /BleedBox
[ 0 0 612 792
] /MediaBox
[ 0 0 612 792
] /Rotate 0 /Annots 78 0 R /ArtBox
[ 0 0 612 792
] /TrimBox
[ 0 0 612 792
] /Resources
<< /Font
<< /C0_0 176 0 R /T1_3 107 0 R /T1_4 104 0 R /T1_5 147 0 R /T1_6 38 0 R /T1_0 174 0 R /T1_1 119 0 R /T1_2 40 0 R
>> /ProcSet
[ /PDF /Text
] /ExtGState
<< /GS0 67 0 R /GS1 197 0 R
>> /ColorSpace
<< /CS0 167 0 R
>>
>> /Parent 137 0 R /Contents 55 0 R /Type /Page
>>
endobj
7 0 obj
<< /FontFile3 188 0 R /CapHeight 621 /Ascent 896 /Flags 34 /ItalicAngle 0 /Descent -233 /FontFamily (Bembo Std) /FontName /GSKFNH+BemboStd /FontStretch /Normal /XHeight 396 /FontBBox
[ -206 -233 1026 896
] /Type /FontDescriptor /FontWeight 400 /StemV 68
>>
endobj
8 0 obj
<< /Rect
[ 379.428000 131.230000 466.299000 140.262000
] /Subtype /Link /A 189 0 R /Border
[ 0 0 0
] /BS
<< /W 0 /Type /Border /S /S
>> /H /N /Type /Annot
>>
endobj
9 0 obj
<< /Subtype /CIDFontType0C /Filter /FlateDecode /Length 687
>>
stream
Hbd`ab`ddrvM,HM,LN K!#C89ij~g]{G{>:%yTXjSR=SRJ2K**23J45--
%
yEE%)z
99
A
AũEe@Q} ny%!
P!%5
@Xe`abX(v2~g;f8 dY]l6~lQh*U0xՆ+6=]j۳ݾInSV(Wk[$>o i`gy>P!ϣ&a̙ww#X<uw\;}%Nn zf,
endstream
endobj
10 0 obj
<< /S /URI /IsMap false /URI (dx.doi.org/10.1038/ni.1641)
>>
endobj
11 0 obj
<< /Type /Encoding /Differences
[ 32 /space 69 /E 74 /J 77 /M 84 /T 97 /a 99 /c /d /e /f 104 /h /i 108 /l /m /n /o /p 114 /r 116 /t /u 120 /x
]
>>
endobj
12 0 obj
<< /Rect
[ 115.668000 577.732000 233.730000 586.764000
] /Subtype /Link /A 155 0 R /Border
[ 0 0 0
] /BS
<< /W 0 /Type /Border /S /S
>> /H /N /Type /Annot
>>
endobj
13 0 obj
<< /OPM 1 /SMask /None /BM /Normal /SA true /Type /ExtGState
>>
endobj
14 0 obj
<< /S /URI /IsMap false /URI (dx.doi.org/10.1016/0165-2478\(93\)90133-M)
>>
endobj
15 0 obj
<< /Subtype /Type1C /Filter /FlateDecode /Length 4938
>>
stream
HTTiTTW~
*igߋqa5(
D4@#`#jC#t#BLB\Aq1EgȨs&9Sor_s~nݯd#&oX!j,Uz:L8g..-9Ay|OuVPR),rS'2v2ٓW+ՙy;t>xl{\oqE:^%iut6#ATktD/qEZIz7*Md &k8QKTiREuC%3ԺLduQmOU![DJ#dĸD1W͘'ҼmJj
S5)뷫¥Ⱦb*adǸ000{f#c1h;0aL3YˬcҙSYB;=o0!a`š[;Ǹ3q"5_[9Yc{e)KGe2.{9:Ayբ{3\n:sj5yJdўX>PUE5݀Žneq0LTQYXR''[!\ܟ
̜"hz=;;tRq",q$up 2$/<Cܵǃ4'FH)p'
c@0ۨmwa5;v7Wf{>Q(=ev &P?Tx<1naVsbTRR=QxJG&jD)ݛ }i_u^/
PTzPQn(M'x)ez7e P&d-˿k-B#U+ܟ!㔄(^ۂ8COxo{{)C
9x
03rFSq+d;W]$#bOat |\ĝ+b:Ox0JiYRܤ@Zm~6r:|+yhsvVaOP?~W"Q;(Yk
NR4P[,ZE:M G wv'
0ƇAv^@7V{k`AVRNø(3ڄ0X۴'&1&z)P]f_mxȭ%Y4ҔP"p=F_&D,ӹA NOC>rAs$M{.)I,jnЯ0̖Ks\kjS#Q}z|ObXbEg nm7ԧYiCeo.MP^ou(,[*YʷcKaw*zj͗#9(G4[v>րQ;5V+9p]zAD
{V\*u)ܢi3]}H1]t
v3eFXymbϩW{
}7Fumr?2i