%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Rachel L. Morgan, Nilofar Behbahani-Nejad, Judith Endres, M. Asif Amin, Nick J. Lepore, Yuxuan Du, Andrew Urquhart, Kevin C. Chung, David A. Fox
Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref010)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref010)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref010)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref011)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref012)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref013)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref013)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref014)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref017)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref018)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref019)>>
endobj
14 0 obj
[27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R]
endobj
27 0 obj
<>stream
q
0.83 0.64 0.02 0 k
222.6331 706.337 m
227.452 706.337 l
h
f*
507.2315 706.337 m
516.8126 706.337 l
h
f*
494.9858 680.315 m
504.5669 680.315 l
h
f*
276.8882 654.3496 m
286.4693 654.3496 l
h
f*
384.7181 615.3449 m
394.3559 615.3449 l
h
f*
396.5102 615.3449 m
406.0913 615.3449 l
h
f*
299.2252 563.3008 m
308.8063 563.3008 l
h
f*
203.4142 537.3354 m
213.052 537.3354 l
h
f*
222.6331 524.2961 m
232.2142 524.2961 l
h
f*
237.3165 524.2961 m
246.9543 524.2961 l
h
f*
499.3512 333.1276 m
508.9323 333.1276 l
h
f*
437.8961 307.1055 m
447.5339 307.1055 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(")-1()5()-5()3()]TJ
1.9162 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(\))]TJ
1.61 0 Td
[(&)11(%)12()]TJ
1.5421 0 Td
[()3()]TJ
0.8447 0 Td
[()4()15(1)]TJ
1.9445 0 Td
[(*)-4()4()15(1)-3()]TJ
2.9707 0 Td
[()6()]TJ
1.0205 0 Td
[(&)-9()]TJ
1.1395 0 Td
[()2(2)11()13()2()5()-7()-6( )]TJ
4.0762 0 Td
[(&)15()]TJ
1.1792 0 Td
[()11()-4()4()1()]TJ
2.3357 0 Td
[(")-1()5()-5()]TJ
1.5591 0 Td
[()-2()-1()-9()2()]TJ
2.5001 0 Td
[()1()4(")6()12(%)2( )1()1()8(+)]TJ
3.9969 0 Td
[(345)]TJ
1.7404 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[(6)]TJ
0 g
[(\))]TJ
2.0863 0 Td
[(.)39()]TJ
0.8561 0 Td
[()3(\n)1()]TJ
1.5533 0 Td
[(\n)-4()3()-7()]TJ
-34.8715 -1.3039 Td
[(&)-9()-6()1()]TJ
2.0976 0 Td
[()2( )2()1()19()-5()1()-11()2()-6( )]TJ
4.0138 0 Td
[()1()]TJ
1.0205 0 Td
[()-7()6()12(%)5(&)6()2()]TJ
3.0274 0 Td
[()-11(\n)2(")-6()-5()2()11()8()]TJ
3.702 0 Td
[()11()]TJ
1.0091 0 Td
[(&)11()2()6()2()1(+)-5()2(")-3(\n)-4()]TJ
4.0592 0 Td
[()-17()12(%)1()2( )3()]TJ
2.6475 0 Td
[()]TJ
2.5682 0 Td
[()3()]TJ
0.8447 0 Td
[(%)12()11()13()-1(+)1(%)-5()-2(\n)18()6()-6( )]TJ
4.955 0 Td
[()1()]TJ
1.0204 0 Td
[(,)-5()]TJ
1.5251 0 Td
[()-1()-3()4()15($)-3()-2(\n)-4()]TJ
-32.4905 -1.2982 Td
[()-17()12(%)1()2( )]TJ
2.0636 0 Td
[(")-1()11()19()-5(\n)8()13()-6( )]TJ
4.2122 0 Td
[()6()]TJ
1.0262 0 Td
[(/)37()]TJ
1.644 0 Td
[()-1()-3()4()15($)-3()-2(\n)-4()]TJ
3.498 0 Td
[()-17()12(%)1()2( )6()]TJ
2.2847 0 Td
[()4()11()-4()3(\n)-4()]TJ
3.1294 0 Td
[()19(%)1()3(\n)8()]TJ
3.0671 0 Td
[()-7()1()-10(%)1()]TJ
2.9196 0 Td
[()11()]TJ
1.0829 0 Td
[(,)-5()]TJ
1.525 0 Td
[()-7()1()-10(%)1()]TJ
2.6986 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[(6)]TJ
0 g
[(\))]TJ
2.0862 0 Td
[()]TJ
2.5682 0 Td
[()3()]TJ
0.8447 0 Td
[(\n)-4()3()-7()]TJ
-34.6504 -1.2983 Td
[()8()11(%)1()4( )]TJ
2.5965 0 Td
[()1()]TJ
1.0204 0 Td
[()-11()5(&)11()13()5(&)6()-2(\n)1()5()]TJ
3.9969 0 Td
[()1()-5(*)10()]TJ
1.6384 0 Td
[()-1()-3()4()15($)-3()2()-9(")-18()-1()6()]TJ
4.8982 0 Td
[(345)]TJ
2.4321 0 Td
[(")-6(%)-5()12()10(%)1()13()]TJ
3.0161 0 Td
[()5(%)12()-9()1()-4()3(\n)18()-6(\n)8()19()]TJ
5.5558 0 Td
[( )2()1()4()11()8()5()-5(\n)18()-5()1()8(+)]TJ
6.0491 0 Td
[()-4()3(\n)18()]TJ
1.7972 0 Td
[()]TJ
2.5625 0 Td
[()3()]TJ
-35.5632 -1.2983 Td
[()13()5()2()-5(\n)1()-7()-6( )]TJ
3.4072 0 Td
[()-11()13()11()]TJ
2.194 0 Td
[(345)]TJ
1.7404 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[(6)]TJ
0 g
[(\))]TJ
2.0863 0 Td
[()]TJ
2.5682 0 Td
[()3(\n)1()]TJ
1.5534 0 Td
[(&)-9()-6()1()]TJ
2.0976 0 Td
[()2( )2()1()19()-5()1()-11()2()-6( )]TJ
4.0138 0 Td
[(\n)1()]TJ
1.0205 0 Td
[(\n)]TJ
0.6576 0 Td
[()-5()-10(%)1()4(")-3(\n)18()6()-6( )]TJ
4.0479 0 Td
[()-7()6()12(%)5(&)6()2()]TJ
3.0274 0 Td
[()11()13()11()6()1()1()]TJ
3.1294 0 Td
[()1()]TJ
1.0205 0 Td
[()19(%)1()3(\n)8()]TJ
-32.5642 -1.3039 Td
[()-7()1()-10(%)1()]TJ
2.6985 0 Td
[(&)15()]TJ
1.1792 0 Td
[(7)97()2()5()6()1()-4()]TJ
3.6 0 Td
[(&)6()2()11(8)]TJ
1.9899 0 Td
[()4()15(1)8()-9($)8()1()64()]TJ
3.8097 0 Td
[(&)-9()-6(")-3(\n)18(%)3()-7()]TJ
3.2939 0 Td
[()]TJ
2.5682 0 Td
[()3()]TJ
0.8447 0 Td
[()2()1(+)-6()-5()7()]TJ
2.7099 0 Td
[()2(2)11()13()2()5()-7()-6( )]TJ
4.0818 0 Td
[()11()]TJ
1.2586 0 Td
[()-4()4()]TJ
1.474 0 Td
[(")-1()5()-5()]TJ
1.5534 0 Td
[()5(%)1()-4()-1(\n)2(")-1()6()]TJ
3.2542 0 Td
[()2(2)-5(\n!)]TJ
-34.316 -1.2982 Td
[(")-1()5()-5()12(%)-5()-2(\n)8()]TJ
3.1294 0 Td
[($)8()2()2()2(")6()2()2()]TJ
3.3902 0 Td
[(1)-7()2()2(")6()]TJ
2.6362 0 Td
[(")-3(\n)8()]TJ
1.6157 0 Td
[()13()1()-17()2()-6(")-6()]TJ
2.6816 0 Td
[()-4()4()]TJ
1.474 0 Td
[()11()13()11()6()1()1()]TJ
3.1294 0 Td
[(")-1()11()19()-9()1()2()12()-5()2()11()]TJ
5.2044 0 Td
[()11()]TJ
1.0091 0 Td
[()-4()4()]TJ
1.474 0 Td
[(")-1()5()-5()]TJ
1.5534 0 Td
[()5(%)1()-4()-1(\n)2(")-1()6()]TJ
3.2542 0 Td
[(\n)8()13()]TJ
1.44 0 Td
[(\n)8()4()11()-4()4()1()]TJ
-31.9916 -1.2983 Td
[()-9()11()6()1()19()-5()-2(\n)-4()]TJ
3.753 0 Td
[()-7()11(%)1()13(")-1()]TJ
2.8063 0 Td
[()11()]TJ
1.0148 0 Td
[()]TJ
2.5625 0 Td
[()1()]TJ
1.0261 0 Td
[(")-1()5()-5()]TJ
1.5534 0 Td
[()-11()13()-6()]TJ
1.7121 0 Td
[()-11(\n)2(")-6()-5()2()11()8()]TJ
3.702 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[()]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(\))]TJ
-16.934 -1.3039 Td
[()-6(2)-5(\n)2(")-1()5()-5()12(%)-5()-2(\n)8()]TJ
5.2667 0 Td
[($)8()2()2()2(")6()2()2()]TJ
3.1748 0 Td
[(\n)8()13()]TJ
1.44 0 Td
[(")-1()11()19()-9()1()-7()-6( )]TJ
4.2746 0 Td
[()11()]TJ
1.0091 0 Td
[(\n)]TJ
0.6633 0 Td
[($)1(\n)8()-4()2()1()-2()]TJ
2.9197 0 Td
[()11()]TJ
1.0091 0 Td
[()2()3(\n)-4()-5()]TJ
2.3358 0 Td
[($)8()2()2()2(")6()2()2()]TJ
3.1747 0 Td
[()1()4(")6()12(%)2( )1()1()8(+)]TJ
3.9912 0 Td
[()2(2)9()1()-7()11()4()2()]TJ
4.2859 0 Td
[()2()2(")13(!)]TJ
-34.7411 -1.2983 Td
[()-5(\n)8()-10()-5()2(")6()2()2()]TJ
3.7643 0 Td
[(\n)8()4( )]TJ
1.7122 0 Td
[(\n)18()-9()11()11()6()11()-5()2(")]TJ
3.9741 0 Td
[(&)-9()-9( )1()2()2()]TJ
2.9934 0 Td
[()41()-9()11()11()6()11()-5()2(")]TJ
4.2236 0 Td
[($)8()2()2()2(")6()2()2()]TJ
3.1634 0 Td
[(\n)8()13()]TJ
1.4287 0 Td
[()13()5()2()-5(\n)1()-7()-6( )]TJ
3.4015 0 Td
[(&)15()]TJ
1.1679 0 Td
[( )7()-3()1()8(+)]TJ
2.4548 0 Td
[(")-1()5()-5()3()]TJ
1.9105 0 Td
[(\n)8()4( )]TJ
1.7121 0 Td
[()2()2(")13()11()-5(\n)8()-10()-5()2(")6()2()2()]TJ
-31.9065 -1.2983 Td
[(\n)8()13()]TJ
1.4399 0 Td
[()13()5()2()-5(\n)1()-7()-6( )]TJ
3.4073 0 Td
[()11()-4()1()3(\n)8()-4()-5()7()]TJ
3.9571 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[()6()-2(\n)18()6()5()2()1()]TJ
3.7021 0 Td
[(&)11(%)12()]TJ
1.542 0 Td
[()2(2)9()1()-7()11()4()2()]TJ
4.0705 0 Td
[(")-3(\n)8()]TJ
1.6158 0 Td
[(&)-9()]TJ
1.1395 0 Td
[()13()5()2()-5(\n)1()-7()-6( )]TJ
3.4072 0 Td
[()-11()13()11()]TJ
2.194 0 Td
[(\n)]TJ
0.6576 0 Td
[(1)-3()2( )2()]TJ
2.0977 0 Td
[($)1(\n)8()-4()2()1()-2()]TJ
2.9196 0 Td
[()11()]TJ
-34.3386 -1.3039 Td
[(")-1()5()-5()]TJ
1.5533 0 Td
[()-2()-1()-9()2()]TJ
2.2847 0 Td
[()1()4(")6()12(%)2( )1()1()8(+)]TJ
3.9969 0 Td
[(345)]TJ
1.7404 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(\))]TJ
2.0863 0 Td
[()-6(2)9()1()-7()11()4()2()]TJ
4.2123 0 Td
[(\n)8()13()]TJ
1.44 0 Td
[()2()3(\n)-4()-5()]TJ
2.3357 0 Td
[(6\(6)]TJ
3.4752 0 Td
[()2()]TJ
1.5761 0 Td
[( )1()-2(\n)8()4()1()6()1()]TJ
4.0989 0 Td
[()1()12()11()2( )]TJ
2.0296 0 Td
[(&)11()-5()-2(\n)18()8()1()]TJ
2.914 0 Td
[($)8()2()2()2(")6()2()2()]TJ
-33.7434 -1.2982 Td
[()-4()3(\n)18()]TJ
1.7914 0 Td
[()-2()-1()11()2(")-3(\n)-4()-5()7()]TJ
3.5773 0 Td
[()2(2)11()13()2()5()]TJ
3.1408 0 Td
[(\n)]TJ
0.6576 0 Td
[()5(%)1()-4()-1(\n)2(")-1()]TJ
3.0331 0 Td
[()11()13()11()-11()-5()2()]TJ
2.8289 0 Td
[()2()1()2()-5()-2(\n)8()]TJ
2.9707 0 Td
[()6()]TJ
1.0262 0 Td
[()-4()3(\n)18()]TJ
1.7915 0 Td
[()11()]TJ
1.0148 0 Td
[()-4()4()]TJ
1.4683 0 Td
[(")-1()5()-5()3()]TJ
1.9219 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[(1)-7()2()2(")6()]TJ
2.6419 0 Td
[()-4()4()-9()]TJ
1.9275 0 Td
[(\n)8()13()]TJ
1.44 0 Td
[()13()5()2()-5(\n)1()-7()-6( )]TJ
-33.4202 -1.2983 Td
[(')]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(\))]TJ
2.0862 0 Td
[()]TJ
2.5625 0 Td
[()3(\n)1()]TJ
1.5591 0 Td
[(&)-9()-6()1()]TJ
2.0919 0 Td
[()11()13()-9($)-3()2()11(%)3()5()7()]TJ
4.3427 0 Td
[( )2()1()4()11()8()5()-5(\n)18()6()-6( )]TJ
5.7259 0 Td
[()11()]TJ
1.2586 0 Td
[()2(2)9()1()-7()11()4()2()]TJ
4.0705 0 Td
[()-11()13()11()]TJ
2.1884 0 Td
[()2()2(")13()1(+)-6()1()-2(\n)-4()]TJ
4.2349 0 Td
[(")-1()5()-5()3()]TJ
1.9219 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()3(\n)1()5()]TJ
-33.7604 -1.3039 Td
[(")-1()5()-5()3()]TJ
1.9162 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(\()]TJ
0.83 0.64 0.02 0 k
[(9)]TJ
0 g
[(\))]TJ
-0.72 -1.2983 Td
[(:)1()4()]TJ
1.7858 0 Td
[(+)7()-5(\n)-4()]TJ
1.8708 0 Td
[()11()]TJ
1.0092 0 Td
[()-4()2()3()]TJ
1.6781 0 Td
[()5()10(%)2( )7()]TJ
2.3924 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()6()]TJ
1.0204 0 Td
[()-7(%)1()-10()-4()4()1()]TJ
3.0161 0 Td
[(%)1()4( )2()1()7()5()-6(\n)8()4( )]TJ
4.7565 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()2(2)11()13()2()5()2()2()11()]TJ
4.4447 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()-7(%)1()4(")-6()-5()2()11()]TJ
3.6 0 Td
[()11()]TJ
1.0148 0 Td
[()]TJ
2.5625 0 Td
[()11()]TJ
-35.2344 -1.2982 Td
[()19(%)1()3(\n)8()]TJ
3.067 0 Td
[(,)-5()]TJ
1.5194 0 Td
[(345)]TJ
1.9615 0 Td
[(7)97()]TJ
1.6101 0 Td
[()2(2\n)8()2()1()4()-6( )]TJ
4.0989 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()1()-11()8()-6(")-6()]TJ
2.3584 0 Td
[()11()]TJ
1.0148 0 Td
[()-4()2()13()-6()]TJ
2.2507 0 Td
[()11()13(!)1()2()-17()-2(\n)8()2()3(\n)18()6()11()-29()]TJ
7.4324 0 Td
[(")-18()-1()6()6(*)-4()1()4()2()]TJ
3.9742 0 Td
[()1()1()-5(*)10()-6( )]TJ
2.7042 0 Td
[()6()]TJ
1.0205 0 Td
[(,)-5()]TJ
1.525 0 Td
[()11()]TJ
-36.0054 -1.2983 Td
[()]TJ
2.5625 0 Td
[()2(2)11()13()2()5()2()2()11()]TJ
4.4446 0 Td
[(&)15()]TJ
1.1793 0 Td
[(,)-5()]TJ
1.525 0 Td
[(345)]TJ
1.9615 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[( )2()1()6()1()-4()2()1()4()-6( )]TJ
4.7962 0 Td
[()4()15(1)]TJ
1.9332 0 Td
[()]TJ
2.5682 0 Td
[()3()]TJ
0.8447 0 Td
[()13()5()2()-5(\n)1()-7()-6( )]TJ
3.4073 0 Td
[()-11()13()11()]TJ
2.194 0 Td
[(345)]TJ
1.9615 0 Td
[(7)97()]TJ
1.6044 0 Td
[(\n)-4()3()-7()]TJ
1.7745 0 Td
[()2(2\n)8(!)]TJ
-34.4747 -1.3039 Td
[()1()4()-6( )]TJ
1.9615 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()-9()1()5()2()5(&)11()-5()1()12()-2()]TJ
4.269 0 Td
[()-4()3(\n)18()]TJ
1.7915 0 Td
[()]TJ
2.5682 0 Td
[()3()]TJ
0.8447 0 Td
[()11()13()2()-7()1()19()]TJ
3.1464 0 Td
[()11()]TJ
1.2643 0 Td
[()2(2)9()1()-7()11()4()2()]TJ
4.0705 0 Td
[()11()]TJ
1.0828 0 Td
[()11()-4()4()1()]TJ
2.3357 0 Td
[()2(2)-5(\n)2(")-1()5()-5()12(%)-5()-2(\n)8()]TJ
5.1194 0 Td
[($)8()2()2()2(")6()2()2()]TJ
3.1748 0 Td
[( )2()1()-4()7($)8()-6( )]TJ
-33.0971 -1.2983 Td
[()-11()13()11()]TJ
2.1883 0 Td
[(345)]TJ
1.7404 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[()11()-4()4()1()]TJ
2.3357 0 Td
[()19(%)1()3(\n)8()]TJ
3.0671 0 Td
[(")-1()5()-5()]TJ
1.5534 0 Td
[()-2()-1()-9()2()]TJ
2.5058 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[()4()-5(\n)1()5(%)1()13()-6( )]TJ
4.0762 0 Td
[()-7()6()12(%)5(&)6()2()]TJ
3.0217 0 Td
[($)8()1()7()5(%)3()]TJ
2.7156 0 Td
[($)8()2()2()2(")6()2()]TJ
2.8063 0 Td
[(&)-9()11(%)1()4( )]TJ
2.8063 0 Td
[()]TJ
2.5625 0 Td
[()1()]TJ
-34.8262 -1.2983 Td
[()-7()1(\n)]TJ
2.0239 0 Td
[()-1()-3()4()15($)-3()-2(\n)-4()]TJ
3.4922 0 Td
[()-17()12(%)1()2( )3()]TJ
2.6476 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[(345)]TJ
1.7405 0 Td
[(")-6(%)-5()12()10(%)1()13()]TJ
3.016 0 Td
[()5(%)12()-9()1()-4()3(\n)18()-6(\n)8()19()]TJ
5.5559 0 Td
[(.)17()]TJ
1.0998 0 Td
[(\n)2( )2( )1()12()-5()2()11()]TJ
3.566 0 Td
[(1)8()]TJ
1.3153 0 Td
[()1()23($)8()2()5()-5()1(+)2(\n)18()6()-6( )]TJ
4.9606 0 Td
[()-9()1()5()2()5(&)6()2()]TJ
3.4015 0 Td
[(\n)18(%)12()6(!)]TJ
-34.5427 -1.3039 Td
[(")-4()1()4()]TJ
2.2223 0 Td
[()1()-11()8()-6(")-6()]TJ
2.7212 0 Td
[()11()]TJ
1.0092 0 Td
[()]TJ
2.5681 0 Td
[()11()]TJ
1.2643 0 Td
[(,)-5()]TJ
1.5193 0 Td
[(345)]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 408.1889 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(Materials)Tj
4.5401 0 Td
(and)Tj
1.9985 0 Td
(Methods)Tj
/F0 1 Tf
-6.5386 -1.4976 Td
(Cell)Tj
1.9275 0 Td
(Culture)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 373.2094 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()-4()-5()]TJ
1.4059 0 Td
[()11()13()-9(")-1()-6( )12(%)1()13()2()]TJ
4.6318 0 Td
[()1()23($)8()6()7($)-3()1()8(+)]TJ
3.9515 0 Td
[()5()-9()-6(")1()4()1()8()]TJ
4.337 0 Td
[()5(&)11()-6(\n)8()1()4()-6( )]TJ
3.7077 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[()19(%)1()3(\n)8()]TJ
3.0671 0 Td
[()5(%)5(&)11(;)-5()-6(")-6()]TJ
3.3562 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-9()1()-4()8()11()-4()4()-6( )]TJ
4.4333 0 Td
[(%)1()4( )2()1()]TJ
2.5852 0 Td
[(\n)]TJ
-35.7616 -1.2982 Td
[()11()13()11()6()-9(")-1()6()]TJ
3.5773 0 Td
[(\n)18()11()11()13()15($)8()-6( )]TJ
3.9628 0 Td
[(&)15()]TJ
1.1792 0 Td
[()-4()4()]TJ
1.4683 0 Td
[(<)42()2()7($)8()1()7()2()12()-2()]TJ
4.3823 0 Td
[()11()]TJ
1.0148 0 Td
[()5()2(")6()2()1(+)2(\n)8()]TJ
4.0139 0 Td
[(.)17()8()5()-5()12()10(%)12()-5()2()11()3(\n)-4()]TJ
5.142 0 Td
[(,)-3()-9($)-3()2()-9(1)]TJ
3.067 0 Td
[(=)-19()-5(\n)8()13( )6()]TJ
2.846 0 Td
[(345)]TJ
1.7405 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(")-6(%)-5(!)]TJ
-34.4917 -1.3039 Td
[()10(%)1()13()-6( )]TJ
2.347 0 Td
[()-11()13()11()]TJ
2.1884 0 Td
[()19(%)1()3(\n)8()]TJ
3.067 0 Td
[()-1()-3()4()15($)-3()-2(\n)-4()]TJ
3.4923 0 Td
[()-5()3()5()5(%)2()]TJ
2.4548 0 Td
[()5(&)11()-6(\n)8()1()4()-6( )]TJ
3.702 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(\n)8()-10()-4()2()13()11()6()-2(\n)1()5()-2()]TJ
5.057 0 Td
[()11()]TJ
1.0885 0 Td
[()-1()-3()4()15($)8()-6(")-6()6()11()23()]TJ
5.4538 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[(,)-5()]TJ
1.5251 0 Td
[(;)-5()11()1()19()]TJ
2.4377 0 Td
[(&)15()]TJ
-35.96 -1.2983 Td
[( )1()1(+)7()2()5()-5()2()11()]TJ
3.8494 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(>)]TJ
1.4513 0 Td
[(")-1()6()-5()-2(\n)6(+)7()1()3(\n)1()-7()]TJ
4.7112 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[()-7()1()-5(\n)8(\n)18()-5()2()11()]TJ
4.371 0 Td
[()-4()2()13()11(%)1(+)-6()]TJ
3.4299 0 Td
[(\n)]TJ
0.6576 0 Td
[(96?)]TJ
2.5796 0 Td
[(")-1()5()-5()]TJ
1.5533 0 Td
[()5()-5(\n)8()1()4()1()]TJ
3.2712 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[(-)]TJ
0 g
[(\))]TJ
2.0863 0 Td
[(345)]TJ
1.7461 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(%)1()2(!)]TJ
-35.5178 -1.2983 Td
[()8()11()-4()-5()7()]TJ
2.8969 0 Td
[()-9()1()2()12()-5()7($)8()]TJ
3.3052 0 Td
[()8()11()]TJ
1.3776 0 Td
[()-4()4()]TJ
1.4741 0 Td
[(345)]TJ
1.7404 0 Td
[()3(\n)8()5(*)10()1()]TJ
3.1068 0 Td
[()-10(\n)2( )-5()4()1()-4()1(!)]TJ
5.4878 0 Td
[(:)1()4()]TJ
1.7858 0 Td
[( )1()-2(\n)6(+)-5()4()1()2()3()]TJ
3.9288 0 Td
[()11()]TJ
1.0148 0 Td
[(,)-5()]TJ
1.5194 0 Td
[()13()-6(@)10(%)1()1()13()-6( )]TJ
3.5999 0 Td
[(\n)18()]TJ
0.9638 0 Td
[()2()-5(\n)1()5()]TJ
1.9899 0 Td
[()8()11(%)1()]TJ
1.8992 0 Td
[()11()]TJ
-36.0904 -1.3039 Td
[()-4()4()]TJ
1.4683 0 Td
[()-7()-9($)8()1()]TJ
2.4208 0 Td
[(0-9)]TJ
2.1373 0 Td
[()3()4()1()-4()2(")-3(\n)8()]TJ
4.1612 0 Td
[()-16()6()-5()2()-1(+)7()]TJ
3.1748 0 Td
[()11()]TJ
1.0091 0 Td
[(,)-13()4()1(%)1()3(\n)18()6()6()2()1(+)-23()]TJ
6.0264 0 Td
[(")-4()12()6()1()-4()-2(\n)]TJ
3.0501 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[(0)]TJ
0 g
[(\))]TJ
2.0863 0 Td
[(345)]TJ
1.7404 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[()3(\n)8()1()19()-6(\n)8()1()4()-6( )]TJ
4.7565 0 Td
[()1()]TJ
1.0204 0 Td
[()-16()11(!)]TJ
-35.1493 -1.2982 Td
[()3(\n)18(%)1(+)-6()19()]TJ
3.0103 0 Td
[()26()-6( )1()2(")-3(\n)-4()]TJ
3.4129 0 Td
[(,)-3()2()-7()-5(\n)8()13(")6()]TJ
3.7871 0 Td
[(4)-15(\n)9(&)-9()11(\n)18()6()11()-29()]TJ
4.6204 0 Td
[(,4)]TJ
3.5943 0 Td
[()4()-6( )1()12(%)1()]TJ
3.5717 0 Td
[(6>)]TJ
2.2733 0 Td
[()8()1()-6(\n)-4()]TJ
1.9162 0 Td
[(&)-9()15($)-3()1()4()]TJ
2.9027 0 Td
[()-7()1()-10(%)1()]TJ
2.6986 0 Td
[('3=5\))]TJ
2.7042 0 Td
[()]TJ
-34.4917 -1.2983 Td
[(4)11(!+)-6()12(%)12()-6(\n)8()2()1()4()6()]TJ
5.3291 0 Td
[(>)]TJ
1.4513 0 Td
[()-9()1()2()2(")-5()-5()1()1(\r)5()-5()13()1()11()6()11()23()8(")1()]TJ
9.8702 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(%)3()-7()-6( )]TJ
2.0466 0 Td
[(&)-9()1()-2(1)8()-6()1()]TJ
3.4923 0 Td
[()-5(\n)1()5()-6(\n)6(+)7()2()]TJ
3.5886 0 Td
[()]TJ
0.6974 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[(6)]TJ
1.3946 0 Td
[(:)99()]TJ
1.338 0 Td
[(\n)18($)8()11()2( )]TJ
-34.7525 -1.3039 Td
[()-4()4()]TJ
1.4683 0 Td
[(")-1()11()2()8()11(%)1()4( )1()1()8(+)]TJ
5.3177 0 Td
[()1()-11()8()-6(")-6()]TJ
2.3585 0 Td
[()11()]TJ
1.0148 0 Td
[()-7()1()-10(%)1()]TJ
2.6985 0 Td
[()]TJ
2.7893 0 Td
[(")-6(%)-5()12()10(%)1()13()2()]TJ
3.3789 0 Td
[(1)8()1()13()]TJ
2.0919 0 Td
[()4()15($)8()-6( )]TJ
2.931 0 Td
[()6()]TJ
1.0262 0 Td
[()-7()1()-10(%)1()]TJ
2.6985 0 Td
[()-11()13()-6()]TJ
1.7121 0 Td
[()4()-6( )1()-2(\n)]TJ
2.6703 0 Td
[()-4(%)-5()5(&)-9()-6(")-1(")-1(A)]TJ
-32.156 -1.2983 Td
[()26()-9( )1()1()-11()2()-6( )]TJ
3.8777 0 Td
[()-12(\n)6(+)-6()2(A)]TJ
2.88 0 Td
[()4()-6( )1()12(%)1(\r3)20(!)]TJ
5.726 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(B)31()1()11()13()1(+)-5()13()15(1)]TJ
4.5921 0 Td
[()-7()1()-10(%)1()]TJ
2.6985 0 Td
[()13()1()6()-2(\n)2(")-1()1()4()1()19()]TJ
5.1194 0 Td
[(B)31()1()11()13()11()6()-6(")6()]TJ
4.8188 0 Td
[(,)-3()-9(")6(*)5()]TJ
2.7043 0 Td
[(C)17()-5()-5()6()]TJ
-34.4067 -1.2983 Td
[(D)]TJ
1.627 0 Td
[(&)-9()1()8()11()13()]TJ
2.7099 0 Td
[()3(\n)8()-29($)8()2()5()-5()1()8(+)-3()]TJ
4.5808 0 Td
[(5)-15()11()4()]TJ
2.4208 0 Td
[(")-6(%)-5()12()10(%)1()13()2()]TJ
3.3788 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[()-5()13()-5(\n)18()6()-6( )]TJ
2.982 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[()11()13()11()6()-5(\n)1()-7()]TJ
3.549 0 Td
[()1()-5()2()5(&)11()12()6()11()7()]TJ
4.1045 0 Td
[()8()11()]TJ
1.3776 0 Td
[(-)]TJ
1.1792 0 Td
[()4()11(%)1()7()]TJ
2.5058 0 Td
[()1()]TJ
-34.503 -1.3039 Td
[()-7()1()-10(%)1()]TJ
2.6985 0 Td
[()-11()13()-6()]TJ
1.7121 0 Td
[()4()-6( )1()12(%)1(E)]TJ
3.7871 0 Td
[()-9()1()1()5()-6(\n)18()-5()1()]TJ
3.8891 0 Td
[()]TJ
0.9071 0 Td
[(5)6()1(+)-5()3(\n!)-4()2( )1()-4()2(")6()]TJ
6.6103 0 Td
[(5)14()-1()]TJ
1.2133 0 Td
[(4)-9()11(%)1()3()]TJ
2.6192 0 Td
[()9(/)]TJ
2.4094 0 Td
[(\n)18()11()13()11()-5()1()2()1()]TJ
3.9515 0 Td
[(5)6()1(+)-5()3(\n!)-4()2( )1()-4()2(")6()]TJ
-29.7976 -1.2982 Td
[(5)14()-1()]TJ
1.2075 0 Td
[(4)-9()11(%)1()3()]TJ
2.6192 0 Td
[()9(/)]TJ
2.4094 0 Td
[()2()1(%)12()-9()1()11()-5()1()]TJ
3.9742 0 Td
[(5)6()1(+)-5()3(\n!)-4()2( )1()-4()2(")6()]TJ
6.6103 0 Td
[(5)14()-1()]TJ
1.2133 0 Td
[(4)-9()11(%)1()3()]TJ
2.6191 0 Td
[()9(/)]TJ
2.4095 0 Td
[(FG66)]TJ
3.7304 0 Td
[(.)17(5)-15()6()12(%)12()-5()2()11()]TJ
4.4446 0 Td
[()]TJ
2.744 0 Td
[()5()-5()-5()1(!)]TJ
-33.9815 -1.2983 Td
[()-9()11()13()6()]TJ
2.2393 0 Td
[()-6(\n)8()-4()8()5()-6(\n)2( )12()-1()]TJ
4.7168 0 Td
[(F)-7()1()-4()3(\n)8()23()]TJ
4.5241 0 Td
[()11()]TJ
1.0885 0 Td
[(!G)]TJ
2.0976 0 Td
[()-2(:)1()4()1()-4()4()]TJ
3.8041 0 Td
[(5)-15(")2()1()19()-5()1()-11()2(")-1()]TJ
4.0762 0 Td
[(7)101(\n)-4()12()-4()3(\n)8()]TJ
4.1839 0 Td
[()]TJ
2.3584 0 Td
[(/)-4()-4()4()1()]TJ
2.5738 0 Td
[(")-6(%)-5()12()10(%)1()13()2()]TJ
3.3789 0 Td
[(1)8()1()13()]TJ
-35.0416 -1.2983 Td
[()-5()13()-5(\n)18()6()-6( )]TJ
2.982 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(")-18()-1()6()6(*)-4()1()4()2(E)]TJ
4.1952 0 Td
[()13()-6(")-1()11()10(&)11()1()3(\n)8()19()]TJ
5.3178 0 Td
[()19(%)1()3(\n)8()]TJ
3.0671 0 Td
[()1()19()6()1()-4()8()1()13()11(!)]TJ
/F10 1 Tf
(\r)Tj
/F6 1 Tf
5.0343 0 Td
[()5(.3)]TJ
/F10 1 Tf
(\r)Tj
/F6 1 Tf
[()]TJ
3.736 0 Td
[(<\r)-5()]TJ
3.3789 0 Td
[()13()-6(")-1()11()10(&)11()1()3(\n)8()19()]TJ
-29.7012 -1.3039 Td
[()19(%)1()3(\n)8()]TJ
3.067 0 Td
[()10(%)1()4()11()]TJ
2.7213 0 Td
[()4()-6(")13()1()2()3()]TJ
3.4525 0 Td
[()-1(\n)2(")-6()6()11()23(!)]TJ
/F10 1 Tf
()Tj
/F6 1 Tf
3.464 0 Td
[()5()75(:3)]TJ
/F10 1 Tf
()Tj
/F6 1 Tf
[(6)8(+\r)-5()]TJ
8.039 0 Td
[()11()]TJ
1.0828 0 Td
[()13()-6(")-1()11()10(&)11()1()3(\n)8()19()]TJ
5.3177 0 Td
[()19(%)1()3(\n)8()]TJ
3.0671 0 Td
[()1()19()6()1()5()2()1(%)-5(*)-4()1(!9)]TJ
-30.2114 -1.2982 Td
[()5(.4)11(!96)8(+\r)-5()]TJ
7.5457 0 Td
[(B)31()1()11()13()11()6()-6(")6()]TJ
4.8189 0 Td
[(,)-3()-9(")6(*)5()]TJ
2.7042 0 Td
[(C)17()-5()-5()6()]TJ
1.9616 0 Td
[(D)]TJ
1.6271 0 Td
[()8()11()]TJ
1.3776 0 Td
[(6)]TJ
0.9184 0 Td
[(6H)]TJ
1.6158 0 Td
[()]TJ
0.9184 0 Td
[()]TJ
0.9184 0 Td
[(G)]TJ
0.9184 0 Td
[(-)]TJ
0.9184 0 Td
[()]TJ
1.4003 0 Td
[()]TJ
1.3947 0 Td
[(-)]TJ
1.4003 0 Td
[()11()]TJ
1.0885 0 Td
[(9)]TJ
1.1792 0 Td
[()4()11(%)1()7()]TJ
2.5001 0 Td
[()1()]TJ
-35.206 -1.2983 Td
[()-7()1()-10(%)1()]TJ
2.6985 0 Td
[()-11()13()-6()]TJ
1.7121 0 Td
[()4()-6( )1()12(%)1()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Sample)Tj
3.5905 0 Td
(Preparation)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(5)16()-3()4()15($)-3()-2(\n)-4()]TJ
3.5943 0 Td
[()-17()12(%)1()2( )]TJ
2.0692 0 Td
[()-6(\n)8()19()6()2()2()]TJ
3.3903 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-5()13()-5(\n)18()6()-6( )]TJ
2.982 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(66H>)]TJ
2.6305 0 Td
[(C)33()1(\n)-4()12(%)1()13()11()2()2( )-2(\n)1()-7()]TJ
6.0605 0 Td
[(&)-9()15($)-3()1()4()]TJ
3.2428 0 Td
[()6()2()5()-5()3()]TJ
2.4491 0 Td
[(5)6()1(+)-5()3(\n!)-4()2( )1()-4()2(")6()]TJ
-30.5062 -1.3039 Td
[(5)14()-1()]TJ
1.2075 0 Td
[(4)-9()11(%)1()3()]TJ
2.6192 0 Td
[()9(/)]TJ
2.1883 0 Td
[()11()4()]TJ
1.6838 0 Td
[( )1()13()11()]TJ
2.126 0 Td
[()-9()1()]TJ
1.525 0 Td
[()]TJ
0.6973 0 Td
[(4)]TJ
1.5647 0 Td
[()-17()12(%)1()2( )]TJ
2.0693 0 Td
[()8()11()]TJ
1.3776 0 Td
[(H)]TJ
0.6974 0 Td
[()2()1()]TJ
2.0522 0 Td
[()-16()5()-5()3()]TJ
2.16 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()7()1()-7()-6( )]TJ
2.2337 0 Td
[()1()]TJ
1.0205 0 Td
[(")-1()5()-5()]TJ
1.559 0 Td
[()7()1()2()3()]TJ
1.9162 0 Td
[(&)11(%)1()-11()8()1()]TJ
2.6079 0 Td
[(6>)]TJ
2.2734 0 Td
[(B)49(!)]TJ
-35.6766 -1.2982 Td
[(6)]TJ
1.3946 0 Td
[(6>)]TJ
1.9332 0 Td
[(B5)11(3)110()]TJ
2.88 0 Td
[(>)]TJ
1.4456 0 Td
[(.)25()-9( )2()-5(\n)2(")-1()1()-5()1()2()1()2()2( )2()6()]TJ
6.9449 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[(6>)]TJ
2.1487 0 Td
[(!G)]TJ
2.0976 0 Td
[()1()]TJ
1.0205 0 Td
[(:)-10(5)]TJ
2.3414 0 Td
[()8()11()]TJ
1.3776 0 Td
[()11()4()]TJ
1.6781 0 Td
[()4()11(%)1()]TJ
2.1373 0 Td
[()11()]TJ
1.2643 0 Td
[()2(")-1()]TJ
1.3152 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()5()11(%)1()]TJ
2.1713 0 Td
[()6()]TJ
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 528.7748 745.7952 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(CD13)Tj
2.7567 0 Td
(on)Tj
1.3181 0 Td
(FLS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(PLOS)Tj
2.8771 0 Td
(ONE)Tj
2.3812 0 Td
(|)Tj
0.4819 0 Td
(DOI:10.1)Tj
3.9827 0 Td
(371/journ)Tj
4.1315 0 Td
(al.pone.0162)Tj
5.7331 0 Td
(008)Tj
2.6504 0 Td
(September)Tj
5.0812 0 Td
(22,)Tj
1.6016 0 Td
(2016)Tj
36.2057 0 Td
(2)Tj
0.7725 0 Td
(/)Tj
0.5031 0 Td
(20)Tj
/F8 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4362 0 Td
(of)Tj
-17.8229 -1.3748 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F7 1 Tf
-1.3677 -2.126 Td
(Competing)Tj
4.3795 0 Td
(Interests)Tj
3.3307 0 Td
(:)Tj
/F8 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
28 0 obj
<>stream
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
BT
10.3394 79.2147 Td
(exist.)Tj
ET
Q
endstream
endobj
40 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 41 0 R/Contents 42 0 R/TrimBox[0 0 612 792]>>
endobj
41 0 obj
[43 0 R 44 0 R 45 0 R]
endobj
43 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref020)>>
endobj
44 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref010)>>
endobj
45 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref021)>>
endobj
42 0 obj
[46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
endobj
46 0 obj
<>stream
q
0.83 0.64 0.02 0 k
411.4205 628.2142 m
421.0016 628.2142 l
h
f*
399.515 329.0457 m
409.0961 329.0457 l
h
f*
510.5197 316.063 m
520.1008 316.063 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()13()1()4()15($)8()]TJ
3.1917 0 Td
[( )2()3(&)11()-4()3()]TJ
2.8687 0 Td
[(345)]TJ
1.7404 0 Td
[(")-6(%)-5()12()10(%)1()13()]TJ
3.0161 0 Td
[()5(%)12()-9()1()-4()3(\n)18()-6(\n)8()19()]TJ
5.3404 0 Td
[(1)8()1()13()]TJ
2.092 0 Td
[(")-1()11()4(")-1()1()19()-5(\n)18()6()-6( )]TJ
5.4028 0 Td
[(&)15()]TJ
1.1792 0 Td
[(")-1()1()19()-5()-4()1()-7(%)1(+)2(\n)18()-5()2()11()]TJ
5.8393 0 Td
[()-4()2()13()11(%)1(+)-6()]TJ
3.4356 0 Td
[(\n)8()]TJ
1.1962 0 Td
[()3()2(!)]TJ
-35.3024 -1.3039 Td
[(")-1()11()]TJ
1.678 0 Td
[(<)6()12()-5(\n)2(")-1()5()]TJ
3.3903 0 Td
[(6I)]TJ
1.8481 0 Td
[()-11()-5()12()6()1()]TJ
2.1033 0 Td
[()]TJ
2.744 0 Td
[()5()-5()-5()1()12()-9()11()13()6()]TJ
4.1499 0 Td
[()-6(\n)8()-4()8()5()-6(\n)2( )12()-1()]TJ
4.7168 0 Td
[(F)-7()1()-4()3(\n)8()23()]TJ
4.524 0 Td
[(B)6()-2(\n)1()2()3(\n)]TJ
3.0898 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()3()-7()6()-2(\n)18()6()-6( )]TJ
3.2711 0 Td
[()-11()13()11()]TJ
-33.2161 -1.2982 Td
[(1)-7()4()6()2()]TJ
2.5965 0 Td
[(&)6()2()-9()-9( )]TJ
2.4944 0 Td
[(%)3()2()1()8(+)]TJ
2.3641 0 Td
[()4()1()-5(\n)8()-4()1()]TJ
3.2995 0 Td
[($)1(\n)2(")-6(%)12()-6(\n)8()1()4()1()]TJ
4.3767 0 Td
[()10(%)5(&)-9()2()]TJ
2.3301 0 Td
[(=)4()]TJ
1.8765 0 Td
[(&)11()2()1()-7(")2()1()4(")-1()2()]TJ
4.8982 0 Td
[(5)-3(\n)8()]TJ
1.6724 0 Td
[(D)20()1()-7()6()]TJ
2.041 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 646.2425 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Exosome)Tj
4.3701 0 Td
(Isolation)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 629.2913 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()-6(2)9()1()-7()11()4()2()]TJ
4.2122 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()3()-7()6()-2(\n)18()6()-6( )]TJ
3.2712 0 Td
[(&)15()]TJ
1.1792 0 Td
[()-7()1()-4()-2(\n)-4()]TJ
2.3187 0 Td
[(%)-5()12()-5(\n)2(")-1()1()19()-5()-4()1()-7(%)1(+)2(\n)18()-5()2()11()]TJ
7.7159 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[(6)]TJ
0 g
[(\))]TJ
2.0863 0 Td
[()-6(2)9()1()-7()11()4()2()]TJ
4.2122 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()3()-7()6()-2(\n)18()6()-6( )]TJ
3.2769 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[()1()12()-4()4()1()]TJ
-34.6561 -1.3039 Td
[()-4()4()]TJ
1.4683 0 Td
[()5(%)12()-9()1()-4()3(\n)18()-6(\n)8()19()]TJ
5.3404 0 Td
[()11()]TJ
1.0148 0 Td
[()]TJ
0.6973 0 Td
[()-17()-2(\n)1()5(*)]TJ
2.4208 0 Td
[()11()]TJ
1.0148 0 Td
[(")-1()11()2()-17()12(%)2()1()19()]TJ
4.0025 0 Td
[(,)-5()]TJ
1.525 0 Td
[(345)]TJ
1.9616 0 Td
[(6)-5()3()]TJ
2.6079 0 Td
[()11()]TJ
1.0091 0 Td
[()6()-2(\n)1()2()3(\n)]TJ
3.2655 0 Td
[()11()]TJ
1.0828 0 Td
[()]TJ
0.703 0 Td
[()-5()]TJ
1.2812 0 Td
[()11()]TJ
1.0148 0 Td
[(,)-5()]TJ
1.5194 0 Td
[()-1()-3()4()15($)-3()-2(\n)-4()]TJ
3.4979 0 Td
[()-17()12(%)1()2( )]TJ
-35.4271 -1.2982 Td
[( )1()-5()12(%)12()6()-6( )]TJ
3.0103 0 Td
[(E)]TJ
1.4003 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[(B)5(=5)]TJ
2.0523 0 Td
[()-16()5()-5()3()]TJ
2.16 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-9()5()-5()2()1()6()-6( )]TJ
3.3165 0 Td
[()11(%)12()]TJ
1.542 0 Td
[(\n)18()]TJ
0.9638 0 Td
[(H66)-10()11()]TJ
3.8381 0 Td
[()8()11()]TJ
1.372 0 Td
[(H)]TJ
0.7029 0 Td
[()2()1()19(%)12()6()2()]TJ
3.6624 0 Td
[(:)1()4()1()]TJ
2.3244 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()5(%)12()-9()1()-4()3(\n)18()-6(\n)8()19()]TJ
-31.9065 -1.2983 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(")6()2()-5(\n)8()13()-6( )]TJ
3.0444 0 Td
[()11()]TJ
1.0091 0 Td
[()4()-5(\n)18($)-3()2()1()]TJ
3.1124 0 Td
[( )2()3(&)11()-4()3()]TJ
2.6476 0 Td
[(&)15()]TJ
1.1792 0 Td
[(")-1()1()19()-5()-4()1()-7(%)1(+)2(\n)18()-5()2()11()]TJ
5.8393 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(66662+)]TJ
3.7701 0 Td
[()8()11()]TJ
1.3776 0 Td
[(6)]TJ
1.1792 0 Td
[()2()1()19(%)12()6()2()]TJ
3.4412 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[(66662+)]TJ
3.7644 0 Td
[()8()11()]TJ
1.3776 0 Td
[()]TJ
-36.5156 -1.3039 Td
[()4()11(%)1()64()]TJ
2.3584 0 Td
[()-6(2)9()1()-7()11()4()2()]TJ
4.2122 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-4()4()1()]TJ
2.0126 0 Td
[()5(&)11()-6(\n)8()1()4()-6( )]TJ
3.7021 0 Td
[(&)15()]TJ
1.1792 0 Td
[(%)-5()12()-5(\n!")-1()1()19()-5()-4()1()-7(%)1(+)2(\n)18()-5()2()11()]TJ
8.073 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(66662+)]TJ
4.2463 0 Td
[()8()11()]TJ
1.3776 0 Td
[(!6)4()11(%)1()7()]TJ
4.5127 0 Td
[()-6(2)9(!)]TJ
-34.7298 -1.2983 Td
[()-7()11()4()]TJ
2.313 0 Td
[()-9()5()-5()2()1()]TJ
2.7439 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[(1)1(\n)1()5()4()-6( )]TJ
3.1691 0 Td
[()1()]TJ
1.0261 0 Td
[(B)5(=5)]TJ
1.8368 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(66662+)]TJ
4.2463 0 Td
[()8()11()]TJ
1.3776 0 Td
[(H)]TJ
1.3947 0 Td
[()4()11(%)1()7(\()15($)8()1()-4()2()1(+)-6()19()]TJ
6.8541 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()13()2()5(%)3()5()-9()1()4( )2()-6( )]TJ
5.193 0 Td
[()1()]TJ
1.0262 0 Td
[()-5()]TJ
-35.9544 -1.2982 Td
[()11()]TJ
1.0091 0 Td
[(B)5(=5)]TJ
2.0579 0 Td
[(5)-15()11()4()]TJ
2.4208 0 Td
[()2(2)9()1()-7()11()4()2()]TJ
4.0648 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[()-7(%)1()-10()-4()4()1()]TJ
3.016 0 Td
[()11(%)1()-4()1()-11()2()-6( )]TJ
3.3789 0 Td
[(%)3()2()1()8(+)]TJ
2.3641 0 Td
[(\n)]TJ
0.6576 0 Td
[( )2()1()8()2()12()-2()]TJ
3.0897 0 Td
[(+)-5(\n)2( )1()2()1()19()-1()]TJ
3.7418 0 Td
[(/)-4()11()-5()12()11()13()1()]TJ
3.8721 0 Td
[(5)6()1(+)-5()3(\n)]TJ
-31.7705 -1.304 Td
[()-4()2( )1()-4()2(")6()]TJ
3.4695 0 Td
[(5)14()-1()]TJ
1.2133 0 Td
[(4)-9()11(%)1()3()]TJ
2.6192 0 Td
[()9(/)]TJ
2.4094 0 Td
[(/)-4()11()-5()12()11()13()1()]TJ
3.8664 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[( )1()-5()12(%)12()6()-6( )]TJ
3.016 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(B)5(=5)]TJ
1.8369 0 Td
[()6()]TJ
1.0261 0 Td
[()11()13()-9( )12(%)2(")-1()]TJ
3.4809 0 Td
[()-4()4()]TJ
1.4741 0 Td
[()8()6()-5()2()15(1)-3()1()8(+)]TJ
3.9514 0 Td
[()-2(\n)18()8()1()7(E)]TJ
2.7326 0 Td
[(H>)]TJ
-34.7865 -1.2982 Td
[(6>)]TJ
2.1486 0 Td
[(H>)]TJ
2.1486 0 Td
[(6>)]TJ
2.1487 0 Td
[(6>)]TJ
2.1486 0 Td
[(6>)]TJ
2.1487 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[(H6>)]TJ
1.9276 0 Td
[(1\r$)]TJ
1.6781 0 Td
[( )2()1()8()2()12()-5()2()2()]TJ
4.0195 0 Td
[()11()]TJ
1.0091 0 Td
[(6)]TJ
2.5795 0 Td
[(6H6)]TJ
2.5739 0 Td
[(6-)]TJ
2.5738 0 Td
[(6)]TJ
2.5795 0 Td
[(G)]TJ
2.5739 0 Td
[(H)]TJ
-33.9815 -1.2983 Td
[(\n)8()4( )]TJ
1.7177 0 Td
[(G-)]TJ
2.3584 0 Td
[(+\r)-5()]TJ
2.6306 0 Td
[(H66?)]TJ
2.4208 0 Td
[()11()]TJ
1.0091 0 Td
[()2(2)-5(\n)]TJ
2.211 0 Td
[(")-1()5()-5()12(%)-5()-2(\n)8()]TJ
3.1294 0 Td
[($)8()2()2()2(")6()2()]TJ
2.8063 0 Td
[()-11(\n)2(")-6()-5()2()11()8()]TJ
3.702 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-17()2()-5(\n)18()6()-6( )]TJ
2.9424 0 Td
[()11()]TJ
1.2642 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()6()11()]TJ
1.5477 0 Td
[()11()]TJ
1.0091 0 Td
[()-4()4()]TJ
1.474 0 Td
[( )2()1()8()2()12()-2()]TJ
-33.7887 -1.2983 Td
[(+)-5(\n)2( )1()2()1()19()]TJ
3.5262 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()-4()4()]TJ
1.474 0 Td
[(+)-5(\n)2( )1()2()1()19()]TJ
3.8891 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[(")-1()1()19()-5()-4()1()-7(%)1(+)7()-6( )]TJ
4.7338 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(666662+)]TJ
4.2463 0 Td
[()8()11()]TJ
1.3776 0 Td
[()4()11(%)1()64()]TJ
2.8346 0 Td
[(3)17(\n)2(")-6()-5()2()11()8()]TJ
3.9345 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(")-3(\n)8()13()1()-7(%)-5()-5()7()]TJ
-32.8873 -1.3039 Td
[()11()12()-9()1()10()6()-6( )]TJ
3.4809 0 Td
[()11()-11()5()]TJ
1.525 0 Td
[(1)1(\n)1()5()4()-6( )]TJ
3.1691 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[(B)5(=5)]TJ
2.0523 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[(")-1()1()19()-5()-4()1()-7(%)1(+)7()-6( )]TJ
4.7338 0 Td
[(\n)18()]TJ
0.9582 0 Td
[(66662+)]TJ
4.2462 0 Td
[()8()11()]TJ
1.3777 0 Td
[()]TJ
0.6973 0 Td
[()4()11(%)1()7()]TJ
2.7269 0 Td
[(B)31()5()-5()2()1()]TJ
2.7836 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[()-4()4()]TJ
1.474 0 Td
[()-11(\n)2("!)]TJ
-35.1323 -1.2982 Td
[()-5()2()11()8()]TJ
2.1883 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()13()2()5(%)3()5()-9()1()4( )2()-6( )]TJ
5.193 0 Td
[()1()]TJ
1.0262 0 Td
[(H66?)]TJ
2.4151 0 Td
[(B)5(=5)]TJ
2.0579 0 Td
[()-6(2)9()1()-7()11()4()]TJ
3.8494 0 Td
[()2(#)-2()]TJ
1.6781 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()4()-5(\n)1()5(%)1()13()-6( )]TJ
4.0762 0 Td
[(&)15()]TJ
1.1792 0 Td
[(%)3()-7()]TJ
1.5251 0 Td
[()11()]TJ
1.0091 0 Td
[(\n)]TJ
0.6633 0 Td
[()25(\n)8()4(5)6()1(+)-6()19()]TJ
-30.6593 -1.2983 Td
[(5H66)]TJ
2.8686 0 Td
[()16(\n)-4()7($)8()1()-4()]TJ
3.9174 0 Td
[(.)17()8()5()-5()-10(%)1()4()1()19()]TJ
5.3121 0 Td
[(5)-3(\n)-4()1()3(&)11(%)1()-29()74()]TJ
4.0649 0 Td
[(<)42()2()12()6()-6( )]TJ
2.9934 0 Td
[(I)7()1()8(+)7( )2()11()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 425.1401 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(CD13)Tj
2.759 0 Td
(Enzyme-Linked)Tj
7.0772 0 Td
(Immunosorbent)Tj
7.1434 0 Td
(Assay)Tj
2.9339 0 Td
(\(ELISA\))Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 408.1322 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(C)17()1(+)-6()]TJ
2.2336 0 Td
[(&)11()1()4( )1()1()8(+)]TJ
3.3052 0 Td
[(4.5)]TJ
2.8063 0 Td
[()6()-2(\n)18()6()2()]TJ
2.5115 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(")-1()-5(\n)18()6()-6( )]TJ
2.8176 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[()-4()4()]TJ
1.474 0 Td
[(\n)8()19()-5(!)]TJ
4.4617 0 Td
[()4()11()4()-9(")6()2()11()3(\n)-4()]TJ
4.972 0 Td
[(\n)8()19()-5()5(&)-9()-9( )7()]TJ
3.7474 0 Td
[(7H)]TJ
3.033 0 Td
[(=)8()2(!)]TJ
-35.4498 -1.2982 Td
[()2()-1(+)7()1()4( )6()]TJ
3.0443 0 Td
[(5)-3(\n)8()]TJ
1.6668 0 Td
[()1()2()-1(+)7()30()]TJ
2.8063 0 Td
[()]TJ
1.9105 0 Td
[()1()]TJ
1.0205 0 Td
[(6)]TJ
2.2847 0 Td
[(")-3(\n)8()-1(&)-9()11()3(\n)18()6()]TJ
4.1442 0 Td
[(&)11(%)1()-11()8()1()]TJ
2.6079 0 Td
[(C)]TJ
1.5023 0 Td
[(0H)]TJ
1.3947 0 Td
[()15($)8()1()-4()2()1(+)-6()19()-1()]TJ
4.2803 0 Td
[(\n)8()4( )]TJ
1.7177 0 Td
[()-4()4()1()]TJ
2.0126 0 Td
[(&)6()2()-9(")6(*)10()-6( )]TJ
3.3165 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[(2)]TJ
-35.7049 -1.3039 Td
[()3()2()1()3(\n)-4()]TJ
3.2087 0 Td
[(3)17()13()-6()]TJ
1.9446 0 Td
[(=)6()2()-9(")6(*)]TJ
2.4605 0 Td
[()-2(J)97()-6(")-6()6()11()]TJ
3.2655 0 Td
[(4)-15(\n)9(&)-9()11(\n)18()6()11()-4()2()2()]TJ
5.4198 0 Td
[(=)7(%)1()5()1()1()8(+)2(\n)8()4()6()]TJ
5.091 0 Td
[()]TJ
1.9105 0 Td
[()15($)8()1()-4()2()1(+)-6()19()-1()]TJ
4.2746 0 Td
[(5)-3(\n)8()19()6()2()2()]TJ
3.4923 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-4()4()1()]TJ
-33.1651 -1.2983 Td
[(\n)18()11()6()1()2()-6( )]TJ
3.1464 0 Td
[()6()]TJ
1.0261 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()6()-2(\n)18()6()2()]TJ
2.5171 0 Td
[()1()12()-4()4()1()]TJ
2.5115 0 Td
[(1)-7()4()6()2()]TJ
2.5965 0 Td
[()11()]TJ
1.0885 0 Td
[( )1()-5()12(%)12()6()-6( )]TJ
3.0104 0 Td
[()1()]TJ
1.0261 0 Td
[(&)6()2()-9(")6(*)]TJ
2.3754 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[(6)]TJ
2.88 0 Td
[()6(:)73()]TJ
3.033 0 Td
[(:)1()4()]TJ
1.7859 0 Td
[()5()-6(\n)8()4( )-2(\n)8()13( )]TJ
3.7133 0 Td
[(")-6(%)1()-29($)8()]TJ
-34.1742 -1.2983 Td
[(1)1(\n)1()]TJ
1.7007 0 Td
[()11()13()1()-5(\n)8()13()-6( )]TJ
3.7871 0 Td
[(%)3()2()1()8(+)]TJ
2.3641 0 Td
[()13()-6(")-1()11()10(&)11()1()3(\n)8()19()]TJ
5.3177 0 Td
[()19(%)1()3(\n)8()]TJ
3.0671 0 Td
[()]TJ
2.5682 0 Td
[(,K)]TJ
2.6192 0 Td
[(5)16()1()5()6()1()8()]TJ
3.6283 0 Td
[()5()1()2()4()-5(\n)18()-9()6()1()3()]TJ
5.4198 0 Td
[()]TJ
2.194 0 Td
[()1()]TJ
1.0205 0 Td
[(&)6()2()-9(")6(*)]TJ
-33.6867 -1.3039 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(6)]TJ
2.8799 0 Td
[()6(:)73()]TJ
3.0331 0 Td
[(9)]TJ
1.9105 0 Td
[(H09)]TJ
5.3065 0 Td
[(<)42()2()7($)8()1()7()2()12()-2()]TJ
4.3823 0 Td
[()11()]TJ
1.0148 0 Td
[()5()2(")6()2()1(+)2(\n)8()]TJ
4.0138 0 Td
[(C)33()-13(&)11()-4()2( )2()11()3(\n)]TJ
4.8359 0 Td
[()-16()11()13()]TJ
2.7269 0 Td
[(\n)8()]TJ
1.1962 0 Td
[(\n)8()19()-5(!)]TJ
-33.2898 -1.2982 Td
[()4()11()4()-9(")6()2()11()3(\n)-4()]TJ
4.9719 0 Td
[(\n)8()19()-5()5(&)-9()-9( )7()]TJ
3.7474 0 Td
[()-4()3(\n)18()]TJ
1.7914 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()13()-6(")-1()1()19()-4()7()]TJ
3.3902 0 Td
[( )2()2()-7(")-4()5(&)-9()-6( )]TJ
4.0025 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[(6)]TJ
0 g
[(\))]TJ
2.0863 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[(&)11()2()11()-5()1()23()-7()-2(\n)18()6()-6( )]TJ
4.9776 0 Td
[(=)8()2()11()-5()1(!L)-22(L)]TJ
4.6601 0 Td
[()5()2(")13()1()-7(")-3(\n)-4()2()]TJ
-33.029 -1.2983 Td
[(B)7()13()11()6()1()1()]TJ
3.1691 0 Td
[(4)-15(\n)9(&)-9()5()1()1()8(+)]TJ
3.6169 0 Td
[(I)7()12()-1()]TJ
1.6725 0 Td
[(4)-5()1()8()]TJ
1.7234 0 Td
[(:)99()-6(")6()2()4()6()2()1(+)-5()2()2()]TJ
5.7146 0 Td
[()-10(\n)8()5()3(&)-5(\n)2( )6()]TJ
3.9685 0 Td
[()]TJ
1.9106 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[(\n)18()11()6()1()2()-6( )]TJ
3.1465 0 Td
[()15($)8()1()-4()2()1(+)-6()19()]TJ
4.0591 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(\))]TJ
2.0863 0 Td
[(5)14()-5()13()1()11()-6(\n)18($)-3(!)]TJ
-32.7909 -1.2983 Td
[( )1()1(!C,B)]TJ
3.838 0 Td
[(=)8()2()6()2()-1(+)7()1()4( )6()]TJ
4.7339 0 Td
[(5)-3(\n)8()]TJ
1.6667 0 Td
[()1()2()-1(+)7()30()]TJ
2.8063 0 Td
[()]TJ
1.9105 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()-4()4()1()]TJ
2.0126 0 Td
[(\n)2( )2( )2()-6( )6()]TJ
2.8573 0 Td
[(=)-19()1()-2(1)8()-6()1()]TJ
3.5773 0 Td
[()5()6()1()1()]TJ
2.194 0 Td
[()6()-2(\n)18()6()2()]TJ
2.5115 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(1)1(\n)1()5()4()-6( )]TJ
3.1691 0 Td
[(1)-3()12()-4()]TJ
-35.0756 -1.3039 Td
[(B)5(=5)]TJ
1.8368 0 Td
[()6()12(%)3()]TJ
1.8765 0 Td
[(66H>)]TJ
2.6305 0 Td
[(:)73(1)8()-6()1()]TJ
3.1068 0 Td
[(:)1()4()]TJ
1.7801 0 Td
[()6()-2(\n)18()6()2()]TJ
2.5172 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[($)-3()3()5(%)-2(\n)-4()1(#)-2()-6( )]TJ
4.1272 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[(:)6(=)]TJ
2.3017 0 Td
[()5(%)5(&)1()5()-5(\n)18()6()]TJ
3.7984 0 Td
[(=)4()]TJ
1.8766 0 Td
[(=)8()2()1()-7(")2()1()4(")-1()2()]TJ
4.9832 0 Td
[(5)-3(\n)8()]TJ
-34.9282 -1.2983 Td
[(D)20()1()-7()6()]TJ
2.0409 0 Td
[()]TJ
2.1316 0 Td
[()5()6()11()11()-9()-6( )]TJ
3.3676 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[()]TJ
1.5874 0 Td
[(C)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 318.7842 276.4913 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 322.4125 278.1354 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(5/)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 334.4881 276.4913 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 338.1165 278.1354 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()]TJ
0.4365 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[(\n)8()3(\n)-4()7(#)-2()-6( )]TJ
3.7021 0 Td
[()11()]TJ
1.2642 0 Td
[(\n)]TJ
0.6576 0 Td
[(")-1()6()2()11()-4()1()4()1()-5()-4()2(")]TJ
5.0854 0 Td
[()6()-2(\n)18()6()]TJ
2.1486 0 Td
[()13()-5(\n)2( )2()1()64()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 242.9858 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(ELISA)Tj
3.0519 0 Td
(for)Tj
1.3843 0 Td
(the)Tj
1.6016 0 Td
(secretion)Tj
4.2614 0 Td
(of)Tj
1.0489 0 Td
(CD13)Tj
2.7638 0 Td
(from)Tj
2.2157 0 Td
(RA)Tj
1.6063 0 Td
(FLS)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 225.9779 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(:)99()]TJ
1.3322 0 Td
[( )2()1()6()1()-4()2()1()4()]TJ
4.2803 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()13()6()2()]TJ
1.7518 0 Td
[()11()]TJ
1.0147 0 Td
[()-5()3()5()5(%)2()]TJ
2.4492 0 Td
[()1()-5()2()5(&)11()12()6()11()7()]TJ
4.1102 0 Td
[()11()]TJ
1.0148 0 Td
[()4()1()-6(\n)-4()-5()2()11()11()13()11()6()1()1()3(\n)1()-7()2()]TJ
7.6818 0 Td
[()-2(:.B)29()]TJ
3.6737 0 Td
[()1()]TJ
1.0205 0 Td
[()-4()4()]TJ
1.474 0 Td
[()-7()-6(")13()1()-5()2()11()]TJ
3.804 0 Td
[()11()]TJ
-35.0756 -1.2982 Td
[()]TJ
2.7836 0 Td
[(,)-5()]TJ
1.525 0 Td
[(345)]TJ
1.7404 0 Td
[(6M6H)]TJ
3.5377 0 Td
[(")-1()5()-5()3()]TJ
2.262 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()6()-2(\n)18()6()-6( )]TJ
2.6702 0 Td
[()1()]TJ
1.0205 0 Td
[(G!1)8()5()-5()]TJ
2.6532 0 Td
[()6()-2(\n)18()6()2()]TJ
2.5115 0 Td
[()1()]TJ
1.0205 0 Td
[(,B.)]TJ
2.6192 0 Td
[(1)-3()12()-4()]TJ
1.9955 0 Td
[(6>)]TJ
1.9276 0 Td
[(3=5)]TJ
2.0126 0 Td
[(7)14()4()1()]TJ
2.6815 0 Td
[(,)-5()]TJ
-35.0586 -1.2983 Td
[(345)]TJ
1.7404 0 Td
[(&)-9()-6(")-3(\n)8()4()]TJ
3.2258 0 Td
[(-H>)]TJ
1.9276 0 Td
[(")-1()11()2()-17()12(%)2()1()19()-1()]TJ
4.2236 0 Td
[()4()-6( )1()-2(\n)]TJ
2.6702 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()-1(1)-3()12()6(")6()4()-6( )]TJ
3.7133 0 Td
[()6()]TJ
1.0205 0 Td
[(,B.)]TJ
2.6192 0 Td
[(")-1()11()19()-6(\n)8()1()2()1()8(+)]TJ
4.4844 0 Td
[(6>)]TJ
2.1486 0 Td
[(3=5)]TJ
2.0126 0 Td
[(,)-5()]TJ
1.525 0 Td
[(345)]TJ
1.7405 0 Td
[(1)8()1()13()]TJ
-34.7525 -1.3039 Td
[()1()4(")-6(%)5(&)-5(\n)18()6()-6( )]TJ
4.1385 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[(:.B)49(!)]TJ
3.668 0 Td
[(:.B)49(!)]TJ
3.4526 0 Td
[()11()]TJ
1.0828 0 Td
[(&)-9()11()-4()]TJ
2.0579 0 Td
[()8()11()]TJ
1.3777 0 Td
[(-)]TJ
1.1792 0 Td
[()4()11(%)1()7()]TJ
2.7212 0 Td
[(4.5)]TJ
2.8063 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()-9()1()-4()8()11()-4()4()-6( )]TJ
4.4333 0 Td
[()6()]TJ
1.0205 0 Td
[( )2()1()6()1()-4()2()1()4()]TJ
4.2746 0 Td
[()-4()4()]TJ
-35.909 -1.2983 Td
[()2()-9($)8()5()3()]TJ
2.3754 0 Td
[()11()]TJ
1.0148 0 Td
[()-7()6()12(%)5(&)6()2()]TJ
3.0217 0 Td
[()]TJ
2.5682 0 Td
[()1()]TJ
1.0204 0 Td
[()-4()4()]TJ
1.474 0 Td
[(")-1()11()4( )1()12()-5()2()11()4()-6( )]TJ
5.006 0 Td
[()4()-6( )1()-2(\n)]TJ
2.8913 0 Td
[()-16()11()4( )1()12()-5()2()11()4()-6( )]TJ
5.2441 0 Td
[()4()-6( )1()-2(\n)]TJ
2.6702 0 Td
[(66)]TJ
2.0012 0 Td
[(?\r1)8()5()-5()]TJ
3.2428 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[(\n)2( )2( )2()-6( )]TJ
-34.2309 -1.2982 Td
[()6()]TJ
1.0204 0 Td
[(0G!1)8()5()-5()]TJ
3.1294 0 Td
[()6()-2(\n)18()6()2()]TJ
2.5172 0 Td
[()-2(:)1()4()1()-4()4()]TJ
3.8041 0 Td
[(5)-15(")2()1()19()-5()1()-11()2(")-1()]TJ
4.0762 0 Td
[(<5)]TJ
2.4547 0 Td
[()8()11()]TJ
1.3777 0 Td
[()]TJ
0.6973 0 Td
[()4()11(%)1()7()]TJ
2.5058 0 Td
[(\n)18()]TJ
0.9581 0 Td
[()13()-9()11()]TJ
2.3981 0 Td
[()6()1()19()-9()1(\n)18()10(%)1()13()6()]TJ
5.3178 0 Td
[()3()-7()6()1()]TJ
2.2847 0 Td
[(&)6()2()-9(")6(*)-4()1()8(+)-3()]TJ
-32.5415 -1.2983 Td
[(\n)8()19()-5(!)]TJ
4.4617 0 Td
[(\n)8()19()-5()5(&)-9()-9( )7()74()]TJ
3.9628 0 Td
[(7H)]TJ
3.2541 0 Td
[(6?+\r)-5()6()]TJ
4.0989 0 Td
[(=)8()2(4)-9()-1(+)7()1()4( )]TJ
4.7962 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[(\n)2( )2( )2()-6( )]TJ
2.6418 0 Td
[()8()11()]TJ
1.3777 0 Td
[()]TJ
0.6973 0 Td
[()4()11(%)1()7()]TJ
2.5058 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(9N)]TJ
2.3867 0 Td
[()3()19()-5(!)]TJ
-32.8419 -1.3039 Td
[()4()11(%)3()-7()]TJ
2.8346 0 Td
[(.)27(+F)]TJ
1.7234 0 Td
[(C,B)49(!)1()1()-5(*)10()-6( )]TJ
4.9946 0 Td
[(\n)8()19()-5()5(&)-9()-9( )7()]TJ
3.7418 0 Td
[(E666)]TJ
3.5262 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[(\n)2( )2( )2()-6( )]TJ
2.6419 0 Td
[()8()11()]TJ
1.3776 0 Td
[()]TJ
0.6973 0 Td
[()4()11(%)1()64()]TJ
2.3584 0 Td
[()3()-7()6()1()]TJ
2.2847 0 Td
[(\n)2( )2( )1()1()8(+)]TJ
2.9594 0 Td
[()-4()4()]TJ
1.474 0 Td
[(:)6(=)]TJ
2.3017 0 Td
[()5(%)5(&!)]TJ
-34.6164 -1.2983 Td
[()5()-5(\n)18()6()]TJ
2.4094 0 Td
[()-7()6()12(%)12()-5()2()11()]TJ
3.4639 0 Td
[(=)4()]TJ
1.8765 0 Td
[(=)8()2()1()-7(")2()1()4(")-1()2()]TJ
5.108 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[()5()6()11()]TJ
1.9105 0 Td
[()-7()6()12(%)12()-5()2()11()]TJ
3.4583 0 Td
[()]TJ
1.7858 0 Td
[(C5/)]TJ
3.7133 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()11()11()-5()2(")-3(\n)-4()]TJ
2.914 0 Td
[( )2()1()8()2()12()-2()]TJ
3.084 0 Td
[(/)9()]TJ
2.3811 0 Td
[(1)1(\n)1()]TJ
-35.2967 -1.2982 Td
[()4()-5(\n)1()5(%)1()13()-6( )]TJ
4.0761 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(H6)]TJ
1.6611 0 Td
[()2()]TJ
1.5761 0 Td
[(&)15()]TJ
1.1792 0 Td
[(\n)]TJ
0.6576 0 Td
[()2()2(")13()11()6()-2(\n)18()6()]TJ
4.5071 0 Td
[()13()-5(\n)2( )2()1()]TJ
2.7439 0 Td
[(=)4(.)11(/!:I)]TJ
4.6375 0 Td
[(<5)]TJ
2.6702 0 Td
[(7)97()]TJ
1.61 0 Td
[(%)3()-7()-6( )]TJ
2.041 0 Td
[(345)]TJ
1.7461 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[()-4()2()13()-6()]TJ
2.2507 0 Td
[( )1()1()-11()8()1()23(!)]TJ
-34.503 -1.304 Td
[()1()19()]TJ
1.4796 0 Td
[(,)-5()]TJ
1.5251 0 Td
[()-5(\n)18()-5()2()1()19()]TJ
3.5886 0 Td
[(=)-19()11()-4()]TJ
2.1373 0 Td
[()1()-5()2()5(&)11()12()6()11()7()]TJ
4.1102 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(%)3()-7()-6( )]TJ
2.041 0 Td
[(\n)18()]TJ
0.9637 0 Td
[(6G)]TJ
1.3947 0 Td
[(?+\r)-5()6()]TJ
2.7949 0 Td
[(:)1()4()2()-7()]TJ
2.5682 0 Td
[(")-1()11()4(")-1()1()19()-5(\n)18()-5()2()11()8()]TJ
6.1285 0 Td
[(\n)8()13()]TJ
1.44 0 Td
[()13()-6(")-1()11(!)]TJ
-32.2694 -1.2982 Td
[()4()1()4( )2()-6( )]TJ
3.4525 0 Td
[(&)15()]TJ
1.1792 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()3(\n)8()19(%)1()-1(\n)2(")-6()10(%)1()13()]TJ
5.2894 0 Td
[()6()]TJ
1.0205 0 Td
[()1()-5()2()5(&)11()12()]TJ
2.8799 0 Td
[(B)29()]TJ
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 528.7748 745.7952 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(CD13)Tj
2.7567 0 Td
(on)Tj
1.3181 0 Td
(FLS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(PLOS)Tj
2.8771 0 Td
(ONE)Tj
2.3812 0 Td
(|)Tj
0.4819 0 Td
(DOI:10.1)Tj
3.9827 0 Td
(371/journ)Tj
4.1315 0 Td
(al.pone.0162)Tj
5.7331 0 Td
(008)Tj
2.6504 0 Td
(September)Tj
5.0812 0 Td
(22,)Tj
1.6016 0 Td
(2016)Tj
36.2057 0 Td
(3)Tj
0.7725 0 Td
(/)Tj
ET
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
BT
66.402 0 Td
(20)Tj
ET
Q
endstream
endobj
53 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Contents 54 0 R/TrimBox[0 0 612 792]>>
endobj
54 0 obj
[55 0 R 56 0 R 57 0 R 58 0 R 59 0 R]
endobj
55 0 obj
<>stream
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Aminopeptidase)Tj
7.3465 0 Td
(enzymatic)Tj
4.7055 0 Td
(activity)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()3()2()1()4()11()-9()1()11()-5()2( )-2(\n)1()-7()]TJ
6.786 0 Td
[(\n)2(")-6()-5()7($)-3()12()-2()]TJ
3.1181 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()4()-5(\n)1()5(%)1()13()-6( )]TJ
4.0819 0 Td
[(&)15()]TJ
1.1792 0 Td
[(")6()2()-5(\n)18($)1(\n)6(+)7()]TJ
3.5149 0 Td
[()11()]TJ
1.0092 0 Td
[(4)11(!4)-9()1(%)2(")1()4(!9!\n)8()2()2( )2(!!)4()]TJ
10.1366 0 Td
[()-4()23()-7()]TJ
1.7631 0 Td
[(")-1()11(%)1()3(\n)8()-4()1()]TJ
-33.2898 -1.3039 Td
[(4)11(!)2()1(%!)9()]TJ
5.4424 0 Td
[(5)6()1(+)-5()3(\n!)-4()2( )1()-4()2(")6()]TJ
6.2646 0 Td
[(5)14()-1()]TJ
1.2132 0 Td
[(4)-9()11(%)1()3()]TJ
2.6192 0 Td
[()9(/)]TJ
2.1883 0 Td
[()6()]TJ
1.0261 0 Td
[()13()5()2()-5(\n)1()-7()]TJ
2.8857 0 Td
[()-4()4()]TJ
1.474 0 Td
[()-17()12(%)2()11()13()2()-7(")-1()1()19()]TJ
4.6091 0 Td
[()4()6()2()-6(")-6(%)-5()2()]TJ
3.8041 0 Td
[()9()]TJ
2.6702 0 Td
[()]TJ
0.9071 0 Td
[()5()-6(\n)8(!)]TJ
-35.104 -1.2982 Td
[( )-2(\n)8()13( )]TJ
2.0636 0 Td
[(")-6(%)1()-29($)8()]TJ
2.3981 0 Td
[(1)1(\n)1()]TJ
1.7007 0 Td
[(")-1()11()8()5()-5()-10(%)2(")-6()6()-6( )]TJ
4.8926 0 Td
[(%)3()2()1()8(+)]TJ
2.3697 0 Td
[()9()]TJ
2.4492 0 Td
[(5)6()1(+)-5()3(\n!)-4()2( )1()-4()2(")6()]TJ
6.6103 0 Td
[(5)14()-1()]TJ
1.2132 0 Td
[(4)-9()11(%)1()3()]TJ
2.6192 0 Td
[()9(/)]TJ
2.4095 0 Td
[(:)1()4()]TJ
1.7801 0 Td
[(\n)1()5()-6(\n)18()]TJ
2.2847 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()-10(%)1()]TJ
1.6498 0 Td
[()1()]TJ
-36.1415 -1.2983 Td
[(6)]TJ
1.3946 0 Td
[()]TJ
1.1112 0 Td
[(:)82()-4()3(!C)11()-5()]TJ
3.8437 0 Td
[(&)11(%)1()-11()8()1()]TJ
2.6079 0 Td
[(C)]TJ
1.8482 0 Td
[(-6)]TJ
1.9615 0 Td
[(5)-3(\n)8()19()6()2()2()]TJ
3.4923 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()1()4(")-6(%)5(&)-5(\n)18()6()-6( )]TJ
4.1386 0 Td
[(1)-3()12()-4()]TJ
1.9955 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()5(%)5(&)1()5()-5(\n)18()6()]TJ
3.7984 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(9N)]TJ
2.1713 0 Td
[()8()11()]TJ
1.3776 0 Td
[()11()4()]TJ
-34.2649 -1.3039 Td
[()4()11(%)1()]TJ
2.1373 0 Td
[()-4()4()1()]TJ
2.0125 0 Td
[()13()-5(\n)2( )]TJ
1.9616 0 Td
[(%)3()2()1()8(+)]TJ
2.3698 0 Td
[(\n)]TJ
0.6576 0 Td
[()-17()12(%)2()11()13()2()-7(")-1()1()19()]TJ
4.6091 0 Td
[()6()-2(\n)18()6()]TJ
2.1486 0 Td
[()13()-5(\n)2( )2()1()]TJ
2.744 0 Td
[(\n)18()]TJ
0.9581 0 Td
[()1()2()3()5()2()2()11()]TJ
3.7473 0 Td
[(H6)]TJ
1.8766 0 Td
[()2(2)9(")12()-6(\n)18()-5()2()11()]TJ
4.1272 0 Td
[(GH)]TJ
1.8822 0 Td
[(,)-3()2()5(%)-5()12()]TJ
3.0557 0 Td
[(1)8()1()13()]TJ
-34.2876 -1.2983 Td
[(")-3(\n)-4()2(")-6(%)-5()-2(\n)18()6()-6( )]TJ
4.1895 0 Td
[(\n)1()]TJ
1.0262 0 Td
[(?\r)2()]TJ
2.8346 0 Td
[()11()]TJ
1.0148 0 Td
[()5(%)5(&)1()5()-5(\n)18()6()]TJ
3.7927 0 Td
[(")6()2()-5(\n)18($)8()-6( )6()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 595.0488 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Western)Tj
3.9354 0 Td
(Blot)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 578.0409 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()-6(2)9()1()-7()11()4()]TJ
3.8494 0 Td
[()7()1()-6(\n)18()6()2()]TJ
3.033 0 Td
[( )2()1()-4()7($)8()-6( )]TJ
3.1805 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[()2(2)9()1()-7()11()4()2()]TJ
4.0705 0 Td
[()3()-7()6()-2(\n)18()6()-6( )]TJ
3.2769 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[(,)-5()]TJ
1.525 0 Td
[(345)]TJ
1.7405 0 Td
[(H)]TJ
1.525 0 Td
[(?)]TJ
1.5421 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(&)-9()11()-5()2()-6( )]TJ
2.6702 0 Td
[()8()11()]TJ
1.3776 0 Td
[(H)]TJ
0.6973 0 Td
[()2()1(!)]TJ
-34.9622 -1.2982 Td
[(%)12()6()2()]TJ
1.8255 0 Td
[()1()]TJ
1.0204 0 Td
[(4)-15(\n)2()1()2()-5()1()33(O)93()]TJ
4.3313 0 Td
[()-6(\n)8()19()6()2()]TJ
3.0217 0 Td
[(&)11(%)1()-11()8()1()]TJ
2.6079 0 Td
[(\n)8()4( )6()]TJ
1.9389 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()5(%)5(&)11(;)-5()-6(")-6()6()-6( )]TJ
3.9345 0 Td
[()6()]TJ
1.0204 0 Td
[(6>5)11(5!)]TJ
3.9515 0 Td
[()-9()6()7()1(\n)2(")-29()-7()-2(\n)8()2()2( )2()]TJ
6.3326 0 Td
[(+)7()5()]TJ
1.3436 0 Td
[()5()2()-6(")-6()-5()13(!)]TJ
-33.4259 -1.2983 Td
[()6()4()11()13()2()2()3()]TJ
3.5432 0 Td
[(B)85()28(F)]TJ
3.4356 0 Td
[()8()6()-5()2()15(1)8()-6( )]TJ
3.6283 0 Td
[(&)15()]TJ
1.1792 0 Td
[(7)97()2()5()6()1()-4()]TJ
3.5943 0 Td
[(&)6()2()11()]TJ
1.7745 0 Td
[(\n)8()3(\n)-4()7()1()2()3()]TJ
3.5603 0 Td
[(:)1()4()]TJ
1.7802 0 Td
[()11()13()11()6()1()1()8()]TJ
3.4979 0 Td
[(1)8()1()13()]TJ
2.0919 0 Td
[()5()2()-6(")-6()-5()13()11()6()4()11()13()1()-5()2(")-3(\n)-4()-5()7()]TJ
-28.0854 -1.3039 Td
[()-5(\n)8()8()2()8()1()-4()13()-6( )]TJ
4.6091 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[()-4()4()]TJ
1.474 0 Td
[(+)7()5()]TJ
1.3436 0 Td
[()11()19()6()]TJ
2.0693 0 Td
[()2()12()-5()13()-9(")-1()5()-5()12(%)-5()2()1()-7()]TJ
5.5785 0 Td
[()4()1()10(&)11(\n)8()4()2()]TJ
4.8869 0 Td
[(%)3()2()1()8(+)]TJ
2.3698 0 Td
[(\n)]TJ
0.6576 0 Td
[(:)82()-4()3(!+)-6()7()8(")1()4()]TJ
4.9833 0 Td
[(&)11(%)1()-11()8()1()64()]TJ
2.8289 0 Td
[(:)99()]TJ
1.338 0 Td
[(&)6()2()-9(")6(*)]TJ
-34.3273 -1.2983 Td
[()4()11()8()5()-9()-6(")1()-11()2(")]TJ
4.7565 0 Td
[(&)11()1()4( )1()1()8(+)-3()]TJ
3.5206 0 Td
[()4()1()10(&)11(\n)8()4()2()]TJ
4.8925 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[()1()4(")-6(%)5(&)-5(\n)18()6()-6( )]TJ
4.1385 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[(H>)]TJ
1.4513 0 Td
[()4()11()2()-1(\n)18()]TJ
2.8346 0 Td
[()2()-5()-5(*)]TJ
2.0353 0 Td
[()1()]TJ
1.0205 0 Td
[(:)82()-4()3(!&)11(%)1()-11()8()1()13()-6( )]TJ
5.5105 0 Td
[()-6(\n)-4()1()1()4()]TJ
-34.2536 -1.2982 Td
[(")-1()11()19()-6(\n)8()1()2()1()8(+)]TJ
4.4843 0 Td
[(66>)]TJ
2.6249 0 Td
[(:)73(1)8()-6()1(!6)]TJ
4.2066 0 Td
[()-2(:=5)10(:)2()]TJ
3.1918 0 Td
[()8()11()]TJ
1.3776 0 Td
[()]TJ
0.6973 0 Td
[()4()11(%)1()]TJ
2.1373 0 Td
[(\n)18()]TJ
0.9638 0 Td
[()13()-9()11()]TJ
2.3981 0 Td
[()6()1()19()-9()1(\n)18()10(%)1()13()6()]TJ
5.3178 0 Td
[(:)1()4()]TJ
1.7858 0 Td
[(&)6()2()11()]TJ
2.1373 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()1()4(")-6(%)5(&)-5(\n)18()6()-6( )]TJ
-33.4202 -1.3039 Td
[()1()]TJ
1.0204 0 Td
[()4()11(%)3()-7()]TJ
2.8403 0 Td
[(\n)8()19()-5()-5()19(%)1()3(\n)8()]TJ
4.6091 0 Td
[(3)2()11()-5()-5()-5()1()1()]TJ
3.3562 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[(0)]TJ
2.0863 0 Td
[(=)4()]TJ
1.8765 0 Td
[(=)8()2()1()-7(")2()1()4(")-1()2()]TJ
5.108 0 Td
[()11()-4()1()3(\n)8()-29()]TJ
3.4412 0 Td
[(\n)8()19()-5()5(&)-9()-9( )1()2()2()]TJ
4.3313 0 Td
[()6()12(%)3()]TJ
1.8766 0 Td
[(H>)]TJ
1.4513 0 Td
[()4()11()2()-1(\n)18()]TJ
-33.7207 -1.2983 Td
[()2()-5()-5(*)]TJ
2.0352 0 Td
[()1()]TJ
1.0205 0 Td
[(:=5)10(:)]TJ
2.5058 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(N)]TJ
1.6894 0 Td
[()15($)8()1()-4()2()1(+)-6()19()-1()]TJ
4.2747 0 Td
[()3()-7()6()1()]TJ
2.2847 0 Td
[(1)1(\n)1()5()2()1()8(+)]TJ
3.4979 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(:=5)10(:)99()]TJ
2.7212 0 Td
[()-4()4()]TJ
1.474 0 Td
[(&)6()2()11()]TJ
2.1374 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()1()4(")-6(%)5(&)-5(\n)18()6()-6( )]TJ
4.1385 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[()4()11()7()-7(!)]TJ
-34.8205 -1.2983 Td
[(\n)2( )1()3()5()]TJ
2.6985 0 Td
[()-9()1()13()16(2)2( )-2(\n)1()-7(\(")-1()11()19(;)10(%)1(+)2(\n)18()]TJ
8.2204 0 Td
[()-6( )]TJ
1.1566 0 Td
[()5()4()-6()1()]TJ
2.4718 0 Td
[(\n)8()19()-5(\()4()11(%)3()-7()]TJ
4.8925 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(+)7()-5(\n)18()]TJ
1.9219 0 Td
[(\n)8()19()-5(\(\n)9(&)5(&)11()12()]TJ
4.6375 0 Td
[(.)27(+F)]TJ
1.7234 0 Td
[(E666)]TJ
3.5263 0 Td
[()8()11()]TJ
1.3776 0 Td
[(H)]TJ
-34.6164 -1.3039 Td
[()2()1()19(%)12()6()2()]TJ
3.4412 0 Td
[(\n)18()]TJ
0.9581 0 Td
[()13()-9()11()]TJ
2.3981 0 Td
[()6()1()19()-9()1(\n)18()10(%)1()13()6()]TJ
5.3234 0 Td
[()3()]TJ
1.4457 0 Td
[(4)]TJ
1.9729 0 Td
[( )2()1()6()-6(")-6()-5()2()11()]TJ
3.9004 0 Td
[()-1()1()5()6()1()]TJ
2.9424 0 Td
[(1)1(\n)1()]TJ
1.7007 0 Td
[(%)3()-7()-6( )]TJ
2.0466 0 Td
[()6()]TJ
1.0205 0 Td
[()2( )2()1()19()-5()1()-17()]TJ
3.2768 0 Td
[()5()-9()-6(")1()-11()2(")]TJ
3.1692 0 Td
[()11()13()11()6()1()1()]TJ
-33.596 -1.2983 Td
[(&)-5(\n)8()4( )3()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 419.0173 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(siRNA)Tj
3.0378 0 Td
(Knockdown)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 402.0094 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(345)]TJ
1.7404 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-5(\n)8()8()2()8()-6(")-6()6()-6( )]TJ
4.5978 0 Td
[(&)15()]TJ
1.1792 0 Td
[()5()2()-6(")-6()-5()13()11()-9()11(\n)18()-5()2()11()]TJ
6.3212 0 Td
[(%)3()2()1()8(+)]TJ
2.3698 0 Td
[(\n)8()]TJ
1.1962 0 Td
[()3()3(\n2\n)]TJ
3.0671 0 Td
[()33(%)2(")6()2()-6()11()8()-6(")-6()6()11()]TJ
5.3631 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()-4()4()]TJ
1.474 0 Td
[()19(%)2(")6()2()-6()11()8()-6(")-6()6()11()]TJ
5.159 0 Td
[(*)-4()12()]TJ
-36.2832 -1.2982 Td
[()8()11()]TJ
1.3662 0 Td
[( )2()1()-4()3(\n)-4()]TJ
3.0161 0 Td
[()-11()5(&)11()13()5(&)6()-2(\n)1()5()]TJ
4.3483 0 Td
[(C)9(3)110()]TJ
3.5319 0 Td
[(4)-9()11(#\n)]TJ
2.8574 0 Td
[(=)-7(\n)1()-7()5()6()]TJ
2.4831 0 Td
[(5)16(1)-3()12()-2(#)-2()1()5()-2(\n)8()4( )]TJ
5.4368 0 Td
[(.)17()]TJ
1.0828 0 Td
[(&)11()-4()2()1()5()]TJ
2.2677 0 Td
[(345)]TJ
1.7348 0 Td
[(1)8()1()13()]TJ
2.0863 0 Td
[()13()5()2()-5(\n)1()-7()-6( )]TJ
3.4016 0 Td
[(&)15()]TJ
1.1678 0 Td
[()-5()-29()-1()1()2()1()]TJ
-34.7808 -1.2983 Td
[(\n)8()4( )]TJ
1.7177 0 Td
[(H26)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 236.296 380.4661 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(H)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 242.0787 376.044 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-5(\n)8()8()2()8()-6(")-6()6()-6( )]TJ
4.5977 0 Td
[()-9()1()]TJ
1.5251 0 Td
[(")-1()11()4( )1()12()-5()2()11()]TJ
4.2859 0 Td
[()-16()5()-5()3()]TJ
2.16 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()13()2()5(%)3()5()-9()1()4( )2()-6( )]TJ
5.1931 0 Td
[()1()]TJ
1.0204 0 Td
[()-5(\n)8()8()2()8()-6(")-6()-5()2()11()]TJ
4.9663 0 Td
[()-7()6()12(%)12()-5()2()11()]TJ
3.4639 0 Td
[(\n)8()4( )]TJ
-35.6141 -1.3039 Td
[()1()12()-4()4()1()]TJ
2.5114 0 Td
[(66)]TJ
3.0897 0 Td
[(B)]TJ
3.5149 0 Td
[()5()4()11()-10()]TJ
2.2847 0 Td
[()1()-5()2()5(&)11()12()6()11()-29()]TJ
4.201 0 Td
[(,)37()]TJ
2.262 0 Td
[()2(,)37(B)]TJ
6.3949 0 Td
[()2(,)37()]TJ
2.8857 0 Td
[()37(H)]TJ
4.1725 0 Td
[()2(,)37()]TJ
-31.3168 -1.2982 Td
[()37(6)]TJ
4.1725 0 Td
[()2(,)37()]TJ
3.1067 0 Td
[()37(9)]TJ
4.1726 0 Td
[()2(,)37()]TJ
2.8856 0 Td
[(\n)-4()-5()6()]TJ
1.7235 0 Td
[()5()6()-5(\n)-4()12()-4()]TJ
2.8289 0 Td
[(,)37()3()]TJ
2.5228 0 Td
[(')-7()1()]TJ
1.6498 0 Td
[()11()]TJ
1.0091 0 Td
[(\))]TJ
1.2643 0 Td
[(4)-5()1()8()]TJ
1.7178 0 Td
[(:)99()-6(")6()2()4()6()2()1(+)-5()2()2()]TJ
5.7202 0 Td
[()-10(\n)8()5()3(&)-5(\n)2( )6()]TJ
-32.7738 -1.2983 Td
[()]TJ
2.1259 0 Td
[()11()]TJ
1.0885 0 Td
[(?+)]TJ
1.6667 0 Td
[()11()3(\n2F3B)]TJ
4.2576 0 Td
[(4)-9()11(#\n)]TJ
3.2088 0 Td
[(=)-7(\n)1()-7()5()6()]TJ
2.4945 0 Td
[(5)16(1)-3()12()-2(#)-2()1()5()-2(\n)8()4( )]TJ
5.227 0 Td
[(1)1(\n)1()]TJ
1.6951 0 Td
[(\n)2( )2( )2()-6( )]TJ
2.6419 0 Td
[()6()]TJ
1.0205 0 Td
[()-5(\n)2(")6()]TJ
2.0239 0 Td
[()-5(\n)8()8()2()8()-6(")-6()-5()2()11()]TJ
4.9663 0 Td
[(")-6(%)7($)8()1()10()6()6()]TJ
-32.4167 -1.3039 Td
[()-16()5()-5()3()]TJ
2.1599 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()5()2()-6(")-6()-5()13()11()-9()11(\n)18()6()-6( )]TJ
5.9527 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()-5(\n)8()8()2()8()1()-4()13()-6( )]TJ
4.6148 0 Td
[()6()]TJ
1.0204 0 Td
[()-17()-2(\n)1()5(*)]TJ
2.4208 0 Td
[(")-1()11()19()-6(\n)8()1()2()1()8(+)]TJ
4.4844 0 Td
[(6>)]TJ
1.9275 0 Td
[(,4)]TJ
3.1294 0 Td
[(:)82(\n)8()8()2()8()-6(")-6()6()-6( )]TJ
4.9153 0 Td
[(")-1()5()-5()3()]TJ
-34.4406 -1.2983 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(+)-5()13()15(1)-3()]TJ
2.7608 0 Td
[()8()11()]TJ
1.3776 0 Td
[(H\(9)]TJ
1.6895 0 Td
[( )-2(\n)18()1()]TJ
2.0069 0 Td
[()-4()4()1()]TJ
2.0126 0 Td
[()-5(\n)8()8()2()8()1()-4()13()-6( )]TJ
4.6091 0 Td
[()6()]TJ
1.0205 0 Td
[()-7()1()-10(%)1()]TJ
2.7042 0 Td
[()-11()13()-6()]TJ
1.7064 0 Td
[()4()-6( )1()12(%)1()]TJ
3.5717 0 Td
[()8()11()]TJ
1.3776 0 Td
[()]TJ
0.6973 0 Td
[( )-2(\n)18()1()]TJ
2.0013 0 Td
[(&)-9()1()8()11()13()]TJ
2.7155 0 Td
[()3(\n)8()-29($)8()2()5()-5()1()8(+)-3()]TJ
-32.3486 -1.2982 Td
[(:)82(\n)8()8()2()8()-6(")-6()-5()2()11()]TJ
5.2779 0 Td
[()11()]TJ
1.0092 0 Td
[(F3B)]TJ
2.0126 0 Td
[(")-1()11()19()-5()13()6()]TJ
3.101 0 Td
[()6()-2(\n)1()2()2()2( )]TJ
3.3903 0 Td
[(1)1(\n)1()]TJ
1.7007 0 Td
[()4()-5(\n)1()5(%)1()13()-6( )]TJ
4.0762 0 Td
[(&)15()]TJ
1.1792 0 Td
[()-17()12(%)2()11()13()2()-7(")-1()1()19()]TJ
4.6091 0 Td
[()2()2(")13()1()-7(")-1()11()15()]TJ
4.8359 0 Td
[()11(J)35(/5)6()-17()6()]TJ
3.7984 0 Td
[()9(F)]TJ
-34.9905 -1.2983 Td
[()5()-5()-5()]TJ
1.8651 0 Td
[()13()-6()5(*)]TJ
2.7836 0 Td
[(7)123()]TJ
2.2223 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[()-17()2()15(1)]TJ
1.9388 0 Td
[(")-18()-1()6()11()4()1()-5()-29()]TJ
4.2577 0 Td
[(=)4()]TJ
1.8765 0 Td
[(=)8()3()-7()-9(")-1()1()1()4(")-1()2()]TJ
4.7678 0 Td
[(3)78()28(5)-10(\n)-4()1()5(&)11(%)1()64()]TJ
5.7657 0 Td
[(5)-3(\n)8()]TJ
1.6667 0 Td
[(D)20()1()-7()6()]TJ
2.0466 0 Td
[()]TJ
2.126 0 Td
[(I)7()4()-9(")6(*!)]TJ
-33.0403 -1.3039 Td
[( )2()15(1)-3()]TJ
2.4604 0 Td
[()1()-11()-11()2(")2()1()4(")-18()]TJ
3.9967 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()4()-5(\n)1()5(%)1()13()-6( )]TJ
4.0762 0 Td
[(&)15()]TJ
1.1792 0 Td
[(@,)32(:)56(!B,)]TJ
4.1499 0 Td
[()11()]TJ
1.0148 0 Td
[(B)]TJ
3.515 0 Td
[(,)37()]TJ
3.0727 0 Td
[(\n)18()]TJ
0.9638 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()-5()1()4()]TJ
2.0126 0 Td
[()11()]TJ
1.0148 0 Td
[()3(\n)8()-29($)8()2()5()]TJ
3.0954 0 Td
[()8()11()]TJ
1.3776 0 Td
[()]TJ
-35.0982 -1.2983 Td
[()4()-5(\n)1()5(%)1()13()1()4()1()19()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 230.0031 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Confocal)Tj
4.1433 0 Td
(Microscopy)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 212.9952 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(,)-5()]TJ
1.5193 0 Td
[(345)]TJ
1.7461 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[(+)-5()13()15(1)-3()]TJ
2.7609 0 Td
[()6()]TJ
1.0261 0 Td
[(06>)]TJ
1.9276 0 Td
[(")-1()11()2()-17()12(%)2()1()4(")-1()]TJ
4.5354 0 Td
[()11()]TJ
1.2642 0 Td
[(-!1)8()5()-5()]TJ
2.6476 0 Td
[(+)-6()-2(\n)1()5()]TJ
2.0976 0 Td
[(")6()3(\n)8()10(&)-9()1()]TJ
3.702 0 Td
[()5()1()2( )2()2()]TJ
2.6192 0 Td
[()-16()5()-5()3()]TJ
2.16 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-11(2)9()-6( )]TJ
2.177 0 Td
[(1)-3()12()-4()]TJ
-34.3783 -1.2982 Td
[(>)]TJ
1.4513 0 Td
[(3)20()11()-4()3(\n)-4()1()1()]TJ
3.9061 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[(&)6()2()-9(")6(*)10()-6( )]TJ
3.3165 0 Td
[(1)-3()12()-4()]TJ
1.9955 0 Td
[(3)20(")]TJ
1.1566 0 Td
[(&)6()2()-9(")6(*)]TJ
2.3754 0 Td
[(6>)]TJ
2.279 0 Td
[()19(%)1()3(\n)8()]TJ
3.0614 0 Td
[()-7()1()-10(%)1(\r6>)]TJ
4.7395 0 Td
[()4()11(%)3()-7()]TJ
2.8347 0 Td
[()-7()1()-10(%)1()]TJ
2.6985 0 Td
[()1()]TJ
1.0262 0 Td
[(B)5(=5)]TJ
2.398 0 Td
[()-16()5()-5()3()]TJ
-34.9622 -1.3039 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()1()4(")-6(%)5(&)-5(\n)18()6()-6( )]TJ
4.1385 0 Td
[()8()11()]TJ
1.3777 0 Td
[()4()11(%)1()]TJ
2.6192 0 Td
[(\n)18()]TJ
0.9581 0 Td
[()13()-9()11()]TJ
2.3981 0 Td
[()6()1()19()-9()1(\n)18()10(%)1()13()]TJ
5.1023 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(\n)8()19()-5(!!3.:)8()]TJ
6.9448 0 Td
[(9)]TJ
2.5966 0 Td
[(?+\r66?)]TJ
4.1952 0 Td
[(\n)8()4( )]TJ
-34.418 -1.2983 Td
[(\n)8()19()-5(!B!B)5()]TJ
6.8938 0 Td
[(")6()2()11()4(-H9)]TJ
5.7883 0 Td
[(,K)40()]TJ
2.4888 0 Td
[()5()1()2()4()-5(\n)18()-9()6()1()3()]TJ
5.4255 0 Td
[()]TJ
2.1883 0 Td
[(G9?+\r66?)]TJ
5.3744 0 Td
[()11()]TJ
1.0829 0 Td
[(\n)8()19()-5(!06!B)5()]TJ
5.9414 0 Td
[(?+\r)]TJ
-35.1834 -1.2983 Td
[(66?)]TJ
2.4207 0 Td
[(6)]TJ
2.7836 0 Td
[(=)8()2()6()2()-1(+)7()1()4( )6()]TJ
4.388 0 Td
[(5)-3(\n)8()]TJ
1.6725 0 Td
[()1()2()-1(+)7()30()]TJ
2.8062 0 Td
[()]TJ
2.126 0 Td
[()-4()-5()]TJ
1.406 0 Td
[()2(2)-9()1()-4()1()4()1()19()]TJ
5.1137 0 Td
[(\n)-4()3()-7()]TJ
1.7744 0 Td
[()1()4(")6()12(%)2( )2()-6( )]TJ
3.668 0 Td
[()5()-6(\n)8()1()2()1()8(+)]TJ
3.3903 0 Td
[(1)-3()12()-4()]TJ
1.9955 0 Td
[(.)27(+F)]TJ
-33.5449 -1.2982 Td
[()3()-7()11()-2()-1()-9()]TJ
3.0443 0 Td
[(")-1()11()19()-5()13()6()3()]TJ
3.464 0 Td
[(.)27(+!3.:)8()]TJ
5.0853 0 Td
[('=)8()2()1()-7(")2()1()4(")-1()2()]TJ
5.7486 0 Td
[(5)-3(\n)8()]TJ
1.6668 0 Td
[()1()2()-1(+)7()30()]TJ
2.8062 0 Td
[(\))]TJ
2.1317 0 Td
[(.)27(+!B)5()]TJ
3.7417 0 Td
[('=)8()2()6()2()-1(+)7()1()4( )6()]TJ
4.7338 0 Td
[(5)-3(\n)8()]TJ
1.6725 0 Td
[()1()2()-1(+)7()30()]TJ
-34.0949 -1.3039 Td
[(\))]TJ
2.2506 0 Td
[(\n)18()]TJ
0.9638 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()-6(\n)8()4()]TJ
2.2563 0 Td
[(")-1()11()4(")-1()1()19()-5(\n)18()-5()2()11()8()]TJ
6.3496 0 Td
[(:)1()4()]TJ
1.7801 0 Td
[()19(%)2(")6()2()1()]TJ
2.6306 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[(")-1()11(%)1()19()6()1()]TJ
3.2825 0 Td
[()5()-6(\n)8()1()4()-6( )]TJ
3.0671 0 Td
[(1)-3()12()-4()]TJ
1.9955 0 Td
[()37(B)5(.)]TJ
2.5342 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(?+\r)-5()6()]TJ
3.2768 0 Td
[()-16()5()-5()3()]TJ
-34.9112 -1.2983 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()4()11(%)1()19()6()-6( )]TJ
3.8381 0 Td
[(%)3()2()1()8(+)]TJ
2.364 0 Td
[(B)7()13(!+)7()6()2( )]TJ
3.7361 0 Td
[(\n)8()19()-5(!)-1(\n)2( )2()]TJ
3.787 0 Td
[()4()-6( )1()-2(\n)]TJ
2.6703 0 Td
[(4)-5()1()8()]TJ
2.0636 0 Td
[(:)99()-6(")6()2()4()6()2()1(+)-5()2()2()]TJ
5.7146 0 Td
[()-10(\n)8()5()3(&)-5(\n)2( )6()]TJ
3.9741 0 Td
[()]TJ
2.126 0 Td
[(.)17()3(\n)6(+)7()2()]TJ
3.0444 0 Td
[(1)8()1()13()]TJ
-35.4158 -1.2983 Td
[()-6(\n)-4(*)10()1()]TJ
2.4094 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(\n)8()]TJ
1.2019 0 Td
[(/)3()7()-3()19()11(%)3()]TJ
3.8891 0 Td
[(3)12(%)2(!J)47()2()-9(1)]TJ
4.422 0 Td
[(H66)]TJ
1.6611 0 Td
[(")-1()11()2()8()-9(")-3(\n)-4()]TJ
3.5773 0 Td
[()2()2(")13()1()-7(")-1()11()-9()]TJ
4.7962 0 Td
[()-1()1()5()6()1()]TJ
2.9423 0 Td
[(<)42()2()7($)8()1()7()2()12()-2()]TJ
4.7225 0 Td
[()11()]TJ
1.0148 0 Td
[()5()2(")6()2()1(+)2(\n)8()]TJ
-32.6265 -1.3039 Td
[()5()2(")13()1()-7(")-1()11()15()]TJ
4.9095 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[(.)17()3(\n)6(+)7()]TJ
2.6815 0 Td
[()3()3(\n)-4()7()1()2()3()]TJ
3.5887 0 Td
[()-16()11()13()]TJ
2.5001 0 Td
[(\n)18()]TJ
0.9581 0 Td
[(G662)]TJ
2.1317 0 Td
[(\n)8()4( 6662)]TJ
4.3256 0 Td
[()-4()-5()]TJ
1.4116 0 Td
[()1()3(\n)6(+)7()2()]TJ
2.9707 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[(")-1()11()-4()13()-6(")-6()6()-6( )]TJ
3.9401 0 Td
[()8()11()]TJ
1.3776 0 Td
[(&)-5(\n)2(")6(*!)]TJ
-34.6164 -1.2983 Td
[(+)-5()13()11(%)1()4( )6()]TJ
3.3448 0 Td
[()-4()2()13()2()5()4()6()2( )3()]TJ
4.371 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[( )2()1()6()1()-4()2()1()4()-6( )]TJ
4.7962 0 Td
[(&)15()]TJ
1.1792 0 Td
[()37(B)5(.)]TJ
2.5342 0 Td
[(\n)-4()2()11()4()6()]TJ
2.5908 0 Td
[(.)27(+!3.:)8()]TJ
4.7395 0 Td
[(\n)-4()2()11()4()6()]TJ
2.5909 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[(.)27(+!B)5()]TJ
3.7473 0 Td
[(\n)-4()2()11()4()6()]TJ
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 528.7748 745.7952 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(CD13)Tj
2.7567 0 Td
(on)Tj
1.3181 0 Td
(FLS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(PLOS)Tj
2.8771 0 Td
(ONE)Tj
2.3812 0 Td
(|)Tj
0.4819 0 Td
(DOI:10.1)Tj
3.9827 0 Td
(371/journ)Tj
4.1315 0 Td
(al.pone.0162)Tj
5.7331 0 Td
(008)Tj
2.6504 0 Td
(September)Tj
5.0812 0 Td
(22,)Tj
1.6016 0 Td
(2016)Tj
36.2057 0 Td
(4)Tj
0.7725 0 Td
(/)Tj
ET
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
BT
66.402 0 Td
(20)Tj
ET
Q
endstream
endobj
60 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 61 0 R/Contents 62 0 R/TrimBox[0 0 612 792]>>
endobj
61 0 obj
[63 0 R 64 0 R]
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.ref010)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpone.0162008.g001)>>
endobj
62 0 obj
[65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R]
endobj
65 0 obj
<>stream
q
0.83 0.64 0.02 0 k
256.8189 185.8961 m
266.4 185.8961 l
h
f*
438.8598 120.926 m
465.1654 120.926 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()-16(!)2()-9(")-3(\n)-4()1(#\n)18()-5()2()11()]TJ
6.3098 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[(\n)8()3(\n)-4()7(#)-2()-6( )]TJ
3.702 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(.)17()3(\n)6(+)7(D)]TJ
3.0047 0 Td
[(%)3()2()1()8(+)]TJ
2.3698 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()6()12(%)1(+!)1()]TJ
3.1295 0 Td
[(P)37()-16()6()2()-9(")-3(\n)-4()1(#\n)18()-5()2()11()81(Q)158()]TJ
6.9675 0 Td
[(&)15()]TJ
1.1792 0 Td
[(B)7()2()1()-4()13()]TJ
2.6078 0 Td
[(=)-19()11(%)1()23(!)]TJ
-34.4293 -1.3039 Td
[( )2()11()4(")6()2()6()]TJ
3.084 0 Td
[(.)17()8()5()-5()12()10(%)12()]TJ
3.1521 0 Td
[(D)28(\n)2(")-1(@)10(%)2()2()]TJ
3.2145 0 Td
[()26()11()4()-9( )6()]TJ
3.3845 0 Td
[(5)-15()1()-29($)-3()2(")-1()]TJ
3.0274 0 Td
[(.)17()3(\n)6(+)7()1()-4()2()6()]TJ
3.9402 0 Td
[(B)22(\n)8()-4()3()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 668.1259 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Quantitative)Tj
5.537 0 Td
(RT-PCR)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 651.1181 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(,)37()]TJ
3.0727 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()3()-7()6()-2(\n)18()6()-6( )]TJ
3.2768 0 Td
[()-11()13()11()]TJ
2.194 0 Td
[(345)]TJ
1.7405 0 Td
[()]TJ
1.0431 0 Td
[(1)8()5()-5()3()]TJ
2.1827 0 Td
[()11()]TJ
1.0091 0 Td
[(\n)]TJ
0.6576 0 Td
[(G!1)8()5()-5()]TJ
2.6476 0 Td
[()6()-2(\n)18()6()]TJ
2.4944 0 Td
[(%)3()2()1()8(+)]TJ
2.3698 0 Td
[()-4()4()]TJ
1.4683 0 Td
[(,)37()26()-5(\n)1()-1()]TJ
3.9458 0 Td
[(I)7()12()]TJ
1.4514 0 Td
[(\n)8()4( )]TJ
1.7177 0 Td
[(R)1()-2(\n)2(")-6(%)5(&)-9()]TJ
-32.9723 -1.2982 Td
[(R)1()-2(\n)6(+)7()1()]TJ
3.6396 0 Td
[(J)97()1()-5()2()30()]TJ
2.846 0 Td
[()25()1()-4()4()1()5()-2(\n)8()4( )3()]TJ
5.6749 0 Td
[(")9()37()]TJ
2.7949 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()11()13()1()-5(\n)8()13()-6( )]TJ
3.7871 0 Td
[(%)3()2()1()8(+)]TJ
2.3641 0 Td
[(\n)]TJ
0.6576 0 Td
[(C)17()1(+)-6()]TJ
2.2337 0 Td
[()-10(\n)18()-5(\n)2(")12()-2()]TJ
3.7133 0 Td
[(")9()37()]TJ
2.795 0 Td
[(I)7()12()]TJ
1.4513 0 Td
[(4)-5()1()8()]TJ
-33.6583 -1.3039 Td
[(:)99()-6(")6()2()4()6()2()1(+)-5()2()2()]TJ
5.7146 0 Td
[()-10(\n)8()5()3(&)-5(\n)2( )6()]TJ
3.9741 0 Td
[()]TJ
2.126 0 Td
[(R)-4(%)-2(\n)8()19()-5()12()-6(\n)18()-5()7($)8()]TJ
5.2044 0 Td
[()13()-9($)8()1()7()-7()]TJ
3.0273 0 Td
[()-5(\n)8()8()-7(")-4()12()11()-5()2()11()]TJ
5.3972 0 Td
[()-9()6()7()-3()4()1(\n)1()-7()]TJ
4.7678 0 Td
[(")6()3(\n)8()1()]TJ
2.4094 0 Td
[()13()-5(\n)2(")-6()-5()2()11()]TJ
-32.6208 -1.2983 Td
[(@,)32(:)56(!B,)]TJ
4.8358 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[( )2()11()4()]TJ
2.2053 0 Td
[(%)3()2()1()8(+)]TJ
2.3641 0 Td
[(:)92(\n)2(@)16(\n)8()]TJ
3.651 0 Td
[(F)-7()1()4()]TJ
2.3074 0 Td
[()-6(2)11()13()2()5()2()2()11()]TJ
4.5864 0 Td
[()16()5()-6(\n)18()1()]TJ
2.9027 0 Td
[()11()]TJ
1.2586 0 Td
[(\n)]TJ
0.6576 0 Td
[(9H66)]TJ
2.143 0 Td
[(,)-3()-5(\n)-4()]TJ
1.9389 0 Td
[(:)15()1()4()]TJ
2.3244 0 Td
[(B,)]TJ
2.0579 0 Td
[(5)16()1(!)]TJ
-34.9339 -1.2983 Td
[()6()1()]TJ
1.7517 0 Td
[(4)-5()1()8()]TJ
2.0637 0 Td
[(:)99()-6(")6()2()4()6()2()1(+)-5()2()2()]TJ
5.7146 0 Td
[()-10(\n)8()5()3(&)-5(\n)2( )6()]TJ
3.9741 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 572.8251 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Flow)Tj
2.3197 0 Td
(cytometry)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 555.8173 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(3)17()5(&)11()13()5(&)6()-2(\n)1()5()]TJ
4.5864 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()13()1()4()15($)8()-6( )]TJ
3.7134 0 Td
[()-11()13()11()]TJ
2.1883 0 Td
[()-17()-2(\n)1()5(*)]TJ
2.4208 0 Td
[(&)15()]TJ
1.1792 0 Td
[()]TJ
2.3981 0 Td
[()6(:)73()]TJ
2.8176 0 Td
[()1()]TJ
1.0261 0 Td
[(B)5(=5)]TJ
2.0523 0 Td
[()-16()5()-5()3()]TJ
2.16 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()5()-6(\n)8()1()4()-6( )]TJ
3.0671 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(.)27(+F)]TJ
-33.7944 -1.2982 Td
[()4()-1(+)2(\n)18()-5()7($)8()]TJ
3.855 0 Td
[(")-1()11()19()-5()13()6()]TJ
3.447 0 Td
[()11()]TJ
1.0828 0 Td
[(\n)8()19()-5(!)]TJ
4.4617 0 Td
[(H09)]TJ
5.4368 0 Td
[()-4()4()1()]TJ
2.0126 0 Td
[(+)7()-5(\n)18()]TJ
1.9162 0 Td
[(\n)8()19()-5(!)4()11(%)3()-7()]TJ
4.7395 0 Td
[(.)27(+F!)-4()2()2(2\n)]TJ
4.337 0 Td
[()-17()12(%)2()11()]TJ
2.1486 0 Td
[(--)]TJ
1.6554 0 Td
[(4)-5()1()8()]TJ
-35.0926 -1.2983 Td
[(:)99()-6(")6()2()4()6()2()1(+)-5()2()2()]TJ
5.7146 0 Td
[()-10(\n)8()5()3(&)-5(\n)2( )6()]TJ
3.9741 0 Td
[()]TJ
2.126 0 Td
[()12()-1()6()11()4()1()-5()-29()]TJ
4.4957 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()-9()1()-4()8()11()-4()4()-6( )]TJ
4.4333 0 Td
[()11()]TJ
1.2586 0 Td
[(\n)]TJ
0.6576 0 Td
[(=)4()]TJ
1.5364 0 Td
[(=)8()2()1()-7(")2()1()4(")-1()2()]TJ
4.7679 0 Td
[(3)78()28(5)-10(\n)-4()1()5(&)11(%)1()64()]TJ
-30.665 -1.3039 Td
[(F)-1(\n)18()-5()1()8(+)]TJ
2.931 0 Td
[(1)1(\n)1()]TJ
1.7007 0 Td
[( )2()11()4()]TJ
2.1997 0 Td
[()6()]TJ
1.0205 0 Td
[()3()-7()6()-2(\n)18()6()]TJ
2.7552 0 Td
[()-4()4()]TJ
1.474 0 Td
[()3(\n)18(;)-5()11()]TJ
2.5852 0 Td
[(")-1()5()-5()]TJ
1.5534 0 Td
[()-9()11()11(%)-5()-2(\n)18()-5()2()11()]TJ
4.5807 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()2(2)9(")6()12(%)2( )2()]TJ
3.2372 0 Td
[( )2()3(&)11()-4()3()]TJ
2.6475 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[( )2()-5(\n)2( )]TJ
2.1146 0 Td
[(")-1()5()-5()3()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 490.5637 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(FLS)Tj
2.0504 0 Td
(Growth)Tj
3.4346 0 Td
(and)Tj
1.8756 0 Td
(Migration)Tj
4.3087 0 Td
(Assays)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 473.5559 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(,)-5()]TJ
1.5193 0 Td
[(345)]TJ
1.7461 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[()-7()-6()-6( )2()-6( )]TJ
2.8743 0 Td
[()11()]TJ
1.2642 0 Td
[()-3()5()-7()1()]TJ
2.4718 0 Td
[(.)17()3(\n)6(+)7()]TJ
2.6816 0 Td
[(4)-9()-9(")6(*)]TJ
2.16 0 Td
[(0G!1)8()5()-5()]TJ
3.1294 0 Td
[()6()-2(\n)18()6()2()]TJ
2.5115 0 Td
[()-3()5()-7()1()]TJ
2.8176 0 Td
[(=)8()2()1()-7(")2()1()4(")-1()6()]TJ
4.6204 0 Td
[()3()2()]TJ
1.9899 0 Td
[()3()-1(&)-9()11()64()]TJ
2.8573 0 Td
[(.)]TJ
-34.7411 -1.2982 Td
[()15($)8()1()-4()2()1(+)-6()19()]TJ
4.0535 0 Td
[(\n)18()]TJ
0.9637 0 Td
[()1()12()-4()4()1()]TJ
2.5115 0 Td
[(666)]TJ
2.3584 0 Td
[(")-1()5()-5()3(\r1)8()5()-5()]TJ
3.8381 0 Td
[()8()11()]TJ
1.3776 0 Td
[(+)-5()13()15(1)-1()-4()]TJ
3.0558 0 Td
[()11()]TJ
1.0828 0 Td
[(6666)]TJ
2.8403 0 Td
[(")-1()5()-5()3(\r1)8()5()-5()]TJ
3.8381 0 Td
[()8()11()]TJ
1.3776 0 Td
[()2()1(+)-5(\n)18()-5()2()11()]TJ
4.3767 0 Td
[(3)20()11()]TJ
1.61 0 Td
[(+)-5()13()15(1)-1()-4()]TJ
3.0558 0 Td
[()-4()4()]TJ
-36.3399 -1.3039 Td
[(6>)]TJ
1.9275 0 Td
[(3=5)]TJ
1.7972 0 Td
[(,4)]TJ
2.9083 0 Td
[()4()-6( )1()-2(\n)]TJ
2.6702 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[()13()1()4()15($)8()-6( )]TJ
3.7133 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[(")-1()5()-5()3()]TJ
1.9162 0 Td
[(1)1(\n)1()5()4()-6( )]TJ
3.1691 0 Td
[(2)]TJ
1.1735 0 Td
[(1)-3()12()-4()]TJ
1.99 0 Td
[(B)5(=5)]TJ
2.0522 0 Td
[(66?)]TJ
2.4208 0 Td
[()11()]TJ
1.0148 0 Td
[()4()-6( )1()12(%)1()]TJ
3.566 0 Td
[(\n)-4()2()11()4()]TJ
-33.7434 -1.2983 Td
[(")-1()11()19()-5()13()6()]TJ
3.787 0 Td
[()11()]TJ
1.0828 0 Td
[()4()-6( )1()12(%)1()]TJ
3.566 0 Td
[(")-1()11()19()-6(\n)8()1()2()1()8(+)]TJ
4.4844 0 Td
[(\n)8()19()-5(!)]TJ
3.9855 0 Td
[(H)]TJ
1.525 0 Td
[()11()]TJ
1.0828 0 Td
[(H6)8(+\r)-5()6()]TJ
3.7871 0 Td
[(/)9(I:)]TJ
2.9423 0 Td
[(%)3()-7()-6( )]TJ
2.041 0 Td
[(\n)1()]TJ
1.0261 0 Td
[(\n)]TJ
0.6576 0 Td
[()4()11(!)13()-5(\n)2(")-6()-5()7($)8()]TJ
5.2328 0 Td
[()3()-7(!)]TJ
-35.2004 -1.2983 Td
[()-2()-1()-9()]TJ
1.9162 0 Td
[(")-1()11()19()-5()13()6()]TJ
3.101 0 Td
[(\n)8()19()-5()5(&)-9()-9( )7()]TJ
3.7417 0 Td
[()1()]TJ
1.0262 0 Td
[()-4()2()3()]TJ
1.6781 0 Td
[()2(2)-9()1()-4()1()4()1()19()]TJ
5.3064 0 Td
[(\n)8()19()-5(!)]TJ
4.4674 0 Td
[(9)]TJ
1.9049 0 Td
[()11()]TJ
1.0884 0 Td
[(7H)]TJ
3.0331 0 Td
[(=)8()2()6()2()-1(+)7()1()4( )6()]TJ
4.7338 0 Td
[(5)-3(\n)8()]TJ
1.6725 0 Td
[()1()2()-1(+)7()30()]TJ
-33.6697 -1.2982 Td
[()]TJ
1.9105 0 Td
[(H)]TJ
1.5193 0 Td
[()11()]TJ
1.0885 0 Td
[(H6)]TJ
1.1793 0 Td
[()8(+\r)-5()]TJ
3.1691 0 Td
[()11()]TJ
1.0828 0 Td
[()]TJ
2.5682 0 Td
[(")6()4()1()2()2(")-3(\n)-4()]TJ
3.7644 0 Td
[()1()-5()2()5(&)11()12()6()11()7()]TJ
4.1102 0 Td
[(\n)2(")-6()-5()1()4()11()2()1()]TJ
4.0251 0 Td
[(5)6()1(+)-5()3(\n!)-4()2( )1()-4()2(")6()]TJ
6.6104 0 Td
[(5)14()-1()]TJ
1.2132 0 Td
[(4)-9()11(%)1()3()]TJ
2.6192 0 Td
[()9(/)]TJ
-34.8602 -1.3039 Td
[()11()]TJ
1.0828 0 Td
[(&)-9()2()5()-6(\n)18()-5()1()]TJ
3.3505 0 Td
[(5)6()1(+)-5()3(\n!)-4()2( )1()-4()2(")6()]TJ
6.6104 0 Td
[(5)14()-1()]TJ
1.2075 0 Td
[(4)-9()11(%)1()3()]TJ
2.6192 0 Td
[()9(/)]TJ
2.194 0 Td
[(6?)]TJ
2.9197 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[(H6?)]TJ
2.5795 0 Td
[()13()2()5()-9()-6(")-6()-5()7($)8()5()7()]TJ
5.2157 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[(\n)2( )2( )2()-6( )]TJ
2.6362 0 Td
[()6()]TJ
1.0261 0 Td
[()-4()4()]TJ
-34.8602 -1.2983 Td
[(1)8()5()-5()3()]TJ
2.398 0 Td
[(.)17()3(\n)6(+)7()2()]TJ
3.0444 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[(")-1()11()2()-17()12(%)2()1()4(")-1()]TJ
4.5354 0 Td
[( )-2(\n)18()-6(\n)]TJ
1.9219 0 Td
[(1)8()1()13()]TJ
2.0919 0 Td
[(")-1()6()-5()2()-6(")-6()6()-6( )]TJ
3.7134 0 Td
[(%)3()2()1()8(+)]TJ
2.3697 0 Td
[(\n)8()]TJ
1.2019 0 Td
[()-3()5()-7()1()]TJ
2.4718 0 Td
[(.)17()4(")-6(%)12()-1()6()]TJ
3.8664 0 Td
[()-3()5()-7()1()]TJ
2.8177 0 Td
[(=)8()2()1()-7(")2()1()4(")-1()6()]TJ
-32.156 -1.2983 Td
[()3()2()]TJ
1.9899 0 Td
[()3()-1(&)-9()11()64()]TJ
2.8573 0 Td
[(.)]TJ
2.0069 0 Td
[(3)20()11()]TJ
1.6044 0 Td
[()-4()4()]TJ
1.474 0 Td
[()-7("\n)18()6(")6()]TJ
3.0557 0 Td
[(1)8()11(%)1()4( )]TJ
2.982 0 Td
[()2()1(+)-5(\n)18()-5()2()11()]TJ
4.1613 0 Td
[(\n)1()5()-6(\n)18()]TJ
2.2847 0 Td
[(1)8()11(%)1()4( )3()]TJ
3.3448 0 Td
[(1)8()1()13()]TJ
2.0977 0 Td
[()3(\n)2( )2()]TJ
2.4094 0 Td
[($)-3()-2(\n)]TJ
1.3776 0 Td
[()-4()4()]TJ
1.474 0 Td
[()-3()5()-7()1()]TJ
-33.1197 -1.3039 Td
[()-7("\n)18()6(")6()]TJ
3.0557 0 Td
[(1)8()11(%)1()4( )]TJ
2.982 0 Td
[()6()-9()6()]TJ
1.7745 0 Td
[()1()]TJ
1.0205 0 Td
[()-4()4()]TJ
1.474 0 Td
[()-7()-6()-6( )2()-6( )]TJ
2.8799 0 Td
[(0G!1)8()5()-5()]TJ
3.1238 0 Td
[()6()-2(\n)18()6()6()]TJ
2.3697 0 Td
[(B)6()-2(\n)18()6()2()]TJ
2.5569 0 Td
[(1)8()1()13()]TJ
2.0976 0 Td
[()-4()4()1()]TJ
2.0126 0 Td
[(1)1(\n)1()5()4()-6( )]TJ
3.1691 0 Td
[(2)]TJ
1.1679 0 Td
[(1)-3()12()-4()]TJ
1.9956 0 Td
[(B)5(=5)]TJ
1.8368 0 Td
[(\n)8()4( )]TJ
-33.5166 -1.2983 Td
[()4()-6( )1()12(%)1()]TJ
3.5546 0 Td
[(1)1(\n)1()]TJ
1.6951 0 Td
[(\n)2( )2( )2()-6( )]TJ
2.6248 0 Td
[()2()1()2()-5()-2(\n)8()]TJ
2.9651 0 Td
[()6()]TJ
1.0148 0 Td
[()-4()4()]TJ
1.4626 0 Td
[(+)-5()13()15(1)-1()-4()]TJ
3.0444 0 Td
[()6()-2(\n)18()6()2()]TJ
2.7269 0 Td
[()-6(\n)18()-6(\n)]TJ
2.1147 0 Td
[(1)8()1()13()]TJ
2.0919 0 Td
[(")-1()6()-5()2()-6(")-6()6()-6( )]TJ
3.702 0 Td
[(\n)8()4( )]TJ
1.7122 0 Td
[()-4()4()]TJ
1.4626 0 Td
[(")-1()11()2()-17()12(%)2()1()4(")-1()]TJ
4.5241 0 Td
[()11()]TJ
1.0772 0 Td
[()13()5()-2(\n!)]TJ
-35.773 -1.2982 Td
[()-5()7($)8()]TJ
1.6554 0 Td
[(1)8()11(%)1()4( )]TJ
2.9877 0 Td
[( )2()1()8()2()12()-2()]TJ
3.084 0 Td
[(")-3(\n)-4()2(")-6(%)-5()-2(\n)18()6()-6( )]TJ
4.1953 0 Td
[(&)15()]TJ
1.1792 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()-3()5()-7()1()]TJ
2.4718 0 Td
[(.)17()4(")-6(%)12()-1()6()6()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 304.2708 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Statistics)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 287.2629 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()-6(\n)18()-6(\n)]TJ
2.1259 0 Td
[(\n)8()13()]TJ
1.44 0 Td
[()2(2)11()13()2()5()-7()-6( )]TJ
4.0762 0 Td
[(\n)1()]TJ
1.0261 0 Td
[()4()-5(\n)8(S)5()-6(\n)8()4( )1(\n)2( )]TJ
6.497 0 Td
[()1()-4()13()11()]TJ
2.2337 0 Td
[()11()]TJ
1.0091 0 Td
[()-4()4()]TJ
1.474 0 Td
[()4()-5(\n)8()]TJ
2.4265 0 Td
[(5)11()]TJ
3.05 0 Td
[(345)]TJ
1.7405 0 Td
[( )-2(\n)18()-6(\n)]TJ
1.9162 0 Td
[(\n)8()13()]TJ
1.44 0 Td
[()2(2)11()13()2()5()-7()-6( )]TJ
4.0819 0 Td
[(\n)1()]TJ
1.0204 0 Td
[(\n)]TJ
-35.5575 -1.2982 Td
[(\n)18()-5()2()]TJ
2.0862 0 Td
[()11()]TJ
1.0092 0 Td
[()-5()13()-5(\n)18()6()-6( )]TJ
2.9877 0 Td
[(345)]TJ
1.7404 0 Td
[()6()]TJ
1.0205 0 Td
[(%)1()19()-5()13()-5(\n)18()6()-6( )]TJ
4.0478 0 Td
[(345)]TJ
1.9616 0 Td
[(5)14()-6(\n)18()-5()3()5()-5()2(")-3(\n)-4()-5()7()]TJ
4.7338 0 Td
[()2()1(+)-5()2()1()-11()2(")-3(\n)8()4(")-1()]TJ
4.8926 0 Td
[(1)1(\n)1()]TJ
1.7008 0 Td
[( )2()1()6()1()-4()2()1()4()-6( )]TJ
4.7962 0 Td
[(&)15()]TJ
1.1792 0 Td
[(%)1()19()-5(\n)8()1()13()-6( )]TJ
3.804 0 Td
[()5()10(%!)]TJ
-35.96 -1.2983 Td
[( )2()1()19()]TJ
2.0012 0 Td
[(:)56(!)6()2()5()-1()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 234.9921 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(Results)Tj
/F0 1 Tf
0 -1.4976 Td
(CD13)Tj
2.759 0 Td
(is)Tj
0.9355 0 Td
(found)Tj
2.7071 0 Td
(on)Tj
1.3275 0 Td
(Extracellular)Tj
5.693 0 Td
(Vesicles)Tj
3.926 0 Td
(Including)Tj
4.1953 0 Td
(Exosomes)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 200.0125 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(.)39()]TJ
0.856 0 Td
[()3(\n)1()]TJ
1.5534 0 Td
[(&)-9()-6()1()]TJ
2.0976 0 Td
[()11()13()-9($)-3()2()11(%)3()5()7()]TJ
4.337 0 Td
[()5()4()15(1)-3()]TJ
2.8403 0 Td
[()-4()3(\n)18()]TJ
1.7915 0 Td
[()]TJ
2.5681 0 Td
[()3()]TJ
0.8448 0 Td
[()11()13()2()-7()1()19()]TJ
3.1464 0 Td
[()1()]TJ
1.0261 0 Td
[()-1()-3()4()15($)-3()-2(\n)-4()]TJ
3.4923 0 Td
[()-17()12(%)1()2( )3()]TJ
2.6475 0 Td
[()-7()1()-10(%)1()]TJ
2.9254 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[(345)]TJ
1.7461 0 Td
[(")-6(%)-5()12()10(%)1()13()]TJ
-33.5903 -1.3039 Td
[()5(%)12()-9()1()-4()3(\n)18()-6(\n)8()19()]TJ
5.3404 0 Td
[(')]TJ
0.83 0.64 0.02 0 k
[(6)]TJ
0 g
[(\))]TJ
2.0863 0 Td
[(C)25()15(1)8()-9($)8()1()64()]TJ
4.0365 0 Td
[()-4()4()]TJ
1.4683 0 Td
[(@)10(%)2()2()5()-5()2()11()]TJ
3.6397 0 Td
[()13()1()3(\n)8()1()8()]TJ
3.4185 0 Td
[(\n)1()]TJ
1.0262 0 Td
[()6()]TJ
1.0204 0 Td
[(1)-7()4()1()-4()4()1()]TJ
3.464 0 Td
[()]TJ
2.5681 0 Td
[()1()]TJ
1.0205 0 Td
[()-4()4()1()-7()]TJ
2.3357 0 Td
[()-17()12(%)1()2( )3()]TJ
2.4321 0 Td
[()3()]TJ
0.8448 0 Td
[(\n)]TJ
0.6576 0 Td
[()-7()6()12(%!)]TJ
-35.3591 -1.2982 Td
[(&)6()2()]TJ
1.3889 0 Td
[()4()6()2()-6(")-6(%)-5()2()]TJ
3.8041 0 Td
[()11()]TJ
1.0828 0 Td
[(&)-9()11(%)1()4( )]TJ
2.8063 0 Td
[()11()]TJ
1.2642 0 Td
[()-4()4()]TJ
1.474 0 Td
[()5(%)1()-4()-1(\n)2(")-1()]TJ
3.0331 0 Td
[()11()]TJ
1.0148 0 Td
[()2(2)-5(\n)2(")-1()5()-5()12(%)-5()-2(\n)8()]TJ
5.1193 0 Td
[($)8()2()2()2(")6()2()2()]TJ
3.3902 0 Td
[(:)99()]TJ
1.3323 0 Td
[()6()2()5()]TJ
1.6101 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()-9()1()5()2()5(&)11()-5()1()12()-2()]TJ
4.269 0 Td
[()-4()3(\n)18()]TJ
1.7915 0 Td
[()2(2)-5(\n!)]TJ
-34.8489 -1.2983 Td
[(")-1()5()-5()12(%)-5()-2(\n)8()]TJ
3.1294 0 Td
[($)8()2()2()2(")6()2()2()]TJ
3.1691 0 Td
[()11(J)]TJ
2.5342 0 Td
[(\n)-4()3()-7()]TJ
1.7744 0 Td
[(")-1()11()19()-6(\n)8()1()]TJ
3.2202 0 Td
[()]TJ
2.7892 0 Td
[(1)8()]TJ
1.3153 0 Td
[()3()-7()6()-2(\n)18()6()-6( )]TJ
3.2712 0 Td
[()11(J)]TJ
1.8481 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[()4()-5(\n)1()5(%)1()13()-6( )]TJ
4.0762 0 Td
[()]TJ
2.5625 0 Td
[()1()]TJ
1.0261 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()11(J)]TJ
1.4853 0 Td
[(\n)8()4( )]TJ
-35.3931 -1.2983 Td
[()-7()6()12(%)5(&)6()2()]TJ
3.0217 0 Td
[()11()13()11()6()1()1()]TJ
3.1294 0 Td
[()-11(\n)2(")-6()-5()2()11()8()]TJ
3.9231 0 Td
[(7)97()]TJ
1.6044 0 Td
[(%)3()-7()-6( )]TJ
2.0466 0 Td
[( )1()1()-11()8()1()13()1()19()-5()-2(\n)-4()]TJ
4.5808 0 Td
[(%)-5()12()-5(\n)2(")-1()1()19()-5()-4()1()-7(%)1(+)2(\n)18()-5()2()11()]TJ
7.7158 0 Td
[()6()]TJ
1.0205 0 Td
[()3()-7()6()-2(\n)18()6()]TJ
2.7553 0 Td
[()11(J)]TJ
1.8481 0 Td
[(")-1()11()-4()13()2()5()-9()11()4( )1()1()8(+)]TJ
-31.6457 -1.3039 Td
[()6()]TJ
1.0204 0 Td
[()-4()4()]TJ
1.474 0 Td
[( )2()1()8()2()12()-2()]TJ
3.0841 0 Td
[()11()]TJ
1.0148 0 Td
[()2(2)9()1()-7()11()4()2()]TJ
4.286 0 Td
[(7)97()]TJ
1.6044 0 Td
[()2( )2()1()19()-5()1()-11()2()-6( )]TJ
4.0195 0 Td
[()]TJ
2.5625 0 Td
[()1()]TJ
1.0261 0 Td
[(&)-9()11()-4()]TJ
2.0523 0 Td
[()-7()6()12(%)5(&)6()2()]TJ
3.0273 0 Td
[()11()13()11()6()1()1()]TJ
3.1295 0 Td
[(\n)8()4( )]TJ
1.7178 0 Td
[()11(J)]TJ
1.4853 0 Td
[()-11(\n)2(")-6()-5()2()11()8()]TJ
3.702 0 Td
[()1()]TJ
-35.206 -1.2982 Td
[()6()-2(\n)1()2()3(\n)]TJ
3.2654 0 Td
[(,)-5()]TJ
1.5194 0 Td
[(345)]TJ
1.7461 0 Td
[(")-6(%)-5()12()10(%)1()13()]TJ
3.0104 0 Td
[()5(%)12()-9()1()-4()3(\n)18()-6(\n)8()19()-1()]TJ
5.193 0 Td
[(\n)8()4( )]TJ
1.7235 0 Td
[(,)-5()]TJ
1.525 0 Td
[()-1()-3()4()15($)-3()-2(\n)-4()]TJ
3.4923 0 Td
[()-17()12(%)1()2( )]TJ
2.0636 0 Td
[()]TJ
0.83 0.64 0.02 0 k
[(3)17()1(+)]TJ
1.8085 0 Td
[()]TJ
0 g
[()]TJ
1.9502 0 Td
[(7)97()]TJ
1.6044 0 Td
[(%)3()-7()-6( )]TJ
2.0466 0 Td
[()-4()4()]TJ
1.4684 0 Td
[()5()-9()-6(")1()-11()2(")]TJ
-32.4168 -1.2983 Td
[()]TJ
2.5625 0 Td
[()-6(\n)8()4( )7(1)-3()2(")6()]TJ
3.9741 0 Td
[(4.5)]TJ
2.8063 0 Td
[(\n)1()5()-6(\n)18()]TJ
2.2847 0 Td
[()6()]TJ
1.0261 0 Td
[()4()-5(\n)1()5(%)1()13()]TJ
3.5547 0 Td
[()]TJ
2.5625 0 Td
[(\n)8()4( )]TJ
1.7234 0 Td
[()-4()4()]TJ
1.474 0 Td
[()4()11(!)5()-9()-6(")1()-11()2(")]TJ
5.108 0 Td
[()1(#)-3()3(\n)18()-5()2(")]TJ
4.286 0 Td
[(\n)1()5()-6(\n)18()]TJ
2.2847 0 Td
[()6()]TJ
1.0204 0 Td
[()4()-5(\n!)]TJ
-34.6674 -1.3039 Td
[()5(%)1()13()]TJ
1.8878 0 Td
[(\n)8()2()1()4()11()-9()1()11()-5()2( )-2(\n)1()-7()]TJ
6.5367 0 Td
[(\n)2(")-6()-5()7($)-3()12()-2()74()]TJ
3.3392 0 Td
[(B)6()-2(\n)1()2()3(\n)]TJ
3.084 0 Td
[(")-1()11()19()-6(\n)8()1()4()-6( )]TJ
4.1613 0 Td
[(\n)8()]TJ
1.2018 0 Td
[(\n)18($)8()1(\n)6(+)7()]TJ
3.2145 0 Td
[()11()]TJ
1.0091 0 Td
[(H9-SG)8(+\r)-5()]TJ
7.4551 0 Td
[()11()]TJ
1.0148 0 Td
[()]TJ
2.5682 0 Td
[()11()]TJ
-35.4725 -1.2983 Td
[()11(J)]TJ
1.8425 0 Td
[(1)-3()12()-4()]TJ
1.9955 0 Td
[(\n)8()]TJ
1.2019 0 Td
[(\n)2(")-6()-5()7($)-3()12()-2()]TJ
3.1181 0 Td
[()11()]TJ
1.0091 0 Td
[(-9S6-H?\r)2()64()]TJ
8.8668 0 Td
[(\n)8()4( )]TJ
1.7177 0 Td
[(H9S-G-)8(+\r)-5()]TJ
7.937 0 Td
[()11()]TJ
1.0148 0 Td
[()-7()6()12(%)5(&)6()2()]TJ
3.0217 0 Td
[()]TJ
2.5682 0 Td
[(1)-3()12()-4()]TJ
1.9899 0 Td
[(\n)8()]TJ
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 528.7748 745.7952 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(CD13)Tj
2.7567 0 Td
(on)Tj
1.3181 0 Td
(FLS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(PLOS)Tj
2.8771 0 Td
(ONE)Tj
2.3812 0 Td
(|)Tj
0.4819 0 Td
(DOI:10.1)Tj
3.9827 0 Td
(371/journ)Tj
4.1315 0 Td
(al.pone.0162)Tj
5.7331 0 Td
(008)Tj
2.6504 0 Td
(September)Tj
5.0812 0 Td
(22,)Tj
1.6016 0 Td
(2016)Tj
36.2057 0 Td
(5)Tj
0.7725 0 Td
(/)Tj
ET
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
BT
66.402 0 Td
(20)Tj
ET
Q
endstream
endobj
74 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Contents 76 0 R/TrimBox[0 0 612 792]>>
endobj
75 0 obj
<>stream
JFIF C
$, !$4.763.22:ASF:=N>22HbINVX]^]8EfmeZlS[]Y C**Y;2;YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY >"
} !1AQa"q2#BR$3br
%&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz
w !1AQaq"2B #3Rbr
$4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? (
%9!~Jk$wZh PKO˴ڽjEZՖOzM:/t.Pd@j((((((((((((((((((((((((((((((((((((((((((((((((((sRIn/$ lSz^I4돳c'Wմ]b^)hӴ6J[[D6