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Agata M. Bogusz, Alexandra E. Kovach, Long P. Le, Derek Feng, Richard H. G. Baxter, Aliyah R. Sohani
Diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression shows evidence of active B-cell receptor signaling by quantitative immunofluorescence
www.plosone.org
www.plosone.org
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()Tj
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(].)Tj
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-34.8885 -1.3039 Td
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(26)Tj
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3.753 0 Td
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7.5515 0 Td
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(31)Tj
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(].)Tj
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(,)Tj
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(].)Tj
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2.0012 0 Td
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3.0728 0 Td
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1.7291 0 Td
(BCL2)Tj
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ET
Q
q
1 j
1 J
0 w
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Q
q
1 j
1 J
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Q
q
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1 J
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Q
q
1 j
1 J
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Q
q
1 j
1 J
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Q
q
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1 J
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Q
q
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1 J
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Q
q
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1 J
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1 J
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q
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1 J
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1 J
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BT
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q
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ET
Q
q
1 j
1 J
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7.9999 0 0 7.9999 147.4582 518.4 cm
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[( )]TJ
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[( )]TJ
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(30)Tj
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(24)Tj
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[( )]TJ
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[( )]TJ
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(25)Tj
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1 J
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BT
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ET
Q
q
1 j
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[( )]TJ
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[( )]TJ
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(45)Tj
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[( )]TJ
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[( )]TJ
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[( )]TJ
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/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 445.8897 509.4425 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[( )]TJ
/F0 1 Tf
(5)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 517.5496 505.8708 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(4)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 535.4078 509.4425 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[( )]TJ
/F0 1 Tf
(5)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 43.9937 493.3984 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(GCB)Tj
13.7552 0 Td
(50)Tj
6.4418 0 Td
(10)Tj
6.4488 0 Td
(40)Tj
6.4985 0 Td
(8)Tj
6.5764 0 Td
(42)Tj
-39.7207 -1.5661 Td
(non-GCB)Tj
13.7552 0 Td
(43)Tj
6.4418 0 Td
(17)Tj
6.4488 0 Td
(26)Tj
6.2221 0 Td
(13)Tj
6.8528 0 Td
(30)Tj
9.2977 0 Td
(ns)Tj
11.1899 0 Td
(ns)Tj
-60.2083 -1.5591 Td
(BCL2)Tj
2.7071 0 Td
(\(%\))Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 78.0661 471.9685 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 147.4582 468.3968 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(45)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(37)Tj
6.4417 0 Td
(69)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(36)Tj
6.4489 0 Td
(36)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(34)Tj
6.2221 0 Td
(86)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(16)Tj
6.8599 0 Td
(34)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(34)Tj
9.0993 0 Td
(2)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 445.8897 471.9685 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[( )]TJ
/F0 1 Tf
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 515.8488 468.3968 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(6)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 533.707 471.9685 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[( )]TJ
/F0 1 Tf
(15)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 43.9937 455.8677 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(CD30)Tj
2.7638 0 Td
(\(%\))Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 78.4629 459.4393 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 149.6692 455.8677 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(8)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(18)Tj
6.4417 0 Td
(4)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(13)Tj
6.1725 0 Td
(10)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(19)Tj
6.4985 0 Td
(4)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(13)Tj
6.5835 0 Td
(10)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(19)Tj
10.1127 0 Td
(ns)Tj
11.1898 0 Td
(ns)Tj
-60.2082 -1.559 Td
(Ki67)Tj
2.211 0 Td
(\(%\))Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 74.0409 446.9669 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 147.4582 443.3952 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(63)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(24)Tj
6.4417 0 Td
(73)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(23)Tj
6.4489 0 Td
(59)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(23)Tj
6.2221 0 Td
(69)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(23)Tj
6.8599 0 Td
(62)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(23)Tj
9.3969 0 Td
(0.009)Tj
11.9056 0 Td
(ns)Tj
-60.2082 -1.5661 Td
(p53)Tj
1.8779 0 Td
(\(%\))Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 71.3763 434.4377 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 147.4582 430.8661 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(19)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(28)Tj
6.4417 0 Td
(29)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(33)Tj
6.4489 0 Td
(14)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(25)Tj
6.2221 0 Td
(27)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(30)Tj
6.8599 0 Td
(16)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(23)Tj
9.6733 0 Td
(0.05)Tj
11.6292 0 Td
(ns)Tj
-61.2074 -1.559 Td
(FISH)Tj
2.5016 0 Td
(\(+ve/-ve/N)Tj
4.6205 0 Td
(D\))Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 101.3669 421.9653 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(5)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 43.9937 405.8645 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(MYC)Tj
/F0 1 Tf
12.9189 0 Td
(7/81/5)Tj
6.4489 0 Td
(5/19/3)Tj
6.4489 0 Td
(2/62/2)Tj
6.2221 0 Td
(4/14/3)Tj
6.8528 0 Td
(3/67/2)Tj
10.1268 0 Td
(ns)Tj
11.1899 0 Td
(ns)Tj
/F15 1 Tf
-60.2083 -1.559 Td
(BCL2)Tj
/F0 1 Tf
12.6497 0 Td
(13/79/1)Tj
6.7181 0 Td
(3/23/1)Tj
6.1725 0 Td
(10/56/0)Tj
6.4985 0 Td
(3/17/1)Tj
6.5764 0 Td
(10/62/0)Tj
10.4032 0 Td
(ns)Tj
11.1899 0 Td
(ns)Tj
/F15 1 Tf
-60.2083 -1.5662 Td
(BCL6)Tj
/F0 1 Tf
12.9189 0 Td
(8/76/9)Tj
6.4489 0 Td
(3/20/4)Tj
6.4489 0 Td
(5/56/5)Tj
6.2221 0 Td
(2/15/4)Tj
6.8528 0 Td
(6/61/5)Tj
10.1268 0 Td
(ns)Tj
11.1899 0 Td
(ns)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 365.6692 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 362.1543 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(MYC)Tj
/F13 1 Tf
2.4378 0 Td
()Tj
/F0 1 Tf
0.9992 0 Td
(40%.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 353.707 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 350.1354 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(MYC)Tj
/F13 1 Tf
2.4378 0 Td
()Tj
/F0 1 Tf
0.9992 0 Td
(40%,)Tj
2.4945 0 Td
(BCL2)Tj
/F13 1 Tf
2.7142 0 Td
()Tj
/F0 1 Tf
0.9992 0 Td
(50%.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 341.6881 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 338.1165 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(p)Tj
/F0 1 Tf
(-value)Tj
3.2456 0 Td
(s)Tj
0.73 0 Td
(are)Tj
1.6653 0 Td
(uncorrecte)Tj
4.6914 0 Td
(d)Tj
0.7795 0 Td
(for)Tj
1.3961 0 Td
(multiple)Tj
3.6426 0 Td
(comparison)Tj
5.1307 0 Td
(s.)Tj
1.0134 0 Td
(Holm-Bon)Tj
4.4079 0 Td
(ferroni)Tj
3.0473 0 Td
(correction)Tj
4.3583 0 Td
(s)Tj
0.7299 0 Td
(\(MYC+)Tj
3.3591 0 Td
(vs.)Tj
1.5024 0 Td
(MYC-\):)Tj
/F15 1 Tf
3.3874 0 Td
(p)Tj
/F0 1 Tf
0.7795 0 Td
(=)Tj
0.815 0 Td
(0.02)Tj
2.1614 0 Td
(\(pLYN\),)Tj
/F15 1 Tf
3.6568 0 Td
(p)Tj
/F0 1 Tf
0.7795 0 Td
(=)Tj
0.8079 0 Td
(0.02)Tj
2.1614 0 Td
(\()Tj
/F13 1 Tf
(h)Tj
/F0 1 Tf
(pSYK,pBTK)Tj
/F13 1 Tf
6.0379 0 Td
(i)Tj
/F0 1 Tf
(\),)Tj
/F15 1 Tf
1.2259 0 Td
(p)Tj
/F0 1 Tf
0.7796 0 Td
(=)Tj
0.8149 0 Td
(2)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 563.8677 341.6881 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[( )]TJ
/F0 1 Tf
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 36 326.1543 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(\()Tj
/F15 1 Tf
(F)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 43.5401 324.7937 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(cyt)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 51.2503 326.1543 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(\),)Tj
/F15 1 Tf
0.8433 0 Td
(p)Tj
/F0 1 Tf
0.7795 0 Td
(=)Tj
0.8079 0 Td
(0.001)Tj
2.7142 0 Td
(\(BCL2\),)Tj
/F15 1 Tf
3.6567 0 Td
(p)Tj
/F0 1 Tf
0.7795 0 Td
(=)Tj
0.815 0 Td
(0.02)Tj
2.1614 0 Td
(\(Ki67\),)Tj
/F15 1 Tf
3.1536 0 Td
(p)Tj
/F0 1 Tf
0.7795 0 Td
(=)Tj
0.815 0 Td
(0.05)Tj
2.1614 0 Td
(\(p53\).)Tj
2.8276 0 Td
(Holm-Bon)Tj
4.4079 0 Td
(ferroni)Tj
3.0473 0 Td
(correction)Tj
4.3583 0 Td
(s)Tj
0.7299 0 Td
(\(DEL)Tj
2.4945 0 Td
(vs.)Tj
1.5095 0 Td
(non-DE)Tj
3.3591 0 Td
(L\):)Tj
/F15 1 Tf
1.396 0 Td
(p)Tj
/F0 1 Tf
0.7796 0 Td
(=)Tj
0.8149 0 Td
(0.08)Tj
2.1615 0 Td
(\(pLYN\),)Tj
/F15 1 Tf
3.6567 0 Td
(p)Tj
/F0 1 Tf
0.7795 0 Td
(=)Tj
0.8079 0 Td
(0.04)Tj
2.1614 0 Td
(\()Tj
/F13 1 Tf
(h)Tj
/F0 1 Tf
(pSYK,pB)Tj
4.7552 0 Td
(TK)Tj
/F13 1 Tf
(i)Tj
/F0 1 Tf
(\),)Tj
/F15 1 Tf
-61.4201 -1.5023 Td
(p)Tj
/F0 1 Tf
0.7796 0 Td
(=)Tj
0.8149 0 Td
(1)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 66.6141 317.707 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[( )]TJ
/F0 1 Tf
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 75.2314 314.1354 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(\()Tj
/F15 1 Tf
(F)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 82.8283 312.8314 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(cyt)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 90.4818 314.1354 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(\),)Tj
/F15 1 Tf
0.8433 0 Td
(p)Tj
/F0 1 Tf
0.7795 0 Td
(=)Tj
0.815 0 Td
(2)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 127.8425 317.707 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[( )]TJ
/F0 1 Tf
(14)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 139.748 314.1354 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(\(BCL2\).)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 305.6881 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 302.1165 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Expres)Tj
3.0897 0 Td
(sed)Tj
1.8355 0 Td
(as)Tj
1.2756 0 Td
(mean)Tj
2.7142 0 Td
(+/-)Tj
1.4244 0 Td
(standard)Tj
4.089 0 Td
(deviation.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 293.6692 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(5)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 290.1543 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(No)Tj
1.4952 0 Td
(cases)Tj
2.8276 0 Td
(of)Tj
/F15 1 Tf
1.063 0 Td
(MYC/BC)Tj
3.8693 0 Td
(L2)Tj
/F0 1 Tf
1.3323 0 Td
(or)Tj
/F15 1 Tf
1.1126 0 Td
(MYC/BC)Tj
3.8694 0 Td
(L6)Tj
/F0 1 Tf
1.3323 0 Td
(double-hit)Tj
4.585 0 Td
(lymphom)Tj
4.0253 0 Td
(a)Tj
0.7795 0 Td
(were)Tj
2.3811 0 Td
(identied.)Tj
-29.3174 -1.5023 Td
(Abbrevia)Tj
3.9117 0 Td
(tions:)Tj
2.6079 0 Td
(CHOPcyclo)Tj
6.1371 0 Td
(phosphamid)Tj
5.4 0 Td
(e,)Tj
1.063 0 Td
(doxorubici)Tj
4.5142 0 Td
(n,)Tj
1.063 0 Td
(vincristine,)Tj
4.9252 0 Td
(and)Tj
1.878 0 Td
(prednisone;)Tj
5.4142 0 Td
(COO)Tj
3.267 0 Td
(cell)Tj
1.715 0 Td
(of)Tj
1.063 0 Td
(origin;)Tj
2.9338 0 Td
(DELd)Tj
3.4725 0 Td
(ouble-expres)Tj
5.7331 0 Td
(sor)Tj
1.6158 0 Td
(lymphom)Tj
4.0252 0 Td
(a;)Tj
1.063 0 Td
(FISH)Tj
-61.8027 -1.5024 Td
(uorescen)Tj
4.5779 0 Td
(ce)Tj
1.2826 0 Td
(in)Tj
0.9993 0 Td
(situ)Tj
1.7716 0 Td
(hybridizati)Tj
4.4646 0 Td
(on;)Tj
1.6158 0 Td
(GCG)Tj
3.2669 0 Td
(germinal)Tj
4.0324 0 Td
(center)Tj
2.9905 0 Td
(B-cell)Tj
2.7142 0 Td
(type;)Tj
2.3882 0 Td
(IHCimmu)Tj
5.1379 0 Td
(nohistoche)Tj
4.7976 0 Td
(mistry;)Tj
3.1749 0 Td
(nsno)Tj
3.1394 0 Td
(t)Tj
0.5173 0 Td
(signic)Tj
3.026 0 Td
(ant;)Tj
1.8921 0 Td
(R-CHOPri)Tj
5.471 0 Td
(tuximab,)Tj
-57.2602 -1.4953 Td
(cyclopho)Tj
3.9117 0 Td
(sphamide,)Tj
4.8119 0 Td
(doxorubici)Tj
4.5142 0 Td
(n,)Tj
1.063 0 Td
(vincristine,)Tj
4.9252 0 Td
(and)Tj
1.878 0 Td
(prednisone;)Tj
5.4142 0 Td
(R-other)Tj
4.3087 0 Td
(rituximab)Tj
4.2591 0 Td
(alone)Tj
2.6504 0 Td
(or)Tj
1.1126 0 Td
(other)Tj
2.4945 0 Td
(rituximab)Tj
4.0252 0 Td
(-containing)Tj
5.0812 0 Td
(regimen;)Tj
4.0961 0 Td
(qIFqu)Tj
3.5362 0 Td
(antitative)Tj
-58.0822 -1.5024 Td
(immunou)Tj
4.5779 0 Td
(orescence)Tj
4.5779 0 Td
(.)Tj
/F8 1 Tf
-0.005 Tc
-9.1558 -2.2464 Td
(doi:)Tj
-0.025 Tc
(10.137)Tj
4.0322 0 Td
(1/journal.pone.)Tj
5.5559 0 Td
(0172364.t)Tj
3.7914 0 Td
(001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 263.5086 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(MYC/BCL2)Tj
5.159 0 Td
(double)Tj
2.9339 0 Td
(-expresso)Tj
4.3158 0 Td
(r)Tj
0.5528 0 Td
(lymphom)Tj
3.9898 0 Td
(a)Tj
0.7653 0 Td
(shows)Tj
3.0119 0 Td
(evidence)Tj
4.1457 0 Td
(of)Tj
1.0417 0 Td
(active)Tj
2.7851 0 Td
(B-cell)Tj
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