%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Wendy Beauvais, Elena V. Gart, Melissa Bean, Anthony Blanco, Jennifer Wilsey, Kallie McWhinney, Laura Bryan, Mary Krath, Ching-Yuan Yang, Diego Manriquez Alvarez, Sushil Paudyal, Kelsey Bryan, Samantha Stewart, Peter W. Cook, Glenn Lahodny, Karina Baumgarten, Raju Gautam, Kendra Nightingale, Sara D. Lawhon, Pablo Pinedo, Renata Ivanek
The prevalence of Escherichia coli O157:H7 fecal shedding in feedlot pens is affected by the water-to-cattle ratio: A randomized controlled trial
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref004)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref007)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref008)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref009)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref010)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref011)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref015)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref016)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref017)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref018)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref019)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref020)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref021)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref022)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref023)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref024)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref027)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref022)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref019)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref028)>>
endobj
41 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref029)>>
endobj
42 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref030)>>
endobj
43 0 obj
<>/Border[0 0 0]/A 44 0 R>>
endobj
44 0 obj
<>
endobj
15 0 obj
[45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R]
endobj
45 0 obj
<>stream
q
0.83 0.64 0.02 0 k
396.5102 662.0031 m
401.2724 662.0031 l
h
f*
480.4157 649.0205 m
485.178 649.0205 l
h
f*
523.6157 635.9811 m
528.3213 635.9811 l
h
f*
406.6583 622.9984 m
411.4205 622.9984 l
h
f*
325.0772 583.9937 m
329.8394 583.9937 l
h
f*
255.8551 558.0283 m
260.6173 558.0283 l
h
f*
419.9244 519.0236 m
424.6866 519.0236 l
h
f*
488.0126 505.9843 m
492.7748 505.9843 l
h
f*
540.4535 493.0016 m
545.1591 493.0016 l
h
f*
549.6378 493.0016 m
559.1622 493.0016 l
h
f*
237.7701 453.9969 m
247.2945 453.9969 l
h
f*
252.4535 453.9969 m
261.978 453.9969 l
h
f*
224.6173 428.0315 m
234.1417 428.0315 l
h
f*
536.7118 428.0315 m
546.2362 428.0315 l
h
f*
294.0661 389.0268 m
303.5906 389.0268 l
h
f*
378.9921 375.9874 m
388.4598 375.9874 l
h
f*
225.411 350.022 m
234.9354 350.022 l
h
f*
498.0472 324 m
507.515 324 l
h
f*
511.9937 324 m
521.5181 324 l
h
f*
397.2472 297.978 m
406.7717 297.978 l
h
f*
442.4315 272.0126 m
451.9559 272.0126 l
h
f*
457.115 272.0126 m
466.6394 272.0126 l
h
f*
286.5827 245.9906 m
296.1071 245.9906 l
h
f*
345.8268 167.9811 m
355.3512 167.9811 l
h
f*
469.9843 128.9764 m
479.5087 128.9764 l
h
f*
481.7764 128.9764 m
491.3008 128.9764 l
h
f*
203.4142 90.0283 m
212.9386 90.0283 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F13 1 Tf
1 TL
-0.004 Tc
0 0 Td
[()-4()-3()13()6()2()-9()4()13()18()4()]TJ
4.6261 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8608 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(predominant)Tj
5.4822 0 Td
(serotype)Tj
3.5773 0 Td
(representing)Tj
5.2384 0 Td
(the)Tj
1.474 0 Td
(Shiga-toxin)Tj
4.8245 0 Td
(producing)Tj
/F13 1 Tf
-32.961 -1.3039 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5533 0 Td
(group)Tj
2.6079 0 Td
(associated)Tj
4.2519 0 Td
(with)Tj
1.9956 0 Td
(human)Tj
3.0784 0 Td
(disease.)Tj
3.2372 0 Td
(It)Tj
0.856 0 Td
(was)Tj
1.7008 0 Td
(first)Tj
1.8028 0 Td
(identified)Tj
4.0535 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(pathogen)Tj
3.9345 0 Td
(in)Tj
1.0374 0 Td
(1982)Tj
2.1203 0 Td
(during)Tj
-34.8885 -1.2982 Td
(an)Tj
1.2018 0 Td
(outbreak)Tj
3.7871 0 Td
(investigation)Tj
5.3574 0 Td
(of)Tj
1.0148 0 Td
(hemorrhagic)Tj
5.3575 0 Td
(colitis)Tj
2.5908 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5988 0 Td
(Human)Tj
3.3221 0 Td
(infections)Tj
4.1499 0 Td
(caused)Tj
2.9197 0 Td
(by)Tj
/F13 1 Tf
1.1792 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5647 0 Td
(O157:)Tj
-35.0359 -1.2983 Td
(H7)Tj
1.4626 0 Td
(result)Tj
2.4491 0 Td
(in)Tj
1.0318 0 Td
(clinical)Tj
3.0784 0 Td
(syndromes)Tj
4.5921 0 Td
(ranging)Tj
3.3222 0 Td
(from)Tj
2.2054 0 Td
(asymptomatic)Tj
5.8563 0 Td
(to)Tj
1.0261 0 Td
(severe)Tj
2.6759 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5988 0 Td
(A)Tj
0.907 0 Td
(few)Tj
1.6158 0 Td
(individuals)Tj
-31.8215 -1.3039 Td
(may)Tj
1.9275 0 Td
(develop)Tj
3.3222 0 Td
(potentially)Tj
4.456 0 Td
(fatal)Tj
1.9219 0 Td
(complications)Tj
5.8393 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(hemolytic)Tj
4.1839 0 Td
(uremic)Tj
3.0558 0 Td
(syndrome)Tj
4.2349 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
1.5987 0 Td
(A)Tj
0.9071 0 Td
(chronic)Tj
-34.5257 -1.2983 Td
(renal)Tj
2.245 0 Td
(sequela)Tj
3.1407 0 Td
(may)Tj
1.9276 0 Td
(persist)Tj
2.8176 0 Td
(among)Tj
2.999 0 Td
(those)Tj
2.3358 0 Td
(that)Tj
1.7801 0 Td
(survive)Tj
3.0784 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
-19.128 -1.2982 Td
(The)Tj
1.7858 0 Td
(Centers)Tj
3.3108 0 Td
(for)Tj
1.3833 0 Td
(Disease)Tj
3.2258 0 Td
(Control)Tj
3.3619 0 Td
(and)Tj
1.7291 0 Td
(Prevention)Tj
4.6261 0 Td
(have)Tj
2.058 0 Td
(estimated)Tj
4.0705 0 Td
(that)Tj
1.7801 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(United)Tj
3.0217 0 Td
(States,)Tj
-34.0552 -1.304 Td
(foodborne)Tj
/F13 1 Tf
4.405 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8665 0 Td
(causes)Tj
2.7495 0 Td
(over)Tj
1.9786 0 Td
(63,000)Tj
2.8233 0 Td
(illnesses)Tj
3.4583 0 Td
(per)Tj
1.5307 0 Td
(year)Tj
1.9048 0 Td
(resulting)Tj
3.7247 0 Td
(in)Tj
1.0375 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(2,100)Tj
-34.401 -1.2982 Td
(hospitalizations)Tj
6.4742 0 Td
(and)Tj
1.7292 0 Td
(20)Tj
1.1735 0 Td
(deaths)Tj
2.7893 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.6044 0 Td
(The)Tj
1.7801 0 Td
(total)Tj
2.0013 0 Td
(annual)Tj
2.9593 0 Td
(economic)Tj
4.1442 0 Td
(burden)Tj
3.1238 0 Td
(of)Tj
1.0148 0 Td
(illness)Tj
2.6759 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
/F13 1 Tf
1.0261 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9922 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
-35.1834 -1.2983 Td
(O157:H7)Tj
3.8607 0 Td
(resulting)Tj
3.7304 0 Td
(from)Tj
2.2053 0 Td
(medical)Tj
3.3619 0 Td
(expenses)Tj
3.7417 0 Td
(and)Tj
1.7291 0 Td
(loss)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(life)Tj
1.4457 0 Td
(and)Tj
1.7291 0 Td
(productivity)Tj
5.1364 0 Td
(is)Tj
0.8503 0 Td
(estimated)Tj
4.0706 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
-35.5972 -1.2983 Td
($405)Tj
2.1203 0 Td
(million)Tj
3.1237 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5987 0 Td
(The)Tj
1.7859 0 Td
(beef)Tj
1.8595 0 Td
(industry)Tj
3.5773 0 Td
(suffers)Tj
2.8403 0 Td
(economic)Tj
4.1385 0 Td
(losses)Tj
2.4775 0 Td
(directly)Tj
3.2371 0 Td
(from)Tj
2.2054 0 Td
(recalls)Tj
2.7269 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
-33.698 -1.3039 Td
(O157:H7-contaminated)Tj
9.7397 0 Td
(raw)Tj
1.7121 0 Td
(non-intact)Tj
4.4447 0 Td
(beef)Tj
1.8596 0 Td
(\(and)Tj
2.0692 0 Td
(its)Tj
1.1509 0 Td
(components\))Tj
5.5105 0 Td
(and)Tj
1.7291 0 Td
(indirectly)Tj
4.0536 0 Td
(from)Tj
2.2053 0 Td
(subse-)Tj
-34.4747 -1.2982 Td
(quent)Tj
2.5228 0 Td
(decline)Tj
3.0784 0 Td
(in)Tj
1.0374 0 Td
(consumer)Tj
4.201 0 Td
(demand)Tj
3.5036 0 Td
(for)Tj
1.3833 0 Td
(beef)Tj
1.8652 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(market.)Tj
/F13 1 Tf
3.2881 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
3.8664 0 Td
(was)Tj
1.6951 0 Td
(responsible)Tj
4.7565 0 Td
(for)Tj
-36.2548 -1.2983 Td
(the)Tj
1.4683 0 Td
(highest)Tj
3.0897 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(beef)Tj
1.8595 0 Td
(recalls)Tj
2.7269 0 Td
(between)Tj
3.532 0 Td
(19821999)Tj
4.541 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.5988 0 Td
(It)Tj
0.8617 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(reported)Tj
3.6624 0 Td
(that)Tj
1.7744 0 Td
(beef)Tj
1.8652 0 Td
(recalls)Tj
-35.0756 -1.3039 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(Food)Tj
2.2904 0 Td
(Safety)Tj
2.5965 0 Td
(Inspection)Tj
4.456 0 Td
(Services)Tj
3.4186 0 Td
(caused)Tj
2.914 0 Td
(a)Tj
0.6576 0 Td
(decline)Tj
3.0784 0 Td
(in)Tj
1.0375 0 Td
(beef)Tj
1.8595 0 Td
(demand)Tj
3.5036 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
1.5987 0 Td
(Consumer)Tj
4.4447 0 Td
(buying)Tj
-34.503 -1.2983 Td
(practices)Tj
3.736 0 Td
(are)Tj
1.4513 0 Td
(greatly)Tj
2.914 0 Td
(influenced)Tj
4.4447 0 Td
(by)Tj
1.1792 0 Td
(perception)Tj
4.5184 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(food)Tj
2.0523 0 Td
(safety)Tj
2.4775 0 Td
(of)Tj
1.0148 0 Td
(any)Tj
1.6554 0 Td
(given)Tj
2.3811 0 Td
(product)Tj
3.3959 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2585 0 Td
(10)Tj
0 g
(].)Tj
-33.766 -1.2982 Td
(There)Tj
2.5795 0 Td
(are)Tj
1.4513 0 Td
(multiple)Tj
3.566 0 Td
(ways)Tj
2.1543 0 Td
(by)Tj
1.1792 0 Td
(which)Tj
2.6475 0 Td
(humans)Tj
3.4413 0 Td
(are)Tj
1.4513 0 Td
(known)Tj
3.0047 0 Td
(to)Tj
1.0205 0 Td
(acquire)Tj
3.1748 0 Td
(an)Tj
/F13 1 Tf
1.2018 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
3.8607 0 Td
(infec-)Tj
-34.486 -1.304 Td
(tion,)Tj
2.0636 0 Td
(including)Tj
4.0421 0 Td
(contaminated)Tj
5.7487 0 Td
(food,)Tj
2.279 0 Td
(water,)Tj
2.6532 0 Td
(and)Tj
1.7348 0 Td
(direct)Tj
2.5285 0 Td
(contact)Tj
3.1521 0 Td
(with)Tj
2.0012 0 Td
(infected)Tj
3.4186 0 Td
(animals)Tj
3.3279 0 Td
(and)Tj
-32.9497 -1.2982 Td
(humans)Tj
3.4355 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
3.549 0 Td
(The)Tj
1.7801 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(human)Tj
3.0784 0 Td
(outbreaks)Tj
4.1443 0 Td
(and)Tj
1.7348 0 Td
(illnesses,)Tj
3.6793 0 Td
(however,)Tj
3.8381 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(linked)Tj
-34.0665 -1.2983 Td
(to)Tj
1.0261 0 Td
(consumption)Tj
5.5445 0 Td
(of)Tj
1.0148 0 Td
(contaminated)Tj
5.7486 0 Td
(food)Tj
2.0523 0 Td
(including)Tj
4.0422 0 Td
(ground)Tj
3.1634 0 Td
(beef,)Tj
2.0863 0 Td
(dairy)Tj
2.2791 0 Td
(products,)Tj
3.9798 0 Td
(and)Tj
1.7291 0 Td
(fresh)Tj
2.1883 0 Td
(pro-)Tj
-34.8545 -1.2983 Td
(duce)Tj
2.1203 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
2.0749 0 Td
(Cattle)Tj
2.5852 0 Td
(are)Tj
1.4513 0 Td
(the)Tj
1.4683 0 Td
(principal)Tj
3.8098 0 Td
(reservoir)Tj
3.7757 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
3.8607 0 Td
(for)Tj
1.389 0 Td
(human)Tj
3.0784 0 Td
(infections)Tj
4.1499 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.075 0 Td
(Cat-)Tj
-35.4045 -1.3039 Td
(tle)Tj
1.1848 0 Td
(that)Tj
1.7802 0 Td
(are)Tj
1.4513 0 Td
(colonized)Tj
4.0819 0 Td
(by)Tj
1.1792 0 Td
(and)Tj
1.7348 0 Td
(shedding)Tj
/F13 1 Tf
3.8664 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
3.8664 0 Td
(are)Tj
1.4457 0 Td
(not)Tj
1.576 0 Td
(only)Tj
1.9729 0 Td
(the)Tj
1.474 0 Td
(source)Tj
2.829 0 Td
(of)Tj
1.0148 0 Td
(food)Tj
-32.0086 -1.2982 Td
(contamination)Tj
6.1227 0 Td
(at)Tj
0.9525 0 Td
(slaughter,)Tj
4.0989 0 Td
(but)Tj
1.5533 0 Td
(their)Tj
2.109 0 Td
(manure)Tj
3.3449 0 Td
(may)Tj
1.9275 0 Td
(also)Tj
1.7688 0 Td
(contaminate)Tj
5.2214 0 Td
(fruits)Tj
2.3301 0 Td
(and)Tj
1.7347 0 Td
(vegetables)Tj
-31.1638 -1.2983 Td
(when)Tj
2.4037 0 Td
(used)Tj
2.058 0 Td
(as)Tj
1.0148 0 Td
(fertilizer)Tj
3.5886 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.0806 0 Td
(Furthermore,)Tj
5.6126 0 Td
(water)Tj
2.4321 0 Td
(supplies)Tj
3.4412 0 Td
(may)Tj
1.9276 0 Td
(be)Tj
1.1508 0 Td
(contaminated)Tj
5.7486 0 Td
(by)Tj
1.1849 0 Td
(runoff)Tj
2.7496 0 Td
(from)Tj
-35.3931 -1.3039 Td
(cattle)Tj
2.3414 0 Td
(farms)Tj
2.4944 0 Td
(which)Tj
2.6532 0 Td
(may)Tj
1.9276 0 Td
(cause)Tj
2.3867 0 Td
(human)Tj
3.0784 0 Td
(illness)Tj
2.6759 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
2.075 0 Td
(Many)Tj
2.5511 0 Td
(human)Tj
3.0785 0 Td
(outbreaks)Tj
4.1442 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
-32.9723 -1.2983 Td
(infections)Tj
4.1498 0 Td
(associated)Tj
4.2577 0 Td
(with)Tj
1.9955 0 Td
(fresh)Tj
2.194 0 Td
(produce)Tj
3.5206 0 Td
(and)Tj
1.7292 0 Td
(water)Tj
2.4321 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.1203 0 Td
(directly)Tj
3.2315 0 Td
(linked)Tj
2.7326 0 Td
(to)Tj
1.0261 0 Td
(cattle)Tj
2.3414 0 Td
(opera-)Tj
-33.7887 -1.2983 Td
(tions)Tj
2.1996 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
-1.0034 -1.3039 Td
(Published)Tj
4.1669 0 Td
(literature)Tj
3.8834 0 Td
(has)Tj
1.542 0 Td
(reported)Tj
3.6624 0 Td
(great)Tj
2.211 0 Td
(variation)Tj
3.8041 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(prevalence)Tj
4.4844 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8664 0 Td
(fecal)Tj
-34.8885 -1.2982 Td
(shedding,)Tj
4.0932 0 Td
(with)Tj
1.9955 0 Td
(estimates)Tj
3.9061 0 Td
(ranging)Tj
3.3222 0 Td
(from)Tj
2.2054 0 Td
(0)Tj
0.6973 0 Td
(to)Tj
1.0205 0 Td
(80%)Tj
1.9332 0 Td
(among)Tj
2.9933 0 Td
(cattle)Tj
2.3414 0 Td
(populations)Tj
4.955 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(22)Tj
0 g
(].)Tj
1.7348 0 Td
(Fecal)Tj
2.279 0 Td
(shed-)Tj
-35.2117 -1.2983 Td
(ding)Tj
2.0182 0 Td
(of)Tj
/F13 1 Tf
1.0091 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9865 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5477 0 Td
(O157:H7)Tj
3.8551 0 Td
(has)Tj
1.5364 0 Td
(a)Tj
0.6406 0 Td
(seasonal)Tj
3.5263 0 Td
(pattern,)Tj
3.3335 0 Td
(with)Tj
1.9842 0 Td
(prevalence)Tj
4.4787 0 Td
(rising)Tj
2.4945 0 Td
(to)Tj
1.0148 0 Td
(a)Tj
0.6463 0 Td
(peak)Tj
2.0806 0 Td
(during)Tj
2.9197 0 Td
(the)Tj
1.4626 0 Td
(sum-)Tj
-35.5348 -1.3039 Td
(mer)Tj
1.8311 0 Td
(months)Tj
3.2825 0 Td
(and)Tj
1.7348 0 Td
(declining)Tj
3.9345 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(winter)Tj
2.8119 0 Td
(months)Tj
3.2825 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
2.075 0 Td
(The)Tj
1.7858 0 Td
(elevated)Tj
3.4526 0 Td
(temperature)Tj
5.125 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
-32.859 -1.2983 Td
(summer)Tj
3.5432 0 Td
(seems)Tj
2.6079 0 Td
(to)Tj
1.0261 0 Td
(provide)Tj
3.2882 0 Td
(favorable)Tj
3.8834 0 Td
(conditions)Tj
4.4787 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(bacteria)Tj
3.3789 0 Td
(to)Tj
1.0261 0 Td
(survive)Tj
3.0784 0 Td
(and)Tj
1.7348 0 Td
(potentially)Tj
4.4617 0 Td
(even)Tj
-35.3591 -1.2982 Td
(multiply)Tj
3.5943 0 Td
(to)Tj
1.0261 0 Td
(increase)Tj
3.4752 0 Td
(numbers)Tj
3.7758 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(operation)Tj
4.0932 0 Td
(environment)Tj
5.4311 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
3.549 0 Td
(Variability)Tj
4.456 0 Td
(in)Tj
1.0375 0 Td
(shedding)Tj
-32.944 -1.2983 Td
(prevalence)Tj
4.4843 0 Td
(has)Tj
1.5421 0 Td
(also)Tj
1.7688 0 Td
(been)Tj
2.1203 0 Td
(observed)Tj
3.7984 0 Td
(between)Tj
3.5263 0 Td
(different)Tj
3.6566 0 Td
(pens)Tj
2.0693 0 Td
(within)Tj
2.8176 0 Td
(a)Tj
0.652 0 Td
(feedlot)Tj
2.9367 0 Td
(at)Tj
0.9467 0 Td
(a)Tj
0.6577 0 Td
(single)Tj
2.5285 0 Td
(time-)Tj
-33.5053 -1.3039 Td
(point,)Tj
2.5851 0 Td
(and)Tj
1.7292 0 Td
(over)Tj
1.9729 0 Td
(time)Tj
2.0295 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.075 0 Td
(This)Tj
1.9899 0 Td
(variability)Tj
4.2236 0 Td
(offers)Tj
2.4548 0 Td
(an)Tj
1.2019 0 Td
(opportunity)Tj
5.0343 0 Td
(to)Tj
1.0261 0 Td
(carefully)Tj
3.6397 0 Td
(examine)Tj
3.5999 0 Td
(environ-)Tj
-33.5619 -1.2983 Td
(mental)Tj
2.9876 0 Td
(and)Tj
1.7292 0 Td
(farm)Tj
2.1373 0 Td
(management)Tj
5.4311 0 Td
(practices)Tj
3.7417 0 Td
(as)Tj
1.0148 0 Td
(potential)Tj
3.7587 0 Td
(driving)Tj
3.1238 0 Td
(forces)Tj
2.5909 0 Td
(and)Tj
1.7348 0 Td
(to)Tj
1.0261 0 Td
(identify)Tj
3.2938 0 Td
(new)Tj
1.8765 0 Td
(targets)Tj
-34.4463 -1.2983 Td
(for)Tj
1.3832 0 Td
(an)Tj
1.2019 0 Td
(effective)Tj
3.515 0 Td
(control)Tj
3.1181 0 Td
(strategy)Tj
3.3278 0 Td
(to)Tj
1.0261 0 Td
(reduce)Tj
2.914 0 Td
(the)Tj
1.4741 0 Td
(shedding)Tj
3.8664 0 Td
(prevalence)Tj
4.4844 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8608 0 Td
(in)Tj
1.0374 0 Td
(cattle.)Tj
-33.5846 -1.3039 Td
(A)Tj
0.9014 0 Td
(considerably)Tj
5.2894 0 Td
(large)Tj
2.1543 0 Td
(body)Tj
2.211 0 Td
(of)Tj
1.0148 0 Td
(research)Tj
3.549 0 Td
(efforts)Tj
2.7552 0 Td
(has)Tj
1.5364 0 Td
(been)Tj
2.1146 0 Td
(directed)Tj
3.4809 0 Td
(towards)Tj
3.4016 0 Td
(reducing)Tj
3.7701 0 Td
(fecal)Tj
2.0296 0 Td
(shed-)Tj
-35.4045 -1.2982 Td
(ding)Tj
2.0295 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9922 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8608 0 Td
(in)Tj
1.0374 0 Td
(cattle)Tj
2.3414 0 Td
(over)Tj
1.9786 0 Td
(recent)Tj
2.7099 0 Td
(years.)Tj
2.4888 0 Td
(Many)Tj
2.5512 0 Td
(intervention)Tj
5.176 0 Td
(strategies)Tj
3.9231 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.126 0 Td
(sug-)Tj
-35.8467 -1.2983 Td
(gested,)Tj
2.9423 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(probiotics,)Tj
4.4731 0 Td
(antibiotics,)Tj
4.6204 0 Td
(vaccinations,)Tj
5.4142 0 Td
(bacteriophages,)Tj
6.4062 0 Td
(dietary)Tj
2.9991 0 Td
(changes,)Tj
-33.9475 -1.3039 Td
(and)Tj
1.7291 0 Td
(improved)Tj
4.1102 0 Td
(animal)Tj
2.965 0 Td
(management)Tj
5.4368 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
2.075 0 Td
(However,)Tj
4.0818 0 Td
(these)Tj
2.2507 0 Td
(interventions)Tj
5.5389 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(shown)Tj
2.846 0 Td
(to)Tj
-35.2174 -1.2983 Td
(have)Tj
2.0579 0 Td
(either)Tj
2.5341 0 Td
(a)Tj
0.652 0 Td
(weak)Tj
2.2564 0 Td
(effect,)Tj
2.5908 0 Td
(or)Tj
1.0999 0 Td
(the)Tj
1.4683 0 Td
(observed)Tj
3.7984 0 Td
(effect)Tj
2.3641 0 Td
(lacks)Tj
2.177 0 Td
(repeatability)Tj
5.1647 0 Td
(when)Tj
2.4037 0 Td
(evaluated)Tj
3.9912 0 Td
(against)Tj
3.0274 0 Td
(nat-)Tj
-35.5859 -1.2983 Td
(urally)Tj
2.5001 0 Td
(colonized)Tj
4.0819 0 Td
(cattle)Tj
2.347 0 Td
(under)Tj
2.6136 0 Td
(field)Tj
1.9729 0 Td
(conditions.)Tj
4.7054 0 Td
(They)Tj
2.2337 0 Td
(may)Tj
1.9276 0 Td
(also)Tj
1.7688 0 Td
(be)Tj
1.1508 0 Td
(logistically)Tj
4.4391 0 Td
(difficult)Tj
3.3505 0 Td
(to)Tj
1.0261 0 Td
(imple-)Tj
-34.1175 -1.3039 Td
(ment,)Tj
2.5341 0 Td
(sometimes)Tj
4.5014 0 Td
(even)Tj
2.0693 0 Td
(failing)Tj
2.7382 0 Td
(to)Tj
1.0262 0 Td
(motivate)Tj
3.719 0 Td
(producers)Tj
4.2519 0 Td
(to)Tj
1.0262 0 Td
(adopt)Tj
2.5001 0 Td
(them)Tj
2.2904 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(].)Tj
-25.4606 -1.2982 Td
(A)Tj
0.907 0 Td
(survey)Tj
2.812 0 Td
(of)Tj
1.0148 0 Td
(selected)Tj
3.3505 0 Td
(feed)Tj
1.8822 0 Td
(yards)Tj
2.3641 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(Texas)Tj
2.5172 0 Td
(Panhandle)Tj
4.4673 0 Td
(indicated)Tj
3.9402 0 Td
(that)Tj
1.7801 0 Td
(feedlot)Tj
2.931 0 Td
(pens)Tj
2.0693 0 Td
(vary)Tj
1.9389 0 Td
(with)Tj
-35.6766 -1.2983 Td
(respect)Tj
3.0387 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(water-to-cattle)Tj
6.0605 0 Td
(ratios,)Tj
2.6815 0 Td
(ranging)Tj
3.3222 0 Td
(between)Tj
3.5263 0 Td
(0.4)Tj
1.4003 0 Td
(and)Tj
1.7291 0 Td
(4.5)Tj
1.3947 0 Td
(\(median)Tj
3.5829 0 Td
(0.9\))Tj
1.7348 0 Td
(liters)Tj
2.1884 0 Td
(per)Tj
1.5307 0 Td
(head)Tj
-34.6845 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(].)Tj
2.0749 0 Td
(Water-to-cattle)Tj
6.3439 0 Td
(ratio)Tj
2.0976 0 Td
(denotes)Tj
3.3109 0 Td
(the)Tj
1.4683 0 Td
(amount)Tj
3.3562 0 Td
(of)Tj
1.0148 0 Td
(standing)Tj
3.668 0 Td
(water)Tj
2.4321 0 Td
(at)Tj
0.9525 0 Td
(a)Tj
0.6519 0 Td
(point)Tj
2.3584 0 Td
(in)Tj
1.0375 0 Td
(time)Tj
2.0296 0 Td
(available)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 303.8173 745.7952 cm
BT
/F6 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Escherich)Tj
4.3157 0 Td
(ia)Tj
0.978 0 Td
(coli)Tj
/F0 1 Tf
1.6866 0 Td
(O157:H7)Tj
4.1599 0 Td
(in)Tj
0.978 0 Td
(cattle)Tj
2.5724 0 Td
(fecal)Tj
2.289 0 Td
(pats)Tj
2.0835 0 Td
(and)Tj
1.8496 0 Td
(water)Tj
2.6292 0 Td
(trough)Tj
3.0047 0 Td
(levels)Tj
2.7213 0 Td
(on)Tj
1.311 0 Td
(feedlots)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01921)Tj
4.089 0 Td
(49)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(7,)Tj
1.0417 0 Td
(2018)Tj
33.7042 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(21)Tj
/F10 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Scholars)Tj
3.4582 0 Td
(Program.)Tj
3.7064 0 Td
(LB)Tj
1.2189 0 Td
(was)Tj
1.7008 0 Td
(supported)Tj
3.9898 0 Td
(by)Tj
1.1197 0 Td
(the)Tj
1.3677 0 Td
(NIH)Tj
-16.5615 -1.3748 Td
(T32)Tj
1.637 0 Td
(grant)Tj
2.1543 0 Td
(\(5)Tj
0.9992 0 Td
(T32)Tj
1.6441 0 Td
(0D)Tj
1.2756 0 Td
(011083-8\).)Tj
4.3725 0 Td
(The)Tj
1.5945 0 Td
(funders)Tj
3.0402 0 Td
(had)Tj
-16.7174 -1.3749 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.9055 0 Td
(data)Tj
1.7859 0 Td
(collection)Tj
3.7417 0 Td
(and)Tj
-14.3646 -1.3748 Td
(analysis,)Tj
3.4086 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9497 0 Td
(publish,)Tj
3.1393 0 Td
(or)Tj
1.0064 0 Td
(prepara)Tj
2.8205 0 Td
(tion)Tj
1.6157 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-17.1851 -1.3748 Td
(manuscript.)Tj
/F9 1 Tf
0 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
BT
10.3394 75.0903 Td
(exist.)Tj
ET
Q
endstream
endobj
72 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 74 0 R/Contents 75 0 R/TrimBox[0 0 612 792]>>
endobj
74 0 obj
[76 0 R 77 0 R 78 0 R 79 0 R 80 0 R]
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref024)>>
endobj
77 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref031)>>
endobj
78 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref032)>>
endobj
79 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192149.ref024)>>
endobj
80 0 obj
<>/Border[0 0 0]/A 81 0 R>>
endobj
81 0 obj
<>
endobj
75 0 obj
[82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R]
endobj
82 0 obj
<>stream
q
0.83 0.64 0.02 0 k
521.6882 680.315 m
531.1559 680.315 l
h
f*
535.6346 680.315 m
545.1591 680.315 l
h
f*
370.148 281.1402 m
379.6724 281.1402 l
h
f*
348.8315 268.1008 m
358.3559 268.1008 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(per)Tj
1.5306 0 Td
(head)Tj
2.1317 0 Td
(of)Tj
1.0148 0 Td
(cattle;)Tj
2.5682 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8504 0 Td
(estimated)Tj
4.0705 0 Td
(by)Tj
1.1792 0 Td
(dividing)Tj
3.549 0 Td
(the)Tj
1.4683 0 Td
(volume)Tj
3.1975 0 Td
(of)Tj
1.0148 0 Td
(water)Tj
2.4321 0 Td
(in)Tj
1.0374 0 Td
(water-troughs)Tj
5.8394 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(pen)Tj
-34.3613 -1.3039 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(animals)Tj
3.3335 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4741 0 Td
(pen.)Tj
1.9332 0 Td
(Water-troughs)Tj
6.1228 0 Td
(have)Tj
2.0579 0 Td
(an)Tj
1.2019 0 Td
(automatic)Tj
4.2293 0 Td
(water)Tj
2.4321 0 Td
(refill)Tj
2.0636 0 Td
(system)Tj
-33.7774 -1.2982 Td
(that)Tj
1.7744 0 Td
(assures)Tj
3.0614 0 Td
(water)Tj
2.4321 0 Td
(refilling)Tj
3.3449 0 Td
(as)Tj
1.0148 0 Td
(cattle)Tj
2.3414 0 Td
(drink.)Tj
2.6589 0 Td
(Prior)Tj
2.296 0 Td
(mathematical)Tj
5.6466 0 Td
(modelling)Tj
4.269 0 Td
(studies)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7347 0 Td
(31)Tj
0 g
(])Tj
1.5137 0 Td
(sug-)Tj
-35.0756 -1.2983 Td
(gest)Tj
1.7688 0 Td
(that)Tj
1.7744 0 Td
(if)Tj
0.7767 0 Td
(the)Tj
1.4684 0 Td
(water)Tj
2.4321 0 Td
(trough)Tj
2.9196 0 Td
(volume)Tj
3.1975 0 Td
(is)Tj
0.8504 0 Td
(high)Tj
2.0069 0 Td
(relative)Tj
3.1351 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(animals)Tj
3.3336 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(pen)Tj
1.7064 0 Td
(\(high)Tj
-34.8035 -1.2983 Td
(water-to-cattle)Tj
6.0604 0 Td
(ratio\),)Tj
2.6645 0 Td
(a)Tj
0.652 0 Td
(large)Tj
2.16 0 Td
(pool)Tj
1.9956 0 Td
(of)Tj
1.0148 0 Td
(standing)Tj
3.6736 0 Td
(water)Tj
2.4321 0 Td
(is)Tj
0.8448 0 Td
(available,)Tj
3.8947 0 Td
(which)Tj
2.6476 0 Td
(in)Tj
1.0375 0 Td
(warm)Tj
2.5285 0 Td
(weather)Tj
3.3845 0 Td
(will)Tj
-34.9906 -1.3039 Td
(heat)Tj
1.9048 0 Td
(up)Tj
1.2643 0 Td
(and)Tj
1.7291 0 Td
(may)Tj
1.9275 0 Td
(promote)Tj
/F13 1 Tf
3.6624 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8608 0 Td
(growth.)Tj
3.2995 0 Td
(Thus,)Tj
2.4718 0 Td
(drinking)Tj
3.7133 0 Td
(water)Tj
2.4321 0 Td
(was)Tj
1.6952 0 Td
(identified)Tj
4.0591 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
-35.5915 -1.2982 Td
(potential)Tj
3.7587 0 Td
(pathway)Tj
3.5716 0 Td
(of)Tj
1.0148 0 Td
(infection)Tj
3.7927 0 Td
(transmission)Tj
5.3631 0 Td
(with)Tj
1.9956 0 Td
(drinking)Tj
3.7134 0 Td
(water-to-cattle)Tj
6.0604 0 Td
(ratio)Tj
2.0976 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(strong)Tj
-33.0347 -1.2983 Td
(modulator)Tj
4.456 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(process.)Tj
3.4072 0 Td
(This)Tj
1.9843 0 Td
(gave)Tj
2.0012 0 Td
(rise)Tj
1.6441 0 Td
(to)Tj
1.0204 0 Td
(a)Tj
0.6577 0 Td
(hypothesis)Tj
4.4617 0 Td
(that)Tj
1.7801 0 Td
(at)Tj
0.9525 0 Td
(a)Tj
0.6519 0 Td
(given)Tj
2.3811 0 Td
(elevated)Tj
3.4526 0 Td
(ambient)Tj
3.5149 0 Td
(tem-)Tj
-34.8545 -1.3039 Td
(perature,)Tj
3.8097 0 Td
(a)Tj
0.6576 0 Td
(lowered)Tj
3.4016 0 Td
(water-to-cattle)Tj
6.0604 0 Td
(ratio)Tj
2.0976 0 Td
(will)Tj
1.6668 0 Td
(secure)Tj
2.7496 0 Td
(a)Tj
0.652 0 Td
(faster)Tj
2.398 0 Td
(refill)Tj
2.058 0 Td
(of)Tj
1.0148 0 Td
(fresh)Tj
2.194 0 Td
(water)Tj
2.4321 0 Td
(and)Tj
1.7291 0 Td
(reduce)Tj
2.9197 0 Td
(the)Tj
-35.841 -1.2983 Td
(growth)Tj
3.0727 0 Td
(and)Tj
1.7291 0 Td
(accumulation)Tj
5.6806 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
3.8607 0 Td
(in)Tj
1.0375 0 Td
(water,)Tj
2.6532 0 Td
(leading)Tj
3.1351 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(reduced)Tj
3.4469 0 Td
(prevalence)Tj
4.4844 0 Td
(and)Tj
-34.3443 -1.2983 Td
(load)Tj
1.9275 0 Td
(of)Tj
1.0091 0 Td
(fecal)Tj
2.0296 0 Td
(shedding)Tj
3.8608 0 Td
(among)Tj
2.9877 0 Td
(cattle.)Tj
2.5625 0 Td
(The)Tj
1.7745 0 Td
(primary)Tj
3.4525 0 Td
(objective)Tj
3.7758 0 Td
(of)Tj
1.0034 0 Td
(this)Tj
1.6724 0 Td
(study)Tj
2.3811 0 Td
(was)Tj
1.6951 0 Td
(to)Tj
1.0148 0 Td
(test)Tj
1.5988 0 Td
(this)Tj
1.6667 0 Td
(hypoth-)Tj
-34.4123 -1.3039 Td
(esis)Tj
1.6327 0 Td
(by)Tj
1.1792 0 Td
(conducting)Tj
4.7565 0 Td
(a)Tj
0.6576 0 Td
(controlled)Tj
4.32 0 Td
(intervention)Tj
5.176 0 Td
(trial)Tj
1.8369 0 Td
(to)Tj
1.0261 0 Td
(assess)Tj
2.5172 0 Td
(the)Tj
1.4683 0 Td
(effectiveness)Tj
5.2044 0 Td
(of)Tj
1.0148 0 Td
(reducing)Tj
3.7757 0 Td
(drink-)Tj
-34.5654 -1.2982 Td
(ing)Tj
1.5023 0 Td
(water-to-cattle)Tj
6.0604 0 Td
(ratio)Tj
2.0977 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(strategy)Tj
3.3279 0 Td
(to)Tj
1.0261 0 Td
(reduce)Tj
/F13 1 Tf
2.914 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8608 0 Td
(fecal)Tj
2.0353 0 Td
(shedding)Tj
3.8664 0 Td
(prevalence)Tj
4.4901 0 Td
(in)Tj
-35.4045 -1.2983 Td
(feedlot)Tj
2.9253 0 Td
(cattle.)Tj
2.5625 0 Td
(The)Tj
1.7745 0 Td
(second)Tj
2.999 0 Td
(objective)Tj
3.7757 0 Td
(was)Tj
1.6895 0 Td
(to)Tj
1.0204 0 Td
(quantify)Tj
3.5376 0 Td
(the)Tj
1.457 0 Td
(variability)Tj
4.218 0 Td
(in)Tj
/F13 1 Tf
1.0261 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9865 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5533 0 Td
(O157:H7)Tj
3.8495 0 Td
(fecal)Tj
2.0296 0 Td
(shed-)Tj
-35.4045 -1.3039 Td
(ding)Tj
2.0295 0 Td
(prevalence)Tj
4.4844 0 Td
(within)Tj
2.812 0 Td
(and)Tj
1.7291 0 Td
(between)Tj
3.5319 0 Td
(pens)Tj
2.0693 0 Td
(under)Tj
2.6192 0 Td
(controlled)Tj
4.32 0 Td
(conditions)Tj
4.473 0 Td
(and)Tj
1.7292 0 Td
(identify)Tj
3.2995 0 Td
(predictors)Tj
-33.0971 -1.2983 Td
(that)Tj
1.7744 0 Td
(explain)Tj
3.1238 0 Td
(this)Tj
1.6724 0 Td
(variability.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 473.2157 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F14 1 Tf
-6.4961 -1.5023 Td
(Overview)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 438.1795 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(A)Tj
0.9014 0 Td
(randomized)Tj
5.0626 0 Td
(controlled)Tj
4.32 0 Td
(trial)Tj
1.8368 0 Td
(was)Tj
1.6951 0 Td
(conducted)Tj
4.4277 0 Td
(between)Tj
3.532 0 Td
(16)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 427.2377 442.6582 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 435.6283 438.1795 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(June)Tj
2.0522 0 Td
(and)Tj
1.7291 0 Td
(21)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 482.9669 442.6582 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 490.0535 438.1795 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(July)Tj
1.7801 0 Td
(in)Tj
1.0375 0 Td
(2014,)Tj
2.347 0 Td
(and)Tj
-34.1685 -1.2982 Td
(repeated)Tj
3.6397 0 Td
(between)Tj
3.5263 0 Td
(16)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 281.1968 429.6188 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 289.5874 425.1968 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(June)Tj
2.0466 0 Td
(and)Tj
1.7291 0 Td
(20)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 336.8692 429.6188 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 345.2598 425.1968 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(July)Tj
1.7801 0 Td
(in)Tj
1.0318 0 Td
(2015.)Tj
2.3471 0 Td
(Pens)Tj
2.1146 0 Td
(within)Tj
2.812 0 Td
(a)Tj
0.6519 0 Td
(single)Tj
2.5342 0 Td
(feedlot,)Tj
3.1578 0 Td
(that)Tj
1.7801 0 Td
(was)Tj
1.7008 0 Td
(previ-)Tj
-34.435 -1.2982 Td
(ously)Tj
2.3131 0 Td
(identified)Tj
4.0592 0 Td
(as)Tj
1.0148 0 Td
(positive)Tj
3.3165 0 Td
(for)Tj
/F13 1 Tf
1.3889 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9922 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5589 0 Td
(O157:H7,)Tj
4.0875 0 Td
(were)Tj
2.1203 0 Td
(first)Tj
1.8085 0 Td
(screened)Tj
3.7247 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
-34.9622 -1.3039 Td
(O157:H7)Tj
3.8608 0 Td
(and)Tj
1.7291 0 Td
(then)Tj
2.0183 0 Td
(a)Tj
0.6576 0 Td
(subset)Tj
2.6986 0 Td
(of)Tj
1.0148 0 Td
(positive)Tj
3.3107 0 Td
(pens)Tj
2.0749 0 Td
(was)Tj
1.6952 0 Td
(randomly)Tj
4.1328 0 Td
(allocated)Tj
3.7588 0 Td
(to)Tj
1.0261 0 Td
(either)Tj
2.5285 0 Td
(intervention)Tj
-30.5062 -1.2983 Td
(group)Tj
2.6079 0 Td
(\(water-trough)Tj
5.8166 0 Td
(filling)Tj
2.5512 0 Td
(level)Tj
2.0126 0 Td
(reduced)Tj
3.4468 0 Td
(by)Tj
1.1792 0 Td
(50%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(baseline)Tj
3.4299 0 Td
(level,)Tj
2.2394 0 Td
(which)Tj
2.6475 0 Td
(was)Tj
1.7008 0 Td
(a)Tj
0.652 0 Td
(near)Tj
-32.7002 -1.2983 Td
(approximation)Tj
6.1738 0 Td
(to)Tj
1.0262 0 Td
(a)Tj
0.6519 0 Td
(50%)Tj
1.9276 0 Td
(reduction)Tj
4.1159 0 Td
(in)Tj
1.0373 0 Td
(water)Tj
2.4265 0 Td
(volume\))Tj
3.5433 0 Td
(or)Tj
1.0941 0 Td
(control)Tj
3.1238 0 Td
(group)Tj
2.6078 0 Td
(\(no)Tj
1.6158 0 Td
(change)Tj
3.0444 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(water-)Tj
-34.8828 -1.2982 Td
(trough)Tj
2.914 0 Td
(level\).)Tj
2.5795 0 Td
(Water-trough)Tj
5.7657 0 Td
(dimensions)Tj
4.8471 0 Td
(varied)Tj
2.6985 0 Td
(among)Tj
2.9934 0 Td
(pens.)Tj
2.2961 0 Td
(It)Tj
0.8617 0 Td
(should)Tj
2.914 0 Td
(be)Tj
1.1508 0 Td
(noted)Tj
2.5285 0 Td
(that)Tj
1.7745 0 Td
(because)Tj
3.3222 0 Td
(of)Tj
-36.646 -1.3039 Td
(automatic)Tj
4.2293 0 Td
(refilling,)Tj
3.5659 0 Td
(the)Tj
1.4741 0 Td
(intervention)Tj
5.176 0 Td
(had)Tj
1.7063 0 Td
(no)Tj
1.2756 0 Td
(effect)Tj
2.3641 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(free)Tj
1.7291 0 Td
(access)Tj
2.6476 0 Td
(of)Tj
1.0148 0 Td
(cattle)Tj
2.3414 0 Td
(to)Tj
1.0261 0 Td
(water.)Tj
2.6589 0 Td
(Fecal)Tj
-33.9531 -1.2983 Td
(samples)Tj
3.3789 0 Td
(were)Tj
2.126 0 Td
(collected)Tj
3.736 0 Td
(both)Tj
2.0636 0 Td
(at)Tj
0.9524 0 Td
(baseline)Tj
3.4298 0 Td
(and)Tj
1.7292 0 Td
(three)Tj
2.2677 0 Td
(weeks)Tj
2.6078 0 Td
(after)Tj
2.0353 0 Td
(the)Tj
1.4683 0 Td
(intervention,)Tj
5.4028 0 Td
(and)Tj
1.7292 0 Td
(tested)Tj
2.5511 0 Td
(for)Tj
-35.4781 -1.2983 Td
(the)Tj
1.4684 0 Td
(presence)Tj
/F13 1 Tf
3.7133 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7.)Tj
4.0875 0 Td
(Also,)Tj
2.245 0 Td
(water)Tj
2.4321 0 Td
(samples)Tj
3.3788 0 Td
(were)Tj
2.126 0 Td
(collected)Tj
3.736 0 Td
(from)Tj
2.211 0 Td
(each)Tj
2.024 0 Td
(pen)Tj
1.7121 0 Td
(trough)Tj
2.914 0 Td
(both)Tj
-34.5994 -1.3039 Td
(pre-)Tj
1.8822 0 Td
(and)Tj
1.7291 0 Td
(post-intervention)Tj
7.2113 0 Td
(and)Tj
1.7291 0 Td
(tested)Tj
2.5511 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(presence)Tj
3.7134 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7,)Tj
4.0876 0 Td
(generic)Tj
/F13 1 Tf
3.1464 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(and)Tj
-35.0246 -1.2983 Td
(coliforms.)Tj
4.235 0 Td
(The)Tj
1.7801 0 Td
(three-week)Tj
4.6431 0 Td
(re-testing)Tj
4.0308 0 Td
(period)Tj
2.8346 0 Td
(was)Tj
1.6951 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(longest)Tj
3.067 0 Td
(length)Tj
2.7326 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
-33.8057 -1.2982 Td
(colonization)Tj
5.1874 0 Td
(in)Tj
1.0318 0 Td
(an)Tj
1.2075 0 Td
(experimental)Tj
5.4539 0 Td
(infection)Tj
3.7926 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(])Tj
1.8538 0 Td
(and)Tj
1.7292 0 Td
(predictions)Tj
4.7338 0 Td
(from)Tj
2.2053 0 Td
(an)Tj
1.2019 0 Td
(unpublished)Tj
5.1987 0 Td
(feedlot)Tj
-33.5959 -1.3039 Td
(adaptation)Tj
4.4844 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(mathematical)Tj
5.6465 0 Td
(model)Tj
2.7439 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
2.0806 0 Td
(For)Tj
1.6214 0 Td
(logistical)Tj
3.736 0 Td
(reasons,)Tj
3.4526 0 Td
(the)Tj
1.4683 0 Td
(pens)Tj
2.075 0 Td
(were)Tj
2.1203 0 Td
(assigned)Tj
3.6056 0 Td
(to)Tj
-34.7014 -1.2983 Td
(three)Tj
2.2621 0 Td
(different)Tj
3.6566 0 Td
(cohorts)Tj
3.2145 0 Td
(each)Tj
2.0296 0 Td
(year,)Tj
2.1316 0 Td
(which)Tj
2.6475 0 Td
(started)Tj
2.9366 0 Td
(1)Tj
0.6917 0 Td
(week)Tj
2.2507 0 Td
(apart)Tj
2.2734 0 Td
(from)Tj
2.2053 0 Td
(each)Tj
2.0296 0 Td
(other.)Tj
2.5738 0 Td
(The)Tj
1.7802 0 Td
(Texas)Tj
2.5171 0 Td
(A&M)Tj
-35.2003 -1.2983 Td
(University's)Tj
4.9776 0 Td
(Institutional)Tj
5.1647 0 Td
(Animal)Tj
3.2145 0 Td
(Care)Tj
2.1145 0 Td
(and)Tj
1.7291 0 Td
(Use)Tj
1.7405 0 Td
(Committee)Tj
4.7395 0 Td
(\(IACUC\))Tj
3.9912 0 Td
(evaluated)Tj
3.9854 0 Td
(the)Tj
1.474 0 Td
(study)Tj
2.3868 0 Td
(and)Tj
-35.5178 -1.3039 Td
(determined)Tj
4.8472 0 Td
(that)Tj
1.7802 0 Td
(it)Tj
0.788 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(require)Tj
3.1124 0 Td
(an)Tj
1.2018 0 Td
(Animal)Tj
3.2202 0 Td
(Use)Tj
1.7404 0 Td
(Protocol)Tj
3.6397 0 Td
(because)Tj
3.3222 0 Td
(it)Tj
0.7823 0 Td
(did)Tj
1.5421 0 Td
(not)Tj
1.576 0 Td
(involve)Tj
3.1238 0 Td
(the)Tj
1.4683 0 Td
(han-)Tj
-35.257 -1.2982 Td
(dling)Tj
2.2734 0 Td
(or)Tj
1.0998 0 Td
(manipulation)Tj
5.6353 0 Td
(of)Tj
1.0148 0 Td
(live)Tj
1.61 0 Td
(animals)Tj
3.3335 0 Td
(to)Tj
1.0204 0 Td
(obtain)Tj
2.7836 0 Td
(samples)Tj
3.3846 0 Td
(for)Tj
1.3833 0 Td
(research)Tj
3.5546 0 Td
(and)Tj
1.7348 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(involve)Tj
3.1238 0 Td
(alter-)Tj
-35.0643 -1.2983 Td
(ing)Tj
1.5024 0 Td
(the)Tj
1.4683 0 Td
(lifestyle)Tj
3.2258 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(animals)Tj
3.3336 0 Td
(for)Tj
1.3833 0 Td
(research)Tj
3.5602 0 Td
(purposes)Tj
3.804 0 Td
(\(decision)Tj
3.8835 0 Td
(letter)Tj
2.2847 0 Td
(dated)Tj
2.4321 0 Td
(October)Tj
3.4923 0 Td
(13,)Tj
1.4003 0 Td
(2013\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 164.9763 cm
BT
/F14 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Study)Tj
2.6173 0 Td
(farm)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 148.0251 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(A)Tj
0.9014 0 Td
(feedlot)Tj
2.9366 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(Texas)Tj
2.5115 0 Td
(Panhandle,)Tj
4.6942 0 Td
(a)Tj
0.6576 0 Td
(major)Tj
2.6079 0 Td
(beef)Tj
1.8595 0 Td
(production)Tj
4.7168 0 Td
(region,)Tj
3.0274 0 Td
(was)Tj
1.7008 0 Td
(selected)Tj
3.3448 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3868 0 Td
(as)Tj
-36.7084 -1.3039 Td
(it)Tj
0.7823 0 Td
(was)Tj
1.7008 0 Td
(considered)Tj
4.6034 0 Td
(a)Tj
0.652 0 Td
(typical)Tj
2.863 0 Td
(feedlot)Tj
2.931 0 Td
(and)Tj
1.7291 0 Td
(had)Tj
/F13 1 Tf
1.7121 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
3.8664 0 Td
(detected)Tj
3.566 0 Td
(from)Tj
2.2053 0 Td
(fecal)Tj
2.0353 0 Td
(samples)Tj
3.3788 0 Td
(prior)Tj
-34.5767 -1.2982 Td
(to)Tj
1.0147 0 Td
(this)Tj
1.6668 0 Td
(study.)Tj
2.6079 0 Td
(In)Tj
1.0998 0 Td
(2014,)Tj
2.3357 0 Td
(the)Tj
1.4627 0 Td
(feedlot)Tj
2.9253 0 Td
(housed)Tj
3.0841 0 Td
(approximately)Tj
5.9697 0 Td
(50,000)Tj
2.812 0 Td
(Holstein)Tj
3.634 0 Td
(steers)Tj
2.4491 0 Td
(from)Tj
2.1997 0 Td
(post)Tj
1.8935 0 Td
(wean-)Tj
-35.155 -1.2983 Td
(ing)Tj
1.5023 0 Td
(age)Tj
1.542 0 Td
(up)Tj
1.2643 0 Td
(to)Tj
1.0261 0 Td
(390)Tj
1.6441 0 Td
(days)Tj
1.9956 0 Td
(in)Tj
1.0375 0 Td
(feeding)Tj
3.1634 0 Td
(\(days)Tj
2.3357 0 Td
(since)Tj
2.2451 0 Td
(arrival)Tj
2.8006 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(feedlot\))Tj
3.2768 0 Td
(in)Tj
1.0318 0 Td
(192)Tj
1.6498 0 Td
(pens.)Tj
2.296 0 Td
(In)Tj
1.1055 0 Td
(2015,)Tj
2.3471 0 Td
(out)Tj
1.5534 0 Td
(of)Tj
-36.561 -1.3039 Td
(203)Tj
1.644 0 Td
(stocked)Tj
3.2599 0 Td
(pens,)Tj
2.296 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(heads)Tj
2.4945 0 Td
(and)Tj
1.7291 0 Td
(days)Tj
1.9956 0 Td
(in)Tj
1.0374 0 Td
(feeding)Tj
3.1635 0 Td
(were)Tj
2.1203 0 Td
(available)Tj
3.668 0 Td
(only)Tj
1.9786 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(pens)Tj
-34.1402 -1.2983 Td
(identified)Tj
4.0591 0 Td
(as)Tj
1.0148 0 Td
(positive.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 303.8173 745.7952 cm
BT
/F6 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Escherich)Tj
4.3157 0 Td
(ia)Tj
0.978 0 Td
(coli)Tj
/F0 1 Tf
1.6866 0 Td
(O157:H7)Tj
4.1599 0 Td
(in)Tj
0.978 0 Td
(cattle)Tj
2.5724 0 Td
(fecal)Tj
2.289 0 Td
(pats)Tj
2.0835 0 Td
(and)Tj
1.8496 0 Td
(water)Tj
2.6292 0 Td
(trough)Tj
3.0047 0 Td
(levels)Tj
2.7213 0 Td
(on)Tj
1.311 0 Td
(feedlots)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01921)Tj
4.089 0 Td
(49)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(7,)Tj
1.0417 0 Td
(2018)Tj
33.7042 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
BT
66.402 0 Td
(21)Tj
ET
Q
endstream
endobj
89 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 92 0 R/Contents 93 0 R/TrimBox[0 0 612 792]>>
endobj
92 0 obj
[94 0 R]
endobj
94 0 obj
<>/Border[0 0 0]/A 95 0 R>>
endobj
95 0 obj
<>
endobj
93 0 obj
[96 0 R 97 0 R 98 0 R 99 0 R 100 0 R]
endobj
96 0 obj
<>stream
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F14 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Environmental)Tj
6.5055 0 Td
(screening)Tj
4.1859 0 Td
(of)Tj
1.0677 0 Td
(pens)Tj
2.1402 0 Td
(for)Tj
/F15 1 Tf
1.4693 0 Td
[()]TJ
/F14 1 Tf
(.)Tj
/F15 1 Tf
1.0252 0 Td
[()3()4()5()]TJ
/F14 1 Tf
1.6535 0 Td
(O157:H7)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Environmental)Tj
6.2531 0 Td
(screening)Tj
4.0536 0 Td
(was)Tj
1.7007 0 Td
(conducted)Tj
4.4277 0 Td
(on)Tj
1.2756 0 Td
(May)Tj
2.0013 0 Td
(30,)Tj
1.3946 0 Td
(2014)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(on)Tj
1.2756 0 Td
(June)Tj
2.0466 0 Td
(4,)Tj
0.9241 0 Td
(2015.)Tj
2.347 0 Td
(All)Tj
1.3947 0 Td
(occupied)Tj
-32.9497 -1.3039 Td
(pens)Tj
2.0692 0 Td
(\(192)Tj
1.9843 0 Td
(in)Tj
1.0374 0 Td
(2014)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(203)Tj
1.6441 0 Td
(in)Tj
1.0375 0 Td
(2015\))Tj
2.4605 0 Td
(were)Tj
2.1259 0 Td
(screened)Tj
3.7191 0 Td
(for)Tj
/F13 1 Tf
1.3889 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
3.8607 0 Td
(by)Tj
1.1849 0 Td
(collecting)Tj
4.0705 0 Td
(a)Tj
0.652 0 Td
(single)Tj
-33.6413 -1.2982 Td
(gauze)Tj
2.4831 0 Td
(swab)Tj
2.2053 0 Td
(\(boot)Tj
2.3811 0 Td
(sock\))Tj
2.3471 0 Td
(sample)Tj
3.0217 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(floor)Tj
2.1373 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(pen)Tj
1.7064 0 Td
(and)Tj
1.7292 0 Td
(conducting)Tj
4.7565 0 Td
(selective)Tj
3.5432 0 Td
(culture)Tj
3.0388 0 Td
(and)Tj
-35.5122 -1.2983 Td
(latex)Tj
2.0862 0 Td
(agglutination)Tj
5.5276 0 Td
(testing.)Tj
3.1067 0 Td
(In)Tj
1.1112 0 Td
(order)Tj
2.4208 0 Td
(to)Tj
1.0204 0 Td
(collect)Tj
2.7893 0 Td
(a)Tj
0.6576 0 Td
(representative)Tj
5.8337 0 Td
(sample)Tj
3.0217 0 Td
(from)Tj
2.2053 0 Td
(each)Tj
2.0296 0 Td
(pen,)Tj
1.9333 0 Td
(the)Tj
1.4683 0 Td
(swab)Tj
-35.2117 -1.3039 Td
(was)Tj
1.6951 0 Td
(placed)Tj
2.7949 0 Td
(over)Tj
1.9786 0 Td
(a)Tj
0.6519 0 Td
(plastic)Tj
2.7666 0 Td
(boot)Tj
2.041 0 Td
(cover)Tj
2.3981 0 Td
(near)Tj
1.9955 0 Td
(the)Tj
1.474 0 Td
(ball)Tj
1.6498 0 Td
(and)Tj
1.7291 0 Td
(in-step)Tj
2.9877 0 Td
(areas)Tj
2.245 0 Td
(of)Tj
1.0148 0 Td
(one)Tj
1.7008 0 Td
(foot)Tj
1.8198 0 Td
(and)Tj
1.7292 0 Td
(sprayed)Tj
-32.6719 -1.2983 Td
(with)Tj
1.9955 0 Td
(distilled)Tj
3.3846 0 Td
(water)Tj
2.4321 0 Td
(if)Tj
0.7767 0 Td
(the)Tj
1.4683 0 Td
(pen)Tj
1.7065 0 Td
(floor)Tj
2.1429 0 Td
(was)Tj
1.7008 0 Td
(very)Tj
1.9219 0 Td
(dry.)Tj
1.7971 0 Td
(The)Tj
1.7859 0 Td
(individual)Tj
4.2859 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(pen)Tj
1.7121 0 Td
(was)Tj
1.6951 0 Td
(then)Tj
2.0183 0 Td
(instructed)Tj
-33.3295 -1.2982 Td
(to)Tj
1.0261 0 Td
(walk)Tj
2.0806 0 Td
(along)Tj
2.4208 0 Td
(the)Tj
1.4683 0 Td
(feed)Tj
1.8822 0 Td
(trough)Tj
2.9197 0 Td
(near)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(edge)Tj
2.0579 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(pen.)Tj
1.9332 0 Td
(Gloves)Tj
2.9254 0 Td
(and)Tj
1.7348 0 Td
(plastic)Tj
2.7666 0 Td
(boot)Tj
2.0352 0 Td
(covers)Tj
2.761 0 Td
(were)Tj
-33.9645 -1.304 Td
(changed)Tj
3.5716 0 Td
(between)Tj
3.5263 0 Td
(each)Tj
2.0296 0 Td
(pen.)Tj
1.9332 0 Td
(Once)Tj
2.364 0 Td
(the)Tj
1.4684 0 Td
(person)Tj
2.948 0 Td
(had)Tj
1.7121 0 Td
(walked)Tj
3.0274 0 Td
(approximately)Tj
5.9754 0 Td
(100)Tj
1.6497 0 Td
(feet,)Tj
1.8766 0 Td
(the)Tj
1.474 0 Td
(swab)Tj
2.2053 0 Td
(was)Tj
-35.7616 -1.2982 Td
(removed)Tj
3.7473 0 Td
(and)Tj
1.7292 0 Td
(placed)Tj
2.7949 0 Td
(into)Tj
1.8368 0 Td
(a)Tj
0.6577 0 Td
(specimen)Tj
4.0025 0 Td
(cup)Tj
1.6894 0 Td
(that)Tj
1.7745 0 Td
(contained)Tj
4.2009 0 Td
(50)Tj
1.1735 0 Td
(ml)Tj
1.2813 0 Td
(of)Tj
1.0148 0 Td
(gram)Tj
2.313 0 Td
(negative)Tj
3.532 0 Td
(broth)Tj
2.4321 0 Td
(contain-)Tj
-34.1799 -1.2983 Td
(ing)Tj
1.5023 0 Td
(vancomycin)Tj
5.0967 0 Td
(\(40)Tj
/F16 1 Tf
1.5137 0 Td
[()]TJ
/F7 1 Tf
(g/ml\),)Tj
3.1521 0 Td
(cefsulodin)Tj
4.3426 0 Td
(\(10)Tj
/F16 1 Tf
1.508 0 Td
[()]TJ
/F7 1 Tf
(g/ml\))Tj
2.931 0 Td
(and)Tj
1.7292 0 Td
(cefixime)Tj
3.5943 0 Td
(\(0.05)Tj
/F16 1 Tf
2.2166 0 Td
[()]TJ
/F7 1 Tf
(g/ml\).)Tj
3.1522 0 Td
(Specimen)Tj
4.1158 0 Td
(cups)Tj
-34.8545 -1.2983 Td
(were)Tj
2.1203 0 Td
(kept)Tj
1.9558 0 Td
(in)Tj
1.0375 0 Td
(coolers)Tj
3.0557 0 Td
(or)Tj
1.0999 0 Td
(refrigerators)Tj
5.176 0 Td
(until)Tj
2.1033 0 Td
(they)Tj
1.9276 0 Td
(were)Tj
2.1203 0 Td
(delivered)Tj
3.8891 0 Td
(to)Tj
1.0204 0 Td
(the)Tj
1.474 0 Td
(microbiology)Tj
5.5616 0 Td
(laboratory)Tj
-32.5415 -1.3039 Td
(at)Tj
0.9524 0 Td
(Texas)Tj
2.5115 0 Td
(A&M)Tj
2.5058 0 Td
(University)Tj
4.3993 0 Td
(within)Tj
2.812 0 Td
(24)Tj
1.1735 0 Td
(hours)Tj
2.5172 0 Td
(where)Tj
2.6475 0 Td
(they)Tj
1.9219 0 Td
(were)Tj
2.1259 0 Td
(placed)Tj
2.7893 0 Td
(in)Tj
1.0375 0 Td
(an)Tj
1.2019 0 Td
(incubator)Tj
4.1045 0 Td
(at)Tj
0.9525 0 Td
(37C)Tj
2.228 0 Td
(and)Tj
-35.8807 -1.2982 Td
(left)Tj
1.474 0 Td
(to)Tj
1.0261 0 Td
(enrich)Tj
2.7836 0 Td
(overnight.)Tj
4.3086 0 Td
(The)Tj
1.7802 0 Td
(next)Tj
1.9559 0 Td
(day)Tj
1.6384 0 Td
(the)Tj
1.4683 0 Td
(samples)Tj
3.3846 0 Td
(underwent)Tj
4.5694 0 Td
(immunomagnetic)Tj
7.3927 0 Td
(bead)Tj
2.109 0 Td
(separa-)Tj
-33.8908 -1.2983 Td
(tion)Tj
1.8425 0 Td
(with)Tj
1.9955 0 Td
(20)Tj
/F16 1 Tf
1.1679 0 Td
[()]TJ
/F7 1 Tf
(l)Tj
0.9751 0 Td
(of)Tj
1.0148 0 Td
(Dynabeads)Tj
4.6488 0 Td
(suspension)Tj
4.6431 0 Td
(\(anti-)Tj
/F13 1 Tf
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
3.2315 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157;)Tj
2.6192 0 Td
(Dynal)Tj
2.6362 0 Td
(Biotech)Tj
3.2485 0 Td
(ASA,)Tj
2.2904 0 Td
(Oslo,)Tj
2.3074 0 Td
(Nor-)Tj
-34.1799 -1.3039 Td
(way\).)Tj
2.3584 0 Td
(From)Tj
2.4434 0 Td
(the)Tj
1.4683 0 Td
(specimen)Tj
4.0082 0 Td
(cup,)Tj
1.9105 0 Td
(1)Tj
0.6974 0 Td
(ml)Tj
1.2869 0 Td
(of)Tj
1.0148 0 Td
(solution)Tj
3.4809 0 Td
(was)Tj
1.7008 0 Td
(removed)Tj
3.7474 0 Td
(and)Tj
1.7291 0 Td
(added)Tj
2.6589 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.6576 0 Td
(microcentrifuge)Tj
-30.1887 -1.2983 Td
(tube)Tj
1.9729 0 Td
(containing)Tj
4.5297 0 Td
(the)Tj
1.4683 0 Td
(beads.)Tj
2.6986 0 Td
(The)Tj
1.7858 0 Td
(samples)Tj
3.3789 0 Td
(then)Tj
2.0182 0 Td
(underwent)Tj
4.5751 0 Td
(immunomagnetic)Tj
7.3871 0 Td
(separation,)Tj
4.6091 0 Td
(selec-)Tj
-34.4237 -1.2982 Td
(tive)Tj
1.661 0 Td
(culture)Tj
3.0388 0 Td
(and)Tj
1.7291 0 Td
(latex)Tj
2.0919 0 Td
(agglutination)Tj
5.5276 0 Td
(testing)Tj
2.8799 0 Td
(as)Tj
1.0148 0 Td
(described)Tj
4.0536 0 Td
(below.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 449.7448 cm
BT
/F14 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Allocation)Tj
4.5874 0 Td
(of)Tj
1.0677 0 Td
(control)Tj
3.2552 0 Td
(and)Tj
1.7952 0 Td
(intervention)Tj
5.4001 0 Td
(pens)Tj
2.1449 0 Td
(and)Tj
1.7906 0 Td
(cohorts)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 432.737 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(All)Tj
1.3946 0 Td
(pens)Tj
2.0693 0 Td
(were)Tj
2.1259 0 Td
(screened)Tj
3.7191 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9922 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8664 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(pen)Tj
1.7121 0 Td
(environment)Tj
5.4311 0 Td
(as)Tj
-32.9553 -1.3039 Td
(described)Tj
4.0535 0 Td
(above.)Tj
2.7666 0 Td
(In)Tj
1.1111 0 Td
(2014)Tj
2.1203 0 Td
(\(year)Tj
2.2451 0 Td
(1\))Tj
1.0374 0 Td
(83%)Tj
1.9276 0 Td
(\(19/)Tj
1.8425 0 Td
(23\))Tj
1.508 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.559 0 Td
(O157:H7)Tj
3.8608 0 Td
(positive)Tj
3.3165 0 Td
(pens)Tj
2.0693 0 Td
(were)Tj
2.1203 0 Td
(included)Tj
-33.5506 -1.2982 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(trial,)Tj
2.0579 0 Td
(while)Tj
2.3697 0 Td
(in)Tj
1.0375 0 Td
(2015)Tj
2.1203 0 Td
(\(year)Tj
2.2451 0 Td
(2\))Tj
1.0374 0 Td
(46%)Tj
1.9276 0 Td
(\(16)Tj
1.5137 0 Td
(of)Tj
1.0148 0 Td
(35\))Tj
1.508 0 Td
(of)Tj
1.0148 0 Td
(positive)Tj
3.3165 0 Td
(pens)Tj
2.0693 0 Td
(were)Tj
2.1259 0 Td
(included)Tj
3.7077 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(trial)Tj
-34.0778 -1.2983 Td
(\(explained)Tj
4.4106 0 Td
(below\).)Tj
3.1521 0 Td
(Pens)Tj
2.1147 0 Td
(were)Tj
2.1203 0 Td
(allocated)Tj
3.7644 0 Td
(to)Tj
1.0204 0 Td
(three)Tj
2.2677 0 Td
(different)Tj
3.6567 0 Td
(cohorts)Tj
3.2145 0 Td
(\(13\),)Tj
2.5965 0 Td
(beginning)Tj
4.2576 0 Td
(on)Tj
1.2756 0 Td
(June)Tj
2.0522 0 Td
(16,)Tj
-35.9033 -1.3039 Td
(June)Tj
2.0466 0 Td
(23)Tj
1.1735 0 Td
(and)Tj
1.7291 0 Td
(June)Tj
2.0523 0 Td
(30)Tj
1.1678 0 Td
(in)Tj
1.0375 0 Td
(2014)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(on)Tj
1.2756 0 Td
(June)Tj
2.0523 0 Td
(16,)Tj
1.3946 0 Td
(June)Tj
2.0523 0 Td
(23)Tj
1.1679 0 Td
(and)Tj
1.7348 0 Td
(June)Tj
2.0466 0 Td
(29)Tj
1.1735 0 Td
(in)Tj
1.0318 0 Td
(2015.)Tj
2.3527 0 Td
(Blocking)Tj
3.7531 0 Td
(was)Tj
1.6951 0 Td
(used)Tj
-34.7865 -1.2983 Td
(in)Tj
1.0318 0 Td
(order)Tj
2.4207 0 Td
(to)Tj
1.0262 0 Td
(ensure)Tj
2.8799 0 Td
(that)Tj
1.7745 0 Td
(cohorts)Tj
3.2145 0 Td
(were)Tj
2.126 0 Td
(similar)Tj
2.9877 0 Td
(with)Tj
1.9955 0 Td
(respect)Tj
3.0388 0 Td
(to)Tj
1.0261 0 Td
(days)Tj
1.9956 0 Td
(in)Tj
1.0374 0 Td
(feeding:)Tj
3.3846 0 Td
(pens)Tj
2.0749 0 Td
(were)Tj
2.1203 0 Td
(first)Tj
-34.1345 -1.2982 Td
(ordered)Tj
3.3732 0 Td
(by)Tj
1.1792 0 Td
(days)Tj
1.9955 0 Td
(in)Tj
1.0375 0 Td
(feeding,)Tj
3.3902 0 Td
(then)Tj
2.0183 0 Td
(systematically)Tj
5.7429 0 Td
(randomly)Tj
4.1273 0 Td
(assigned)Tj
3.6056 0 Td
(to)Tj
1.0261 0 Td
(cohorts)Tj
3.2145 0 Td
(1,)Tj
0.9241 0 Td
(2)Tj
0.6973 0 Td
(or)Tj
1.0942 0 Td
(3)Tj
0.6973 0 Td
(by)Tj
1.1792 0 Td
(allo-)Tj
-35.3024 -1.2983 Td
(cating)Tj
2.6532 0 Td
(two)Tj
1.7121 0 Td
(successive)Tj
4.2462 0 Td
(pens)Tj
2.0693 0 Td
(\(a)Tj
0.9921 0 Td
(control)Tj
3.1238 0 Td
(and)Tj
1.7291 0 Td
(intervention)Tj
5.1761 0 Td
(pen\))Tj
2.0522 0 Td
(to)Tj
1.0262 0 Td
(a)Tj
0.6519 0 Td
(different)Tj
3.6567 0 Td
(cohort.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 310.337 cm
BT
/F14 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Adaptation)Tj
4.9937 0 Td
(to)Tj
1.0772 0 Td
(trial)Tj
1.9937 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 293.3858 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(year)Tj
1.9048 0 Td
(2,)Tj
0.9241 0 Td
(several)Tj
2.931 0 Td
(commercial)Tj
4.9549 0 Td
(field)Tj
1.9729 0 Td
(trials)Tj
2.1997 0 Td
(were)Tj
2.1203 0 Td
(also)Tj
1.7688 0 Td
(being)Tj
2.4321 0 Td
(conducted)Tj
4.4277 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(participating)Tj
5.3291 0 Td
(feedlot,)Tj
-34.4917 -1.3039 Td
(which)Tj
2.6475 0 Td
(had)Tj
1.7121 0 Td
(started)Tj
2.931 0 Td
(operating)Tj
4.0535 0 Td
(under)Tj
2.6192 0 Td
(new)Tj
1.8766 0 Td
(management.)Tj
5.6579 0 Td
(As)Tj
1.2699 0 Td
(a)Tj
0.6519 0 Td
(result,)Tj
2.6759 0 Td
(the)Tj
1.4684 0 Td
(pen)Tj
1.7064 0 Td
(selection)Tj
3.719 0 Td
(and)Tj
1.7292 0 Td
(treat-)Tj
-34.7185 -1.2982 Td
(ment)Tj
2.3017 0 Td
(assignment)Tj
4.7395 0 Td
(method)Tj
3.3165 0 Td
(used)Tj
2.0579 0 Td
(in)Tj
1.0262 0 Td
(our)Tj
1.6214 0 Td
(study)Tj
2.381 0 Td
(excluded)Tj
3.7814 0 Td
(pens)Tj
2.0637 0 Td
(that)Tj
1.7688 0 Td
(were)Tj
2.1146 0 Td
(being)Tj
2.4264 0 Td
(used)Tj
2.0523 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4627 0 Td
(underly-)Tj
-34.1459 -1.2983 Td
(ing)Tj
1.5023 0 Td
(commercial)Tj
4.9549 0 Td
(field)Tj
1.9729 0 Td
(trials)Tj
2.194 0 Td
(when)Tj
2.4038 0 Td
(experimental)Tj
5.4595 0 Td
(groups)Tj
2.9707 0 Td
(and)Tj
1.7291 0 Td
(replicates)Tj
3.9855 0 Td
(could)Tj
2.4548 0 Td
(not)Tj
1.5704 0 Td
(be)Tj
1.1508 0 Td
(balanced)Tj
3.7644 0 Td
(in)Tj
-36.1131 -1.3039 Td
(their)Tj
2.1089 0 Td
(commercial)Tj
4.9549 0 Td
(trials.)Tj
2.4208 0 Td
(The)Tj
1.7858 0 Td
(information)Tj
5.074 0 Td
(about)Tj
2.4945 0 Td
(the)Tj
1.4683 0 Td
(nature)Tj
2.8233 0 Td
(of)Tj
1.0148 0 Td
(their)Tj
2.109 0 Td
(trials)Tj
2.1996 0 Td
(was)Tj
1.6952 0 Td
(proprietary)Tj
4.7565 0 Td
(and)Tj
-34.9056 -1.2983 Td
(was)Tj
1.6951 0 Td
(not)Tj
1.576 0 Td
(shared)Tj
2.863 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4684 0 Td
(authors.)Tj
3.4696 0 Td
(Out)Tj
1.7971 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(total)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(35)Tj
/F13 1 Tf
1.1735 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7( )10(\n)12()]TJ
/F7 1 Tf
1.5591 0 Td
(O157:H7)Tj
3.8664 0 Td
(positive)Tj
3.3165 0 Td
(pens,)Tj
2.2904 0 Td
(9)Tj
0.6973 0 Td
(were)Tj
-34.2649 -1.2982 Td
(available)Tj
3.668 0 Td
(for)Tj
1.3833 0 Td
(selection)Tj
3.719 0 Td
(as)Tj
1.0148 0 Td
(intervention)Tj
5.176 0 Td
(pens,)Tj
2.2961 0 Td
(of)Tj
1.0148 0 Td
(which)Tj
2.6475 0 Td
(8)Tj
0.6973 0 Td
(were)Tj
2.126 0 Td
(selected.)Tj
3.5716 0 Td
(A)Tj
0.9014 0 Td
(pen)Tj
1.7122 0 Td
(that)Tj
1.7744 0 Td
(was)Tj
1.7008 0 Td
(376)Tj
1.6498 0 Td
(days)Tj
-35.053 -1.304 Td
(in)Tj
1.0318 0 Td
(feeding)Tj
3.1634 0 Td
(was)Tj
1.7008 0 Td
(excluded)Tj
3.787 0 Td
(because)Tj
3.3166 0 Td
(it)Tj
0.788 0 Td
(was)Tj
1.7008 0 Td
(scheduled)Tj
4.2065 0 Td
(for)Tj
1.389 0 Td
(slaughter.)Tj
4.0989 0 Td
(The)Tj
1.7801 0 Td
(remaining)Tj
4.3654 0 Td
(26)Tj
1.1735 0 Td
(positive)Tj
-32.5018 -1.2982 Td
(pens)Tj
2.0692 0 Td
(were)Tj
2.1203 0 Td
(available)Tj
3.668 0 Td
(for)Tj
1.389 0 Td
(enrollment)Tj
4.6488 0 Td
(as)Tj
1.0148 0 Td
(control)Tj
3.1238 0 Td
(pens)Tj
2.0692 0 Td
(and)Tj
1.7292 0 Td
(8)Tj
0.6973 0 Td
(pens)Tj
2.0693 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4683 0 Td
(distribution)Tj
4.9663 0 Td
(of)Tj
1.0148 0 Td
(days)Tj
1.9956 0 Td
(in)Tj
-36.0451 -1.2983 Td
(feeding)Tj
3.1634 0 Td
(similar)Tj
2.9877 0 Td
(to)Tj
1.0205 0 Td
(that)Tj
1.7801 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(intervention)Tj
5.176 0 Td
(pens)Tj
2.0693 0 Td
(were)Tj
2.126 0 Td
(allocated)Tj
3.7587 0 Td
(as)Tj
1.0148 0 Td
(control)Tj
3.1181 0 Td
(pens.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 145.0204 cm
BT
/F14 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Sample)Tj
3.2787 0 Td
(selection)Tj
3.8741 0 Td
(and)Tj
1.7953 0 Td
(transport)Tj
4.1716 0 Td
(to)Tj
1.0772 0 Td
(laboratory)Tj
4.6016 0 Td
(for)Tj
1.4693 0 Td
(processing)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 128.0125 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(following)Tj
3.9798 0 Td
(samples)Tj
3.3846 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(from)Tj
2.2053 0 Td
(each)Tj
2.0296 0 Td
(pen)Tj
1.7064 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(start)Tj
1.9843 0 Td
(and)Tj
1.7291 0 Td
(end)Tj
1.7234 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(trial)Tj
1.8368 0 Td
(\(three)Tj
-33.1254 -1.3039 Td
(weeks)Tj
2.6078 0 Td
(later\).)Tj
-2.6078 -1.8992 Td
(1.)Tj
1.2018 0 Td
(Forty)Tj
2.3755 0 Td
(individual)Tj
4.2916 0 Td
(well-formed,)Tj
5.3291 0 Td
(freshly)Tj
2.897 0 Td
(voided)Tj
2.9253 0 Td
(fecal)Tj
2.0353 0 Td
(pats)Tj
1.8311 0 Td
(were)Tj
2.1203 0 Td
(randomly)Tj
4.1329 0 Td
(sampled)Tj
3.549 0 Td
(from)Tj
2.2053 0 Td
(each)Tj
-33.6924 -1.2982 Td
(pen.)Tj
1.9332 0 Td
(Using)Tj
2.5966 0 Td
(a)Tj
0.6576 0 Td
(disposable)Tj
4.371 0 Td
(spoon,)Tj
2.8856 0 Td
(approximately)Tj
5.9754 0 Td
(20)Tj
1.1679 0 Td
(g)Tj
0.686 0 Td
(of)Tj
1.0148 0 Td
(feces)Tj
2.143 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(per)Tj
1.5307 0 Td
(sample)Tj
3.0217 0 Td
(into)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 303.8173 745.7952 cm
BT
/F6 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Escherich)Tj
4.3157 0 Td
(ia)Tj
0.978 0 Td
(coli)Tj
/F0 1 Tf
1.6866 0 Td
(O157:H7)Tj
4.1599 0 Td
(in)Tj
0.978 0 Td
(cattle)Tj
2.5724 0 Td
(fecal)Tj
2.289 0 Td
(pats)Tj
2.0835 0 Td
(and)Tj
1.8496 0 Td
(water)Tj
2.6292 0 Td
(trough)Tj
3.0047 0 Td
(levels)Tj
2.7213 0 Td
(on)Tj
1.311 0 Td
(feedlots)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01921)Tj
4.089 0 Td
(49)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(7,)Tj
1.0417 0 Td
(2018)Tj
33.7042 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
97 0 obj
<>stream
endstream
endobj
98 0 obj
<>stream
endstream
endobj
99 0 obj
<>stream
endstream
endobj
100 0 obj
<>stream
BT
66.402 0 Td
(21)Tj
ET
Q
endstream
endobj
101 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 103 0 R/Contents 104 0 R/TrimBox[0 0 612 792]>>
endobj
102 0 obj
<>
endobj
105 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
15 beginbfchar
<0010><002D>
<0014><0031>
<0016><0033>
<0018><0035>
<0024><0041>
<0025><0042>
<0026><0043>
<0029><0046>
<002A><0047>
<002B><0048>
<0034><0051>
<0037><0054>
<0044><0061>
<0050><006D>
<00B6><2019>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
106 0 obj
<>/FontDescriptor 107 0 R/DW 600>>
endobj
107 0 obj
<>
endobj
108 0 obj
<>stream
`DSIG EBDTL\ iX EBLC+\ mL 4GDEF̥
r GSUBLcu| s NOS/2
0M VVDMX2M' B bdatL\ bloc+\ 4cmapX[ Bcvt a d fpgm62 _ gasp + @ glyf v head)x l 6hhea{<