%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Ivana Musilova, Lenka Pliskova, Romana Gerychova, Petr Janku, Ondrej Simetka, Petr Matlak, Bo Jacobsson, Marian Kacerovsky
Maternal white blood cell count cannot identify the presence of microbial invasion of the amniotic cavity or intra-amniotic inflammation in women with preterm prelabor rupture of membranes
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref001)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref006)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref008)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref010)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref011)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref012)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref012)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref011)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref013)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref015)>>
endobj
29 0 obj
<>/Border[0 0 0]/A 30 0 R>>
endobj
30 0 obj
<>
endobj
15 0 obj
[31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R]
endobj
31 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 506.6144 m
199.9998 506.6144 l
199.9998 507.1144 l
575.9997 507.1144 l
f*
0.83 0.64 0.02 0 k
380.9197 393.9024 m
385.6819 393.9024 l
h
f*
390.1606 393.9024 m
394.9228 393.9024 l
h
f*
439.1433 354.8976 m
443.9055 354.8976 l
h
f*
449.1213 354.8976 m
453.8835 354.8976 l
h
f*
260.3906 328.9323 m
265.1528 328.9323 l
h
f*
256.5354 289.9276 m
261.2976 289.9276 l
h
f*
266.4567 289.9276 m
275.9811 289.9276 l
h
f*
249.6189 224.9008 m
259.1433 224.9008 l
h
f*
263.5654 224.9008 m
273.0898 224.9008 l
h
f*
232.4409 211.9181 m
241.9654 211.9181 l
h
f*
267.3071 107.9433 m
276.8315 107.9433 l
h
f*
281.2535 107.9433 m
290.778 107.9433 l
h
f*
295.937 107.9433 m
305.4614 107.9433 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0168 Tc
0 0 Td
(without)Tj
3.2643 0 Td
(IAI:)Tj
1.6649 0 Td
(median,)Tj
3.6463 0 Td
(11.9)Tj
/F7 1 Tf
2.0946 0 Td
[( )]TJ
/F0 1 Tf
0.7877 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.1248 0 0 6.3325 319.0677 711.9496 cm
BT
/F0 1 Tf
1 TL
-0.0224 Tc
0 0 Td
(9)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 322.8094 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0168 Tc
0 0 Td
(/L;)Tj
/F6 1 Tf
1.289 0 Td
(p)Tj
/F7 1 Tf
0.7519 0 Td
[( )]TJ
/F0 1 Tf
0.7877 0 Td
(0.0001\).)Tj
3.7477 0 Td
(When)Tj
2.763 0 Td
(the)Tj
1.5576 0 Td
(women)Tj
3.3478 0 Td
(were)Tj
2.3095 0 Td
(divided)Tj
3.2524 0 Td
(into)Tj
1.7605 0 Td
(four)Tj
1.8738 0 Td
(sub-)Tj
-36.3668 -1.474 Td
(groups)Tj
3.1629 0 Td
(based)Tj
2.8465 0 Td
(on)Tj
1.295 0 Td
(the)Tj
1.5576 0 Td
(presence)Tj
4.1832 0 Td
(of)Tj
1.0205 0 Td
(MIAC)Tj
2.6615 0 Td
(and/or)Tj
2.9421 0 Td
(IAI,)Tj
1.665 0 Td
(the)Tj
1.5575 0 Td
(women)Tj
3.3479 0 Td
(with)Tj
1.9275 0 Td
(both)Tj
2.0947 0 Td
(MIAC)Tj
2.6556 0 Td
(and)Tj
1.8261 0 Td
(IAI)Tj
1.4024 0 Td
(had)Tj
1.8321 0 Td
(a)Tj
-37.9781 -1.474 Td
(higher)Tj
2.8824 0 Td
(WBC)Tj
2.5064 0 Td
(count)Tj
2.578 0 Td
(than)Tj
2.0947 0 Td
(those)Tj
2.572 0 Td
(with)Tj
1.9275 0 Td
(either)Tj
2.6138 0 Td
(IAI)Tj
1.4024 0 Td
(or)Tj
1.0682 0 Td
(MIAC)Tj
2.6616 0 Td
(alone,)Tj
2.8287 0 Td
(and)Tj
1.8261 0 Td
(those)Tj
2.578 0 Td
(without)Tj
3.2643 0 Td
(MIAC)Tj
2.6556 0 Td
(and)Tj
1.8321 0 Td
(IAI)Tj
-37.2918 -1.474 Td
([both)Tj
2.3572 0 Td
(MIAC)Tj
2.6556 0 Td
(and)Tj
1.8261 0 Td
(IAI:)Tj
1.665 0 Td
(median,)Tj
3.6522 0 Td
(14.0)Tj
/F7 1 Tf
2.0946 0 Td
[( )]TJ
/F0 1 Tf
0.7877 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.1248 0 0 6.3325 353.0267 669.9401 cm
BT
/F0 1 Tf
1 TL
-0.0224 Tc
0 0 Td
(9)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 356.8251 665.7448 cm
BT
/F0 1 Tf
1 TL
-0.0168 Tc
0 0 Td
(/L;)Tj
1.283 0 Td
(IAI)Tj
1.4024 0 Td
(alone:)Tj
2.8346 0 Td
(12.1)Tj
/F7 1 Tf
2.0887 0 Td
[( )]TJ
/F0 1 Tf
0.7877 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.1248 0 0 6.3325 446.7968 669.9401 cm
BT
/F0 1 Tf
1 TL
-0.0224 Tc
0 0 Td
(9)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 450.5385 665.7448 cm
BT
/F0 1 Tf
1 TL
-0.0168 Tc
0 0 Td
(/L)Tj
1.0264 0 Td
(\()Tj
/F6 1 Tf
(p)Tj
/F0 1 Tf
1.0682 0 Td
(=)Tj
0.7877 0 Td
(0.03\);)Tj
2.6795 0 Td
(MIAC)Tj
2.6556 0 Td
(alone:)Tj
2.8287 0 Td
(12.1)Tj
/F7 1 Tf
-37.4171 -1.474 Td
[( )]TJ
/F0 1 Tf
0.7877 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.1248 0 0 6.3325 217.644 655.937 cm
BT
/F0 1 Tf
1 TL
-0.0224 Tc
0 0 Td
(9)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 221.4425 651.7417 cm
BT
/F0 1 Tf
1 TL
-0.0168 Tc
0 0 Td
(/L)Tj
1.0204 0 Td
(\()Tj
/F6 1 Tf
(p)Tj
/F0 1 Tf
1.0742 0 Td
(=)Tj
0.7877 0 Td
(0.0001\);)Tj
3.7477 0 Td
(and)Tj
1.8261 0 Td
(without)Tj
3.2643 0 Td
(MIAC)Tj
2.6556 0 Td
(and)Tj
1.8261 0 Td
(IAI:)Tj
1.665 0 Td
(median,)Tj
3.6522 0 Td
(11.8)Tj
/F7 1 Tf
2.0947 0 Td
[( )]TJ
/F0 1 Tf
0.7877 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.1248 0 0 6.3325 463.4078 655.937 cm
BT
/F0 1 Tf
1 TL
-0.0224 Tc
0 0 Td
(9)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 467.2062 651.7417 cm
BT
/F0 1 Tf
1 TL
-0.0168 Tc
0 0 Td
(/L)Tj
1.0204 0 Td
(\()Tj
/F6 1 Tf
(p)Tj
/F7 1 Tf
1.0742 0 Td
[( )]TJ
/F0 1 Tf
0.7877 0 Td
(0.0001\)].)Tj
4.0103 0 Td
(No)Tj
1.4621 0 Td
(differ-)Tj
-36.4802 -1.474 Td
(ences)Tj
2.7929 0 Td
(in)Tj
0.9607 0 Td
(the)Tj
1.5576 0 Td
(WBC)Tj
2.5064 0 Td
(counts)Tj
3.0614 0 Td
(were)Tj
2.3095 0 Td
(found)Tj
2.6317 0 Td
(among)Tj
3.1808 0 Td
(the)Tj
1.5576 0 Td
(women)Tj
3.3478 0 Td
(with)Tj
1.9276 0 Td
(IAI)Tj
1.4024 0 Td
(alone,)Tj
2.8285 0 Td
(MIAC)Tj
2.6556 0 Td
(alone,)Tj
2.8347 0 Td
(and)Tj
1.8261 0 Td
(with-)Tj
-37.3813 -1.474 Td
(out)Tj
1.5575 0 Td
(MIAC)Tj
2.6557 0 Td
(and)Tj
1.8261 0 Td
(IAI.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 593.1212 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusion)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 576.1133 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(The)Tj
1.9275 0 Td
(women)Tj
3.4135 0 Td
(with)Tj
1.9753 0 Td
(both)Tj
2.1424 0 Td
(MIAC)Tj
2.7093 0 Td
(and)Tj
1.8679 0 Td
(IAI)Tj
1.4382 0 Td
(had)Tj
1.8619 0 Td
(a)Tj
0.7698 0 Td
(higher)Tj
2.96 0 Td
(maternal)Tj
4.0699 0 Td
(WBC)Tj
2.5422 0 Td
(count)Tj
2.6377 0 Td
(at)Tj
1.0503 0 Td
(the)Tj
1.5934 0 Td
(time)Tj
2.0887 0 Td
(of)Tj
1.0503 0 Td
(hospital)Tj
-36.0983 -1.474 Td
(admission)Tj
4.6667 0 Td
(than)Tj
2.1423 0 Td
(the)Tj
1.5934 0 Td
(remaining)Tj
4.5593 0 Td
(women)Tj
3.4075 0 Td
(with)Tj
1.9813 0 Td
(PPROM.)Tj
4.1475 0 Td
(The)Tj
1.9276 0 Td
(maternal)Tj
4.0639 0 Td
(WBC)Tj
2.5482 0 Td
(count)Tj
2.6377 0 Td
(at)Tj
1.0503 0 Td
(the)Tj
1.5934 0 Td
(time)Tj
2.0887 0 Td
(of)Tj
-38.4078 -1.474 Td
(admission)Tj
4.6667 0 Td
(showed)Tj
3.6283 0 Td
(poor)Tj
2.1961 0 Td
(diagnostic)Tj
4.6607 0 Td
(indices)Tj
3.2882 0 Td
(for)Tj
1.3785 0 Td
(the)Tj
1.5934 0 Td
(identification)Tj
5.7051 0 Td
(of)Tj
1.0443 0 Td
(the)Tj
1.5934 0 Td
(presence)Tj
4.2848 0 Td
(of)Tj
1.0503 0 Td
(both)Tj
-35.0898 -1.474 Td
(MIAC)Tj
2.7033 0 Td
(and)Tj
1.8679 0 Td
(IAI.)Tj
1.7187 0 Td
(Maternal)Tj
4.0639 0 Td
(WBC)Tj
2.5482 0 Td
(count)Tj
2.6377 0 Td
(at)Tj
1.0444 0 Td
(the)Tj
1.5993 0 Td
(time)Tj
2.0887 0 Td
(of)Tj
1.0443 0 Td
(admission)Tj
4.6727 0 Td
(cannot)Tj
3.1867 0 Td
(serve)Tj
2.6377 0 Td
(as)Tj
1.2652 0 Td
(a)Tj
0.7698 0 Td
(non-invasive)Tj
-33.8485 -1.474 Td
(screening)Tj
4.4996 0 Td
(tool)Tj
1.8082 0 Td
(for)Tj
1.3785 0 Td
(identifying)Tj
4.6607 0 Td
(these)Tj
2.6377 0 Td
(complications)Tj
6.2064 0 Td
(in)Tj
0.9847 0 Td
(women)Tj
3.4135 0 Td
(with)Tj
1.9752 0 Td
(PPROM.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 450.9921 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 433.9842 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Preterm)Tj
3.4865 0 Td
(prelabor)Tj
3.5944 0 Td
(rupture)Tj
3.2598 0 Td
(of)Tj
1.0148 0 Td
(membranes)Tj
4.9266 0 Td
(\(PPROM\),)Tj
4.507 0 Td
(characterized)Tj
5.5559 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(rupture)Tj
3.2541 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(fetal)Tj
-34.7411 -1.2982 Td
(membranes,)Tj
5.1533 0 Td
(with)Tj
1.9956 0 Td
(leakage)Tj
3.1407 0 Td
(of)Tj
1.0148 0 Td
(amniotic)Tj
3.7871 0 Td
(fluid,)Tj
2.3017 0 Td
(before)Tj
2.7439 0 Td
(spontaneous)Tj
5.2498 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(regular)Tj
3.0614 0 Td
(uterine)Tj
3.0784 0 Td
(con-)Tj
-34.8999 -1.2983 Td
(tractions)Tj
3.7247 0 Td
(prior)Tj
2.2563 0 Td
(to)Tj
1.0261 0 Td
(37)Tj
1.1679 0 Td
(weeks)Tj
2.6079 0 Td
(of)Tj
1.0148 0 Td
(gestation,)Tj
4.0478 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1259 0 Td
(considered)Tj
4.5978 0 Td
(a)Tj
0.6576 0 Td
(difficult,)Tj
3.5773 0 Td
(serious,)Tj
3.2599 0 Td
(and)Tj
1.7347 0 Td
(controver-)Tj
-33.3408 -1.3039 Td
(sial)Tj
1.525 0 Td
(perinatal)Tj
3.7644 0 Td
(complication)Tj
5.4765 0 Td
(since)Tj
2.245 0 Td
(many)Tj
2.4775 0 Td
(years)Tj
2.262 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(2)Tj
0 g
(].)Tj
1.2586 0 Td
(Characterization)Tj
6.8995 0 Td
(of)Tj
1.0148 0 Td
(PPROM)Tj
3.6 0 Td
(pregnancies)Tj
-31.7875 -1.2983 Td
(differs)Tj
2.7439 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2755 0 Td
(their)Tj
2.109 0 Td
(causality)Tj
3.668 0 Td
(and)Tj
1.7291 0 Td
(pathophysiology:)Tj
7.0413 0 Td
(i\))Tj
0.822 0 Td
(infection)Tj
3.7927 0 Td
(and)Tj
1.7292 0 Td
(inflammation)Tj
5.7032 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
-34.1175 -1.2982 Td
(choriodecidual)Tj
6.2021 0 Td
(space)Tj
2.3754 0 Td
(and)Tj
1.7292 0 Td
(amniotic)Tj
3.787 0 Td
(cavity;)Tj
2.778 0 Td
(ii\))Tj
1.0941 0 Td
(bleeding)Tj
3.6283 0 Td
(associated)Tj
4.2577 0 Td
(with)Tj
1.9955 0 Td
(placental)Tj
3.7928 0 Td
(abruption;)Tj
4.422 0 Td
(and)Tj
-36.0621 -1.3039 Td
(iii\))Tj
1.3606 0 Td
(non-infectious)Tj
6.0831 0 Td
(premature)Tj
4.4107 0 Td
(aging)Tj
2.3981 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(fetal)Tj
1.9105 0 Td
(membranes)Tj
4.9266 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
2.5965 0 Td
(Regardless)Tj
4.4561 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(PPROM)Tj
-33.1084 -1.2983 Td
(etiology)Tj
3.3902 0 Td
(and)Tj
1.7291 0 Td
(pathophysiology,)Tj
7.0355 0 Td
(PPROM)Tj
3.6 0 Td
(might)Tj
2.5965 0 Td
(jeopardize)Tj
4.3597 0 Td
(the)Tj
1.474 0 Td
(fetus)Tj
2.1146 0 Td
(by)Tj
1.1849 0 Td
(premature)Tj
4.405 0 Td
(birth)Tj
2.194 0 Td
(and)Tj
1.7291 0 Td
(its)Tj
-35.8126 -1.2983 Td
(consequences)Tj
5.6976 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.5987 0 Td
(In)Tj
1.1112 0 Td
(addition,)Tj
3.821 0 Td
(PPROM)Tj
3.6 0 Td
(might)Tj
2.5965 0 Td
(threaten)Tj
3.549 0 Td
(both)Tj
2.0579 0 Td
(the)Tj
1.4684 0 Td
(fetus)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(mother)Tj
3.1691 0 Td
(because)Tj
-33.9871 -1.2982 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(microbial)Tj
4.0592 0 Td
(invasion)Tj
3.6113 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(amniotic)Tj
3.787 0 Td
(cavity)Tj
2.5512 0 Td
(\(MIAC\))Tj
3.4809 0 Td
(and)Tj
1.7292 0 Td
(intra-amniotic)Tj
-28.9132 -1.304 Td
(inflammation)Tj
5.6976 0 Td
(\(IAI\),)Tj
2.4888 0 Td
(which)Tj
2.6532 0 Td
(may)Tj
1.9275 0 Td
(lead)Tj
1.8482 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(development)Tj
5.4141 0 Td
(of)Tj
1.0148 0 Td
(histological)Tj
4.7678 0 Td
(and)Tj
1.7292 0 Td
(even)Tj
2.0692 0 Td
(clinical)Tj
3.0785 0 Td
(chor-)Tj
-35.1834 -1.2982 Td
(ioamnionitis)Tj
5.312 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
-4.1158 -1.2983 Td
(At)Tj
1.2075 0 Td
(this)Tj
1.6724 0 Td
(stage,)Tj
2.4265 0 Td
(evaluation)Tj
4.3596 0 Td
(of)Tj
1.0148 0 Td
(amniotic)Tj
3.7871 0 Td
(fluid)Tj
2.075 0 Td
(samples)Tj
3.3845 0 Td
(alone,)Tj
2.6022 0 Td
(obtained)Tj
3.736 0 Td
(via)Tj
1.372 0 Td
(transabdominal)Tj
-28.8338 -1.3039 Td
(amniocentesis,)Tj
6.1284 0 Td
(might)Tj
2.5965 0 Td
(present)Tj
3.1635 0 Td
(precise)Tj
3.0047 0 Td
(information)Tj
5.0796 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4684 0 Td
(intra-amniotic)Tj
6.0547 0 Td
(environment.)Tj
5.6579 0 Td
(The)Tj
-34.4293 -1.2983 Td
(feasibility)Tj
4.0308 0 Td
(of)Tj
1.0148 0 Td
(transabdominal)Tj
6.5253 0 Td
(amniocentesis)Tj
5.9017 0 Td
(in)Tj
1.0375 0 Td
(PPROM)Tj
3.5999 0 Td
(dramatically)Tj
5.1761 0 Td
(changes)Tj
3.4015 0 Td
(over)Tj
1.9786 0 Td
(time)Tj
2.0296 0 Td
(\(the)Tj
-34.6958 -1.2982 Td
(success)Tj
3.101 0 Td
(rate)Tj
1.7462 0 Td
(has)Tj
1.542 0 Td
(increased)Tj
4.0025 0 Td
(from)Tj
2.2053 0 Td
(49%)Tj
1.9276 0 Td
(to)Tj
1.0261 0 Td
(96%\),)Tj
2.4945 0 Td
(mainly)Tj
2.9877 0 Td
(owing)Tj
2.6929 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(progress)Tj
3.5999 0 Td
(in)Tj
1.0318 0 Td
(ultrasound)Tj
-30.852 -1.3039 Td
(technology)Tj
4.6204 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(12)Tj
0 g
(].)Tj
1.7404 0 Td
(In)Tj
1.1056 0 Td
(addition,)Tj
3.8267 0 Td
(this)Tj
1.6724 0 Td
(procedure)Tj
4.3143 0 Td
(can)Tj
1.6214 0 Td
(be)Tj
1.1509 0 Td
(considered)Tj
4.6034 0 Td
(safe)Tj
1.7235 0 Td
(for)Tj
1.389 0 Td
(both)Tj
2.0579 0 Td
(mothers)Tj
3.5319 0 Td
(and)Tj
-35.0926 -1.2983 Td
(fetuses)Tj
2.9026 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
2.075 0 Td
(Nonetheless,)Tj
5.3007 0 Td
(the)Tj
1.474 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(obstetricians)Tj
5.2838 0 Td
(are)Tj
1.4513 0 Td
(reluctant)Tj
3.7927 0 Td
(to)Tj
1.0205 0 Td
(perform)Tj
3.5206 0 Td
(amniocentesis)Tj
-31.4643 -1.2983 Td
(in)Tj
1.0318 0 Td
(women)Tj
3.2031 0 Td
(with)Tj
2.0012 0 Td
(PPROM)Tj
3.6 0 Td
(owing)Tj
2.6872 0 Td
(to)Tj
1.0262 0 Td
(its)Tj
1.1452 0 Td
(invasiveness)Tj
5.125 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(relative)Tj
3.1351 0 Td
(technical)Tj
3.8154 0 Td
(difficulty)Tj
3.8097 0 Td
(associ-)Tj
-33.783 -1.3039 Td
(ated)Tj
1.9048 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(scenario,)Tj
3.7814 0 Td
(which)Tj
2.6532 0 Td
(involves)Tj
3.481 0 Td
(a)Tj
0.6519 0 Td
(very)Tj
1.9276 0 Td
(low)Tj
1.6554 0 Td
(volume)Tj
3.1975 0 Td
(of)Tj
1.0148 0 Td
(residual)Tj
3.3788 0 Td
(amniotic)Tj
3.7871 0 Td
(fluid.)Tj
2.3017 0 Td
(Therefore,)Tj
-33.1991 -1.2983 Td
(non-invasive)Tj
5.3857 0 Td
(markers)Tj
3.498 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(identification)Tj
5.5899 0 Td
(of)Tj
1.0148 0 Td
(intra-amniotic)Tj
6.0548 0 Td
(complications)Tj
5.8393 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
-34.4917 -1.2982 Td
(PPROM)Tj
3.5999 0 Td
(are)Tj
1.4457 0 Td
(still)Tj
1.6384 0 Td
(needed.)Tj
-5.4878 -1.2983 Td
(Various)Tj
3.3845 0 Td
(markers)Tj
3.4979 0 Td
(from)Tj
2.2054 0 Td
(non-invasively)Tj
6.0888 0 Td
(obtained)Tj
3.7303 0 Td
(body)Tj
2.2167 0 Td
(fluids)Tj
2.4378 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(suggested)Tj
4.0705 0 Td
(over)Tj
1.9786 0 Td
(the)Tj
-34.9906 -1.3039 Td
(decades;)Tj
3.5659 0 Td
(however,)Tj
3.8381 0 Td
(the)Tj
1.4683 0 Td
(evaluation)Tj
4.3597 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7984 0 Td
(white)Tj
2.4208 0 Td
(blood)Tj
2.5114 0 Td
(cell)Tj
1.5591 0 Td
(\(WBC\))Tj
3.1124 0 Td
(count)Tj
2.5228 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(1990s)Tj
-32.6775 -1.2983 Td
(could)Tj
2.4491 0 Td
(be)Tj
1.1508 0 Td
(considered)Tj
4.6035 0 Td
(an)Tj
1.2018 0 Td
(important)Tj
4.2803 0 Td
(pioneering)Tj
4.5581 0 Td
(step)Tj
1.8198 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(process)Tj
3.1861 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(non-invasive)Tj
5.3858 0 Td
(biomarker-)Tj
-32.8079 -1.2982 Td
(seeking)Tj
3.2031 0 Td
(process)Tj
3.1861 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(13)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
3.2088 0 Td
(Currently,)Tj
4.3483 0 Td
(the)Tj
1.4683 0 Td
(WBC)Tj
2.4322 0 Td
(count)Tj
2.5228 0 Td
(has)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(been)Tj
2.1203 0 Td
(taken)Tj
2.4207 0 Td
(into)Tj
1.8426 0 Td
(consideration)Tj
-31.6061 -1.304 Td
(as)Tj
1.0147 0 Td
(a)Tj
0.652 0 Td
(very)Tj
1.9276 0 Td
(useful)Tj
2.5908 0 Td
(marker)Tj
3.1351 0 Td
(for)Tj
1.389 0 Td
(infection-related)Tj
6.8654 0 Td
(and)Tj
1.7292 0 Td
(inflammatory)Tj
5.7089 0 Td
(intra-amniotic)Tj
6.0548 0 Td
(PPROM)Tj
3.5999 0 Td
(com-)Tj
-34.6674 -1.2982 Td
(plications)Tj
4.0875 0 Td
(for)Tj
1.389 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9786 0 Td
(two)Tj
1.7121 0 Td
(reasons:)Tj
3.4525 0 Td
(i\))Tj
0.8278 0 Td
(a)Tj
0.6519 0 Td
(wide)Tj
2.1203 0 Td
(range)Tj
2.4662 0 Td
(of)Tj
1.0147 0 Td
(normal)Tj
3.1465 0 Td
(maternal)Tj
3.7927 0 Td
(WBC)Tj
2.4321 0 Td
(count)Tj
2.5228 0 Td
(during)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 405.7511 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(WBC)Tj
2.537 0 Td
(and)Tj
1.8496 0 Td
(intra-amnioti)Tj
5.4 0 Td
(c)Tj
0.7158 0 Td
(complica)Tj
3.8693 0 Td
(tions)Tj
2.2961 0 Td
(in)Tj
0.978 0 Td
(PPROM)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01893)Tj
4.089 0 Td
(94)Tj
0 g
2.0906 0 Td
(December)Tj
4.7622 0 Td
(12,)Tj
1.5875 0 Td
(2017)Tj
32.5561 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(17)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
BT
10.3394 82.7156 Td
(exist.)Tj
ET
Q
endstream
endobj
43 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 45 0 R/Contents 46 0 R/TrimBox[0 0 612 792]>>
endobj
45 0 obj
[47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R]
endobj
47 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref016)>>
endobj
48 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref010)>>
endobj
49 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref011)>>
endobj
50 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref013)>>
endobj
51 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref015)>>
endobj
52 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref017)>>
endobj
53 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189394.ref024)>>
endobj
54 0 obj
<>/Border[0 0 0]/A 55 0 R>>
endobj
55 0 obj
<>
endobj
46 0 obj
[56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R]
endobj
56 0 obj
<>stream
q
0.83 0.64 0.02 0 k
247.4646 706.337 m
256.989 706.337 l
h
f*
449.8583 680.315 m
459.3827 680.315 l
h
f*
463.8047 680.315 m
473.3291 680.315 l
h
f*
477.8079 680.315 m
487.2756 680.315 l
h
f*
492.4913 680.315 m
501.9591 680.315 l
h
f*
506.4378 680.315 m
515.9622 680.315 l
h
f*
521.1213 680.315 m
530.6457 680.315 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(pregnancy)Tj
4.405 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(])Tj
1.8538 0 Td
(and)Tj
1.7291 0 Td
(ii\))Tj
1.0942 0 Td
(the)Tj
1.4683 0 Td
(studies)Tj
2.9877 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(presence)Tj
3.7134 0 Td
(of)Tj
1.0148 0 Td
(acute)Tj
2.3301 0 Td
(histological)Tj
4.7678 0 Td
(chorioamnionitis,)Tj
-28.8281 -1.3039 Td
(clinical)Tj
3.0727 0 Td
(chorioamnionitis,)Tj
7.37 0 Td
(and)Tj
1.7291 0 Td
(neonatal)Tj
3.6624 0 Td
(infection)Tj
3.787 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(outcomes)Tj
4.0876 0 Td
(have)Tj
2.0579 0 Td
(reported)Tj
3.6624 0 Td
(that)Tj
1.7744 0 Td
(maternal)Tj
-33.6923 -1.2982 Td
(WBC)Tj
2.4264 0 Td
(counts)Tj
2.8856 0 Td
(were)Tj
2.126 0 Td
(poor)Tj
2.1203 0 Td
(diagnostic)Tj
4.32 0 Td
(indices)Tj
3.0387 0 Td
(for)Tj
1.3833 0 Td
(these)Tj
2.2564 0 Td
(outcomes)Tj
4.0875 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4003 0 Td
(13)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
2.863 0 Td
(17)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
3.2031 0 Td
(Despite)Tj
-33.8454 -1.2983 Td
(these)Tj
2.2506 0 Td
(data,)Tj
2.143 0 Td
(the)Tj
1.4684 0 Td
(evaluation)Tj
4.3596 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7984 0 Td
(WBC)Tj
2.4265 0 Td
(count)Tj
2.5284 0 Td
(is)Tj
0.8448 0 Td
(still)Tj
1.6384 0 Td
(a)Tj
0.6576 0 Td
(part)Tj
1.8369 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4741 0 Td
(clinical)Tj
3.0727 0 Td
(protocol)Tj
3.6 0 Td
(in)Tj
-34.1289 -1.2983 Td
(women)Tj
3.2031 0 Td
(with)Tj
1.9956 0 Td
(PPROM)Tj
3.5999 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(countries)Tj
3.9458 0 Td
(worldwide.)Tj
-17.671 -1.3039 Td
(Since)Tj
2.3584 0 Td
(women)Tj
3.2031 0 Td
(with)Tj
2.0012 0 Td
(PPROM)Tj
3.6 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(34)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 380.5795 646.8661 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 388.97 642.3874 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(completed)Tj
4.405 0 Td
(gestational)Tj
4.5014 0 Td
(week)Tj
2.2506 0 Td
(are)Tj
1.4457 0 Td
(typically)Tj
-31.4983 -1.2982 Td
(treated)Tj
2.9934 0 Td
(expectantly,)Tj
4.9833 0 Td
(the)Tj
1.4683 0 Td
(latency)Tj
3.0501 0 Td
(\(the)Tj
1.8085 0 Td
(interval)Tj
3.2654 0 Td
(between)Tj
3.5262 0 Td
(rupture)Tj
3.2542 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(membranes)Tj
4.9266 0 Td
(and)Tj
1.7291 0 Td
(delivery\))Tj
-33.4939 -1.2983 Td
(might)Tj
2.5965 0 Td
(be)Tj
1.1509 0 Td
(long.)Tj
2.211 0 Td
(Therefore,)Tj
4.3937 0 Td
(the)Tj
1.4683 0 Td
(presence)Tj
3.7134 0 Td
(of)Tj
1.0148 0 Td
(histological)Tj
4.7677 0 Td
(chorioamnionitis)Tj
7.1433 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(development)Tj
-31.6627 -1.3039 Td
(of)Tj
1.0148 0 Td
(neonatal)Tj
3.6567 0 Td
(infection)Tj
3.7927 0 Td
(as)Tj
1.0148 0 Td
(outcomes,)Tj
4.3143 0 Td
(cannot)Tj
2.982 0 Td
(appropriately)Tj
5.5785 0 Td
(describe)Tj
3.5206 0 Td
(the)Tj
1.474 0 Td
(actual)Tj
2.5795 0 Td
(intra-amniotic)Tj
-29.9279 -1.2983 Td
(environment)Tj
5.4312 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(admission)Tj
4.3143 0 Td
(to)Tj
1.0205 0 Td
(hospital)Tj
3.3788 0 Td
(of)Tj
1.0148 0 Td
(women)Tj
3.2031 0 Td
(with)Tj
2.0012 0 Td
(PPROM.)Tj
3.8211 0 Td
(For)Tj
1.6271 0 Td
(this)Tj
1.6724 0 Td
(reason,)Tj
-32.9496 -1.2982 Td
(MIAC)Tj
2.8006 0 Td
(and)Tj
1.7292 0 Td
(IAI)Tj
1.5817 0 Td
(appear)Tj
2.9196 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(ideal)Tj
2.1147 0 Td
(outcomes,)Tj
4.3143 0 Td
(since)Tj
2.2449 0 Td
(the)Tj
1.4683 0 Td
(sampling)Tj
3.8778 0 Td
(of)Tj
1.0148 0 Td
(both)Tj
2.0636 0 Td
(the)Tj
1.4684 0 Td
(maternal)Tj
3.7927 0 Td
(and)Tj
1.7348 0 Td
(intra-)Tj
-35.3024 -1.3039 Td
(amniotic)Tj
3.7814 0 Td
(environment)Tj
5.4312 0 Td
(might)Tj
2.6021 0 Td
(be)Tj
1.1509 0 Td
(performed)Tj
4.4674 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2563 0 Td
(time.)Tj
2.2564 0 Td
(Nevertheless,)Tj
5.4935 0 Td
(there)Tj
2.2677 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6576 0 Td
(paucity)Tj
3.1408 0 Td
(of)Tj
-36.7707 -1.2983 Td
(information)Tj
5.074 0 Td
(to)Tj
1.0261 0 Td
(whether)Tj
3.4753 0 Td
(and)Tj
1.7291 0 Td
(how)Tj
1.9389 0 Td
(the)Tj
1.474 0 Td
(presence)Tj
3.7077 0 Td
(of)Tj
1.0147 0 Td
(MIAC)Tj
2.8006 0 Td
(and/or)Tj
2.9424 0 Td
(IAI)Tj
1.5817 0 Td
(affects)Tj
2.7382 0 Td
(the)Tj
1.4684 0 Td
(maternal)Tj
3.7927 0 Td
(WBC)Tj
-34.7638 -1.2983 Td
(count)Tj
2.5228 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(admission)Tj
4.3143 0 Td
(of)Tj
1.0148 0 Td
(women)Tj
3.2031 0 Td
(with)Tj
1.9956 0 Td
(PPROM.)Tj
-17.3196 -1.3039 Td
(Therefore,)Tj
4.3937 0 Td
(the)Tj
1.4683 0 Td
(main)Tj
2.2904 0 Td
(aim)Tj
1.7405 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6781 0 Td
(study)Tj
2.3867 0 Td
(was)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(determine)Tj
4.3199 0 Td
(the)Tj
1.4684 0 Td
(relationship)Tj
4.9889 0 Td
(between)Tj
3.532 0 Td
(maternal)Tj
-33.2048 -1.2983 Td
(WBC)Tj
2.4265 0 Td
(counts)Tj
2.8856 0 Td
(on)Tj
1.2756 0 Td
(admission)Tj
4.3143 0 Td
(to)Tj
1.0261 0 Td
(hospital)Tj
3.3789 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7132 0 Td
(of)Tj
1.0148 0 Td
(MIAC)Tj
2.8006 0 Td
(and)Tj
1.7292 0 Td
(IAI)Tj
1.5874 0 Td
(in)Tj
1.0318 0 Td
(women)Tj
3.2031 0 Td
(with)Tj
-33.5846 -1.2982 Td
(PPROM.)Tj
3.8211 0 Td
(The)Tj
1.7858 0 Td
(second)Tj
3.0104 0 Td
(aim)Tj
1.7405 0 Td
(of)Tj
1.0147 0 Td
(this)Tj
1.6725 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(assess)Tj
2.5228 0 Td
(the)Tj
1.4683 0 Td
(association)Tj
4.6318 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
(maternal)Tj
-31.7761 -1.2983 Td
(WBC)Tj
2.4265 0 Td
(count)Tj
2.5285 0 Td
(and)Tj
1.7291 0 Td
(amniotic)Tj
3.7814 0 Td
(fluid)Tj
2.0806 0 Td
(interleukin)Tj
4.6374 0 Td
(\(IL\)-6)Tj
2.6021 0 Td
(concentrations)Tj
6.1852 0 Td
(at)Tj
0.9467 0 Td
(the)Tj
1.4741 0 Td
(time)Tj
2.0295 0 Td
(of)Tj
1.0148 0 Td
(admission.)Tj
4.5354 0 Td
(The)Tj
-35.9713 -1.3039 Td
(final)Tj
2.0013 0 Td
(aim)Tj
1.7404 0 Td
(was)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(characterize)Tj
5.0287 0 Td
(the)Tj
1.4683 0 Td
(maternal)Tj
3.7984 0 Td
(WBC)Tj
2.4264 0 Td
(count)Tj
2.5284 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(admission)Tj
4.3143 0 Td
(in)Tj
1.0318 0 Td
(four)Tj
1.9162 0 Td
(sub-)Tj
-34.4463 -1.2983 Td
(groups)Tj
2.9707 0 Td
(of)Tj
1.0148 0 Td
(women)Tj
3.2031 0 Td
(with)Tj
1.9956 0 Td
(PPROM)Tj
3.6 0 Td
(subdivided)Tj
4.6091 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4682 0 Td
(basis)Tj
2.1487 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(presence)Tj
3.7077 0 Td
(and/or)Tj
2.9423 0 Td
(absence)Tj
3.3392 0 Td
(of)Tj
-34.7638 -1.2982 Td
(MIAC)Tj
2.8006 0 Td
(and/or)Tj
2.9367 0 Td
(IAI.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 411.9874 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 394.9795 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(prospective)Tj
4.7848 0 Td
(cohort)Tj
2.8573 0 Td
(study)Tj
2.3868 0 Td
(was)Tj
1.7008 0 Td
(conducted)Tj
4.4277 0 Td
(between)Tj
3.5262 0 Td
(February)Tj
3.8381 0 Td
(2012)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(June)Tj
2.0466 0 Td
(2017.)Tj
2.3471 0 Td
(Women)Tj
-33.7547 -1.2982 Td
(admitted)Tj
3.8097 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.4626 0 Td
(Department)Tj
5.0853 0 Td
(of)Tj
1.0092 0 Td
(Obstetrics)Tj
4.2689 0 Td
(and)Tj
1.7235 0 Td
(Gynecology,)Tj
5.1873 0 Td
(University)Tj
4.3937 0 Td
(Hospital)Tj
3.6113 0 Td
(in)Tj
1.0318 0 Td
(Hradec)Tj
3.1635 0 Td
(Kra-)Tj
-35.7673 -1.2983 Td
(love,)Tj
2.0749 0 Td
(Czech)Tj
2.6702 0 Td
(Republic,)Tj
3.9798 0 Td
(were)Tj
2.126 0 Td
(recruited)Tj
3.8494 0 Td
(if)Tj
0.7767 0 Td
(they)Tj
1.9276 0 Td
(had)Tj
1.7064 0 Td
(pregnancies)Tj
5.006 0 Td
(complicated)Tj
5.108 0 Td
(by)Tj
1.1792 0 Td
(PPROM)Tj
3.5999 0 Td
(between)Tj
-34.0041 -1.3039 Td
(gestational)Tj
4.5013 0 Td
(ages)Tj
1.9049 0 Td
(24+0)Tj
2.228 0 Td
(and)Tj
1.7291 0 Td
(36+6)Tj
2.2281 0 Td
(weeks.)Tj
2.8289 0 Td
(Only)Tj
2.2167 0 Td
(women)Tj
3.2031 0 Td
(aged)Tj
2.075 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9786 0 Td
(18)Tj
1.1735 0 Td
(years)Tj
2.2621 0 Td
(with)Tj
2.0012 0 Td
(a)Tj
0.652 0 Td
(singleton)Tj
-31.9349 -1.2983 Td
(pregnancy)Tj
4.405 0 Td
(were)Tj
2.1203 0 Td
(eligible)Tj
3.067 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(study.)Tj
2.6136 0 Td
(Women)Tj
3.4866 0 Td
(with)Tj
1.9955 0 Td
(any)Tj
1.6555 0 Td
(medical)Tj
3.3618 0 Td
(complications)Tj
5.845 0 Td
(\(e.g.,)Tj
2.1203 0 Td
(hyperten-)Tj
-33.5279 -1.2982 Td
(sion,)Tj
2.1259 0 Td
(preeclampsia,)Tj
5.6863 0 Td
(diabetes)Tj
3.4582 0 Td
(mellitus,)Tj
3.6397 0 Td
(and)Tj
1.7291 0 Td
(thyroid)Tj
3.1748 0 Td
(disease\),)Tj
3.583 0 Td
(fetal)Tj
1.9105 0 Td
(growth)Tj
3.0727 0 Td
(restriction,)Tj
4.5808 0 Td
(gross)Tj
-32.961 -1.2983 Td
(vaginal)Tj
3.067 0 Td
(bleeding,)Tj
3.8551 0 Td
(signs)Tj
2.2224 0 Td
(of)Tj
1.0148 0 Td
(fetal)Tj
1.9105 0 Td
(hypoxia,)Tj
3.617 0 Td
(and)Tj
1.7291 0 Td
(structural)Tj
4.0819 0 Td
(malformations)Tj
6.1228 0 Td
(or)Tj
1.0998 0 Td
(chromosomal)Tj
5.743 0 Td
(abnor-)Tj
-34.4634 -1.3039 Td
(malities)Tj
3.3335 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(fetus)Tj
2.1146 0 Td
(were)Tj
2.126 0 Td
(excluded)Tj
3.7814 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.474 0 Td
(study.)Tj
2.6135 0 Td
(Gestational)Tj
4.7509 0 Td
(age)Tj
1.542 0 Td
(was)Tj
1.7008 0 Td
(established)Tj
4.5978 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1508 0 Td
(preg-)Tj
-35.2627 -1.2983 Td
(nancies)Tj
3.2258 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(trimester)Tj
3.8551 0 Td
(ultrasound)Tj
4.5694 0 Td
(results.)Tj
-17.4783 -1.2982 Td
(PPROM)Tj
3.5999 0 Td
(was)Tj
1.7008 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(leakage)Tj
3.1464 0 Td
(of)Tj
1.0148 0 Td
(amniotic)Tj
3.7814 0 Td
(fluid)Tj
2.0806 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(labor)Tj
2.2847 0 Td
(and)Tj
1.7348 0 Td
(was)Tj
-34.367 -1.304 Td
(diagnosed)Tj
4.2802 0 Td
(visually)Tj
3.2145 0 Td
(via)Tj
1.372 0 Td
(a)Tj
0.6576 0 Td
(sterile)Tj
2.6079 0 Td
(speculum)Tj
4.0648 0 Td
(examination)Tj
5.2327 0 Td
(to)Tj
1.0262 0 Td
(confirm)Tj
3.4469 0 Td
(the)Tj
1.4683 0 Td
(pooling)Tj
3.2768 0 Td
(of)Tj
1.0148 0 Td
(amniotic)Tj
3.7871 0 Td
(fluid)Tj
-35.4498 -1.2982 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(vagina.)Tj
3.0444 0 Td
(In)Tj
1.1111 0 Td
(case)Tj
1.8595 0 Td
(of)Tj
1.0148 0 Td
(clinical)Tj
3.0784 0 Td
(doubt,)Tj
2.812 0 Td
(PPROM)Tj
3.6 0 Td
(was)Tj
1.7007 0 Td
(confirmed)Tj
4.3937 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(presence)Tj
3.7134 0 Td
(of)Tj
1.0148 0 Td
(insulin-like)Tj
-32.5018 -1.2983 Td
(growth)Tj
3.0727 0 Td
(factor-binding)Tj
6.0207 0 Td
(protein)Tj
3.1578 0 Td
(\(ACTIM)Tj
3.7474 0 Td
(PROM)Tj
3.0444 0 Td
(test;)Tj
1.8255 0 Td
(Medix)Tj
2.7949 0 Td
(Biochemica,)Tj
5.1194 0 Td
(Kauniainen,)Tj
5.1193 0 Td
(Finland\))Tj
-33.9021 -1.3039 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(vaginal)Tj
3.067 0 Td
(fluid.)Tj
-4.3766 -1.2983 Td
(Women)Tj
3.4866 0 Td
(with)Tj
1.9955 0 Td
(PPROM)Tj
3.6 0 Td
(at)Tj
0.9524 0 Td
(less)Tj
1.6101 0 Td
(than)Tj
2.0296 0 Td
(34)Tj
1.1735 0 Td
(weeks)Tj
2.6079 0 Td
(of)Tj
1.0148 0 Td
(gestation)Tj
3.8211 0 Td
(were)Tj
2.1259 0 Td
(treated)Tj
2.9934 0 Td
(using)Tj
2.3924 0 Td
(tocolytics)Tj
4.0025 0 Td
(for)Tj
1.389 0 Td
(48)Tj
-36.3909 -1.2982 Td
(hours,)Tj
2.7382 0 Td
(antibiotics,)Tj
4.6261 0 Td
(and)Tj
1.7291 0 Td
(corticosteroids)Tj
6.1342 0 Td
(to)Tj
1.0261 0 Td
(accelerate)Tj
4.1216 0 Td
(lung)Tj
2.0069 0 Td
(maturation.)Tj
4.9492 0 Td
(Those)Tj
2.6532 0 Td
(with)Tj
1.9956 0 Td
(PPROM)Tj
-31.9802 -1.3039 Td
(beyond)Tj
3.1861 0 Td
(34)Tj
1.1735 0 Td
(weeks)Tj
2.6079 0 Td
(of)Tj
1.0148 0 Td
(gestation)Tj
3.821 0 Td
(were)Tj
2.126 0 Td
(treated)Tj
2.9934 0 Td
(only)Tj
1.9785 0 Td
(with)Tj
1.9956 0 Td
(antibiotics.)Tj
4.6261 0 Td
(The)Tj
1.7802 0 Td
(women)Tj
3.2031 0 Td
(with)Tj
1.9956 0 Td
(PPROM)Tj
-32.5018 -1.2983 Td
(included)Tj
3.7133 0 Td
(in)Tj
1.0318 0 Td
(this)Tj
1.6781 0 Td
(study)Tj
2.3868 0 Td
(were)Tj
2.1203 0 Td
(managed)Tj
3.8777 0 Td
(with)Tj
1.9956 0 Td
(two)Tj
1.7065 0 Td
(different)Tj
3.6566 0 Td
(approaches.)Tj
4.9606 0 Td
(Between)Tj
3.6057 0 Td
(February)Tj
3.8381 0 Td
(2012)Tj
-34.5711 -1.2983 Td
(and)Tj
1.7291 0 Td
(December)Tj
4.3483 0 Td
(2013,)Tj
2.3471 0 Td
(transabdominal)Tj
6.5253 0 Td
(amniocenteses)Tj
6.0604 0 Td
(were)Tj
2.1203 0 Td
(performed)Tj
4.4674 0 Td
(only)Tj
1.9786 0 Td
(for)Tj
1.3889 0 Td
(research)Tj
3.5546 0 Td
(pur-)Tj
-34.52 -1.2982 Td
(poses,)Tj
2.6135 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(results)Tj
2.812 0 Td
(from)Tj
2.2053 0 Td
(amniotic)Tj
3.7871 0 Td
(fluid)Tj
2.0749 0 Td
(analyses)Tj
3.481 0 Td
(were)Tj
2.1259 0 Td
(not)Tj
1.5704 0 Td
(used)Tj
2.0636 0 Td
(for)Tj
1.3833 0 Td
(clinical)Tj
3.0784 0 Td
(management.)Tj
-30.3928 -1.304 Td
(During)Tj
3.135 0 Td
(this)Tj
1.6668 0 Td
(period)Tj
2.8346 0 Td
(women)Tj
3.1975 0 Td
(with)Tj
1.9956 0 Td
(PPROM)Tj
3.6 0 Td
(were)Tj
2.1146 0 Td
(treated)Tj
2.999 0 Td
(actively)Tj
3.2202 0 Td
(\(except)Tj
3.1067 0 Td
(those)Tj
2.3357 0 Td
(at)Tj
/F12 1 Tf
0 Tc
0.9468 0 Td
(<)Tj
/F8 1 Tf
-0.004 Tc
0.9921 0 Td
(28)Tj
1.1679 0 Td
(gestational)Tj
-33.3125 -1.2982 Td
(weeks\).)Tj
3.1747 0 Td
(Labor)Tj
2.5739 0 Td
(was)Tj
1.7008 0 Td
(induced,)Tj
3.6906 0 Td
(or)Tj
1.0999 0 Td
(an)Tj
1.2019 0 Td
(elective)Tj
3.1804 0 Td
(cesarean)Tj
3.6397 0 Td
(section)Tj
3.05 0 Td
(was)Tj
1.6951 0 Td
(performed)Tj
4.4731 0 Td
(no)Tj
1.2756 0 Td
(later)Tj
1.9899 0 Td
(than)Tj
2.0296 0 Td
(72)Tj
-34.7752 -1.2983 Td
(hours)Tj
2.5114 0 Td
(after)Tj
2.0353 0 Td
(the)Tj
1.474 0 Td
(rupture)Tj
3.2542 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(membranes,)Tj
5.1533 0 Td
(depending)Tj
4.4731 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(gestational)Tj
4.5014 0 Td
(age)Tj
1.542 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(pregnancy,)Tj
-32.6605 -1.3039 Td
(fetal)Tj
1.9105 0 Td
(status,)Tj
2.7212 0 Td
(and)Tj
1.7348 0 Td
(maternal)Tj
3.7928 0 Td
(serum)Tj
2.7269 0 Td
(C-reactive)Tj
4.3256 0 Td
(protein)Tj
3.1521 0 Td
(concentrations.)Tj
6.4063 0 Td
(Since)Tj
2.3584 0 Td
(January)Tj
3.3222 0 Td
(2014,)Tj
2.347 0 Td
(the)Tj
-34.7978 -1.2983 Td
(performance)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(transabdominal)Tj
6.5253 0 Td
(amniocentesis)Tj
5.9017 0 Td
(procedures)Tj
4.6714 0 Td
(and)Tj
1.7348 0 Td
(collection)Tj
4.1102 0 Td
(of)Tj
1.0148 0 Td
(information)Tj
5.074 0 Td
(on)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 405.7511 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(WBC)Tj
2.537 0 Td
(and)Tj
1.8496 0 Td
(intra-amnioti)Tj
5.4 0 Td
(c)Tj
0.7158 0 Td
(complica)Tj
3.8693 0 Td
(tions)Tj
2.2961 0 Td
(in)Tj
0.978 0 Td
(PPROM)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01893)Tj
4.089 0 Td
(94)Tj
0 g
2.0906 0 Td
(December)Tj
4.7622 0 Td
(12,)Tj
1.5875 0 Td
(2017)Tj
32.5561 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
BT
66.402 0 Td
(17)Tj
ET
Q
endstream
endobj
65 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 70 0 R/Contents 71 0 R/TrimBox[0 0 612 792]>>
endobj
69 0 obj
<>
endobj
72 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
1 beginbfchar
<010C><03B2>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
73 0 obj
<>/FontDescriptor 74 0 R/DW 250/W[268[495]]>>
endobj
74 0 obj
<>
endobj
75 0 obj
<>stream
cvt f6 fpgm2Msf bglyf&( head5@ 6hhea1 $hmtx&O