%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Laura Mantecón, Mª Agustina Alonso, Vanessa Moya, Ana Gloria Andrés, Noelia Avello, Eduardo Martínez-Morillo, Fernando Santos
Marker of vitamin D status in healthy children: Free or total 25-hydroxyvitamin D?
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref004)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref007)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref008)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref009)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref010)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref011)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref012)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref013)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref014)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref006)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref009)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref015)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref016)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref017)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref008)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref018)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref021)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0202237.ref022)>>
endobj
38 0 obj
<>/Border[0 0 0]/A 39 0 R>>
endobj
39 0 obj
<>
endobj
15 0 obj
[40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R]
endobj
40 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 661.9102 m
199.9998 661.9102 l
199.9998 662.4102 l
575.9997 662.4102 l
f*
0.83 0.64 0.02 0 k
524.4094 603.8362 m
529.1717 603.8362 l
h
f*
225.6378 564.8882 m
230.4 564.8882 l
h
f*
232.611 564.8882 m
237.3732 564.8882 l
h
f*
239.6409 564.8882 m
244.4031 564.8882 l
h
f*
229.0394 512.8441 m
233.7449 512.8441 l
h
f*
238.8472 512.8441 m
243.5528 512.8441 l
h
f*
203.3575 499.8614 m
208.063 499.8614 l
h
f*
210.2173 499.8614 m
214.9228 499.8614 l
h
f*
346.1669 486.8787 m
355.578 486.8787 l
h
f*
203.3575 473.8394 m
212.7118 473.8394 l
h
f*
214.9228 473.8394 m
224.3339 473.8394 l
h
f*
411.6472 460.8567 m
421.0583 460.8567 l
h
f*
350.6457 421.852 m
360.0567 421.852 l
h
f*
264.3024 395.8866 m
269.0079 395.8866 l
h
f*
546.5197 395.8866 m
551.2252 395.8866 l
h
f*
525.0898 343.8425 m
534.6142 343.8425 l
h
f*
503.6031 317.8772 m
513.1276 317.8772 l
h
f*
266.5701 304.8378 m
276.0945 304.8378 l
h
f*
401.6126 304.8378 m
406.3748 304.8378 l
h
f*
340.8945 291.8551 m
350.4189 291.8551 l
h
f*
355.578 291.8551 m
365.1024 291.8551 l
h
f*
438.3496 291.8551 m
447.8173 291.8551 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(These)Tj
2.9718 0 Td
(findings)Tj
3.6224 0 Td
(do)Tj
1.3129 0 Td
(not)Tj
1.5993 0 Td
(support)Tj
3.515 0 Td
(that)Tj
1.8738 0 Td
(free)Tj
1.9216 0 Td
(25OHD)Tj
3.5269 0 Td
(is)Tj
0.9309 0 Td
(a)Tj
0.7699 0 Td
(better)Tj
2.7511 0 Td
(marker)Tj
3.306 0 Td
(of)Tj
1.0444 0 Td
(vitamin)Tj
3.3538 0 Td
(D)Tj
0.9369 0 Td
(deficiency)Tj
-33.4367 -1.474 Td
(than)Tj
2.1423 0 Td
(total)Tj
2.0887 0 Td
(25OHD)Tj
3.5269 0 Td
(in)Tj
0.9847 0 Td
(healthy)Tj
3.4015 0 Td
(pediatric)Tj
3.9506 0 Td
(population.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 634.9606 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 617.9527 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(status)Tj
2.5001 0 Td
(of)Tj
1.0148 0 Td
(vitamin)Tj
3.3109 0 Td
(D)Tj
0.9581 0 Td
(is)Tj
0.8447 0 Td
(clinically)Tj
3.7757 0 Td
(estimated)Tj
4.0762 0 Td
(by)Tj
1.1792 0 Td
(measuring)Tj
4.4391 0 Td
(total)Tj
2.0069 0 Td
(serum)Tj
2.7212 0 Td
(25-hydroxyvitamin)Tj
-28.607 -1.3039 Td
(D)Tj
0.9524 0 Td
(\(25OHD\).)Tj
4.3313 0 Td
(Vitamin)Tj
3.549 0 Td
(D)Tj
0.9524 0 Td
(plays)Tj
2.2337 0 Td
(a)Tj
0.6576 0 Td
(key)Tj
1.5931 0 Td
(role)Tj
1.7688 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(regulation)Tj
4.3086 0 Td
(of)Tj
1.0148 0 Td
(mineral)Tj
3.3279 0 Td
(metabolism)Tj
4.9039 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(],)Tj
1.6044 0 Td
(but)Tj
1.5534 0 Td
(in)Tj
-35.2571 -1.2982 Td
(recent)Tj
2.7099 0 Td
(years)Tj
2.262 0 Td
(a)Tj
0.652 0 Td
(growing)Tj
3.5319 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(clinical)Tj
3.0727 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.0579 0 Td
(claimed)Tj
3.3619 0 Td
(an)Tj
1.2019 0 Td
(association)Tj
4.6318 0 Td
(between)Tj
3.5262 0 Td
(low)Tj
-34.4293 -1.2983 Td
(vitamin)Tj
3.3108 0 Td
(25OHD)Tj
3.4186 0 Td
(concentrations)Tj
6.1794 0 Td
(and)Tj
1.7292 0 Td
(increased)Tj
4.0025 0 Td
(susceptibility)Tj
5.4424 0 Td
(to)Tj
1.0205 0 Td
(certain)Tj
2.9877 0 Td
(acute)Tj
2.3301 0 Td
(and)Tj
1.7291 0 Td
(chronic)Tj
3.2882 0 Td
(dis-)Tj
-35.4385 -1.2983 Td
(eases)Tj
2.2223 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
3.0047 0 Td
(This)Tj
1.9842 0 Td
(potential)Tj
3.7588 0 Td
(role)Tj
1.7688 0 Td
(of)Tj
1.0148 0 Td
(vitamin)Tj
3.3108 0 Td
(D)Tj
0.9581 0 Td
(has)Tj
1.5421 0 Td
(prompted)Tj
4.2009 0 Td
(an)Tj
1.2019 0 Td
(increasing)Tj
4.3313 0 Td
(interest)Tj
3.2088 0 Td
(in)Tj
1.0374 0 Td
(detecting)Tj
-33.5449 -1.3039 Td
(vitamin)Tj
3.3108 0 Td
(D)Tj
0.9524 0 Td
(deficiency.)Tj
-3.067 -1.2982 Td
(25OHD)Tj
3.4242 0 Td
(circulates)Tj
3.9968 0 Td
(in)Tj
1.0375 0 Td
(blood)Tj
2.5115 0 Td
(mostly)Tj
2.9083 0 Td
(bound)Tj
2.8346 0 Td
(\(8590%\))Tj
4.0819 0 Td
(to)Tj
1.0205 0 Td
(its)Tj
1.1508 0 Td
(specific)Tj
3.1861 0 Td
(binding)Tj
3.3562 0 Td
(protein)Tj
3.1521 0 Td
(\(DBP\))Tj
-0.01 Tc
-33.8567 -1.2983 Td
(and)Tj
1.7121 0 Td
(weakly)Tj
2.9196 0 Td
(to)Tj
1.0148 0 Td
(plasma)Tj
2.9991 0 Td
(albumin)Tj
3.5262 0 Td
(\(1015%\),)Tj
4.2463 0 Td
(while)Tj
2.3414 0 Td
(a)Tj
0.6463 0 Td
(small)Tj
2.2961 0 Td
(fraction)Tj
3.3108 0 Td
(\()Tj
/F11 1 Tf
0 Tc
(<)Tj
/F7 1 Tf
-0.01 Tc
(1%\))Tj
2.88 0 Td
(constitutes)Tj
4.473 0 Td
(its)Tj
1.1282 0 Td
(free)Tj
-33.4939 -1.3039 Td
(form)Tj
2.5681 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
2.5569 0 Td
(The)Tj
1.7631 0 Td
(bioavailable)Tj
4.8756 0 Td
(fraction)Tj
3.3108 0 Td
(is)Tj
0.8391 0 Td
(the)Tj
1.4513 0 Td
(sum)Tj
1.9105 0 Td
(of)Tj
0.9978 0 Td
(the)Tj
1.457 0 Td
(free)Tj
1.7008 0 Td
(25OHD)Tj
3.3902 0 Td
(and)Tj
1.7121 0 Td
(that)Tj
1.7575 0 Td
(bound)Tj
2.8063 0 Td
(to)Tj
1.0148 0 Td
(albumin)Tj
-34.1119 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
2.2677 0 Td
(The)Tj
1.7631 0 Td
(free-hormone)Tj
6.0944 0 Td
(hypothesis)Tj
4.7906 0 Td
(states)Tj
2.364 0 Td
(that)Tj
1.7518 0 Td
(the)Tj
1.4514 0 Td
(biologic)Tj
3.3618 0 Td
(activity)Tj
3.0728 0 Td
(of)Tj
0.9978 0 Td
(hormones)Tj
4.2406 0 Td
(lies)Tj
1.491 0 Td
(in)Tj
1.0261 0 Td
(the)Tj
-34.6731 -1.2983 Td
(free)Tj
1.7007 0 Td
(or)Tj
1.0885 0 Td
(non-bound)Tj
4.7395 0 Td
(fractions)Tj
3.6624 0 Td
(to)Tj
1.0148 0 Td
(DBP)Tj
2.0749 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(],)Tj
2.0466 0 Td
(as)Tj
1.0035 0 Td
(it)Tj
0.771 0 Td
(occurs)Tj
2.8006 0 Td
(with)Tj
1.9729 0 Td
(sex)Tj
1.4513 0 Td
(steroids)Tj
3.2882 0 Td
(or)Tj
1.0885 0 Td
(thyroid)Tj
3.1294 0 Td
(hormones)Tj
-31.8328 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(],)Tj
3.2031 0 Td
(DBP)Tj
2.0806 0 Td
(is)Tj
0.8334 0 Td
(a)Tj
0.6463 0 Td
(protein)Tj
3.1124 0 Td
(with)Tj
1.9729 0 Td
(various)Tj
3.1011 0 Td
(genetic)Tj
3.0274 0 Td
(variations)Tj
4.1045 0 Td
(or)Tj
1.0885 0 Td
(polymorphisms)Tj
6.4176 0 Td
(that)Tj
1.7518 0 Td
(appear)Tj
2.8856 0 Td
(to)Tj
1.0092 0 Td
(mod-)Tj
-35.2344 -1.2982 Td
(ify)Tj
1.2132 0 Td
(their)Tj
2.0749 0 Td
(affinity)Tj
3.0161 0 Td
(for)Tj
1.3719 0 Td
(25OHD)Tj
3.3902 0 Td
(and)Tj
1.7122 0 Td
(thus)Tj
1.9105 0 Td
(its)Tj
1.1282 0 Td
(free)Tj
1.7007 0 Td
(fraction)Tj
3.3109 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(],)Tj
2.0466 0 Td
(This)Tj
1.9672 0 Td
(might)Tj
2.5682 0 Td
(explain)Tj
3.0784 0 Td
(that)Tj
1.7518 0 Td
(similar)Tj
2.948 0 Td
(con-)Tj
-35.189 -1.2983 Td
(centrations)Tj
4.6317 0 Td
(of)Tj
1.0035 0 Td
(bioavailable)Tj
4.8755 0 Td
(25OHD)Tj
3.3959 0 Td
(have)Tj
2.0353 0 Td
(been)Tj
2.0976 0 Td
(found)Tj
2.5909 0 Td
(in)Tj
1.0204 0 Td
(two)Tj
1.6895 0 Td
(groups)Tj
2.9366 0 Td
(of)Tj
1.0035 0 Td
(white)Tj
2.3924 0 Td
(and)Tj
1.7121 0 Td
(black)Tj
2.2961 0 Td
(people,)Tj
-33.681 -1.3039 Td
(despite)Tj
2.9933 0 Td
(lower)Tj
2.4265 0 Td
(serum)Tj
2.6929 0 Td
(levels)Tj
2.3357 0 Td
(of)Tj
1.0034 0 Td
(total)Tj
1.9729 0 Td
(25OHD)Tj
3.3959 0 Td
(and)Tj
1.7121 0 Td
(DBP)Tj
2.075 0 Td
(in)Tj
1.0261 0 Td
(the)Tj
1.4514 0 Td
(group)Tj
2.5795 0 Td
(of)Tj
0.9978 0 Td
(black)Tj
2.3017 0 Td
(individuals,)Tj
4.8018 0 Td
(which)Tj
-33.766 -1.2983 Td
(also)Tj
1.7404 0 Td
(had)Tj
1.6951 0 Td
(higher)Tj
2.7666 0 Td
(bone)Tj
2.1827 0 Td
(mineral)Tj
3.2881 0 Td
(density)Tj
3.0558 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
2.0466 0 Td
(Variations)Tj
4.3426 0 Td
(in)Tj
1.0262 0 Td
(DBP)Tj
2.0749 0 Td
(concentrations)Tj
6.1001 0 Td
(and/or)Tj
2.9027 0 Td
(its)Tj
1.1282 0 Td
(differ-)Tj
-34.35 -1.2982 Td
(ent)Tj
1.474 0 Td
(genotypes)Tj
4.1612 0 Td
(might)Tj
2.5682 0 Td
(be)Tj
1.1395 0 Td
(confusing)Tj
4.1045 0 Td
(factors)Tj
2.8573 0 Td
(on)Tj
1.2643 0 Td
(the)Tj
1.4513 0 Td
(interpretation)Tj
5.7146 0 Td
(of)Tj
0.9978 0 Td
(serum)Tj
2.6986 0 Td
(total)Tj
1.9729 0 Td
(and)Tj
1.7121 0 Td
(free)Tj
1.7008 0 Td
(25OHD)Tj
-33.8171 -1.2983 Td
(concentrations)Tj
6.0944 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5761 0 Td
(In)Tj
1.0998 0 Td
(addition,)Tj
3.77 0 Td
(the)Tj
1.4514 0 Td
(normal)Tj
3.1067 0 Td
(values)Tj
2.6306 0 Td
(of)Tj
1.0034 0 Td
(DBP)Tj
2.0806 0 Td
(concentrations)Tj
6.0945 0 Td
(vary)Tj
1.9105 0 Td
(with)Tj
1.9729 0 Td
(age)Tj
1.5251 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
-0.004 Tc
-33.1198 -1.3039 Td
(This)Tj
1.9899 0 Td
(free-hormone)Tj
6.1738 0 Td
(hypothesis)Tj
4.8585 0 Td
(suggests)Tj
3.481 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4683 0 Td
(binding)Tj
3.3506 0 Td
(to)Tj
1.0261 0 Td
(DBP)Tj
2.092 0 Td
(impairs)Tj
3.2598 0 Td
(the)Tj
1.4683 0 Td
(delivery)Tj
3.3902 0 Td
(of)Tj
-35.5348 -1.2983 Td
(25OHD)Tj
3.4185 0 Td
(to)Tj
1.0261 0 Td
(vitamin)Tj
3.3109 0 Td
(D-activating)Tj
5.1987 0 Td
(1-alpha-hydroxylase)Tj
8.3281 0 Td
(in)Tj
1.0375 0 Td
(target)Tj
2.5058 0 Td
(cells,)Tj
2.1487 0 Td
(and)Tj
1.7291 0 Td
(therefore)Tj
3.8551 0 Td
(the)Tj
1.4683 0 Td
(free)Tj
1.7291 0 Td
(vita-)Tj
-35.7559 -1.2983 Td
(min)Tj
1.8538 0 Td
(D)Tj
0.9581 0 Td
(fraction)Tj
3.3562 0 Td
(would)Tj
2.7099 0 Td
(better)Tj
2.5455 0 Td
(reflect)Tj
2.6929 0 Td
(the)Tj
1.4683 0 Td
(functional)Tj
4.3087 0 Td
(status)Tj
2.5001 0 Td
(of)Tj
1.0148 0 Td
(vitamin)Tj
3.3109 0 Td
(D.)Tj
1.1848 0 Td
(Thus,)Tj
2.4718 0 Td
(the)Tj
1.4684 0 Td
(reliability)Tj
4.0025 0 Td
(of)Tj
-35.8467 -1.3039 Td
(assessing)Tj
3.7984 0 Td
(vitamin)Tj
3.3108 0 Td
(D)Tj
0.9581 0 Td
(status)Tj
2.5001 0 Td
(by)Tj
1.1792 0 Td
(measuring)Tj
4.4391 0 Td
(total)Tj
2.0069 0 Td
(serum)Tj
2.7212 0 Td
(25OHD)Tj
3.4243 0 Td
(levels)Tj
2.3697 0 Td
(is)Tj
0.8504 0 Td
(questioned)Tj
4.6091 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0806 0 Td
(Free)Tj
-34.2479 -1.2982 Td
(25OHD)Tj
3.4185 0 Td
(or)Tj
1.0998 0 Td
(its)Tj
1.1452 0 Td
(bioavailable)Tj
4.9493 0 Td
(fraction)Tj
3.3562 0 Td
(was)Tj
1.7008 0 Td
(more)Tj
2.3414 0 Td
(strongly)Tj
3.4696 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0012 0 Td
(bone)Tj
2.2054 0 Td
(mineral)Tj
3.3278 0 Td
(density)Tj
-33.2728 -1.2983 Td
(and)Tj
1.7291 0 Td
(mineral)Tj
3.3278 0 Td
(bone)Tj
2.211 0 Td
(parameters)Tj
4.6715 0 Td
(than)Tj
2.0296 0 Td
(the)Tj
1.4683 0 Td
(total)Tj
2.0013 0 Td
(25OHD)Tj
3.4242 0 Td
(levels)Tj
2.3754 0 Td
(in)Tj
1.0375 0 Td
(healthy)Tj
3.1294 0 Td
(adults)Tj
2.6136 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(],)Tj
2.0806 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
-35.4668 -1.3039 Td
(kidney)Tj
2.9366 0 Td
(diseases)Tj
3.3789 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(])Tj
1.8538 0 Td
(and)Tj
1.7292 0 Td
(postmenopausal)Tj
6.718 0 Td
(women)Tj
3.2032 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
1.6044 0 Td
(Recent)Tj
2.9593 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.058 0 Td
(reported)Tj
3.6623 0 Td
(directly)Tj
-33.0914 -1.2983 Td
(measured)Tj
4.1045 0 Td
(free)Tj
1.7291 0 Td
(vitamin)Tj
3.3109 0 Td
(D)Tj
0.9524 0 Td
(in)Tj
1.0375 0 Td
(adults)Tj
2.6135 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
3.3222 0 Td
(or)Tj
1.0998 0 Td
(sick)Tj
1.7688 0 Td
(children)Tj
3.5546 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(],)Tj
2.075 0 Td
(but)Tj
1.5534 0 Td
(there)Tj
2.262 0 Td
(are)Tj
1.4513 0 Td
(no)Tj
1.2756 0 Td
(studies)Tj
2.9877 0 Td
(on)Tj
-35.0983 -1.2983 Td
(free)Tj
1.7234 0 Td
(25OHD)Tj
3.4242 0 Td
(and)Tj
1.7292 0 Td
(DBP)Tj
2.0976 0 Td
(levels)Tj
2.3754 0 Td
(in)Tj
1.0318 0 Td
(healthy)Tj
3.1351 0 Td
(children)Tj
3.5546 0 Td
(so)Tj
1.0885 0 Td
(far.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 252.9637 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Objectives)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 235.9559 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(present)Tj
3.1634 0 Td
(study)Tj
2.3925 0 Td
(was)Tj
1.6951 0 Td
(designed)Tj
3.7644 0 Td
(to)Tj
1.0261 0 Td
(determine)Tj
4.3256 0 Td
(serum)Tj
2.7213 0 Td
(free)Tj
1.7291 0 Td
(25OHD)Tj
3.4186 0 Td
(concentrations)Tj
6.1795 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(healthy)Tj
-33.8851 -1.2982 Td
(paediatric)Tj
4.1839 0 Td
(population)Tj
4.5864 0 Td
(living)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(poorly)Tj
2.8233 0 Td
(sunlit)Tj
2.4718 0 Td
(geographical)Tj
5.3008 0 Td
(area)Tj
1.8822 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0261 0 Td
(analyze)Tj
3.1748 0 Td
(the)Tj
1.4683 0 Td
(correlation)Tj
-32.8079 -1.2983 Td
(between)Tj
3.5262 0 Td
(serum)Tj
2.7269 0 Td
(concentrations)Tj
6.1795 0 Td
(of)Tj
1.0148 0 Td
(free)Tj
1.7235 0 Td
(25OHD)Tj
3.4242 0 Td
(and)Tj
1.7291 0 Td
(serum)Tj
2.7213 0 Td
(total)Tj
2.0069 0 Td
(25OHD,)Tj
3.6453 0 Td
(PTH)Tj
2.16 0 Td
(and)Tj
1.7291 0 Td
(DBP)Tj
2.092 0 Td
(con-)Tj
-34.6788 -1.3039 Td
(centrations)Tj
4.6998 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(correlation)Tj
4.6205 0 Td
(between)Tj
3.5262 0 Td
(directly)Tj
3.2315 0 Td
(measured)Tj
4.1102 0 Td
(and)Tj
1.7292 0 Td
(mathematically)Tj
6.3495 0 Td
(calculated)Tj
-33.5846 -1.2983 Td
(free)Tj
1.7234 0 Td
(25OHD)Tj
3.4242 0 Td
(concentrations.)Tj
6.4063 0 Td
(Secondary)Tj
4.3823 0 Td
(outcomes)Tj
4.0876 0 Td
(were)Tj
2.1259 0 Td
(to)Tj
1.0262 0 Td
(assess)Tj
2.5171 0 Td
(the)Tj
1.4684 0 Td
(influence)Tj
3.9174 0 Td
(of)Tj
1.0148 0 Td
(variables)Tj
-32.0936 -1.2982 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(sex,)Tj
1.6951 0 Td
(age,)Tj
1.7688 0 Td
(ethnicity,)Tj
3.9515 0 Td
(BMI,)Tj
2.262 0 Td
(season)Tj
2.8516 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(year,)Tj
2.126 0 Td
(sun)Tj
1.6554 0 Td
(exposure,)Tj
4.0422 0 Td
(vitamin)Tj
3.3109 0 Td
(D)Tj
0.9581 0 Td
(supplements,)Tj
5.4878 0 Td
(diet,)Tj
-35.6709 -1.3039 Td
(and)Tj
1.7291 0 Td
(albumin)Tj
3.5716 0 Td
(concentrations)Tj
6.1795 0 Td
(on)Tj
1.2756 0 Td
(free)Tj
1.7234 0 Td
(25OHD)Tj
3.4243 0 Td
(levels.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 131.0173 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Material)Tj
3.959 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F12 1 Tf
-5.948 -1.5023 Td
(Design,)Tj
3.3685 0 Td
(setting)Tj
3.052 0 Td
(and)Tj
1.7905 0 Td
(subjects)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(A)Tj
0.9014 0 Td
(clinical,)Tj
3.3051 0 Td
(prospective,)Tj
5.006 0 Td
(and)Tj
1.7348 0 Td
(cross-sectional)Tj
6.1001 0 Td
(study)Tj
2.3924 0 Td
(approved)Tj
3.9685 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(Regional)Tj
3.7304 0 Td
(Ethics)Tj
2.6702 0 Td
(Committee)Tj
-32.4621 -1.2982 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(Principality)Tj
4.8755 0 Td
(of)Tj
1.0148 0 Td
(Asturias)Tj
3.5206 0 Td
(was)Tj
1.7008 0 Td
(conducted.)Tj
4.6545 0 Td
(Written)Tj
3.3902 0 Td
(informed)Tj
3.9741 0 Td
(consents)Tj
3.6907 0 Td
(were)Tj
2.126 0 Td
(obtained)Tj
3.7304 0 Td
(from)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 422.7023 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Free)Tj
2.2464 0 Td
(25-hydr)Tj
3.3237 0 Td
(oxyvitamin)Tj
4.8685 0 Td
(D)Tj
0.9284 0 Td
(in)Tj
0.9779 0 Td
(healthy)Tj
3.3875 0 Td
(childre)Tj
2.8771 0 Td
(n)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02022)Tj
4.089 0 Td
(37)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(23,)Tj
1.5874 0 Td
(2018)Tj
34.0302 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(12)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7418 0 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
-16.7245 -1.3748 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F8 1 Tf
-10.9063 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
BT
10.3394 79.2147 Td
(exist.)Tj
ET
Q
endstream
endobj
65 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 70 0 R/Contents 71 0 R/TrimBox[0 0 612 792]>>
endobj
66 0 obj
<>
endobj
72 0 obj
<>
endobj
73 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Roman def
/FontType 1 def
/FontBBox {-31 -250 1000 750} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Roman) readonly def
/BaseFontName (TeX_CM_Roman) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤.vA2*Sr 2@Y0}S/8W}efFz~"7Mԗ3T3#mAE=90}c:o|y$)|DKf{(!✱դs'Xt{r6\C~-x{jFҘ{@]##')\}7l"ۂ8c.)a0KcyZ$FX(uØ!{uh\[l^d*BֿAJyPOM lJvNab?$h:`/A[ 88hxtXX*UT<NoR^@z
!cef WE(3ZmC:A~Y&w$ř/LGjq6Sπ4E0rrdyrx˫3JLqT|heT[?bqv\6Kw0ֻ#[[#Fo碜m w#ojsnlϴ=9 Żԕ)~\]G˧Ž9#iiՋToI.9[ڔl6l_vtK"JfKPč+:
Α/ (kw}
>qoF6EQO8Ql68ůĊɻ֕GNKEvw*70Uz7+*t8w͌`уg;5unV#/-VPoWHY+H%5̶bGPgsPU
v
"h$9;Ap52@\_A-0@i:0&"MW\45@27wRItgtEa5 ew#oH}TȒ)HEY$@W`rTmŽ^xlIC' U:* 3?RCG
hk~sA9+cUɅ;eoYyv@54oR
UeYPΚmu[*՛4z3vIk9UBřR29kӧf4ی4o0H?ǚ<._VhZu*`h>S
ao҄Ã(Kh',9s&/b$fGX==s2:=x?B<Ӂ:ͪbJ*EgDEg|s8, 1 4f&raBڶ]٠}$*U"*/y"7.VgS+'Q6h"3$\އ7U9چۯj1}21WH;=|{pb=x@OѢ^[ngoDU'suIҢ!+VCAb2BsSm
x\=Q,pt響m!.;jX2_f;_$䦐>{ןŌR"=@M
k9٦LnQkջy{yg+_CJ;DU.2qKf ]cj[6$i/@f ^$JnY:4*itKD"_U5Zay";4\.a`a=Bhlru M:%_8Rx=mo9ިӍj&q&dWf?K
$r\;7oU'c{apDT=Zţ!.% c/=3tg|}AGd`#oe )hZ#Č4vQnTERz*uhc}(<T~?ԀlifF!W_Qo0>Tc?gߝv|K{&h{Qza
x
2)3jd@"wSt@![*SZ4\z;,ܵ
❦u@HpΒRMroҜq{z
(`wN
PcT(Sݣ\.]ƿ}/xb)7!P3hQRwYBІd|ՔF ֺw"m%r8= (Ah&x|Fz&E{fup&rxyzNt[AqR9M9N#C1cc9w\GCUN!RaoB$e W-U7ޓweaBoֳD(c6֧droG2tʈmV):ƣDa)r8>HrVm" cu40q?$-@;o,ZUHL6$ {%c#lV_.MBa6[+U3D?rfgv,m,۠8?4}ݏşcVRy5NRP_\Wz囔Zf}&5}Hf
ڗrm@0|NL}B婭$=;Ӻ֚Dȷ;NXf9&SR85+&W]
(
ţ8q ZITrM|bd
s娶 u" ]'Q+>@2Yƭ_vh\goܡn<g$wn_` _u\J!!.5^ ϓ/q
-s#+GzKcggh҇*FAV4cOcBGcf)=Bh(CX\@"8O{J
vXgn8nڧML'D/)(tD~/wF+Ќ:/+=z
EE0\a47 =c]c9H5vEYu{[7_G7>;12ч%V3iw\i ejS}K 74E.bo(/@Q-}]8TIռqw=5ѤrXO96z 96$oXIHLg_FeBP$f`>(R6q]htif N}HjV*dMv^?;[:4HFAe@5$۬x"mS~_wOn['[]a5N1&/8yiw; Dm֣@2Ur>xHDAɵFO\[D(ki=|[2Bo)ʽɢ=ȐU;,Э(W]lC!\OV5, aeI+u